Melatonin

Success in falling asleep

Change in Total Fat Mass and Total Free Fat Mass (DXA)

Patient Sleep Quality

Delirium

The incidence of postoperative delirium (POD)

the Abnormal Involuntary Movement Scale (AIMS)

Changes in Bone Mineral Density (BMD)

Left ventricle global longitudinal strain

Follicular fluid melatonin concentration

preoperative anxiety

A mean difference of total analgesic (pethidine) consumption.

Postoperative pain

preoperative anxiety

Postoperative pain intensity measured using the VAS (Visual Analogue Scale)

Ramsey sedation scale recorded before starting the MRI exam.Ramsey sedation scale is a 6-point scoring system used to assess a patient's level of arousal and sedation. The scores range from 1 (anxious and agitated) to 6 (unresponsive to pain).

Insomnia Severity Index (ISI)

Time to first analgesic requirement

preoperative anxiety

Intensity of postoperative pain

Epithelialisation

Circadian phase, as measured by the shift of the endogenous melatonin rhythm (measured during each inpatient visit)

Clinically assessment (Modified visual analogue scale)

Number of cycles in six months of therapy

Total sleep time (TST)

The efficacy of oral Melatonin in preventing Postoperative Delirium after general anesthesia

Relative gene expression by real-time PCR (polymerase chain reaction)

Quality of sleep

Assessment of change in the mean arterial pressure measured in mmHg.

-choroidal blood flow -oxygen consumption -Co2 production -skin temperatures -rectal temperatures -blood pressure -eye tension

Circadian Phase Marker, as Measured by the Melatonin Levels in Serial Salivary and/or Plasma Samples.

24h melatonin levels

Circadian Phase Marker, as Measured by the Melatonin Levels in Serial Salivary and/or Plasma Samples.

Change in sleep duration

To compare the effects of melatonin and ketamine on postoperative sleep disturbances.

Total number of patients with the Riker sedation-agitation score ≥5

Mortality at 90 days

preoperative sedation using ramsay sedation scale

The incidence of POD

Change in VAS Anxiety Score Relative to Baseline After Premedication

VAS

a change in CAC score at 6 months measured by coronary CTA

Smoke-induced Vascular Injury and Melatonin's Effect in This Process Assessed by the Concentration of Fbg.

A Mean Difference of Total Analgesic (Pethidine) Consumption.

Melatonin effects on patients under CEA assessed by the concentration of SOD

recurrence of febrile seizures during febrile illness

perioperative anxiety

liver enzymes

insulin resistance in patients under carotid revascularization assessed by the concentration of insulin

morphine consumption at 24 hours after surgery.)

Pittsburgh Sleep Quality Index

Efficacy of Melatonin gel by determine the change on measurements of clinical parameter in chronic periodontitis.

Changes in Clinical Global Impression scale

Sleep Efficiency as measured by total sleep time over time in bed

Body sway

implant stability

- Radiographic evaluation of the changes in the intrabony defect

Inflammatoric markers

The Change From Baseline in Subjective Sleep Latency.

Postoperative delirium incidence

Neurodevelopmental performance at 2 years of life among survivors of early onset FGR.

Acute kidney injury

Delirium

Change in low back pain intensity

Difference in change in average pain intensity during the last 7 days between groups

pregnancy

Organic failure measurement by the Sequential Organ Failure Assessment Score (SOFA)

Change from baseline in mean Total Sleep Time (TST) measured by Sleep Diary

change in insulin sensitivity

Number of patients that develop metastases in Melatonin vs. Control arm, evaluated as relative risk (RR).

Change in functional outcome and mortality

Total sleep time

Oxidative stress

1.Change in PH 2.Serum LDH(U/L)

Improvement of vitality (dimension quality of life) by 15 points (RAND SF 36)

Clinical Response as Measured by RECIST 1.1. Criteria

Blood Pressure Measurement

Pulmonary arterial pressure

Bone density

Progression of diabetic retinopathy, oscillary potential

Change in anxiety level scores as assessed by the data collection sheet given to patients at all three time points (listed below)

Development of delirium, as determined by the Confusion Assessment Method (CAM) criteria

Measuring marginal bone level

Change of delir prevalence

SARS-CoV 2 infection rate

Delirium incidence

Major Depression Inventory (MDI)

Neurosensory Activity

Total number of retrieved mature oocytes

Fatigue as Measured by the Physical Fatigue Scale in the The Multidimensional Fatigue Inventory (MFI) (Smets EM, Garssen B, Bonke B, et al., J Psychosom Res 39:315-325, 1995)

Change from Baseline in pain on Fibromyalgia Impact Questionnaire (FIQ) at week 6

Major Depression Inventory (MDI)- Depression at One Point in the Study

central macular thickness (CMT)

Total number of participants enrolled in each Appendix

Infarct size

Comparison of average daily sleep duration between melatonin and placebo post acute pediatric concussion

Total Ureteral Stent Symptom Questionnaire Score at Postoperative Day 7

The Score on the Clinical Global Impression-Improvement (CGI-I) at Week 6

Number Of Days Prior To Elevation of Platelet Count Among Dengue Fever with Warningn Signs Patient Given Melatonin 20mg.

Incidence of delirium occurrence

Response rate

Acute Kidney Injury according to RIFLE criteria

Pain reduction

Mean Migraine/Migrainous Days in Weeks 5-8 of Randomized Treatment Phase in Melatonin Treated Participants vs. Placebo.

Feasibility: Study adherence

The Success Rate of Treatment Regimens in Achieving Clinical Pregnancy

Postoperative narcotic consumption

improvement in jet lag symptoms

Migraine attack frequency

Fasting plasma glucose (FPG)

MRI of the heart

number of incontinence episodes

Metabolic Syndrome Components

Mean Nighttime Systolic Blood Pressure (SBP)

Change from baseline in weight at week eight

To evaluate the response to melatonin as a sleep-wake rhythm synchronizer on the effects induced by chemotherapy in women with breast cancer.

Number of Migraine/Migrainous Days Per 28 Day Period

Feasibility: Enrollment rate

gingival thickness

Peak Melatonin Level

To determine the most effective dose of melatonin to improve sleep quality in autistic children.

Number of relapses

Blood pressure.

Sleep Disturbances Scale for Children

Change in bother related to nocturia as measured by a standardised validated questionnaire(ICIQ-N)

To Find the Dose of Melatonin Required to Achieve Physiological Blood Levels in the Preterm Infants Similar to That of the Mother.

Total sleep time

Sleep Latency Wakefulness After Sleep Onset (WASO)

sleep

To Estimate Treatment Effect of 12 Weeks of 5 mg/Day Supplementation With Melatonin on UC Remission, and to Use the Estimate of This Effect and Its Variability to Calculate the Sample Size Needed for a Presumably Larger and More Definitive Trial.

compare between the two groups regarding the incidence of developing Delirium among the elderly patients

Number Of Preterm Infants Who Developed Necrotizing Enterocolits After Melatonin 6mg Tablet Prophylaxis

pain will be assessed by verbal pain score (VPS) of 10 (0 = no pain and 10 = worst pain imaginable)

measurement of clinical periodontal parameters

Response type to chemotherapy using Residual Cancer Burden (RCB) index.

Length of hospital stay

Insulin sensitivity

Rates of neurological impairment

Hot flashes log

Concentration-time profile after 2.5, 5, and 10 mg Melatonin niosomes (MN) oral gel single dose administration

Change in Sleep Disturbance as Measured by Epworth Sleep Score (ESS)

IUFD and neonatal death

Change From Baseline for Bond and Lader Visual Analogue Scale (BL-VAS) on Days 1, 4, 7, 10, 14, 15 and 16 - Alertness

Subjective pain perception

To compare propofol consumption among both groups.

Change in level of melatonin (pg/ml) from baseline

Reduction of erythema assessed by digital image analysis (Image J) after treatment with melatonin/placebo before sun exposure.

Number of participants in each dose group with adverse events

EEG Power density in slow wave frequencies during NREM sleep

Circadian variation of hemostatic factors

Maximum tolerated daily dose of melatonin.

Objective Sleep Response of Patients

Pain Relieve

Absolute Plasma Estradiol Levels After 4 Month Course of Melatonin or Placebo

To identify the maximum tolerated dose of Melatonin

Fasting blood sugar (FBS)

Pain score (VAS) at 24 h postoperatively

Bone mineral density

blood pressure monitoring , pre and post treatment with melatonin

Inhaled isoflurane requirement (volume%) to maintain entropy readings 40-60

Urine Melatonin Levels

To determine the effects of selenium on anterior chamber (AC ) malondialdehyde (MDA) and AC glutathione (GSH) levels in patients with Ocular ischemic syndrome

cardiac autonomic function - heart rate variability