Progesterone

All-cause dementia

LIVE BIRTH

Frequency of Preterm Birth (<37 Weeks)

Rate of preterm birth <37 weeks of gestation by any cause

Ongoing pregnancy rate

Serum progesterone level

Menstrual improvement

Time from randomization to delivery

Preterm birth before 34 weeks of gestation

ongoing pregnancy rate

Rate of clinical pregnancy

Percent of Rectal Mucosal Cluster of Differentiation 4 (CD4+) T Cells Expressing C-C Chemokine Receptor Type 5 (CCR5) in Cohort 1

Percentage of Women With Ongoing Pregnancy After a Corifollitropin Alfa COS Cycle in Base Study and ≥1 Live Born Infant During Follow-up (Live Birth Rate)

Preterm birth <34 weeks

Number of Participants With 7-day Point Prevalence Abstinence From Smoking at Week 4

The number of oocytes retrieved per patient

The change in endometrial thickness

Number of Mature (MII) Oocytes Retrieved

Number of the retrieved oocytes

Embryo implantation rate

Clinical pregnancy rate

Weeks Gestation at Birth Among Patients Receiving the Active Drug.

Clinical pregnancy rate

Incidence of ovulation rates

Number of bleeding days

Overactive bladder symptoms

Clinical pregnancy rate

Live Birth Rate

Time from preterm labor pain to delivery

clinical pregnancy rate per cycle

Recruitment feasibility

Number of euploid embryos as compared between the 2 ovarian stimulation cycles

Progesterone dosage 1

Endometrial biopsy

Changes in Brain Activation Patterns in Verbal Tasks Determined With the Functional Magnetic Resonance Imaging (fMRI) Scans

Luteinizing Hormone Pulse Amplitude

Preterm delivery (before completed 37th week of gestation)

Cmax (Maximal Serum Concentration of Medroxyprogesterone Acetate (MPA))

Change in Progesterone Sensitivity Index Before and After Metformin Treatment.

Estradiol

Pregnancy Rate percentage, Implantation Rate percentage, Live Birth Rate percentage

Changes in Prefrontal Cortex Brain Activation at 6 Months

The Time Required for Complete Remission for the First Time

Preterm delivery

Complete remission (CR) rate

To Determine the Impact of GABA-A Receptor Agonists (Benzodiazepines, Allopregnanolone) and Other GABA-modulating Agents (Fluoxetine) on Cortical GABA Levels by Menstrual Cycle Phase as Measured Using 1H-MRS in Healthy Controls.

Relaxin measurement

Total to HDL Cholesterol Ratio

Slope of the Percent Change in Luteinizing Hormone (LH) Pulses as a Function of Day 7 Progesterone Level

Incidence of Preeclampsia

Ongoing pregnancy beyond the 20th gestational week rate

Number of participants with live birth

implantation rate

Clinical pregnancy rate

Serum estradiol

clinical pregnancy rate

clinical pregnancy rate

Proportion of spontaneous preterm birth before 34 weeks of gestation

Preterm delivery <34 weeks

Percentage of Participants With Ongoing Pregnancy at Week 8

Regression of hyperplasia related to treatment arm after 6 months of therapy

Percentage of efficacy

ongoing pregnancy rate

Adequate Adherence to Study Product

Ongoing pregnancy rate

Serum Progesterone (P4) Level in the Morning of the Day of Human Chorionic Gonadotrophin (hCG) Administration

Ongoing Pregnancy Rate

Patients' satisfaction with the treatment

Changes in Striatal Activation Between Groups during the MID task

Preterm labor

Levels of progesterone in the mid-luteal phase.

Change in lumbar spine bone mineral density assessed by dual-energy x-ray absorptiometry (DXA)

Preparation and treatment for Assisted Human Reproduction procedures and in the case opf pregnancy, follow up.

Cyclical Change in Suicidal Ideation (SI) Severity

Composite measure of study feasibility

Cessation of Bleeding Within 5 Days

latency period

Ongoing pregnancy rate per cycle

Change in 24 hour ambulatory blood pressure

pregnancy occurrence, pregnancy loss

Mean IDAS Ill Temper Scale Score Over Time

endometrial receptivity gene expression profile

Gestational age at birth

Perimenstrual Change in Self-Injurious Thoughts and Behaviors Interview (SITBI) Suicidal Ideation Score

Serotonin-1A receptor binding potential

Molecular endometrial level using illumina RNA-seq

Time (in Days) That a Patient Reports Symptoms From Their Concussion.

Clinical pregnancy rate of micronized vaginal progesterone (Endometrin, Ferring Pharmaceuticals) compared to intramuscular progesterone supplementation for luteal phase support after IVF-ET from previously vitrified donor eggs

Mean change in resting energy expenditure

Myocardial Infarction

Live birth

Favorable Outcome as Determined by the Glasgow Outcome Scale-Extended (GOSE)

Ongoing pregnancy rate

efficacy

Disease-free survival

Ongoing Pregnancy Rate

Delivery prior to 35 weeks 0 days gestation

live birth rate

Live birth, defined as the presence of a live birth after 22 weeks' gestation. Twin pregnancies will be counted as a single birth.

Recurrence free survival (RFS)

Mammographic breast density

Number of Participants With Birth <=32 6/7 Weeks Gestation.

Overall survival

Overall survival

Cumulative Rate of Spontaneous Abortions Occurring on or Before 12 Weeks Post-oocyte Retrieval

Live birth

live birth rate

Endometrial pathologic diagnosis

mean minimal coronary-artery diameter

Percent of Women Who Show a Greater Than 50% Decline in Average Daily Seizure Frequency

The total number of oocytes obtained during the start-up period

Spontaneous delivery before 34 completed weeks (238 days) of gestation.

Rate of evolutionary gestation in each cycle

preterm delivery before 34 and 37 weeks

Compare the efficacy of the three regimens

Live birth rate

Height Standard Deviation Score (SDS) (National Center for Health Statistics [NCHS]), Change From Baseline to Last Measurement, As Randomized Population

Ongoing clinical pregnancy rate

Spontaneous preterm birth

the Number of M2 Oocytes Retrieved

Frequency of moderate to severe vasomotor symptoms at 12 weeks

Rate of Recurrent Preterm Birth

• The proportion of subjects at Cycle 3 Day 24 ± 1 day on active treatment compared to placebo with complete secretory activity on endometrial biopsy.

Ongoing pregnancy rate at 12 weeks of gestation

preterm birth before 34 weeks of gestation rate in singleton pregnancies

Newborn Respiratory Distress Syndrome (RDS)

Pathologic Response

Complete response rate

Cocaine Abstinence Based on Urine Toxicology Results

Reduction in Delivery Rate Prior to 37 Weeks Gestation

Embryo implantation rate

Miscarriage

Clinical Pregnancy

Percent Change From Baseline in Bone Mineral Density of the Spine at Week 24

The frequency of spontaneous abortion before 28 weeks

Evaluate the ongoing pregnancy rate

Cannabis Craving

Tissue response to progestin therapy

Progression-free survival (PFS)

Vasomotor symptoms prospectively recorded in the final month of therapy by therapy assignment, with pre-therapy baseline vasomotor symptoms as a covariate.

Motor Scale of the Bayley Scales of Infant and Toddler Development-III

Change in STAI-6 Score

Pathological cumulative complete response rate;

endometrial thickness change towards baseline (mm)

Change in glandular cellularity

Edinburgh Postnatal Depression Scale (EPDS) Mean Total Score

Success Rate of Treatment Regimens in Preventing Preterm Birth and/or Improving Pregnancy Duration

ovulation inhibition

Clinical Benefit Rate (CR + PR + SD > 6 Months).

Mean Threat Processing Bias During Visual Dot-probe Paradigm Over Time

Correlation Coefficient Between FFNP Uptake and Allred Score

Behavioral

neurological outcome

Primary endpoint: progesterone level in endometrium and in serum

The primary biological end points in this trial will be suppression of spermatogenesis and gonadotropins while monitoring for any adverse changes in lipid metabolism, sexual side effects or in general health

Continuing Pregnancy Based on Ultrasound Examination

Implantation rate

To assess number of women at high risk of Preterm Labour (PTL) withdraw from the combination therapy of Progesterone (P4) and aminophylline due to side effects, in comparison to P4 alone.

Cmax

Smoking topography; measured by carbon monoxide levels and self-report at Day 4

Systemic pharmacokinetics of progesterone, Concentration over 24 hours

HPA responses to stress

baseline-adjusted AUCt

Endometrial dating through histopathologic criteria.

Logarithm of the ratio of the normalized growth hormone secretion rate over the first 10 hr.

LH pulse frequency (number of LH pulses per hour)

Change in Number of LH Pulses Per Hour

Pharmacokinetic model

Number of participants suffering neuronal infarction

Pathologic complete remission rate of endometrial curettage tissues

Mean Post-treatment Tumor Progesterone Receptor H-score (Histology Score)

endometrial receptivity measured by pathology

Change in mean FSH concentration with progesterone administration

Endometrial Gene Expression Profile