Blutwerte · Marker

8-OHdG

8-Hydroxy-2-deoxyguanosine · Oxidative DNA Damage Marker

Longevity & Biohacking

Einheit:: nM/μg/μl

8-OHdG quantifies oxidative DNA damage, specifically the modification of guanine bases in DNA due to oxidative stress.

Reference Ranges

Reference

0.5–5nM/μg/μl

0.5

LowNormalHigh

Reference

Unit · nM/μg/μl

Reference ranges may vary based on the method of measurement and biological specimen (e.g., blood, urine).

Overview

Übersicht

8-Hydroxy-2-deoxyguanosine (8-OHdG) is a biomarker that measures oxidative DNA damage, specifically reflecting the oxidative modification of guanine bases in DNA. It is a product of DNA repair processes and serves as an indicator of oxidative stress at the cellular level. Clinically, elevated levels of 8-OHdG are associated with various conditions, including cancer, cardiovascular diseases, and neurodegenerative disorders, as they reflect increased oxidative stress and potential DNA damage. In the context of longevity and biohacking, 8-OHdG is of interest because it provides insights into the oxidative stress burden on the body, which is a factor in aging and age-related diseases. Monitoring this biomarker can help individuals optimize their antioxidant defenses and mitigate oxidative damage, potentially contributing to improved healthspan and lifespan. However, the interpretation of 8-OHdG levels can be complicated by factors such as smoking, environmental exposures, and methodological differences in measurement. Additionally, variations in levels can occur due to inter-individual differences and confounding factors, making it essential to consider these aspects when assessing 8-OHdG as a biomarker.

Klinische Bedeutung
Elevated 8-OHdG levels indicate increased oxidative stress and potential DNA damage, which are associated with cancer, cardiovascular diseases, and neurodegenerative disorders. Lower levels suggest reduced oxidative stress and DNA damage.

Dynamics

Trend Interpretation

Rising Values

Progressively rising values suggest increasing oxidative stress, warranting lifestyle and dietary modifications. Retest in 3-6 months.

Falling Values

Progressively falling values indicate reduced oxidative stress and improved antioxidant status.

Re-test Interval

6 months if outside optimal range

Etiology

Causes — High & Low

Cause

Elevated Levels

Smoking
Environmental pollutants
Chronic inflammation
High oxidative stress
Exposure to radiation

Cause

Low Levels

Effective antioxidant defenses
Low oxidative stress
Minimal environmental exposure
Healthy lifestyle
Balanced diet

Protocol

How to Optimize

Lever

Lifestyle

Regular physical activity
Stress management techniques
Adequate sleep
Avoiding smoking

Lever

Nutrition

Diet rich in antioxidants
Increased intake of fruits and vegetables
Consumption of green tea
Inclusion of nuts and seeds

Lever

Supplementation

Vitamin C
Vitamin E
Coenzyme Q10
Alpha-lipoic acid

Note:

Consult a healthcare provider before starting any supplementation, especially if you have underlying health conditions.

Testing Guidelines

✓Fasting Not Required

✓Not Time-Sensitive

Collect samples at the same time of day for consistency due to potential diurnal variations.

Testing Frequency

Annually for general health monitoring, more frequently if managing specific conditions.

Interfering Factors

Recent intense exercise
Dietary antioxidants
Medication use

Open Research Questions

Current research suggests that there is a lack of consensus on reference ranges and the impact of confounders, such as smoking and measurement methods, on 8-OHdG levels. Emerging research directions include exploring its role in various conditions like heart failure and depression, as well as its relationship with environmental exposures. However, researchers have not yet established optimal targets for 8-OHdG in clinical practice, leaving questions about its utility in disease monitoring and prognosis unanswered.

52 Research Publications

3,967

Total Citations

Human/RCT

6.5

Avg. Influence

2024

Latest

Sort

Filter

01Top

#01

8-hydroxy-2' -deoxyguanosine (8-OHdG): A critical biomarker of oxidative stress and carcinogenesis.

Valavanidis Athanasios, et al. · Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews · 2009

ReviewInfluence56.0

1956

This study highlighted 8-OHdG as a critical biomarker for oxidative stress and carcinogenesis, emphasizing its role in assessing DNA damage related to cancer risk. Researchers noted that 8-OHdG is widely used in studies evaluating oxidative DNA damage.

Key findings

018-OHdG is a key biomarker used to assess oxidative damage to DNA.
02Urinary levels of 8-OHdG can help evaluate cancer risk and other diseases.
03The European Standards Committee for Oxidative DNA Damage was established to improve measurement techniques for this biomarker.

View on PubMed

02Top

#02

Is depression associated with increased oxidative stress? A systematic review and meta-analysis.

Meta-AnalysisInfluence19.0

675

This meta-analysis quantified the association between depression and oxidative stress markers, including 8-OHdG. Researchers found that 8-OHdG levels were significantly increased in individuals with depression, indicating a link between oxidative stress and depressive symptoms.

View on PubMed

03Top

#03

8-Hydroxy-2'-deoxyguanosine as a marker of oxidative DNA damage related to occupational and environmental exposures.

Pilger A & Rüdiger H W · International archives of occupational and environmental health · 2006

ReviewInfluence14.0

337

This study investigated the role of 8-OHdG as a biomarker of oxidative DNA damage related to occupational and environmental exposures. Researchers found that while 8-OHdG is a promising marker for oxidative stress, inconsistencies in study results highlight the need for further research.

Key findings

01Researchers observed that 8-OHdG can indicate oxidative stress related to chemical exposure.
02The effects of different workplace exposures on 8-OHdG levels showed inconsistent results.
03Smoking was identified as a confounding factor, but studies did not consistently show higher 8-OHdG levels in smokers.

View on PubMed

#04

8-Hydroxy-2'-deoxyguanosine (8-OHdG) as a biomarker of oxidative DNA damage induced by occupational exposure to nanomaterials: a systematic review.

Omari Shekaftik Soqrat & Nasirzadeh Nafiseh · Nanotoxicology · 2021

ReviewInfluence1.0

123

This systematic review assessed the use of 8-hydroxy-2'-deoxyguanosine (8-OHdG) as a biomarker for oxidative DNA damage from occupational exposure to nanomaterials. Researchers found a significant relationship between job exposure and 8-OHdG levels, suggesting it could serve as a useful biomarker for assessing oxidative damage in workers.

Key findings

01Researchers observed that higher levels of 8-OHdG are associated with occupational exposure to nanomaterials.
02The study highlighted a consistent pattern of oxidative DNA damage linked to various types of nanomaterials.
03Findings suggest that monitoring 8-OHdG could be important for assessing the health risks of nanomaterial exposure.

View on PubMed

#05

Novel Biomarkers of Heart Failure.

ReviewInfluence4.0

114

This review examined various biomarkers related to heart failure (HF) and highlighted the role of 8-hydroxy-2'-deoxyguanosine (8-OHdG) as a marker of oxidative stress in HF. Researchers found that the clinical value of individual biomarkers is limited, suggesting a multimarker panel approach for better diagnosis and outcome prediction in HF.

View on PubMed

#06

Preheparin serum lipoprotein lipase mass might be a biomarker of metabolic syndrome.

HumanInfluence4.0

Researchers observed a negative correlation between preheparin lipoprotein lipase mass and urinary 8-OHdG levels in a study on metabolic syndrome. This suggests that lower lipoprotein lipase mass may reflect systemic oxidative stress related to metabolic syndrome severity.

View on PubMed

#07

Prognostic significance of 8-hydroxy-2'-deoxyguanosine in solid tumors: a meta-analysis.

Meta-AnalysisInfluence1.0

This meta-analysis assessed the prognostic significance of 8-OHdG in solid tumors. Researchers found that elevated 8-OHdG levels were significantly associated with poor overall survival in cancer patients, suggesting its potential as a prognostic biomarker.

View on PubMed

#08

Analytics of oxidative stress markers in the early diagnosis of oxygen DNA damage.

ReviewInfluence5.0

Researchers discussed various methods for measuring 8-OHdG as a biomarker of oxidative DNA damage. The study emphasizes the importance of understanding the expression of 8-OHdG in different biological materials for early diagnosis of oxidative stress-related conditions.

View on PubMed

#09

Salivary biomarkers of inflammation and oxidative stress in healthy adults.

HumanInfluence2.0

Researchers investigated the reliability of saliva as a diagnostic medium for inflammatory and oxidative stress biomarkers, including 8-OHdG. The study found that while correlations between saliva and blood biomarkers were variable, 8-OHdG levels were measurable in saliva.

View on PubMed

#10

Using 8-Hydroxy-2'-Deoxiguanosine (8-OHdG) as a Reliable Biomarker for Assessing Periodontal Disease Associated with Diabetes.

Goriuc Ancuta, et al. · International journal of molecular sciences · 2024

ResearchInfluence2.0

This study observed that 8-OHdG levels increase in conditions like diabetes and periodontal disease, suggesting its role as a biomarker for oxidative DNA damage. Researchers emphasized the importance of 8-OHdG in understanding the link between oxidative stress and chronic inflammatory conditions.

Key findings

01Researchers observed that oxidative stress contributes to inflammation in both diabetes and periodontal disease.
02They identified 8-OHdG as a reliable biomarker for measuring oxidative DNA damage in these conditions.
03The study emphasizes the need for further research to improve diagnosis and treatment strategies for chronic periodontitis.

NCT06937775COMPLETED

Sponsor

Recep Tayyip Erdogan University Training and Research Hospital

Enrollment

Started

2016

Primary outcome

Biochemical analyses - 8-OHdG

Maxillary Expansion

Using Behavioral Economics to Achieve Improved Healthy Behavior Outcomes in Breast Cancer Survivors

NCT02938780COMPLETED

Sponsor

Texas Tech University Health Sciences Center

Enrollment

310

Started

2015

Primary outcome

Urinary levels of 8-OHdG

Breast Cancer Female

The Effects of Obesity on 8-Hydroxy-Deoxyguanosine Levels in Patients With and Without Periodontal Disease

NCT02316093COMPLETED

Sponsor

Bulent Ecevit University

Enrollment

Started

2013

Primary outcome

plasma, saliva and GCF levels of 8-OHdG

Obesity

Publication Trend

Research publications about 8-OHdG over time

9total

'09

'17

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'22

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