Lever
Lifestyle
- Reduce exposure to environmental toxins
- Engage in regular physical activity
- Manage stress effectively
Blutwerte · Marker
8-OHdG
8-Hydroxy-2-deoxyguanosine · Oxidative DNA Damage Marker
Longevity & Biohacking
- Einheit:
- ng/mL
8-OHdG quantifies the oxidative damage to DNA caused by reactive oxygen species.
Reference Ranges
Reference
0.5–5ng/mL
0.5
5
LowNormalHigh
Reference
Unit · ng/mLReference ranges may vary based on sex, age, and specific laboratory methods.
Overview
Übersicht
8-Hydroxy-2-deoxyguanosine (8-OHdG) is a biomarker that quantifies oxidative damage to DNA, specifically measuring the lesions caused by reactive oxygen species (ROS) in nuclear and mitochondrial DNA. It is a predominant form of oxidative DNA damage, often used to assess the extent of oxidative stress in biological systems. Researchers have found that 8-OHdG is a critical indicator of oxidative stress and is implicated in the pathogenesis of various diseases, including cancer and degenerative disorders. Clinically, elevated levels of 8-OHdG are associated with increased risk of carcinogenesis and have been used to evaluate DNA damage in individuals exposed to carcinogenic agents such as tobacco smoke and ionizing radiation. In the context of longevity and biohacking, 8-OHdG is relevant as it reflects the body's oxidative stress burden, which is a key factor in aging and age-related diseases. Biohackers and athletes might monitor 8-OHdG levels to optimize antioxidant defenses and potentially enhance longevity. However, several caveats exist, including variability due to external factors like occupational exposure to nanomaterials and medical ionizing radiation. Additionally, the measurement of 8-OHdG can be influenced by methodological issues, such as artifactual oxidation during sample processing. Researchers recommend using multiple biomarkers alongside 8-OHdG for a comprehensive assessment of oxidative stress.
Klinische Bedeutung
Elevated 8-OHdG levels indicate increased oxidative stress and are associated with higher risks of cancer and degenerative diseases. It serves as a marker for DNA damage due to exposure to carcinogens.
Dynamics
Trend Interpretation
Rising Values
Progressively rising 8-OHdG values suggest increasing oxidative stress, warranting lifestyle and dietary interventions. Re-test in 3-6 months.
Falling Values
Falling values indicate reduced oxidative stress, potentially reflecting improved antioxidant defenses.
Re-test Interval
3-6 months if outside optimal range
Etiology
Causes — High & Low
Cause
Elevated Levels
- Exposure to ionizing radiation
- Smoking
- Occupational exposure to nanomaterials
- High oxidative stress
- Chronic inflammation
Cause
Low Levels
- Effective antioxidant defense
- Low oxidative stress
- Minimal exposure to environmental toxins
- Healthy lifestyle
- Optimal DNA repair mechanisms
Protocol
How to Optimize
Lever
Nutrition
- Consume a diet rich in antioxidants
- Increase intake of fruits and vegetables
- Limit processed foods
Lever
Supplementation
- Vitamin C
- Vitamin E
- Coenzyme Q10
Note:
Consult a healthcare provider before starting any new supplementation, especially if you have underlying health conditions.
Testing Guidelines
✓Fasting Not Required
✓Not Time-Sensitive
Levels may vary throughout the day; consistent timing is recommended for repeat tests.
Testing Frequency
Annually for general health monitoring; more frequently if exposed to high oxidative stress environments.
Interfering Factors
- Recent intense exercise
- Dietary antioxidant intake
- Environmental pollutant exposure
Open Research Questions
Current research suggests that the optimal reference ranges for 8-OHdG levels and the influence of confounders, such as age and lifestyle factors, on its measurement remain debated. Researchers have not yet established standardized protocols for quantifying 8-OHdG across different biological samples, which complicates its clinical application. Additionally, unanswered clinical questions include the precise role of 8-OHdG in cancer prognosis across various tumor types and its potential as a therapeutic target in oxidative stress-related diseases.
31 Research Publications
2,864
Total Citations
10
Human/RCT
7.1
Avg. Influence
2024
Latest
Sort
Filter
01Top
#01
8-hydroxy-2' -deoxyguanosine (8-OHdG): A critical biomarker of oxidative stress and carcinogenesis.
Valavanidis Athanasios, et al. · Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews · 2009
ReviewInfluence53.0
1922
This study highlighted 8-OHdG as a critical biomarker for oxidative stress and cancer risk. Researchers found that elevated urinary levels of 8-OHdG are associated with increased risk for various cancers and degenerative diseases. The study emphasizes the importance of standardizing measurement techniques to improve the reliability of 8-OHdG as a biomarker.
Key findings
- 018-OHdG is a key biomarker used to assess oxidative damage to DNA.
- 02Urinary levels of 8-OHdG can help evaluate cancer risk and other diseases.
- 03The European Standards Committee for Oxidative DNA Damage was established to improve measurement techniques for this biomarker.
02Top
#02
8-Hydroxy-2'-deoxyguanosine as a marker of oxidative DNA damage related to occupational and environmental exposures.
Pilger A & Rüdiger H W · International archives of occupational and environmental health · 2006
ReviewInfluence14.0
335
This study reviewed the role of 8-OHdG as a biomarker for oxidative DNA damage related to occupational and environmental exposures. Researchers noted that while 8-OHdG is a promising biomarker, there is still a lack of established dose-response relationships between exposures and 8-OHdG levels, highlighting the need for further research.
Key findings
- 01Researchers observed that 8-OHdG can indicate oxidative stress related to chemical exposure.
- 02The effects of different workplace exposures on 8-OHdG levels showed inconsistent results.
- 03Smoking was identified as a confounding factor, but studies did not consistently show higher 8-OHdG levels in smokers.
03Top
#03
8-Hydroxy-2'-deoxyguanosine (8-OHdG) as a biomarker of oxidative DNA damage induced by occupational exposure to nanomaterials: a systematic review.
Omari Shekaftik Soqrat & Nasirzadeh Nafiseh · Nanotoxicology · 2021
ReviewInfluence1.0
121
This systematic review examined the relationship between occupational exposure to nanomaterials and oxidative DNA damage, specifically using the biomarker 8-OHdG. Researchers found a significant correlation between job title, nanomaterial exposure, and 8-OHdG levels, indicating potential oxidative damage in workers. The study suggests that while blood and exhaled breath condensate levels of 8-OHdG can be useful, urinary levels should be interpreted with caution.
Key findings
- 01Researchers observed that higher levels of 8-OHdG are associated with occupational exposure to nanomaterials.
- 02The study highlighted a consistent pattern of oxidative DNA damage linked to various types of nanomaterials.
- 03Findings suggest that monitoring 8-OHdG could be important for assessing the health risks of nanomaterial exposure.
04
#04
Novel Biomarkers of Heart Failure.
ReviewInfluence4.0
113
This review identified 8-OHdG as a biomarker associated with oxidative stress in heart failure. Researchers noted that while 8-OHdG is part of a broader panel of biomarkers, its clinical value is limited when considered alone, suggesting a multimarker approach may be more effective.
05
#05
Prognostic significance of 8-hydroxy-2'-deoxyguanosine in solid tumors: a meta-analysis.
Meta-AnalysisInfluence1.0
78
This meta-analysis assessed the prognostic significance of 8-OHdG in solid tumors. Researchers found that higher levels of 8-OHdG are significantly associated with poorer overall survival in cancer patients. The study suggests that 8-OHdG could serve as an independent prognostic marker across various cancer types.
06
#06
Analytics of oxidative stress markers in the early diagnosis of oxygen DNA damage.
ReviewInfluence5.0
62
Researchers discussed various methods for measuring 8-OHdG as a biomarker of oxidative DNA damage. The study emphasizes the importance of understanding the expression of 8-OHdG in different biological materials for early diagnosis of oxidative stress-related conditions.
07
#07
Using 8-Hydroxy-2'-Deoxiguanosine (8-OHdG) as a Reliable Biomarker for Assessing Periodontal Disease Associated with Diabetes.
Goriuc Ancuta, et al. · International journal of molecular sciences · 2024
UnknownInfluence1.0
43
Researchers explored the role of 8-OHdG as a biomarker for oxidative DNA damage in periodontal disease related to diabetes. The study indicated that elevated 8-OHdG levels could reflect oxidative stress in chronic inflammatory conditions, highlighting its relevance in dental research.
Key findings
- 01Researchers observed that oxidative stress contributes to inflammation in both diabetes and periodontal disease.
- 02They identified 8-OHdG as a reliable biomarker for measuring oxidative DNA damage in these conditions.
- 03The study emphasizes the need for further research to improve diagnosis and treatment strategies for chronic periodontitis.
08
#08
Methodological considerations and factors affecting 8-hydroxy-2-deoxyguanosine analysis.
ReviewInfluence1.0
34
This paper discussed methodological considerations affecting the analysis of 8-OHdG as a biomarker for oxidative stress. Researchers highlighted various factors that can lead to inaccurate measurements, emphasizing the need for careful handling and analysis to ensure reliable results.
09
#09
8-Hydroxy-2-Deoxyguanosine as Oxidative DNA Damage Biomarker of Medical Ionizing Radiation: A Scoping Review.
ReviewInfluence2.0
33
This scoping review investigated the use of 8-OHdG as a biomarker for oxidative DNA damage due to medical ionizing radiation. Researchers found mixed results regarding the relationship between radiation dose and 8-OHdG levels, indicating that while 8-OHdG can be a promising biomarker, external factors may influence its levels.
10
#10
Electronic waste exposure and DNA damage: a systematic review and meta-analysis.
Systematic Review
24
This systematic review found that exposure to electronic waste is associated with increased DNA damage, including elevated levels of 8-OHdG. The study highlighted the need for further research in diverse populations to confirm these findings.
Clinical Trials (2)
2
Total Trials
1,336
Total Enrolled
ESTxENDS Trial-Substudy on Oxidative Stress Induced by Electronic Nicotine Delivery Systems (ENDS) Measured in Urine
NCT03612375COMPLETED
Sponsor
University of Bern
Enrollment
1,246
Started
2018
Primary outcome
Urinary 8-OHdG concentrations to asses oxidative stress_1
Smoking CessationOxidative Stress
The Effects of Obesity on 8-Hydroxy-Deoxyguanosine Levels in Patients With and Without Periodontal Disease
NCT02316093COMPLETED
Sponsor
Bulent Ecevit University
Enrollment
90
Started
2013
Primary outcome
plasma, saliva and GCF levels of 8-OHdG
Obesity
Publication Trend
Research publications about 8-OHdG over time
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