Lever
Lifestyle
- Regular physical exercise
- Adequate hydration
- Stress management
Blutwerte · Marker
Albumin
Serum Albumin · ALB
Leberwerte
- Einheit:
- g/dL
- Abbreviation
- ALB
Albumin test quantifies the concentration of serum albumin, a protein synthesized by the liver, in the blood.
Reference Ranges
Reference
3.5–5g/dL
3.5
4
4.5
5
LowNormalHigh
Reference
Optimal
Unit · g/dLReference ranges may vary slightly by laboratory; generally consistent across age and sex.
Overview
Übersicht
Albumin, abbreviated as ALB, is a major protein found in the blood plasma, primarily synthesized by the liver. It plays a crucial role in maintaining oncotic pressure and serves as a carrier for various endogenous and exogenous substances, including hormones, fatty acids, and drugs. Researchers have found that albumin levels are indicative of the body's nutritional status and liver function. Clinically, hypoalbuminemia, or low serum albumin levels, is often associated with inflammation, liver disease, and malnutrition. It reflects an inflammatory state and is linked to poor outcomes in conditions like surgery or chemotherapy, reduced quality of life, and decreased longevity. For athletes and biohackers, maintaining optimal albumin levels is important as it contributes to the body's antioxidative capacity and overall protein status, which can affect recovery and performance. However, albumin levels can be influenced by various factors, including hydration status, acute illness, and protein intake. Researchers observed that time-of-day variations and fasting states do not significantly impact albumin levels, making it a stable marker for clinical evaluation.
Klinische Bedeutung
Elevated albumin levels are rare and usually not clinically significant, but may indicate dehydration. Reduced albumin levels, or hypoalbuminemia, suggest liver dysfunction, inflammation, or malnutrition and are associated with poor clinical outcomes.
Dynamics
Trend Interpretation
Rising Values
Progressively rising albumin levels may suggest dehydration or an acute stress response. Re-test if clinically indicated.
Falling Values
Progressively falling albumin levels suggest worsening liver function, malnutrition, or increased inflammation.
Re-test Interval
4 weeks if outside optimal range
Etiology
Causes — High & Low
Cause
Elevated Levels
- Dehydration
- High protein diet
- Anabolic steroid use
- Acute stress response
Cause
Low Levels
- Liver disease
- Chronic inflammation
- Malnutrition
- Nephrotic syndrome
- Heart failure
Protocol
How to Optimize
Lever
Nutrition
- High-protein diet
- Balanced nutrient intake
- Adequate caloric consumption
Lever
Supplementation
- Whey protein
- Branched-chain amino acids
- Omega-3 supplements
Note:
Consult a healthcare provider for personalized advice, especially in the presence of underlying health conditions.
Testing Guidelines
✓Fasting Not Required
✓Not Time-Sensitive
Albumin levels can vary slightly throughout the day; consistency in testing time is recommended.
Testing Frequency
Annually for routine health check-ups, more frequently if monitoring liver function or nutritional status.
Interfering Factors
- Severe dehydration
- Acute illness
- Recent surgery
Open Research Questions
Current research suggests that the pathogenesis and clinical significance of hypoalbuminemia remain debated, particularly regarding reference ranges and the impact of inflammation on albumin levels. Researchers have not yet established optimal targets for albumin infusion in inflammatory states or clarified the confounding effects of aging and comorbidities on serum albumin levels. Additionally, unanswered clinical questions include the effectiveness of albumin as a biomarker for glycemic control and its role in drug binding alterations due to modifications.
51 Research Publications
2,502
Total Citations
30
Human/RCT
4.9
Avg. Influence
2025
Latest
Sort
Filter
01Top
#01
Hypoalbuminemia: Pathogenesis and Clinical Significance.
ReviewInfluence45.0
1356
Researchers found that hypoalbuminemia is linked to inflammation and reflects the body's inflammatory state. They observed that managing hypoalbuminemia should focus on addressing underlying inflammation rather than albumin infusion. Additionally, they noted that serum albumin levels can indicate clinical improvement or deterioration.
02Top
#02
Review: Glycation of human serum albumin.
ReviewInfluence12.0
361
This study examined the glycation of human serum albumin (HSA) and its implications for diabetes management. Researchers found that glycated HSA can serve as a marker for glycemic control. They also discussed the structural changes and potential effects of glycation on HSA's binding properties.
03Top
#03
Serum Albumin Levels: A Biomarker to Be Repurposed in Different Disease Settings in Clinical Practice.
ReviewInfluence4.0
161
Researchers reviewed the prognostic significance of serum albumin levels across various diseases, finding that low levels are associated with poor outcomes in conditions like cardiovascular disease and COVID-19. The study emphasizes albumin's role as a valuable clinical biomarker.
04
#04
Serum Albumin Redox States: More Than Oxidative Stress Biomarker.
ReviewInfluence7.0
112
Researchers found that the redox state of serum albumin can indicate systemic oxidative stress and may also reflect protein nutrition status. This study highlighted the importance of albumin's redox state in various diseases, suggesting a shift in understanding its role in health.
05
#05
Increased levels of aflatoxin-albumin adducts are associated with CYP3A5 polymorphisms in The Gambia, West Africa.
HumanInfluence2.0
68
06
#06
Glycated albumin: from biochemistry and laboratory medicine to clinical practice.
ReviewInfluence3.0
55
This review summarized the implications of glycated albumin as a biomarker for diabetes management. Researchers found that high levels of glycated albumin are associated with long-term complications of diabetes, emphasizing its utility in clinical practice.
07
#07
Serum albumin, inflammation, and nutrition in end-stage renal disease: C-reactive protein is needed for optimal assessment.
HumanInfluence1.0
53
This study found that low serum albumin levels in end-stage renal disease patients are linked to increased mortality risk, particularly in the presence of systemic inflammation. Researchers concluded that serum albumin should not be used alone to assess nutritional status in these patients.
08
#08
Pre-treatment serum albumin and mutational burden as biomarkers of response to immune checkpoint blockade.
UnknownInfluence2.0
41
09
#09
Pilot survey of aflatoxin-albumin adducts in sera from Egypt.
HumanInfluence2.0
38
This pilot survey measured aflatoxin-albumin adducts in serum samples from Egypt to assess exposure to aflatoxins. Researchers found detectable levels of these adducts in both HCC-negative and HCC-positive individuals, suggesting potential health risks from dietary aflatoxin exposure. The findings highlight the need for further investigation.
10
#10
Prognostic Significance of Serum Albumin Level and Albumin-Based Mono- and Combination Biomarkers in Patients with Hepatocellular Carcinoma.
ReviewInfluence1.0
37
Researchers reviewed the prognostic significance of serum albumin levels in patients with hepatocellular carcinoma (HCC). They found that low serum albumin levels are significant independent biomarkers for poor prognosis in HCC patients. The study emphasized the need for reliable biomarkers to improve treatment outcomes for these patients.
Clinical Trials (17)
17
Total Trials
1,490
Total Enrolled
Effects of Recombinant Human Growth Hormone in Elderly Patients With Moderate to Severe Acute Brain Injury (GH-ABI-RCT)
Sponsor
Anhui Provincial Hospital
Enrollment
160
Started
2026
Primary outcome
Change in Plasma Albumin Level from Baseline to Week 2
Acute Brain InjuriesModerate to Severe Traumatic Brain Injury
Non-Surgical Periodontal Therapy and Cardiac Biomarkers in Stable Angina
NCT07412795NOT_YET_RECRUITING
Sponsor
Ondokuz Mayıs University
Enrollment
60
Started
2026
Primary outcome
Change in serum ischemia-modified albumin (IMA) concentration after non-surgical periodontal therapy
Stable AnginaPeriodontitis
Predictive Value of the Uric Acid/Albumin Ratio and Lactate in Sepsis Patients
NCT07332715NOT_YET_RECRUITING
Sponsor
Istinye University
Enrollment
80
Started
2026
Primary outcome
Development of Acute Kidney Injury (AKI)
Sepsis-Related MortalityAcute Kidney Injury
The Relation of Albumin/Globulin Ratio and Platelet/Albumin Ratio to Lupus Nephritis
NCT07130448NOT_YET_RECRUITING
Sponsor
Assiut University
Enrollment
120
Started
2025
Primary outcome
Association of Albumin/Globulin (A/G) and Platelet/ Albumin (P/A) ratios with the presence of lupus nephritis
Lupus Nephritis (LN)SLE - Systemic Lupus ErythematosusBiomarkers
Effects of Neutrophil/Lymphocyte, Platelet/Lymphocyte, CRP/Albumin and Lactate on Mortality in Trauma Patients Admitted to Intensive Care
NCT06667310COMPLETED
Sponsor
Harran University
Enrollment
150
Started
2024
Primary outcome
Primary outcome
Intensive Care
Systemic Inflammation Response Index and C-Reactive Protein to Albumin Ratio in Acute Lymphoblastic Leukemia
NCT06674850NOT_YET_RECRUITING
Sponsor
Assiut University
Enrollment
36
Started
2024
Primary outcome
Assessment of C-reactive protein to Albumin ratio(CAR) as a biomarker for acute lymphoblastic leukemia prognosis
Acute Lymphoblastic Leukemia
CRP/Albumin Ratio as a Predictive Inflammatory Marker for Postoperative SIRS and/or Sepsis
NCT06050759COMPLETED
Sponsor
Ain Shams University
Enrollment
100
Started
2023
Primary outcome
Evaluate the relation of CRP/ albumin ratio to the prediction of postoperative SIRS or sepsis in polytrauma patients.
Crp
Can Albumin/C-reactive Protein Ratio be Utilized for Predicting Gestational Diabetes Diagnosis or the Adverse Outcomes
NCT06761053COMPLETED
Sponsor
ALI BAHADIRLI
Enrollment
146
Started
2021
Primary outcome
Comparison of Albumin to High-Sensitivity C-Reactive Protein (hsCRP) Ratio Between GDM and Control Groups
Gestational Diabetes Mellitus in Pregnancy
Effects of SGLT2 Inhibition Treatment on Different Levels of Albuminuria in Patients With Type 2 Diabetes
Sponsor
Zhongshan Hospital Xiamen University
Enrollment
70
Started
2019
Primary outcome
Change in urinary albuminuria
Type 2 DiabetesDiabetic Nephropathy
Phase 2 Study of TMX-049 in Subjects With Type 2 Diabetes and Albuminuria
Sponsor
Teijin America, Inc.
Enrollment
130
Started
2018
Primary outcome
Changes in Log-transformed Urinary Albumin-to-creatinine Ratio (UACR) at Week 12
Diabetic Kidney Disease
Volume Kinetics for Hyperoncotic Albumin in Burn Patients as Well as for Healthy Subjects
Sponsor
University Hospital, Linkoeping
Enrollment
30
Started
2016
Primary outcome
Plasma volume
Burns
Trial of Carbamylation in Renal Disease-Modulation With Amino Acid Therapy
NCT02472834COMPLETED
Sponsor
Massachusetts General Hospital
Enrollment
54
Started
2016
Primary outcome
Differences in plasma carbamylated albumin (C-Alb) levels
End Stage Renal Failure on Dialysis
Markers of Oxidative Stress in a Early Week Miscarriage: Ischemia of Modified Albumin
NCT01988740UNKNOWN
Sponsor
Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Enrollment
180
Started
2013
Primary outcome
first trimester pregnant women
First Trimester PregnancyFetal Heart Activity AbsentAbsence of Fetal Pole on Ultrasonographic Examination.
Paclitaxel Albumin-Stabilized Nanoparticle Formulation, Gemcitabine, and Bevacizumab in Treating Patients With Metastatic Breast Cancer
Sponsor
Alliance for Clinical Trials in Oncology
Enrollment
50
Started
2008
Primary outcome
6-month Progression-free Survival (PFS) Rate
Breast Cancer
Tetrahydrobiopterin in Patients With Chronic Kidney Disease (CKD) and Albuminuria
Sponsor
University of Michigan
Enrollment
17
Started
2008
Primary outcome
The Primary Outcome Measure is Level of Albuminuria.
Kidney DiseaseAlbuminuria
Bevacizumab, Doxorubicin, and Cyclophosphamide Followed By Paclitaxel Albumin-Stabilized Nanoparticle Formulation and Bevacizumab in Treating Patients Who Have Undergone Surgery for Early-Stage Breast Cancer
NCT00436709UNKNOWN
Sponsor
Memorial Sloan Kettering Cancer Center
Enrollment
75
Started
2006
Primary outcome
Safety
Breast Cancer
Study of Albumin-bound Paclitaxel (Abraxane) in Combination With Carboplatin and Herceptin in Patients With Advanced Breast Cancer
Sponsor
Celgene
Enrollment
32
Started
2004
Primary outcome
Percentage of Participants Who Achieved an Objective Confirmed Complete or Partial Overall Response
Breast Cancer
Publication Trend
Research publications about Albumin over time
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