Lever
Lifestyle
- Manage stress levels
- Avoid known allergens
- Regular exercise
- Adequate sleep
Blutwerte · Marker
Basophile
Basophils · Basophile Granulozyten
Blutbild
- Einheit:
- x10^9/L
- Abbreviation
- BASO
Basophils measure the count of basophil white blood cells in the blood, reflecting immune and allergic activity.
Reference Ranges
Reference
0–0.2x10^9/L
0
0.2
LowNormalHigh
Reference
Unit · x10^9/LReference ranges may vary slightly based on laboratory and population. No significant sex-specific differences.
Overview
Übersicht
Basophils, also known as basophile granulozyten, are a type of white blood cell and part of the body's immune system. They are classified as granulocytes due to the presence of granules in their cytoplasm, which contain histamine and other chemicals that play a role in inflammatory responses. Basophils are involved in the body's allergic reactions and are known to release histamine and other mediators upon activation. Clinically, basophils are important in the context of allergic diseases such as urticaria and anaphylaxis. Researchers have found that alterations in basophil counts and function can reflect underlying allergic conditions and immune responses. For instance, in chronic spontaneous urticaria, basophils may show altered degranulation patterns and changes in IgE receptor signaling. In the context of athletic performance, biohacking, or longevity, basophils are not directly targeted, but their role in immune function and inflammation may indirectly affect recovery and overall health. Researchers observed that basophil counts can be influenced by various factors, including infections and allergic reactions, which can confound interpretation. Time-of-day variations are not significant for basophils, but acute stress or recent infections can alter their levels, necessitating careful consideration when interpreting results.
Klinische Bedeutung
Elevated basophil levels can indicate allergic reactions, chronic inflammation, or myeloproliferative disorders. Reduced basophil levels may be seen in acute allergic reactions or during stress responses.
Dynamics
Trend Interpretation
Rising Values
Progressively rising basophil levels may suggest worsening allergic reactions or chronic inflammation. Re-test in 4 weeks if levels remain elevated.
Falling Values
Falling basophil levels may indicate resolution of an allergic response or effective treatment.
Re-test Interval
4 weeks if outside optimal range
Etiology
Causes — High & Low
Cause
Elevated Levels
- Allergic reactions
- Chronic inflammation
- Myeloproliferative disorders
- Infections
- Hypothyroidism
Cause
Low Levels
- Acute allergic reactions
- Stress response
- Hyperthyroidism
- Corticosteroid use
- Severe infections
Protocol
How to Optimize
Lever
Nutrition
- Anti-inflammatory diet
- Omega-3 fatty acids
- Fruits and vegetables
- Probiotics
Lever
Supplementation
- Quercetin
- Vitamin C
- Omega-3 supplements
Note:
Consult a healthcare provider before starting any new supplement regimen, especially if you have underlying health conditions.
Testing Guidelines
✓Fasting Not Required
✓Not Time-Sensitive
Basophil counts may vary slightly throughout the day.
Testing Frequency
As part of a complete blood count during routine check-ups or if symptoms suggestive of allergic reactions are present.
Interfering Factors
- Recent infections
- Acute stress
- Corticosteroid use
Open Research Questions
Current research suggests that the role of blood basophils in chronic spontaneous urticaria (CSU) is not fully understood, particularly regarding reference ranges and the impact of altered IgE receptor signaling on their function. Researchers have not yet established optimal targets for basophil phenotyping as a biomarker in CSU. Additionally, clinical questions remain unanswered about the precise mechanisms by which basophils contribute to disease expression and their potential as therapeutic targets.
17 Research Publications
289
Total Citations
2
Human/RCT
3.8
Avg. Influence
2025
Latest
Sort
Filter
01Top
#01
Acute and Chronic Urticaria: Evaluation and Treatment.
ReviewInfluence6.0
83
This study examined urticaria, a common skin condition characterized by itchy wheals. Researchers found that basophils play a role in the disease, with changes in their function observed during active chronic spontaneous urticaria. The findings suggest that altered basophil phenotypes may serve as potential biomarkers for the condition.
02Top
#02
Malignant or benign leukocytosis.
ReviewInfluence6.0
72
This study focused on leukocytosis, which is an elevated white blood cell count. Researchers found that distinguishing between malignant and benign leukocytosis is crucial for patient management, and basophils are important in the differential diagnosis of myeloid malignancies. The study emphasizes the need for careful examination of blood cell differentials.
03Top
#03
9. Anaphylaxis.
Review
41
This study examined anaphylaxis, a severe allergic reaction often involving basophils and mast cells. Researchers found that anaphylaxis can be triggered by various agents and that prompt treatment with epinephrine is crucial. The study emphasizes the importance of understanding allergen sensitization and risk assessment for future episodes.
04
#04
A proinflammatory stem cell niche drives myelofibrosis through a targetable galectin-1 axis.
In VitroInfluence3.0
28
This study investigated the role of basophils in myelofibrosis, a type of blood cancer. Researchers found that basophils contribute to a proinflammatory environment that drives disease progression. The study identified galectin-1 as a potential biomarker for myelofibrosis and a target for therapeutic intervention.
05
#05
Urticaria and basophils.
ReviewInfluence3.0
21
This study investigated the role of blood basophils in chronic spontaneous urticaria (CSU). Researchers observed that blood basophils showed altered degranulation patterns in active CSU, and their recruitment to skin lesions was noted. The findings suggest that basophil characteristics may be useful as biomarkers for CSU.
06
#06
Anaphylaxis: Mediators, Biomarkers, and Microenvironments.
Fernandez-Bravo S, et al. · Journal of investigational allergology & clinical immunology · 2022
Review
15
This review examined the mediators and potential biomarkers involved in anaphylaxis. Researchers found that basophils are key players in the IgE-mediated activation during anaphylactic reactions. The study discusses various molecular products that could serve as biomarkers, although none are currently used in clinical practice.
Key findings
- 01Researchers observed that the main test for confirming anaphylaxis is measuring serum tryptase levels, but no biomarkers can predict the reaction.
- 02They identified various molecular products, including proteins and lipids, that change in patients with anaphylaxis and could be explored as potential biomarkers.
- 03The study highlights the need for better understanding of the biological processes involved in anaphylaxis to improve clinical practices.
07
#07
OMIP-109: 45-color full spectrum flow cytometry panel for deep immunophenotyping of the major lineages present in human peripheral blood mononuclear cells with emphasis on the T cell memory compartment.
In VitroInfluence1.0
15
Researchers developed a 45-color flow cytometry panel to deeply characterize various immune cell lineages, including basophils. This study highlighted the panel's ability to discern distinct phenotypes and activation states of T cells, which may enhance understanding of immune responses. The findings support its application in immunological research and biomarker discovery.
08
#08
The ontogenesis and heterogeneity of basophils.
Review
6
This review focused on the development and heterogeneity of basophils, the rarest type of leukocyte. Researchers observed that basophils play essential roles in various immune responses and that recent advances have improved understanding of their biology. The study highlights the significance of basophil development in health and disease.
09
#09
Urticaria and Angioedema.
Review
5
This study explored the causes of urticaria and angioedema, which involve the release of histamine from mast cells and basophils. Researchers found that a clinical diagnosis is essential, and a limited laboratory workup is recommended unless specific conditions are suspected. The findings highlight the importance of identifying triggers for effective management.
10
#10
Update on Urticaria and Angioedema.
Human
3
This study updated knowledge on urticaria and angioedema, emphasizing the role of basophils in releasing inflammatory mediators. Researchers found that a limited laboratory workup is often sufficient for diagnosis, and the main treatment approach is avoidance of triggers when possible.
Publication Trend
Research publications about Basophile over time
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