Lever
Lifestyle
- Manage stress levels
- Avoid known allergens
- Regular physical activity
Blutwerte · Marker
Basophile
Basophils · Basophile Granulozyten
Blutbild
- Einheit:
- x10^9/L
- Abbreviation
- BASO
Basophil count measures the number of basophils in the blood, which are involved in immune responses and inflammation.
Reference Ranges
Reference
0–0.2x10^9/L
0
0.2
LowNormalHigh
Reference
Unit · x10^9/LReference ranges may vary slightly depending on the laboratory and population.
Overview
Übersicht
Basophils, abbreviated as BASO, are a type of white blood cell and part of the immune system. They are one of the granulocytes, which also include eosinophils and neutrophils, and are characterized by the presence of granules in their cytoplasm. Basophils play a role in inflammatory reactions and are involved in the body's response to allergens and parasites. They release histamine and other mediators that contribute to the inflammatory process. Clinically, basophils are important in the context of allergic reactions, such as urticaria, and can be involved in chronic inflammatory conditions. Elevated basophil counts may indicate allergic reactions, chronic inflammation, or myeloproliferative disorders, while low counts can be seen in acute infections or hyperthyroidism. For athletes and biohackers, monitoring basophil levels can provide insights into immune function and inflammation, which may impact recovery and performance. However, basophil counts can be influenced by various factors, including stress, infections, and medications, which should be considered when interpreting results.
Klinische Bedeutung
Elevated basophil levels can indicate allergic reactions, chronic inflammation, or myeloproliferative disorders. Low basophil levels may be associated with acute infections or hyperthyroidism.
Dynamics
Trend Interpretation
Rising Values
Progressively rising basophil counts may suggest worsening allergic or inflammatory conditions. Re-test in 4-6 weeks if elevated.
Falling Values
Progressively falling basophil counts may indicate resolution of an allergic or inflammatory condition.
Re-test Interval
4 weeks if outside optimal range
Etiology
Causes — High & Low
Cause
Elevated Levels
- Allergic reactions
- Chronic inflammation
- Myeloproliferative disorders
- Infections
- Hypothyroidism
Cause
Low Levels
- Acute infections
- Hyperthyroidism
- Stress
- Use of corticosteroids
Protocol
How to Optimize
Lever
Nutrition
- Anti-inflammatory diet
- Adequate hydration
Note:
Consult a healthcare provider for personalized advice, especially if considering supplements.
Testing Guidelines
✓Fasting Not Required
✓Not Time-Sensitive
Basophil levels may vary with circadian rhythms; consistent timing of tests is recommended.
Testing Frequency
Annually for routine health check-ups, more frequently if monitoring a specific condition.
Interfering Factors
- Recent infections
- Use of corticosteroids
- Stress
Open Research Questions
Current research suggests that the role of basophils in chronic spontaneous urticaria (CSU) and their altered degranulation patterns remain understudied, with unclear reference ranges and optimal targets for therapeutic interventions. Researchers have not yet established the precise mechanisms by which basophil phenotypes contribute to CSU disease expression. Additionally, clinical questions regarding the predictive value of basophil counts in myeloproliferative neoplasms and their relationship with disease progression remain unanswered.
17 Research Publications
269
Total Citations
2
Human/RCT
4.0
Avg. Influence
2025
Latest
Sort
Filter
01Top
#01
Acute and Chronic Urticaria: Evaluation and Treatment.
UnknownInfluence6.0
80
Researchers found that urticaria, often triggered by mast cells and basophils, can cause significant discomfort and may represent serious systemic diseases. The study highlights the role of basophils in the allergic response and the importance of identifying triggers for effective management.
02Top
#02
Malignant or benign leukocytosis.
ReviewInfluence6.0
72
This study examined the distinction between malignant and benign leukocytosis, emphasizing the importance of blood cell counts and differentials. Researchers found that manual differentials are crucial for identifying myeloid malignancies and that basophils play a role in this differentiation process.
03Top
#03
9. Anaphylaxis.
Unknown
40
This study analyzed anaphylaxis, highlighting the role of basophils in allergic reactions mediated by IgE. Researchers observed that prompt treatment is critical, and understanding basophil involvement can aid in managing future episodes.
04
#04
A proinflammatory stem cell niche drives myelofibrosis through a targetable galectin-1 axis.
UnknownInfluence2.0
20
This study explored the role of basophils in myelofibrosis, identifying them as part of a signaling hub that influences disease progression. Researchers found that galectin-1, linked to basophils, serves as a biomarker for poor survival in myelofibrosis patients.
05
#05
Urticaria and basophils.
UnknownInfluence2.0
19
This study focused on chronic spontaneous urticaria (CSU) and the role of blood basophils in the disease. Researchers observed that blood basopenia occurs during active CSU and that altered basophil function may serve as a potential biomarker for the disease.
06
#06
Anaphylaxis: Mediators, Biomarkers, and Microenvironments.
Fernandez-Bravo S, et al. · Journal of investigational allergology & clinical immunology · 2022
Review
15
This review examined the mediators and potential biomarkers involved in anaphylaxis. Researchers found that basophils are key players in the IgE-mediated activation during anaphylactic reactions. The study discusses various molecular products that could serve as biomarkers, although none are currently used in clinical practice.
Key findings
- 01Researchers observed that the main test for confirming anaphylaxis is measuring serum tryptase levels, but no biomarkers can predict the reaction.
- 02They identified various molecular products, including proteins and lipids, that change in patients with anaphylaxis and could be explored as potential biomarkers.
- 03The study highlights the need for better understanding of the biological processes involved in anaphylaxis to improve clinical practices.
07
#07
OMIP-109: 45-color full spectrum flow cytometry panel for deep immunophenotyping of the major lineages present in human peripheral blood mononuclear cells with emphasis on the T cell memory compartment.
Unknown
10
Researchers developed a 45-color flow cytometry panel for detailed analysis of immune cell lineages, including basophils. This study highlights the panel's ability to characterize immune responses and its potential for biomarker discovery in various diseases.
08
#08
Urticaria and Angioedema.
Unknown
5
Researchers examined the causes of urticaria and angioedema, noting the involvement of basophils in the release of inflammatory mediators. The study emphasizes the importance of identifying triggers and the role of basophils in allergic reactions.
09
#09
The ontogenesis and heterogeneity of basophils.
Review
5
Researchers reviewed the development and heterogeneity of basophils, emphasizing their roles in various diseases. The study provides insights into basophil biology and development, contributing to a better understanding of their clinical significance.
10
#10
Update on Urticaria and Angioedema.
Human
3
This study updated knowledge on urticaria and angioedema, emphasizing the role of basophils in releasing inflammatory mediators. Researchers found that a limited laboratory workup is often sufficient for diagnosis, and the main treatment approach is avoidance of triggers when possible.
Publication Trend
Research publications about Basophile over time
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