Lever
Lifestyle
- Manage stress levels
- Avoid known allergens
- Regular moderate exercise
Blutwerte · Marker
Basophile
Basophils · Basophile Granulozyten
BlutbildZeitabhängig
- Einheit:
- x10^9/L
- Abbreviation
- BASO
Basophils measure the number of basophil white blood cells in the blood, reflecting immune system activity.
Reference Ranges
Reference
0.01–0.1x10^9/L
0.01
0.1
LowNormalHigh
Reference
Unit · x10^9/LReference ranges may vary slightly between laboratories.
Overview
Übersicht
Basophils, abbreviated as BASO, are a type of white blood cell and a component of the immune system. They are part of the granulocyte family, which also includes neutrophils and eosinophils. Basophils play a crucial role in the body's immune response by releasing histamine and other chemicals during allergic reactions and asthma, contributing to inflammation and the body's defense mechanisms. Clinically, basophils are important in diagnosing and monitoring allergic conditions, such as urticaria, and certain types of leukemia, such as chronic basophilic leukemia. Elevated basophil counts can indicate allergic reactions, chronic inflammation, or myeloproliferative disorders, while low counts may be seen in acute infections or severe allergic reactions. For athletes and biohackers, understanding basophil levels can provide insights into immune function and potential allergic responses, which may impact performance and recovery. However, basophil counts can be influenced by various factors, including stress, medications, and time of day, as levels may fluctuate due to circadian rhythms. Therefore, it is important to consider these factors when interpreting basophil levels.
Klinische Bedeutung
Elevated basophil levels may indicate allergic reactions, chronic inflammation, or myeloproliferative disorders. Reduced levels can occur in acute infections or severe allergic reactions.
Dynamics
Trend Interpretation
Rising Values
Progressively rising basophil levels suggest worsening allergic reactions or chronic inflammation. Re-test in 4 weeks if outside optimal range.
Falling Values
Progressively falling basophil levels may indicate resolution of an allergic reaction or effective treatment of underlying conditions.
Re-test Interval
4 weeks if outside optimal range
Etiology
Causes — High & Low
Cause
Elevated Levels
- Allergic reactions
- Chronic inflammation
- Myeloproliferative disorders
- Chronic basophilic leukemia
- Hypothyroidism
Cause
Low Levels
- Acute infections
- Severe allergic reactions
- Hyperthyroidism
- Prolonged stress
- Use of corticosteroids
Protocol
How to Optimize
Lever
Nutrition
- Anti-inflammatory diet
- Omega-3 fatty acids
- Rich in fruits and vegetables
Lever
Supplementation
- Quercetin
- Probiotics
Note:
Consult a healthcare provider before making significant lifestyle or dietary changes.
Testing Guidelines
✓Fasting Not Required
🕐Time-Sensitive
Basophil levels may fluctuate with circadian rhythms; consistent timing is recommended.
Testing Frequency
Annually for healthy adults or as advised by a healthcare provider.
Interfering Factors
- Recent intense exercise
- Corticosteroid use
- Acute stress
Open Research Questions
Current research suggests that the role of basophils as biomarkers in predicting outcomes of allergen immunotherapy remains poorly defined, with no consistent biomarkers established for therapy prognosis. Researchers have not yet established optimal reference ranges for basophil activation tests in various clinical contexts, particularly in chronic urticaria and chronic basophilic leukemia. Additionally, unanswered clinical questions include the specific mechanisms by which basophils contribute to allergic responses and their potential role in distinguishing between benign and malignant leukocytosis.
35 Research Publications
954
Total Citations
9
Human/RCT
2.8
Avg. Influence
2025
Latest
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Filter
01Top
#01
Diagnostic tests based on human basophils: more potentials and perspectives than pitfalls.
ReviewInfluence7.0
193
This study explored the potential of basophil activation tests for allergy diagnosis. Researchers found that these tests can yield reproducible results across various allergens, indicating their clinical utility. The study suggests that despite some limitations, basophil activation tests can be reliably performed in laboratories with appropriate expertise.
02Top
#02
Earth Mover's Distance (EMD): A True Metric for Comparing Biomarker Expression Levels in Cell Populations.
UnknownInfluence5.0
121
Researchers introduced the Earth Mover's Distance (EMD) as a metric for analyzing biomarker expression levels in cell populations. They demonstrated that EMD could reveal clinically relevant shifts in basophil markers in response to allergens.
03Top
#03
Acute and Chronic Urticaria: Evaluation and Treatment.
ReviewInfluence6.0
87
This study examined the role of basophils in urticaria, a common skin condition characterized by itchy welts. Researchers found that basophils are involved in the disease process and that their altered function may serve as a potential biomarker for chronic spontaneous urticaria. Additionally, blood basophil levels were noted to change during active disease and remission.
04
#04
Malignant or benign leukocytosis.
ReviewInfluence6.0
75
This study focused on the diagnostic challenges of distinguishing between malignant and benign leukocytosis, emphasizing the importance of basophil counts in the differential diagnosis. Researchers observed that accurate identification of basophils is crucial for diagnosing myeloid malignancies. The findings suggest that manual differentials may be necessary for reliable diagnosis.
05
#05
Novel Biologicals for the Treatment of Allergic Diseases and Asthma.
ReviewInfluence2.0
70
Researchers reviewed the development of biological therapies targeting allergic diseases, focusing on the role of basophils in the type 2 immune response. They found that basophils are involved in the pathophysiology of allergies and that novel treatments may be tailored to specific immune profiles. The study emphasizes the need for further research on basophil-related biomarkers.
06
#06
The role of basophils as innate immune regulatory cells in allergy and immunotherapy.
ReviewInfluence1.0
51
This study reviewed the role of basophils as regulatory cells in allergy and immunotherapy. Researchers found that while basophils are often considered effector cells, they may primarily function in immune regulation. The study emphasizes the need to reevaluate the role of basophils in allergic responses and their potential in immunotherapy.
07
08
#08
9. Anaphylaxis.
Review
41
This study examined anaphylaxis, an acute allergic reaction, and its association with basophils. Researchers found that basophils play a critical role in the allergic response, and their activation is often mediated by IgE. The study highlights the importance of understanding basophil involvement in anaphylaxis for better risk assessment and management.
09
#09
Characteristics of laboratory indexes in COVID-19 patients with non-severe symptoms in Hefei City, China: diagnostic value in organ injuries.
HumanInfluence3.0
39
This study compared laboratory indexes in non-severe COVID-19 patients to healthy controls, finding significant decreases in basophil counts among the patients. The results suggest that SARS-CoV-2 infection can impact various hematological parameters.
10
#10
A proinflammatory stem cell niche drives myelofibrosis through a targetable galectin-1 axis.
HumanInfluence4.0
37
Researchers mapped interactions in myelofibrotic bone marrow, identifying basophils as part of a signaling hub that contributes to inflammation and fibrosis. They found galectin-1 as a potential biomarker for disease progression and a target for therapy, indicating a complex interplay of immune cells.
Publication Trend
Research publications about Basophile over time
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