Lever
Lifestyle
- Regular aerobic exercise
- Stress management
- Adequate sleep
Blutwerte · Marker
Coenzym Q10
CoQ10 · Ubiquinol · Ubiquinone · Coenzyme Q10
Vitamine & NährstoffeZeitabhängig
- Einheit:
- mg/L
- Abbreviation
- CoQ10
CoQ10 quantifies the concentration of coenzyme Q10 in the blood, reflecting mitochondrial function and antioxidant capacity.
Reference Ranges
Reference
0.5–2.5mg/L
0.5
1
2
2.5
LowNormalHigh
Reference
Optimal
Unit · mg/LRanges may vary based on age and health status; fasting not required.
Overview
Übersicht
Coenzyme Q10 (CoQ10), also known as ubiquinol or ubiquinone, is a fat-soluble compound that plays a critical role in the electron transport chain within mitochondria, facilitating ATP production. It functions as an antioxidant, protecting cells from oxidative damage. Clinically, CoQ10 levels are significant in conditions like chronic heart failure, where low levels correlate with disease severity. Researchers found that CoQ10 supplementation can improve symptoms and reduce adverse cardiovascular events in heart failure patients. Additionally, CoQ10 has been studied for its potential benefits in autism spectrum disorder, myalgic encephalomyelitis/chronic fatigue syndrome, and glaucoma, where its antioxidant properties may alleviate symptoms or slow disease progression. In the context of athletic performance and biohacking, CoQ10 is valued for its role in enhancing mitochondrial efficiency and reducing oxidative stress, which may improve endurance and recovery. However, CoQ10 levels can be influenced by factors such as age, medication use (e.g., statins), and dietary intake. Testing for CoQ10 does not typically require fasting, but levels may vary based on the time of day and individual metabolic states. Researchers emphasize the need for standardized testing protocols to ensure accurate assessment of CoQ10 status.
Klinische Bedeutung
Elevated CoQ10 levels are generally not associated with adverse effects, while reduced levels may indicate mitochondrial dysfunction, increased oxidative stress, or cardiovascular disease risk.
Dynamics
Trend Interpretation
Rising Values
Increasing CoQ10 levels suggest improved mitochondrial function or supplementation effect. Re-test in 3-6 months if levels are significantly above optimal.
Falling Values
Decreasing levels may indicate increased oxidative stress or statin use; consider evaluating mitochondrial health.
Re-test Interval
6 months if levels are outside the optimal range
Etiology
Causes — High & Low
Cause
Elevated Levels
- Supplementation
- High dietary intake
- Genetic factors
- Reduced clearance
- Increased endogenous production
Cause
Low Levels
- Statin use
- Aging
- Chronic diseases
- Nutritional deficiencies
- Mitochondrial disorders
Protocol
How to Optimize
Lever
Nutrition
- Increase intake of oily fish
- Consume organ meats
- Include nuts and seeds
Lever
Supplementation
- CoQ10 supplements
- Ubiquinol
- NADH
Note:
Consult a healthcare provider before starting any new supplementation, especially if on medication.
Testing Guidelines
✓Fasting Not Required
🕐Time-Sensitive
CoQ10 levels may vary throughout the day; consistent timing is recommended for repeat tests.
Testing Frequency
Annually for those with chronic conditions or on statins; otherwise, as needed.
Interfering Factors
- Recent intense exercise
- Statin medication
- Dietary fat intake
Related Peptides & Hormones
Atp
hormone or peptideCorrelated with
Open Research Questions
Current research suggests that reference ranges for Coenzyme Q10 (CoQ10) levels in various populations, including those with autism spectrum disorder and chronic fatigue syndrome, remain poorly defined. Researchers have not yet established optimal targets for CoQ10 supplementation or its confounding effects on other biomarkers. Additionally, clinical questions remain unanswered regarding the long-term efficacy of CoQ10 in diverse patient populations and its mechanistic role in conditions like heart failure and neurodevelopmental disorders.
19 Research Publications
1,112
Total Citations
8
Human/RCT
3.6
Avg. Influence
2025
Latest
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01Top
#01
Bioenergetic and antioxidant properties of coenzyme Q10: recent developments.
ReviewInfluence7.0
443
Researchers summarized the bioenergetic and antioxidant properties of coenzyme Q10, emphasizing its role in mitochondrial function and lipid peroxidation inhibition. The study discussed its potential benefits in cardiovascular health and endothelial function, suggesting further exploration of its clinical applications.
02Top
#02
The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: a randomized double-blind trial.
Mortensen Svend A, et al. · JACC. Heart failure · 2014
HumanInfluence10.0
408
This randomized controlled trial evaluated the effects of coenzyme Q10 (CoQ10) in patients with chronic heart failure. Researchers found that long-term CoQ10 treatment significantly reduced cardiovascular and all-cause mortality compared to placebo. Additionally, CoQ10 improved functional capacity and symptoms in these patients.
Key findings
- 0115% of patients taking CoQ10 experienced major adverse cardiovascular events compared to 26% in the placebo group.
- 02Cardiovascular mortality was lower in the CoQ10 group (9%) compared to the placebo group (16%).
- 03Patients taking CoQ10 showed significant improvement in their heart failure symptoms after two years.
03Top
#03
Biomarkers of mitochondrial dysfunction in autism spectrum disorder: A systematic review and meta-analysis.
Frye Richard E, et al. · Neurobiology of disease · 2024
Meta-AnalysisInfluence5.0
85
This systematic review examined biomarkers of mitochondrial dysfunction in individuals with autism spectrum disorder (ASD). Researchers found significant elevations in lactate, pyruvate, and CoQ10 levels associated with ASD severity. They also noted alterations in mitochondrial metabolism in mothers of children with ASD and in neonates who develop ASD.
Key findings
- 01Researchers observed significant increases in biomarkers related to mitochondrial function, including lactate and pyruvate, in individuals with ASD.
- 02The study identified variations in mitochondrial DNA and its association with ASD severity and clinical features.
- 03Researchers noted that mitochondrial dysfunction may contribute to developmental challenges and other health issues commonly seen in individuals with ASD.
04
#04
Effect of Dietary Coenzyme Q10 Plus NADH Supplementation on Fatigue Perception and Health-Related Quality of Life in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial.
HumanInfluence6.0
48
This randomized, double-blind trial investigated the effects of coenzyme Q10 and NADH supplementation on fatigue and quality of life in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) patients. Researchers found significant reductions in cognitive fatigue perception and improvements in health-related quality of life among those receiving the supplements.
05
#05
Characterization of CoQ₁₀ biosynthesis in fibroblasts of patients with primary and secondary CoQ₁₀ deficiency.
HumanInfluence1.0
29
Researchers developed a non-invasive method for quantifying coenzyme Q10 biosynthesis in fibroblasts, which could help diagnose primary coenzyme Q10 deficiencies. The study validated this method through patient analysis, indicating its potential for early diagnosis and treatment.
06
#06
Novel Multi-Ingredient Supplement Facilitates Weight Loss and Improves Body Composition in Overweight and Obese Individuals: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
HumanInfluence1.0
28
This clinical trial assessed a multi-ingredient nutritional supplement, including CoQ10, for weight loss in overweight individuals. Researchers found significant reductions in body weight and fat mass after 12 weeks of supplementation. Additionally, improvements in molecular markers of liver health and metabolism were observed in the supplement group.
07
#07
Nutritional supplementation in the prevention and treatment of glaucoma.
ReviewInfluence1.0
21
This review assessed the potential of nutritional supplementation, including CoQ10, in preventing and treating glaucoma. Researchers found that while antioxidants show promise in reducing oxidative stress, most clinical findings remain inconclusive, indicating a need for further investigation into their effects on glaucoma.
08
#08
Coenzyme Q10 Supplementation in Reducing Inflammation: An Umbrella Review.
Review
16
This umbrella review analyzed meta-analyses on coenzyme Q10 supplementation's effects on inflammation. Researchers found that CoQ10 significantly decreased proinflammatory cytokines IL-6 and TNF-α in several studies, although significant heterogeneity was observed, warranting cautious interpretation of the results.
09
#09
Simvastatin overcomes the pPCK1-pLDHA-SPRINGlac axis-mediated ferroptosis and chemo-immunotherapy resistance in AKT-hyperactivated intrahepatic cholangiocarcinoma.
Zhu Jinghan, et al. · Cancer communications (London, England) · 2025
AnimalInfluence2.0
15
This study explored the role of the pAKT-pPCK1-pLDHA-SPRINGlac axis in intrahepatic cholangiocarcinoma and its resistance to therapy. Researchers observed that targeting this axis could enhance the efficacy of chemo-immunotherapy in AKT-hyperactivated cancer models. CoQ10 was linked to metabolic reprogramming in this context.
Key findings
- 01Researchers observed that the pAKT-pPCK1-pLDHA-SPRINGlac axis is linked to resistance against ferroptosis in intrahepatic cholangiocarcinoma.
- 02Inhibiting the phosphorylation of PCK1 or using simvastatin improved the effectiveness of chemo-immunotherapy in preclinical models.
- 03Clinical data suggested that levels of phosphorylated AKT and pPCK1 could serve as potential biomarkers for predicting treatment response.
10
#10
Dihydroorotate Dehydrogenase in Mitochondrial Ferroptosis and Cancer Therapy.
ReviewInfluence1.0
10
This review focused on dihydroorotate dehydrogenase (DHODH) and its role in ferroptosis and cancer therapy. Researchers highlighted that DHODH regulates CoQ10 levels and may serve as a target for enhancing cancer treatment efficacy. The study suggests that inhibiting DHODH could sensitize tumors to ferroptosis.
Publication Trend
Research publications about Coenzym Q10 over time
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