Lever
Lifestyle
- Regular exercise
- Stress management
- Adequate sleep
Blutwerte · Marker
Coenzym Q10
CoQ10 · Ubiquinol · Ubiquinone · Coenzyme Q10
Vitamine & NährstoffeZeitabhängig
- Einheit:
- mg/L
- Abbreviation
- CoQ10
CoQ10 levels in the blood, reflecting mitochondrial function and antioxidant capacity.
Reference Ranges
Reference
0.5–2mg/L
0.5
1
2
LowNormalHigh
Reference
Optimal
Unit · mg/LLevels may vary with age and medication use, particularly statins.
Overview
Übersicht
Coenzyme Q10 (CoQ10), also known as ubiquinone or ubiquinol, is a lipid-soluble antioxidant and a vital component of the electron transport chain in mitochondria, playing a crucial role in cellular energy production. It is naturally synthesized in the body and is found in every cell, with the highest concentrations in organs with high energy demands such as the heart, liver, and kidneys. CoQ10 levels can be measured in blood plasma to assess its status in the body. Clinically, CoQ10 is significant in conditions like chronic heart failure, where researchers have found that supplementation can improve symptoms and reduce adverse cardiovascular events. It is also studied in neurodevelopmental disorders such as autism spectrum disorder (ASD), where mitochondrial dysfunction is a common feature, and CoQ10 supplementation may offer therapeutic benefits. In the context of athletic performance and biohacking, CoQ10 is valued for its potential to enhance energy production, reduce oxidative stress, and improve recovery times, making it popular among athletes and those seeking longevity benefits. However, CoQ10 levels can be influenced by factors such as age, medication use (e.g., statins), and dietary intake. Testing for CoQ10 does not typically require fasting, but levels may vary throughout the day, so consistency in testing time is advised. Researchers have observed that CoQ10 supplementation is generally safe, but individuals should consult healthcare providers before starting any new supplement regimen, especially if they are on medications or have underlying health conditions.
Klinische Bedeutung
Elevated CoQ10 levels are generally not associated with adverse effects, while low levels may indicate mitochondrial dysfunction, increased oxidative stress, or statin use.
Dynamics
Trend Interpretation
Rising Values
Rising CoQ10 levels may indicate effective supplementation or improved mitochondrial function. Re-test in 6 months if levels are high.
Falling Values
Falling levels may suggest increased oxidative stress or statin use.
Re-test Interval
6 months if outside optimal range
Etiology
Causes — High & Low
Cause
Elevated Levels
- Supplementation
- High dietary intake
- Reduced oxidative stress
- Genetic factors
- Improved mitochondrial function
Cause
Low Levels
- Statin use
- Aging
- Mitochondrial dysfunction
- Increased oxidative stress
- Nutritional deficiencies
Protocol
How to Optimize
Lever
Nutrition
- Increase intake of oily fish
- Consume nuts and seeds
- Include organ meats
Lever
Supplementation
- CoQ10 supplements
- Vitamin E
- Alpha-lipoic acid
Note:
Consult a healthcare provider before starting CoQ10 supplements, especially if on medication.
Testing Guidelines
✓Fasting Not Required
🕐Time-Sensitive
CoQ10 levels may vary; test at the same time of day for consistency.
Testing Frequency
Annually for those on statins or with chronic conditions.
Interfering Factors
- Statin use
- Recent intense exercise
- High-fat meal before testing
Related Peptides & Hormones
Atp
hormone or peptideCorrelated with
Open Research Questions
Current research suggests that reference ranges and optimal targets for Coenzyme Q10 (CoQ10) levels in various populations, including those with autism spectrum disorder and chronic fatigue syndrome, remain poorly defined. Researchers have not yet established the specific confounders affecting CoQ10 efficacy, such as genetic variations or dietary influences. Additionally, clinical questions remain unanswered regarding the long-term effects of CoQ10 supplementation on diverse health outcomes and its mechanisms of action in different conditions.
18 Research Publications
1,079
Total Citations
8
Human/RCT
4.1
Avg. Influence
2025
Latest
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01Top
#01
Bioenergetic and antioxidant properties of coenzyme Q10: recent developments.
ReviewInfluence7.0
443
Researchers summarized the bioenergetic and antioxidant properties of coenzyme Q10, emphasizing its role in mitochondrial function and lipid peroxidation inhibition. The study discussed its potential benefits in cardiovascular health and endothelial function, suggesting further exploration of its clinical applications.
02Top
#02
The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: a randomized double-blind trial.
Mortensen Svend A, et al. · JACC. Heart failure · 2014
HumanInfluence10.0
403
This randomized controlled trial evaluated the effects of coenzyme Q10 (CoQ10) in patients with chronic heart failure. Researchers observed a significant reduction in major adverse cardiovascular events in the CoQ10 group compared to placebo. Additionally, CoQ10 treatment was associated with lower cardiovascular and all-cause mortality.
Key findings
- 0115% of patients taking CoQ10 experienced major adverse cardiovascular events compared to 26% in the placebo group.
- 02Cardiovascular mortality was lower in the CoQ10 group (9%) compared to the placebo group (16%).
- 03Patients taking CoQ10 showed significant improvement in their heart failure symptoms after two years.
03Top
#03
Biomarkers of mitochondrial dysfunction in autism spectrum disorder: A systematic review and meta-analysis.
Frye Richard E, et al. · Neurobiology of disease · 2024
Meta-AnalysisInfluence3.0
73
This systematic review examined mitochondrial dysfunction biomarkers in individuals with autism spectrum disorder (ASD). Researchers found significant elevations in lactate, pyruvate, and CoQ10 levels associated with ASD severity. The study highlights the potential link between mitochondrial dysfunction and various physiological abnormalities in ASD.
Key findings
- 01Researchers observed significant increases in biomarkers related to mitochondrial function, including lactate and pyruvate, in individuals with ASD.
- 02The study identified variations in mitochondrial DNA and its association with ASD severity and clinical features.
- 03Researchers noted that mitochondrial dysfunction may contribute to developmental challenges and other health issues commonly seen in individuals with ASD.
04
#04
Effect of Dietary Coenzyme Q10 Plus NADH Supplementation on Fatigue Perception and Health-Related Quality of Life in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial.
HumanInfluence5.0
46
This randomized controlled trial assessed the impact of coenzyme Q10 and NADH supplementation on fatigue in individuals with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Researchers observed significant reductions in cognitive fatigue and improvements in health-related quality of life among participants receiving the supplements.
05
#05
Characterization of CoQ₁₀ biosynthesis in fibroblasts of patients with primary and secondary CoQ₁₀ deficiency.
HumanInfluence1.0
29
Researchers developed a non-invasive method for quantifying coenzyme Q10 biosynthesis in fibroblasts, which could help diagnose primary coenzyme Q10 deficiencies. The study validated this method through patient analysis, indicating its potential for early diagnosis and treatment.
06
#06
Novel Multi-Ingredient Supplement Facilitates Weight Loss and Improves Body Composition in Overweight and Obese Individuals: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
Human
25
This clinical trial investigated a multi-ingredient supplement aimed at improving mitochondrial function in overweight individuals. Researchers found significant reductions in weight and fat mass after 12 weeks of supplementation, alongside improvements in biomarkers related to liver health and metabolism.
07
#07
Nutritional supplementation in the prevention and treatment of glaucoma.
Review
20
Researchers reviewed the potential of nutritional supplementation, including CoQ10, in reducing oxidative stress related to glaucoma. While some antioxidants showed promise, the findings were mostly inconclusive, indicating that further investigation into CoQ10 and other compounds is warranted for glaucoma treatment and prevention.
08
#08
Coenzyme Q10 Supplementation in Reducing Inflammation: An Umbrella Review.
Review
15
This umbrella review analyzed meta-analyses on coenzyme Q10 supplementation and its effects on inflammation. Researchers found that CoQ10 significantly reduced inflammatory markers IL-6 and TNF-α in several studies, although significant heterogeneity was noted across the analyses.
09
#09
Simvastatin overcomes the pPCK1-pLDHA-SPRINGlac axis-mediated ferroptosis and chemo-immunotherapy resistance in AKT-hyperactivated intrahepatic cholangiocarcinoma.
Zhu Jinghan, et al. · Cancer communications (London, England) · 2025
AnimalInfluence1.0
14
This study explored the role of the pAKT-pPCK1-pLDHA-SPRINGlac axis in intrahepatic cholangiocarcinoma and its resistance to therapy. Researchers found that AKT hyperactivation enhances ubiquinol synthesis, linking it to treatment resistance. Targeting this axis may improve treatment outcomes in patients with this cancer.
Key findings
- 01Researchers observed that the pAKT-pPCK1-pLDHA-SPRINGlac axis is linked to resistance against ferroptosis in intrahepatic cholangiocarcinoma.
- 02Inhibiting the phosphorylation of PCK1 or using simvastatin improved the effectiveness of chemo-immunotherapy in preclinical models.
- 03Clinical data suggested that levels of phosphorylated AKT and pPCK1 could serve as potential biomarkers for predicting treatment response.
10
#10
Examining the Effects of Nutrient Supplementation on Metabolic Pathways via Mitochondrial Ferredoxin in Aging Ovaries.
HumanInfluence2.0
7
This study examined the effects of nutritional supplementation, including CoQ10, on metabolic pathways in aging ovaries. Researchers found that supplementation significantly elevated levels of the biomarker FDX1, suggesting enhanced mitochondrial function. The findings indicate potential benefits for improving oocyte quality in older women.
Publication Trend
Research publications about Coenzym Q10 over time
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