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- Stress management
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Blutwerte · Marker
Coenzym Q10
CoQ10 · Ubiquinol · Ubiquinone · Coenzyme Q10
Vitamine & Nährstoffe
- Einheit:
- mg/L
- Abbreviation
- CoQ10
CoQ10 levels measure the concentration of coenzyme Q10 in the blood, reflecting mitochondrial function and antioxidant capacity.
Reference Ranges
Reference
0.5–2mg/L
0.5
1
2
LowNormalHigh
Reference
Optimal
Unit · mg/LReference ranges may vary based on age, sex, and health status.
Overview
Übersicht
Coenzyme Q10 (CoQ10), also known as ubiquinone or ubiquinol, is a lipid-soluble antioxidant that plays a crucial role in the mitochondrial electron transport chain, facilitating ATP production. It is a key component in cellular energy metabolism and also functions as a powerful antioxidant, protecting cells from oxidative damage. CoQ10 is naturally present in the body and can be obtained through dietary sources and supplementation. Clinically, CoQ10 is important in conditions associated with mitochondrial dysfunction and oxidative stress, such as heart failure, neurodegenerative diseases like Alzheimer's, and certain metabolic disorders. Researchers have found that CoQ10 supplementation can improve symptoms and reduce adverse cardiovascular events in chronic heart failure, and it may have a role in mitigating inflammation by reducing pro-inflammatory cytokines. In the context of athletic performance and biohacking, CoQ10 is valued for its potential to enhance energy production, reduce exercise-induced oxidative stress, and improve recovery. Some studies suggest that CoQ10 may support longevity by maintaining mitochondrial function and reducing oxidative damage over time. However, the effectiveness of CoQ10 can be influenced by factors such as age, genetic variations, and the presence of certain diseases. Testing for CoQ10 levels should consider potential confounders such as recent supplementation, fasting status, and time of day, as levels may fluctuate based on these factors.
Klinische Bedeutung
Elevated CoQ10 levels may indicate supplementation or increased endogenous production, while low levels can suggest mitochondrial dysfunction, increased oxidative stress, or a need for supplementation, particularly in conditions like heart failure or neurodegenerative diseases.
Dynamics
Trend Interpretation
Rising Values
Progressively rising CoQ10 levels may indicate excessive supplementation. Re-test in 4 weeks if levels exceed optimal range.
Falling Values
Progressively falling levels may suggest increased oxidative stress or mitochondrial dysfunction.
Re-test Interval
4 weeks if outside optimal range
Etiology
Causes — High & Low
Cause
Elevated Levels
- Supplementation
- Increased endogenous production
- Genetic factors
- Dietary intake
Cause
Low Levels
- Mitochondrial dysfunction
- Oxidative stress
- Chronic diseases
- Nutritional deficiencies
Protocol
How to Optimize
Lever
Nutrition
- Consume foods rich in CoQ10 like fatty fish
- Increase intake of nuts and seeds
- Include whole grains
Lever
Supplementation
- CoQ10 supplements
- Ubiquinol supplements
Note:
Consult a healthcare provider before starting any new supplementation, especially if on medication.
Testing Guidelines
✓Fasting Not Required
✓Not Time-Sensitive
Draw at the same time of day for consistency.
Testing Frequency
Annually for general health monitoring, more frequently if managing a chronic condition.
Interfering Factors
- Recent supplementation
- Dietary intake
- Genetic variations
Related Peptides & Hormones
Cholesterol
hormone or peptideMay affect
Open Research Questions
Current research suggests that reference ranges for Coenzyme Q10 (CoQ10) levels in various populations, particularly in neurodevelopmental disorders like autism spectrum disorder (ASD) and Alzheimer's disease, remain poorly defined. Researchers have not yet established optimal targets for CoQ10 supplementation or its confounding effects on inflammatory biomarkers. Emerging research directions include the exploration of CoQ10's role in mitochondrial dysfunction across various diseases, while clinical questions remain regarding its efficacy in specific patient subgroups and long-term outcomes.
41 Research Publications
1,635
Total Citations
16
Human/RCT
2.9
Avg. Influence
2025
Latest
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Filter
01Top
#01
Bioenergetic and antioxidant properties of coenzyme Q10: recent developments.
ReviewInfluence7.0
443
Researchers summarized the bioenergetic and antioxidant properties of coenzyme Q10, emphasizing its role in mitochondrial function and lipid peroxidation inhibition. The study discussed its potential benefits in cardiovascular health and endothelial function, suggesting further exploration of its clinical applications.
02Top
#02
The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: a randomized double-blind trial.
Mortensen Svend A, et al. · JACC. Heart failure · 2014
HumanInfluence12.0
422
This randomized controlled trial evaluated the effects of coenzyme Q10 (CoQ10) on patients with chronic heart failure. Researchers found that long-term CoQ10 treatment significantly reduced cardiovascular mortality and improved symptoms compared to placebo. The study indicates that CoQ10 may be a safe adjunctive therapy in managing chronic heart failure.
Key findings
- 0115% of patients taking CoQ10 experienced major adverse cardiovascular events compared to 26% in the placebo group.
- 02Cardiovascular mortality was lower in the CoQ10 group (9%) compared to the placebo group (16%).
- 03Patients taking CoQ10 showed significant improvement in their heart failure symptoms after two years.
03Top
#03
Generator-specific targets of mitochondrial reactive oxygen species.
AnimalInfluence6.0
169
04
#04
Biomarkers of mitochondrial dysfunction in autism spectrum disorder: A systematic review and meta-analysis.
Frye Richard E, et al. · Neurobiology of disease · 2024
Meta-AnalysisInfluence7.0
113
This systematic review examined biomarkers of mitochondrial dysfunction in individuals with autism spectrum disorder (ASD). Researchers found significant elevations in lactate, pyruvate, and CoQ10 levels associated with ASD severity. The study suggests that mitochondrial dysfunction may play a central role in the clinical features of ASD.
Key findings
- 01Researchers observed significant increases in biomarkers related to mitochondrial function, including lactate and pyruvate, in individuals with ASD.
- 02The study identified variations in mitochondrial DNA and its association with ASD severity and clinical features.
- 03Researchers noted that mitochondrial dysfunction may contribute to developmental challenges and other health issues commonly seen in individuals with ASD.
05
#05
Effect of Dietary Coenzyme Q10 Plus NADH Supplementation on Fatigue Perception and Health-Related Quality of Life in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial.
HumanInfluence6.0
49
This prospective trial investigated the effects of coenzyme Q10 and NADH supplementation on fatigue and quality of life in patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Researchers found significant reductions in cognitive fatigue and improvements in health-related quality of life among those receiving the supplements. The study supports the potential benefits of CoQ10 and NADH for ME/CFS patients.
06
#06
CoQ10 in progressive supranuclear palsy: A randomized, placebo-controlled, double-blind trial.
Human
40
This randomized, placebo-controlled trial evaluated the safety and efficacy of coenzyme Q10 in progressive supranuclear palsy (PSP). Researchers found no significant differences in clinical outcomes between CoQ10 and placebo groups, highlighting challenges in conducting trials in this patient population.
07
#07
Statin Treatment Decreases Mitochondrial Respiration But Muscle Coenzyme Q10 Levels Are Unaltered: The LIFESTAT Study.
HumanInfluence1.0
39
This study explored the relationship between statin treatment and muscle Coenzyme Q10 (CoQ10) levels in patients experiencing myalgia. Researchers observed that while mitochondrial respiration was impaired in statin users, intramuscular CoQ10 levels remained unchanged across groups. The findings suggest that myalgia may not be directly linked to reduced CoQ10 levels.
08
#08
CoQ10 and Mitochondrial Dysfunction in Alzheimer's Disease.
ReviewInfluence1.0
32
This review focused on the potential role of coenzyme Q10 (CoQ10) in Alzheimer's disease (AD). Researchers highlighted that CoQ10 may help restore mitochondrial function and prevent the onset of amyloid and tau pathology associated with AD. The study emphasizes the need for further research on CoQ10 as a therapeutic option in AD.
09
10
#10
Characterization of CoQ₁₀ biosynthesis in fibroblasts of patients with primary and secondary CoQ₁₀ deficiency.
HumanInfluence1.0
29
Researchers developed a non-invasive method for quantifying coenzyme Q10 biosynthesis in fibroblasts, which could help diagnose primary coenzyme Q10 deficiencies. The study validated this method through patient analysis, indicating its potential for early diagnosis and treatment.
Publication Trend
Research publications about Coenzym Q10 over time
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