Lever
Lifestyle
- Regular monitoring of iron levels
- Avoid excessive alcohol consumption
- Regular exercise
Blutwerte · Marker
Eisen
Serum Iron · Serumeisen · Fe
Eisen & AnämieNüchtern erforderlichZeitabhängig
- Einheit:
- µmol/L
- Abbreviation
- Fe
Serum iron quantifies the amount of iron present in the blood, bound to transferrin.
Reference Ranges
Reference
10.7–28.6µmol/L
10.7
13
25
28.6
LowNormalHigh
Reference
Optimal
Unit · µmol/LReference ranges may vary slightly based on laboratory standards and patient demographics.
Overview
Übersicht
Serum iron, denoted as Fe, is a critical biomarker that measures the concentration of iron circulating in the blood. It plays a vital role in various physiological processes, including oxygen transport, DNA synthesis, and electron transport. Researchers have identified serum iron as a key indicator of iron status, often used alongside other markers such as ferritin and transferrin saturation to diagnose iron deficiency and related disorders. Clinically, serum iron is significant in diagnosing conditions like iron deficiency anemia (IDA), where low levels indicate insufficient iron for hemoglobin production. Elevated serum iron may suggest conditions such as hemochromatosis or iron overload disorders. In the context of athletic performance and biohacking, maintaining optimal iron levels is crucial for oxygen delivery and energy metabolism, impacting endurance and recovery. However, researchers observed that serum iron levels can be influenced by various factors, including diurnal variation, recent dietary intake, and inflammatory states, which may confound results. It is recommended to interpret serum iron alongside other iron status markers for a comprehensive assessment.
Klinische Bedeutung
Reduced serum iron levels are indicative of iron deficiency anemia and may reflect chronic blood loss or inadequate dietary intake. Elevated levels can indicate iron overload conditions such as hemochromatosis.
Dynamics
Trend Interpretation
Rising Values
Progressively rising serum iron may suggest iron overload or reduced utilization; re-test in 4 weeks if outside optimal range.
Falling Values
Progressively falling serum iron suggests worsening iron deficiency or increased loss.
Re-test Interval
4 weeks if outside optimal range
Etiology
Causes — High & Low
Cause
Elevated Levels
- Hemochromatosis
- Iron supplementation
- Repeated blood transfusions
- Liver disease
- Hemolytic anemia
Cause
Low Levels
- Iron deficiency anemia
- Chronic blood loss
- Poor dietary intake
- Malabsorption syndromes
- Chronic kidney disease
Protocol
How to Optimize
Lever
Nutrition
- Consume iron-rich foods like red meat and leafy greens
- Include vitamin C-rich foods to enhance absorption
- Limit intake of calcium-rich foods with iron meals
Lever
Supplementation
- Iron supplements
- Vitamin C supplements
- Avoid unnecessary iron supplementation without medical advice
Note:
Consult a healthcare provider before starting iron supplementation, especially in the presence of chronic conditions.
Testing Guidelines
🍽️Fasting Required
🕐Time-Sensitive
Iron levels can vary throughout the day; morning samples are preferred.
Testing Frequency
Annually for healthy adults, more frequently if diagnosed with iron-related disorders.
Interfering Factors
- Recent iron supplementation
- Inflammatory conditions
- Recent blood transfusion
Related Peptides & Hormones
Hepcidin
hormone or peptideMay affect
Open Research Questions
Current research suggests that reference ranges for biomarkers like hepcidin and soluble transferrin receptor are not universally established, leading to debates on their optimal targets and confounders such as inflammation. Emerging research directions include the validation of novel biomarkers and the development of comprehensive assessment methods for iron status. However, clinical questions remain unanswered regarding the best strategies for differentiating between iron deficiency anemia and other types of anemia, particularly in complex clinical scenarios.
43 Research Publications
1,095
Total Citations
20
Human/RCT
4.4
Avg. Influence
2025
Latest
Sort
Filter
01Top
#01
Evaluation of anemia in children.
ReviewInfluence8.0
179
This study focused on the evaluation of anemia in children, identifying microcytic anemia as a common type that may respond to oral iron therapy. Researchers noted that severe cases or those unresponsive to treatment require further investigation for gastrointestinal blood loss. The study emphasizes the importance of screening high-risk children for anemia.
02Top
#02
A laboratory index for predicting relapse in asymptomatic patients with Crohn's disease.
HumanInfluence3.0
166
03Top
#03
Iron overload syndromes and the liver.
ReviewInfluence7.0
159
This article reviewed the conditions leading to iron accumulation in the liver. Researchers discussed the diagnostic tools available to pathologists for assessing iron overload, including histologic examination and laboratory iron tests. The review emphasizes the importance of understanding the underlying causes of iron accumulation for accurate diagnosis.
04
#04
Serotonin syndrome vs neuroleptic malignant syndrome: a contrast of causes, diagnoses, and management.
ReviewInfluence11.0
107
This study contrasted serotonin syndrome and neuroleptic malignant syndrome, focusing on their clinical presentations and laboratory findings. Researchers observed that neuroleptic malignant syndrome is associated with low serum iron levels, which helps distinguish it from serotonin syndrome. The study underscores the importance of immediate discontinuation of causative agents for both conditions.
05
#05
Meta-Analysis of Copper and Iron in Parkinson's Disease Brain and Biofluids.
Meta-AnalysisInfluence2.0
79
This meta-analysis assessed copper and iron levels in Parkinson's disease. Researchers confirmed that iron levels were elevated in the substantia nigra of Parkinson's patients, while copper levels were decreased. Additionally, serum iron was found to be lower in Parkinson's disease compared to controls, highlighting the complex role of these metals in the disease.
06
#06
Diagnosing iron deficiency: Controversies and novel metrics.
Rusch Jody A, et al. · Best practice & research. Clinical anaesthesiology · 2023
ReviewInfluence5.0
71
This review examined various established and novel biomarkers for diagnosing iron deficiency, including serum iron, ferritin, transferrin, and hepcidin. Researchers found that understanding these markers can improve the diagnosis of different anemic conditions and enhance patient care. The review highlights the need for precise diagnostic methods in clinical settings.
Key findings
- 01Researchers observed that established markers like serum iron and ferritin are commonly used but have limitations.
- 02The review identified novel biomarkers, such as soluble transferrin receptor and hepcidin, which may enhance diagnosis.
- 03Researchers noted the importance of distinguishing between different types of anemia to improve clinical outcomes.
07
#07
Anemia of chronic disease.
Review
55
This review examined anemia of chronic disease (ACD), noting its common occurrence among hospitalized patients. Researchers found that ACD is characterized by low serum iron with normal or increased ferritin levels, distinguishing it from iron deficiency anemia, and often resolves with treatment of underlying conditions.
08
#08
Evaluation of microcytosis.
Van Vranken Michele · American family physician · 2010
Review
50
This study evaluated microcytosis, commonly found in asymptomatic patients, and identified iron deficiency anemia as a leading cause. Researchers recommended serum ferritin measurement as the first test for diagnosis, highlighting the importance of identifying underlying causes of iron deficiency for effective treatment.
Key findings
- 01The primary causes of microcytosis include iron deficiency anemia and thalassemia trait.
- 02Low serum ferritin levels indicate iron deficiency, which is often linked to blood loss.
- 03Further tests may be needed if ferritin levels are normal, including assessments of iron levels and hemoglobin types.
09
#09
Preprint Déjà Vu.
UnknownInfluence5.0
43
This abstract discusses the historical context of preprint sharing in biomedical research, focusing on the evolution of platforms like arXiv.org. It highlights the importance of sharing research findings pre-publication to enhance collaboration and dissemination of knowledge among scientists.
10
#10
Changes in micronutrient and inflammation serum biomarker concentrations after a norovirus human challenge.
Human
38
This study modeled the inflammatory response to norovirus infection and its impact on micronutrient biomarkers. Researchers observed that inflammation affected serum concentrations of ferritin and hepcidin, while serum iron and transferrin saturation decreased during the inflammatory response. The findings highlight the need to consider inflammation when assessing nutritional status.
Clinical Trials (76)
76
Total Trials
11,670
Total Enrolled
Dipyridamole for Early-Onset Preeclampsia: A Pilot Study of Feasibility, Pharmacokinetics, and Biological Effects
Sponsor
Hadassah Medical Organization
Enrollment
15
Started
2026
Primary outcome
Protocol Feasibility
Preeclampsia (PE)Hypertension ,Pregnancy
Combination Therapy of Deferiprone and N-Acetylcysteine for Treating Negative Symptoms in Schizophrenia
Sponsor
Amit Lotan
Enrollment
80
Started
2026
Primary outcome
Change in Total PANSS Score
Schizoaffecitve DisorderSchizophrenia and Schizoaffective DisorderSchizophrenia and Predominant Negative Symptoms
Global Reference Ranges - Mexico
NCT07664982NOT_YET_RECRUITING
Sponsor
Perspectum
Enrollment
50
Started
2026
Primary outcome
Reference intervals for liver cT1
Healthy Adult Participants
Effects on Remission of Type 2 Diabetes Mellitus Following Gastric Bypass Alone vs Gastric Bypass Combined With Truncal Vagotomy
NCT07278115RECRUITING
Sponsor
University Research Institute for the Study of Genetic & Malignant Disorders in Childhood
Enrollment
40
Started
2026
Primary outcome
Complete remission of Type 2 Diabetes Mellitus at 12 Months Post-Surgery
Diabetes Mellitus Type 2
Absorption of Iron From Stabilized Lactoferrin: A Study in Women With Iron Deficiency
NCT07394972RECRUITING
Sponsor
Nicole Stoffel
Enrollment
45
Started
2026
Primary outcome
Fractional iron absorption (%)
Iron Deficiency (Without Anemia)
The Effect of Cardiac Rehabilitation on Ferroptosis in Patients With Coronary Artery Disease
NCT07722637RECRUITING
Sponsor
TC Erciyes University
Enrollment
90
Started
2026
Primary outcome
Change in GPX4 Gene Expression
Coronary Artery Disease (CAD)Cardiac RehabFerroptosis
The Effect of a Protective Oral Care Protocol Using Peppermint Oil Mouthwash
NCT07179094NOT_YET_RECRUITING
Sponsor
Şule Güzle
Enrollment
72
Started
2025
Primary outcome
Nausea-Vomiting-Retching Symptoms
Hematologic NeoplasmsNauseaVomitingAnorexia
The Effects of Acute Erythropoietin on Hepcidin and Dietary Iron Absorption Following Military-relevant Exercise in Energy Deficit: Pilot Study
NCT07517562ACTIVE_NOT_RECRUITING
Sponsor
Pennington Biomedical Research Center
Enrollment
6
Started
2025
Primary outcome
Fractional iron absorption
Iron Absorption
Goat Milk-Derived Formula vs. Undiluted Goat Milk in Infants Unable to Exclusively Breastfeed: Growth and Biomarker Analysis
NCT07225153RECRUITING
Sponsor
Aga Khan University
Enrollment
15
Started
2025
Primary outcome
Change in lipidomic markers among infants receiving Goat Milk-Derived Formula Alternative (GMDFA) compared to undiluted goat milk and breastfeeding groups.
Malnutrition (Calorie)Infant Nutrition DisorderGrowth FlateringGut MicrobiomeLipidomics
TRIMODAL PREHABILITATION IN GASTROINTESTINAL CANCER
NCT07281248RECRUITING
Sponsor
Puerta de Hierro University Hospital
Enrollment
30
Started
2025
Primary outcome
Demonstrate the feasibility of a trimodal prehabilitation program with motivational strategies during chemotherapy in a multidisciplinary hospital setting.
Digestive Neoplasms
Determination of Iron Absorption and Losses in People Living at High Altitude to Investigate the Requirements in This Population Group Using a Newly Developed Technique
NCT07142590RECRUITING
Sponsor
Diego Moretti
Enrollment
120
Started
2025
Primary outcome
57Fe tracer concentration in the circulation
Iron AbsorptionIron RequirementsAltitude
Effect of Acute Exercise on Biochemical Parameters in Normal-Weight and Overweight/Obese Adolescent.
NCT07103889COMPLETED
Sponsor
High Institute of Sports and Physical Education of Kef
Enrollment
35
Started
2025
Primary outcome
Concentration of Blood Glucose (mg/dL)
Obese AdolescentsOverweight
VertiGreens Investigating the Effects of Iron Biofortification of Microgreens on Iron Status in Women
NCT06972927COMPLETED
Sponsor
University of Aberdeen
Enrollment
30
Started
2025
Primary outcome
Haemoglobin status change from baseline
Iron Biomarkers/Status
Nutritional Status and Emotional Well-being of the Worker-consumer in the Food Supply Chain.
NCT06896877COMPLETED
Sponsor
Fondazione Don Carlo Gnocchi ETS
Enrollment
40
Started
2025
Primary outcome
The difference in the bioimpedance vectors between two groups of patients (active workers versus sedentary workers), according to BIVA
Healthy
Effect of Chitin and Ascorbic Acid on Dietary Insect Iron Absorption
NCT06822062RECRUITING
Sponsor
Swiss Distance University of Applied Sciences
Enrollment
25
Started
2025
Primary outcome
Fractional iron absorption
Iron Deficiency (Without Anemia)
Iron Deficiency in Pediatric Celiac Disease: Diet vs. Iron Supplementation Trial
NCT06921343NOT_YET_RECRUITING
Sponsor
Kaplan Medical Center
Enrollment
150
Started
2025
Primary outcome
Change in ferritin levels from baseline to 12 months
Celiac Disease in ChildrenIron Deficiency
Breath-holding Spells and Its Management Study
NCT06628271RECRUITING
Sponsor
Region Skane
Enrollment
120
Started
2024
Primary outcome
Safety of the guidelines
Breath-holding Spell
Effect of Perioperative Roxadustat in Elective Lumbar Interbody Fusion Surgery.
Sponsor
Second Affiliated Hospital, Zhejiang University, School of Medicine
Enrollment
158
Started
2024
Primary outcome
Perioperative RBC transfusion requirement
Perioperative Anemia
Effect of Yoga Breathing Exercises Versus Aerobic Exercise on Hematological Parameters
NCT05949437UNKNOWN
Sponsor
Shokry Mahmoud Youssef Mohamed
Enrollment
60
Started
2023
Primary outcome
serum iron level
Iron Deficiency Anemia
Nutrient And Non-Nutrient Intake, Relative Biomarkers and Their Health Effects In Apparently Healthy Participants
NCT07110805ACTIVE_NOT_RECRUITING
Sponsor
University of Milan
Enrollment
200
Started
2023
Primary outcome
Dietary intake assessment
Participants With/Without Risk Factors for Metabolic Diseases
Hypertension Explored in Long-term Postpartum Follow-up in Later Life
NCT06187012RECRUITING
Sponsor
University of Oxford
Enrollment
200
Started
2023
Primary outcome
Cardiac right ventricular mass
HypertensionCardiovascular DiseasesCerebrovascular DisordersVascular Diseases
Feasibility of a Whole-Food, Plant-Based Diet for Patients With Low-Risk Chronic Lymphocytic Leukemia (CLL)
NCT06377501COMPLETED
Sponsor
University of California, San Diego
Enrollment
19
Started
2023
Primary outcome
Adherence to the Dietary Intervention
Chronic Lymphocytic Leukemia Stage A(0)
Effectiveness of a Cardiac Rehabilitation Program in Elderly Patients With Heart Failure.
NCT05393362COMPLETED
Sponsor
University of Malaga
Enrollment
65
Started
2023
Primary outcome
Physiological biomarkers_Cardiopulmonary Exercise Testing (CPET)-(Peak VO2)
Heart Failure With Preserved Ejection FractionSarcopeniaFrail Elderly SyndromeComorbidities and Coexisting Conditions
Study of the Safety and Efficacy of Roxadustat in the Treatment of Heart Failure With Chronic Kidney Disease and Anemia
Sponsor
China-Japan Friendship Hospital
Enrollment
300
Started
2023
Primary outcome
Change in the hemoglobin from baseline
Heart FailureChronic Kidney DiseasesAnemia
Effects of Kefir Consumption on Health Outcomes: Gastrointestinal System, Immunity, Biochemical Parameters, Body Composition, Sleep Quality and Mental Well Being in Healthy Adults
NCT06612164COMPLETED
Sponsor
Medipol University
Enrollment
65
Started
2023
Primary outcome
Evaluation of Gastrointestinal Health
Effect of Kefir on Healthy Adults
Study of Multiply-fortified Salt Among Women of Reproductive Age and Preschool Children in India
NCT05166980COMPLETED
Sponsor
University of California, San Francisco
Enrollment
1,389
Started
2022
Primary outcome
Change in serum ferritin
Nutrient Deficiency
Evaluation of Inflammatory Markers in ph Negative Myeloproliferative Neoplasms: Impact on Outcome and Response to Therapy. Multicenter Retro-prospective Observational Study. The INFLA-ME (INFLAmmation in Myeloproliferative Disease) Study.
NCT05553873RECRUITING
Sponsor
University of Milano Bicocca
Enrollment
500
Started
2022
Primary outcome
CBC with leukocyte formula and calculation of the NLR and PLR ratio
Myeloproliferative DiseaseInflammatory Markers
Perioperative Exercise and Nutritional Optimisation Prehabilitation Before Surgery for Patients With Peritoneal Malignancy
NCT05305820UNKNOWN
Sponsor
Dublin City University
Enrollment
36
Started
2022
Primary outcome
Feasibility of Adherence to the Intervention
Peritoneal MalignancyOvarian CancerRectum CancerAppendix CancerColon Cancer
Tolerability and Safety of CARDIOMEMS™ Intracardiac Continuous Cardiac Hemodynamic Monitoring Device in Patients with Cardio Renal Syndrome with Severe Renal Impairment
NCT05428631RECRUITING
Sponsor
Centre Hospitalier Universitaire de Nīmes
Enrollment
10
Started
2022
Primary outcome
Adverse events
Heart FailureRenal Insufficiency
Effect of Altitude on Iron Absorption in Iron Depleted Women
NCT05500014UNKNOWN
Sponsor
Swiss Distance University of Applied Sciences
Enrollment
80
Started
2022
Primary outcome
Iron absorption
Iron Deficiency AnemiaIron Deficiency (Without Anemia)Altitude Hypoxia
Effect of Dried Miracle Berry on the Olfactory-gustative Perception in Malnourished Cancer Patients
NCT05486260COMPLETED
Sponsor
Instituto de Investigación Hospital Universitario La Paz
Enrollment
21
Started
2022
Primary outcome
Electrogustometry
CancerDysgeusiaHypogeusiaAgeusiaChemotherapy EffectMalnutrition
A Study to Evaluate the Efficacy and Safety of Mitapivat in Pediatric Participants With Pyruvate Kinase Deficiency (PKD) Who Are Regularly Transfused, Followed by a 5-Year Extension Period
Sponsor
Agios Pharmaceuticals, Inc.
Enrollment
49
Started
2022
Primary outcome
Percentage of Participants Achieving Transfusion Reduction Response (TRR)
Pediatric Pyruvate Kinase DeficiencyPediatric Hemolytic Anemia
Investigation of the Effects of Curcumin and Resveratrol Supplements Added to the Mediterranean Diet on Disease Severity and Inflammatory Biomarkers in Patients With Ulcerative Colitis
NCT05761327COMPLETED
Sponsor
Ardahan University
Enrollment
48
Started
2022
Primary outcome
Inflammatory Bowel Disease Questionnaire (IBDQ)
Ulcerative Colitis
Physical Training for People With Parkinson's Disease and Multiple Sclerosis: Effect on Mind and Body
NCT05357638UNKNOWN
Sponsor
Amsterdam UMC, location VUmc
Enrollment
48
Started
2022
Primary outcome
Change in anxiety and depressive symptoms
Parkinson DiseaseMultiple Sclerosis
Dietary Intervention Study on Food Based Dietary Guidelines for Sustainable and Healthy Lifestyles
NCT05253547COMPLETED
Sponsor
University College Dublin
Enrollment
355
Started
2022
Primary outcome
Diet-related greenhouse gas emissions reported as kilograms of carbon dioxide equivalents per day
Dietary HabitsHealthy DietHealthy NutritionPersonalized Nutrition
Safety and Efficacy Study of Ferric Maltol To Treat Iron Deficiency Anaemia in Chinese Patients With Inflammatory Bowel Disease
Sponsor
Jiangsu Aosaikang Pharmaceutical Co., Ltd.
Enrollment
122
Started
2021
Primary outcome
Change in Haemoglobin (Hb) Concentration From Baseline to Week 12
Iron Deficiency Anaemia
Potential of Prebiotic Galacto-oligosaccharides in Improving Efficacy and Safety of Oral Iron Supplementation in HIV-infected Children
NCT04931641COMPLETED
Sponsor
Swiss Federal Institute of Technology
Enrollment
86
Started
2021
Primary outcome
Iron status: Serum Ferritin (ug/L) (SF)
Iron DeficiencyHIV
Dose, Safety, Tolerability and Immunogenicity of an Influenza H10 Stabilized Stem Ferritin Vaccine, VRC-FLUNPF0103-00-VP, in Healthy Adults
Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Enrollment
25
Started
2020
Primary outcome
Number of Participants Reporting Local Reactogenicity Signs and Symptoms Within 7 Days of Each H10ssF-6473 Product Administration
Influenza
Serum Bovine Immunoglobulin (SBI) in Children and Young Adults With Inflammatory Bowel Disease (IBD)
Sponsor
Monisha Hitesh Shah
Enrollment
6
Started
2020
Primary outcome
Effects of Serum Bovine Immunoglobulin (SBI) on nutrition of pediatric patients with inflammatory Bowel Disease
Inflammatory Bowel DiseasesUlcerative ColitisCrohn Disease
School-Based Nutrition Education in Improving Dietary Diversity Among Adolescent Girls
NCT04116593UNKNOWN
Sponsor
International Centre for Diarrhoeal Disease Research, Bangladesh
Enrollment
296
Started
2020
Primary outcome
Changes in the percentage of dietary diversity (based on different food groups) from baseline.
Nutritional Deficiency
Iron Supplements Effect on b-Phe Levels in PKU Patients During 3 Years Study
Sponsor
ASST Santi Paolo e Carlo
Enrollment
84
Started
2020
Primary outcome
a significant decrease of Plasma Phe levels in Group A
Phenylketonuria (PKU)
Effect of a Fortified Balanced Energy-Protein Supplement on Birth Outcome and Child Growth in Houndé District, Burkina Faso.
Sponsor
University Ghent
Enrollment
1,788
Started
2019
Primary outcome
Small-for-Gestational-age (SGA)
Small for Gestational Age at DeliveryLow Birth WeightPrematurityInfant Malnutrition
LITMUS Imaging Study
NCT05479721ACTIVE_NOT_RECRUITING
Sponsor
University of Oxford
Enrollment
450
Started
2019
Primary outcome
Diagnostic accuracy of imaging biomarkers for severity of liver fibrosis on histology as reference standard
NAFLDNASHNASH - Nonalcoholic SteatohepatitisFibrosis, LiverSteatosis of Liver
Study in Beta-thalassaemia or Myelodysplastic Syndrome Patients to Investigate the Safety and Tolerability of SLN124
Sponsor
Silence Therapeutics plc
Enrollment
0
Started
2019
Primary outcome
# of participants with all AEs as assessed by CTCAE V4.0 included injection site reaction, will be measured from baseline to post dose follow up
Non-transfusion-dependent ThalassemiaLow Risk Myelodysplastic Syndrome
Effect of Phytin on Human Gut Microbiome (EPoM)
NCT03917693COMPLETED
Sponsor
Quadram Institute Bioscience
Enrollment
14
Started
2019
Primary outcome
Relative abundance of Enterobacteriaceae
Diet Modification
Dose, Safety, Tolerability and Immunogenicity of an Influenza H1 Stabilized Stem Ferritin Vaccine in Healthy Adults
Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Enrollment
52
Started
2019
Primary outcome
Number of Participants Reporting Local Reactogenicity Signs and Symptoms Within 7 Days of Each H1ssF_3928 Product Administration
Influenza Infection
Efficacy and Safety of Ferrous Iron on the Prevention of Vascular Cognitive Impairment Among Patients With Cerebral Infarction/TIA (FAVORITE)
Sponsor
Beijing Tiantan Hospital
Enrollment
1,006
Started
2019
Primary outcome
prevalence of vascular cognitive impairment in patients given Ferrous succinate versus placebo
Vascular Cognitive ImpairmentDementia, VascularIron-deficiencyCerebral InfarctionTIA
Effect Of Multiple Biofortified Food Crops On Micronutrient Status And Immune Function Among Indian Infants and Their Mothers
NCT02648893UNKNOWN
Sponsor
Cornell University
Enrollment
200
Started
2019
Primary outcome
Biomarkers of vitamin A, iron, and zinc status
Vitamin A DeficiencyIron DeficiencyZinc Deficiency
The Effect of Blood Donation on Hematological and Iron Indices and Detection of Autologous Blood Transfusion
NCT04514978UNKNOWN
Sponsor
University of Copenhagen
Enrollment
48
Started
2018
Primary outcome
Hemoglobin centration
Healthy
Study the Effect of Blood Transfusion on Oxidant-antioxidant Status in Term and Near-term Neonates
Sponsor
Rania Ali El-Farrash
Enrollment
65
Started
2018
Primary outcome
malondialdehyde
Blood Transfusion ComplicationOxidative Stress
Deferiprone to Delay Dementia (The 3D Study)
Sponsor
Neuroscience Trials Australia
Enrollment
81
Started
2018
Primary outcome
Efficacy of Deferiprone
Mild Cognitive ImpairmentProdromal Alzheimer's DiseaseMild Alzheimer's Disease
Effect of 60-days Saccharomyces Boulardii and Superoxide Dismutase Supplementation in Obese Adults
NCT04919850COMPLETED
Sponsor
Azienda di Servizi alla Persona di Pavia
Enrollment
25
Started
2018
Primary outcome
Change on concentration of biochemical parameters for hunger sensation and hormonal status
ObesitySuperoxide Dismutase
The Efficacy and Safety of HYDROXYUREA in Management of Beta Thalassemia Patients in Karachi Pakistan
Sponsor
Dr.Saqib Hussain Ansari
Enrollment
100
Started
2017
Primary outcome
No. of participants who become responders or partial responders
Thalassemia, Beta
Effects of rhLactoferrin on Chronic Inflammation in the Elderly
Sponsor
Johns Hopkins University
Enrollment
36
Started
2017
Primary outcome
The Effect of Rhlactoferrin on Serum Levels of Interleukin-6 (IL-6)
InflammationCognitive Deterioration
Open-label, Multicenter Study Assessing Preference for Deferasirox Film-coated Tablet Compared to Dispersible Tablet
Sponsor
Novartis Pharmaceuticals
Enrollment
148
Started
2017
Primary outcome
Number of Participants Preferring Deferasirox FCT or DT at Week 48 Based on Preference Questionnaire (Item 2)
Transfusion-dependent ThalassemiaNon-transfusion-dependent Thalassemia
Intravenous Iron in paTients With Heart failURe and Reduced Ejection fracTion (HFREF) pLus Iron dEficiency
Sponsor
RWTH Aachen University
Enrollment
23
Started
2017
Primary outcome
changes in blood intact FGF23 after infusion of 1000 mg ferric carboxymaltose
Heart Failure, SystolicIron Deficiency
Deferasirox in Treating Patients With Very Low, Low, or Intermediate-Risk Red Blood Cell Transfusion Dependent Anemia or Myelodysplastic Syndrome
Sponsor
Fred Hutchinson Cancer Center
Enrollment
2
Started
2017
Primary outcome
Proportion of Patients That Achieve Erythroid Hematologic Improvement.
AnemiaMyelodysplastic Syndrome
Potential Adverse Developmental and Nutritional Consequences of Helicobacter Pylori Infection in Israeli Children
NCT02654197UNKNOWN
Sponsor
Hillel Yaffe Medical Center
Enrollment
600
Started
2016
Primary outcome
Changes in means of differences in height
Helicobacter Pylori InfectionIron Deficiency AnemiaChild Development
Confounder-Corrected Quantitative MRI Biomarker of Hepatic Iron Content
NCT02025543COMPLETED
Sponsor
University of Wisconsin, Madison
Enrollment
207
Started
2015
Primary outcome
Calibration curve of liver R2* vs LIC measured by Ferriscan at each of the sites
Iron OverloadHemochromatosisHemosiderosis
A Study Evaluating the Safety and Efficacy of Lovo-cel in Severe Sickle Cell Disease
Sponsor
Genetix Biotherapeutics Inc.
Enrollment
54
Started
2015
Primary outcome
Percentage of Group C Participants Who Achieved Complete Resolution of Vaso-occlusive Events (VOE-CR)
Sickle Cell Disease
Optimizing Iron Suppletion After Roux-en-Y Gastric Bypass
Sponsor
Rijnstate Hospital
Enrollment
120
Started
2014
Primary outcome
normal value serum ferritin
Iron Deficiency
HEPFER-Evaluation of a New Phenotypic Biological Marker in Genetic Type 1 Hemochromatosis
NCT01784939COMPLETED
Sponsor
Rennes University Hospital
Enrollment
31
Started
2013
Primary outcome
distribution of values of Hepcidin / ferritin plasma ratio
Hereditary Hemochromatosis C282Y Homozygous
Bovine Lactoferrin in Reducing Taste Disturbances in Patients With Colorectal Cancer Receiving Oxaliplatin-Based Chemotherapy
NCT01596634COMPLETED
Sponsor
Wake Forest University Health Sciences
Enrollment
12
Started
2013
Primary outcome
Change in the Taste Visual Analog Scale (VAS) and taste and smell questionnaire responses
Colorectal CancerDysgeusiaOral Complications of Chemotherapy
Safety and Efficacy of MK-8457 and Methotrexate (MTX) in Participants With Active Rheumatoid Arthritis Despite MTX Therapy (P08683, MK-8457-008)
Sponsor
Merck Sharp & Dohme LLC
Enrollment
82
Started
2012
Primary outcome
Percentage of Participants Achieving an American College of Rheumatology (ACR) 20 Response at Week 12
Rheumatoid Arthritis (RA)
IVICA: Intravenous Iron in Colorectal Cancer Associated Anaemia
Sponsor
Nottingham University Hospitals NHS Trust
Enrollment
116
Started
2012
Primary outcome
To determine if the use of intravenous ferric carboxymaltose can reduce the need for allogeneic blood transfusion compare to oral ferrous sulphate in patients with colorectal adenocarcinoma related anaemia
AnemiaColorectal Neoplasm
Effect of Iron Reduction by Phlebotomy for Type 2 Diabetes
NCT02468037COMPLETED
Sponsor
University of Utah
Enrollment
12
Started
2012
Primary outcome
Improvement in glucose area under the curve.
Type 2 Diabetes MellitusPrediabetes
Effect of Weight Reduction on Immunity
Sponsor
Shiraz University of Medical Sciences
Enrollment
29
Started
2012
Primary outcome
lymphocyte subgroups
LymphocytesWeight LossViral DiseasesImmunityAnti-obesity Agents
Optimizing Fluid Status
NCT01492634COMPLETED
Sponsor
Francisco Maduell
Enrollment
56
Started
2011
Primary outcome
intra-individual difference in TAFO between study start and study end
Hypotension During Dialysis
Safety and Efficacy Study of Oral Ferric Iron To Treat Iron Deficiency Anaemia in Quiescent Crohn's Disease (AEGIS-2)
Sponsor
Shield Therapeutics
Enrollment
128
Started
2011
Primary outcome
Change in Haemoglobin (Hb) Concentration From Baseline to Week 12 (Full Analysis Set, FAS)
Iron Deficiency AnaemiaInflammatory Bowel DiseaseCrohn's Disease
Effect of Sprinkles With and w/o Fe on Zn Absorption in Kenyan Toddlers
NCT02101723COMPLETED
Sponsor
University of Colorado, Denver
Enrollment
63
Started
2011
Primary outcome
Changes in GI microbiome
Micronutrient Deficiencies
Magnetic Resonance Angiography for Peripheral Arterial Disease (PAD)
Sponsor
AMAG Pharmaceuticals, Inc.
Enrollment
119
Started
2008
Primary outcome
Segment-level Sensitivity and Specificity of VE-MRI at 3 Ferumoxytol Dosing Levels and Differences in Sensitivity and Specificity by Dose Group
Peripheral Arterial Disease (PAD)
A Study of Subcutaneous Mircera for the Maintenance Treatment of Dialysis Patients With Chronic Renal Anemia.
Sponsor
Hoffmann-La Roche
Enrollment
233
Started
2008
Primary outcome
Percentage of Participants Maintaining Their Mean Hemoglobin Concentration Within Plus or Minus 1 Gram/Deciliter of Their Reference Hemoglobin and Between the Target Range During Efficacy Evaluation Period
Anemia
Phase I Study to Examine the Effect of Deferasirox on Renal Hemodynamics in β-thalassemia Patients With Transfusional Iron Overload
Sponsor
Novartis Pharmaceuticals
Enrollment
11
Started
2007
Primary outcome
Effect of deferasirox on renal hemodynamics in patients with β-thalassemia and transfusional iron overload.
β-thalassemiaTransfusional Iron Overload
Evaluation the Effect of Exjade on Oxidative Stress in Low Risk Myelodysplastic Syndrome Patients With Iron Over Load
Sponsor
Wolfson Medical Center
Enrollment
21
Started
2007
Primary outcome
To evaluate the antioxidative effect of Exjade therapy in MDS patients
Myelodysplastic Syndrome
Effects Of Atorvastatin On Macrophage Activity And Plaque Inflammation Using Magnetic Resonance Imaging
NCT00368589COMPLETED
Sponsor
GlaxoSmithKline
Enrollment
47
Started
2006
Primary outcome
Changes from baseline in USPIO-enhanced MRI signal in carotid plaques at 6 weeks and 12-weeks in low and high dose atorvastatin groups (within groups' comparison).
Atherosclerotic Carotid DiseaseAtheromaAtherosclerosis
An Extension Study of Iron Chelation Therapy With Deferasirox (ICL670) in β-thalassemia Patients With Transfusional Iron Overload
Sponsor
Novartis Pharmaceuticals
Enrollment
506
Started
2004
Primary outcome
Long Term Safety and Tolerability Profile of ICL670 Based on the Number of Participants Who Experienced Any Adverse Event
Transfusional Iron Overload in β-thalassemia
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