Lever
Lifestyle
- Manage allergies effectively
- Avoid known allergens
- Regular exercise
- Stress management techniques
Blutwerte · Marker
Eosinophile
Eosinophils · Eosinophile Granulozyten
BlutbildZeitabhängig
- Einheit:
- x10^9/L
- Abbreviation
- EOS
The eosinophil count measures the number of eosinophils in the blood, a type of white blood cell involved in immune responses.
Reference Ranges
Reference
0–0.5x10^9/L
0
100
300
0.5
LowNormalHigh
Reference
Optimal
Unit · x10^9/LReference ranges can vary slightly depending on the laboratory and population. No significant sex-specific differences.
Overview
Übersicht
Eosinophils (EOS) are a type of white blood cell that play a crucial role in the body's immune response, particularly in allergic reactions and parasitic infections. They are granulocytes, characterized by the presence of granules in their cytoplasm, which contain enzymes and proteins that are released during immune responses. Eosinophils are involved in the pathogenesis of various diseases, including eosinophilic lung disease and atopic conditions, where they mediate T-helper 2 cell responses and contribute to inflammation. Clinically, eosinophilia, or elevated eosinophil counts, can indicate allergic reactions, parasitic infections, autoimmune diseases, and certain malignancies. Conversely, low eosinophil levels are not typically associated with specific health issues, as researchers have found that eosinophil deficiency does not lead to characteristic abnormalities. In the context of athletic performance and biohacking, eosinophil levels may be monitored to assess immune function and inflammation, although their direct impact on performance and longevity is less clear. Researchers observed that eosinophil counts can be influenced by various factors, including circadian rhythms and recent infections, which should be considered when interpreting results. Blood samples for eosinophil counts are typically collected as part of a complete blood count (CBC), and fasting is not required. However, time-of-day variations may affect eosinophil levels, with counts typically peaking during the night and early morning.
Klinische Bedeutung
Elevated eosinophil levels (eosinophilia) can indicate allergic reactions, parasitic infections, or autoimmune diseases. Low eosinophil levels are generally not associated with specific health issues.
Dynamics
Trend Interpretation
Rising Values
Progressively rising eosinophil levels may suggest worsening of allergic or parasitic conditions. Re-test in 4 weeks if levels continue to rise.
Falling Values
Falling eosinophil levels may indicate resolution of an allergic reaction or effective treatment of an underlying condition.
Re-test Interval
4 weeks if outside optimal range
Etiology
Causes — High & Low
Cause
Elevated Levels
- Allergic reactions
- Parasitic infections
- Autoimmune diseases
- Certain cancers
- Medication reactions
Cause
Low Levels
- Corticosteroid use
- Acute infections
- Stress responses
- Cushing's syndrome
Protocol
How to Optimize
Lever
Nutrition
- Consume anti-inflammatory foods
- Maintain a balanced diet
- Ensure adequate vitamin D levels
Lever
Supplementation
- Vitamin D
- Omega-3 fatty acids
Note:
Consult a healthcare provider before making significant lifestyle or dietary changes, especially if managing chronic conditions.
Testing Guidelines
✓Fasting Not Required
🕐Time-Sensitive
Eosinophil counts may be higher at night and early morning; consider consistent timing for repeat tests.
Testing Frequency
Annually as part of a complete blood count or more frequently if monitoring specific conditions.
Interfering Factors
- Recent infections
- Corticosteroid use
- Stress levels
Open Research Questions
Current research suggests that the role of eosinophils as a biomarker in atopic diseases remains debated, particularly regarding optimal reference ranges and confounding factors affecting eosinophil counts. Emerging research directions include the impact of various immunotherapy modalities on eosinophil-driven responses and their predictive value for treatment outcomes. Clinical questions remain unanswered regarding the long-term safety of eosinophil-depleting therapies and the specific mechanisms underlying eosinophilia in different disease contexts.
48 Research Publications
1,160
Total Citations
20
Human/RCT
4.1
Avg. Influence
2026
Latest
Sort
Filter
01Top
#01
Blood eosinophils as a marker of response to inhaled corticosteroids in COPD.
HumanInfluence18.0
248
Researchers analyzed data from COPD patients to determine if blood eosinophil counts predict response to inhaled corticosteroids (ICS). They found that patients with eosinophils ≥2% experienced a greater reduction in exacerbation rates when treated with ICS. This suggests eosinophil counts may help guide treatment decisions in COPD.
02Top
#02
Eosinophils in COPD: just another biomarker?
ReviewInfluence5.0
214
This review explored the role of eosinophils as a biomarker in COPD, noting their association with disease exacerbations and treatment responses. Researchers highlighted the need for further studies to clarify the role of eosinophils in COPD pathogenesis and their potential as a treatment guide. The variability in blood eosinophil counts was also discussed.
03Top
#03
Eosinophilic inflammation in COPD: from an inflammatory marker to a treatable trait.
ReviewInfluence5.0
194
This study explored eosinophils as a potential treatable trait in COPD. Researchers observed that eosinophilic inflammation may be linked to treatment responses, highlighting the need for further investigation into eosinophils' role in COPD management.
04
#04
Association of sputum and blood eosinophil concentrations with clinical measures of COPD severity: an analysis of the SPIROMICS cohort.
HumanInfluence6.0
156
This study analyzed the association between blood and sputum eosinophil concentrations and COPD severity. Researchers found that high sputum eosinophil levels were linked to more severe disease and exacerbations, while blood eosinophil counts were less reliable as a biomarker for COPD severity. The findings highlight the importance of assessing sputum eosinophils in clinical practice.
05
#05
Cluster Analysis of Inflammatory Biomarker Expression in the International Severe Asthma Registry.
Denton Eve, et al. · The journal of allergy and clinical immunology. In practice · 2021
HumanInfluence6.0
84
This study characterized inflammatory biomarker expression in adults with severe asthma, finding significant overlap in eosinophil positivity among patients. Researchers identified distinct clusters based on biomarker levels, suggesting different underlying inflammatory pathways. The findings provide insights into the complexity of severe asthma and the potential for tailored biologic therapies.
Key findings
- 01Researchers observed that 64% of the study participants were female, with an average age of 53 years.
- 02They identified significant overlap in the presence of inflammatory biomarkers among patients with severe asthma.
- 03Distinct clusters of biomarker expression were associated with unique clinical features, indicating different inflammatory pathways.
06
#06
Eosinophils in COPD-Current Concepts and Clinical Implications.
ReviewInfluence1.0
38
This review summarized current concepts regarding eosinophils in COPD, noting their potential as a treatment target. Researchers discussed the challenges in using blood eosinophil counts as a predictor for airway inflammation and treatment response. The study called for more research to clarify the role of eosinophils in COPD management.
07
#07
Utility of eosinophil peroxidase as a biomarker of eosinophilic inflammation in asthma.
Tang Monica, et al. · The Journal of allergy and clinical immunology · 2024
HumanInfluence4.0
37
Researchers investigated the utility of eosinophil peroxidase (EPX) as a biomarker for eosinophilic inflammation in asthma. They found that serum EPX levels were elevated in a significant percentage of asthma patients, indicating systemic eosinophilic inflammation, while sputum EPX levels were more sensitive for detecting airway inflammation. The study suggests that EPX could be a valuable biomarker for assessing asthma severity and treatment response.
Key findings
- 01EPX levels were elevated in 27% to 31% of serum samples and 36% to 53% of sputum samples from asthma patients.
- 02EPX in serum is a valid marker for systemic inflammation, while sputum EPX is more sensitive for detecting airway inflammation.
- 03Blood eosinophil counts often miss airway inflammation, and treatment with mepolizumab may not fully normalize airway inflammation despite normalizing systemic levels.
08
#08
Blood eosinophils and fractional exhaled nitric oxide are prognostic and predictive biomarkers in childhood asthma.
Bacharier Leonard B, et al. · The Journal of allergy and clinical immunology · 2024
HumanInfluence1.0
36
This study evaluated blood eosinophils and fractional exhaled nitric oxide as biomarkers in childhood asthma. Researchers found that higher eosinophil counts were associated with increased risk of exacerbations and better responses to dupilumab treatment.
Key findings
- 01Higher levels of blood eosinophils and Feno are linked to an increased risk of asthma exacerbations in children.
- 02Children with elevated biomarkers showed a greater response to the asthma medication dupilumab.
- 03These biomarkers can help identify which children may benefit most from specific asthma treatments.
09
#09
Endo-phenotyping of COPD patients.
ReviewInfluence2.0
30
This study focused on endo-phenotyping in COPD patients, highlighting the importance of blood eosinophil levels in predicting exacerbations and treatment efficacy. Researchers observed that patients with increased eosinophils tend to experience more frequent exacerbations and respond better to inhaled corticosteroids. The findings support the use of eosinophil counts as a biomarker for personalized therapy in COPD.
10
#10
Eosinophil Inflammation and Hyperresponsiveness in the Airways as Phenotypes of COPD, and Usefulness of Inhaled Glucocorticosteroids.
Human
23
Researchers examined the prevalence of airway eosinophilia and hyperresponsiveness in patients with COPD who had no history of asthma. The study found that these phenotypes are present in a significant portion of COPD patients and are associated with exacerbation frequency. The findings suggest that eosinophilia may influence treatment responses in COPD management.
Publication Trend
Research publications about Eosinophile over time
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