Lever
Lifestyle
- Manage stress through relaxation techniques
- Avoid known allergens
- Regular moderate exercise
Blutwerte · Marker
Eosinophile
Eosinophils · Eosinophile Granulozyten
BlutbildZeitabhängig
- Einheit:
- cells/µL
- Abbreviation
- EOS
Eosinophil count measures the number of eosinophils in the blood, reflecting immune system activity and inflammation.
Reference Ranges
Reference
0–500cells/µL
0
100
300
500
LowNormalHigh
Reference
Optimal
Unit · cells/µLReference ranges may vary slightly based on laboratory standards and population demographics.
Overview
Übersicht
Eosinophils are a type of white blood cell that play a crucial role in the body's immune response, particularly in combating parasitic infections and in mediating allergic reactions. They are characterized by their ability to release granules containing enzymes and proteins that contribute to inflammation and tissue remodeling. Clinically, eosinophil counts are important as they can reflect underlying conditions such as allergies, asthma, and certain infections. Elevated eosinophil levels, known as eosinophilia, can indicate an ongoing allergic response, parasitic infection, or other systemic conditions like autoimmune diseases. In the context of athletic performance and biohacking, eosinophil levels might be monitored to assess immune function and inflammation status, although their direct impact on performance is less clear. Elevated eosinophil levels could potentially indicate overtraining or an allergic response to environmental factors. However, eosinophil counts can be influenced by various factors such as recent infections, medication use, and even time of day, as levels may fluctuate throughout the day. Therefore, consistent testing conditions are recommended to ensure accurate interpretation of results.
Klinische Bedeutung
Elevated eosinophil levels may indicate allergic reactions, parasitic infections, or autoimmune diseases. Low levels are generally not clinically significant but may occur with certain infections or stress.
Dynamics
Trend Interpretation
Rising Values
Progressively rising eosinophil levels suggest worsening allergic or inflammatory conditions. Re-test in 4-6 weeks if levels are elevated.
Falling Values
Falling eosinophil levels may indicate resolution of an allergic or inflammatory condition.
Re-test Interval
4-6 weeks if outside optimal range
Etiology
Causes — High & Low
Cause
Elevated Levels
- Allergic reactions
- Parasitic infections
- Autoimmune diseases
- Certain cancers
- Drug reactions
Cause
Low Levels
- Acute infections
- Stress response
- Corticosteroid use
- Cushing's syndrome
Protocol
How to Optimize
Lever
Nutrition
- Consume anti-inflammatory foods
- Ensure adequate vitamin D intake
Lever
Supplementation
- Omega-3 supplements
- Probiotics
- Vitamin D
- Quercetin
Note:
Consult a healthcare provider for personalized advice, especially if considering supplements.
Testing Guidelines
✓Fasting Not Required
🕐Time-Sensitive
Eosinophil levels can vary throughout the day; morning samples may provide more consistent results.
Testing Frequency
Annually for general health monitoring, more frequently if managing a specific condition.
Interfering Factors
- Recent infections
- Medication use
- Time of day variations
Open Research Questions
Current research suggests that the optimal eosinophil count thresholds for predicting treatment responses in COPD and asthma remain debated, with varying reference ranges across studies. Researchers have not yet established a unified consensus on the clinical application of eosinophil counts as biomarkers, particularly regarding their role in distinguishing between asthma and COPD phenotypes. Additionally, unanswered clinical questions include the mechanisms driving eosinophilic inflammation and the long-term implications of eosinophilia in treatment outcomes.
24 Research Publications
838
Total Citations
10
Human/RCT
3.2
Avg. Influence
2026
Latest
Sort
Filter
01Top
#01
Eosinophils in COPD: just another biomarker?
ReviewInfluence5.0
212
Researchers explored the role of eosinophils as a biomarker in COPD. They found that blood eosinophil counts are associated with exacerbation risks and treatment responses, although their predictive value for sputum eosinophilia is limited. The study calls for more research to clarify the role of eosinophils in COPD.
02Top
#02
Eosinophilic inflammation in COPD: from an inflammatory marker to a treatable trait.
ReviewInfluence5.0
187
This study examined the role of blood eosinophil counts in chronic obstructive pulmonary disease (COPD) management. Researchers found that higher eosinophil levels may correlate with better responses to inhaled corticosteroids, although the underlying mechanisms remain unclear. The study emphasizes the need for further research to establish eosinophils as a reliable biomarker for treatment strategies in COPD.
03Top
#03
Association of sputum and blood eosinophil concentrations with clinical measures of COPD severity: an analysis of the SPIROMICS cohort.
HumanInfluence6.0
156
This study analyzed the association between blood and sputum eosinophil concentrations and COPD severity. Researchers found that high sputum eosinophil levels were linked to more severe disease and exacerbations, while blood eosinophil counts were less reliable as a biomarker for COPD severity. The findings highlight the importance of assessing sputum eosinophils in clinical practice.
04
#04
Cluster Analysis of Inflammatory Biomarker Expression in the International Severe Asthma Registry.
Denton Eve, et al. · The journal of allergy and clinical immunology. In practice · 2021
HumanInfluence6.0
84
This study characterized inflammatory biomarker expression in adults with severe asthma. Researchers found significant overlap in biomarker positivity, with distinct clusters of patients exhibiting unique clinical characteristics based on eosinophil levels. This suggests that eosinophils may play a role in understanding the pathogenesis of severe asthma.
Key findings
- 01Researchers observed that 64% of the study participants were female, with an average age of 53 years.
- 02They identified significant overlap in the presence of inflammatory biomarkers among patients with severe asthma.
- 03Distinct clusters of biomarker expression were associated with unique clinical features, indicating different inflammatory pathways.
05
#05
Eosinophils in COPD-Current Concepts and Clinical Implications.
ReviewInfluence1.0
37
This review summarized current knowledge on eosinophils in COPD and their potential as biomarkers. Researchers found that while blood eosinophil counts may predict responses to corticosteroids, their reliability is variable. The study highlights the need for more research to understand the role of eosinophils in COPD pathogenesis.
06
#06
Utility of eosinophil peroxidase as a biomarker of eosinophilic inflammation in asthma.
Tang Monica, et al. · The Journal of allergy and clinical immunology · 2024
HumanInfluence3.0
32
Researchers investigated the utility of eosinophil peroxidase (EPX) as a biomarker for eosinophilic inflammation in asthma. They found that serum EPX levels were higher in asthma patients compared to healthy controls, indicating its potential as a sensitive marker for airway inflammation.
Key findings
- 01EPX levels were elevated in 27% to 31% of serum samples and 36% to 53% of sputum samples from asthma patients.
- 02EPX in serum is a valid marker for systemic inflammation, while sputum EPX is more sensitive for detecting airway inflammation.
- 03Blood eosinophil counts often miss airway inflammation, and treatment with mepolizumab may not fully normalize airway inflammation despite normalizing systemic levels.
07
#07
Endo-phenotyping of COPD patients.
ReviewInfluence2.0
29
This study discussed the various phenotypes of COPD and their implications for treatment. Researchers highlighted that increased blood eosinophils are associated with more frequent exacerbations and better responses to inhaled corticosteroids, suggesting their role as a useful biomarker in COPD management.
08
#08
Blood eosinophils and fractional exhaled nitric oxide are prognostic and predictive biomarkers in childhood asthma.
Bacharier Leonard B, et al. · The Journal of allergy and clinical immunology · 2024
HumanInfluence1.0
28
Researchers evaluated the relationship between blood eosinophil counts and treatment responses in children with asthma. They found that higher baseline eosinophil levels were associated with increased risk of exacerbations and better responses to the medication dupilumab. This suggests that eosinophil counts can serve as important biomarkers for predicting asthma exacerbations in children.
Key findings
- 01Higher levels of blood eosinophils and Feno are linked to an increased risk of asthma exacerbations in children.
- 02Children with elevated biomarkers showed a greater response to the asthma medication dupilumab.
- 03These biomarkers can help identify which children may benefit most from specific asthma treatments.
09
#09
Eosinophil Inflammation and Hyperresponsiveness in the Airways as Phenotypes of COPD, and Usefulness of Inhaled Glucocorticosteroids.
Human
23
This clinical study examined the prevalence of airway eosinophilia in patients with COPD without asthma history. Researchers found that airway eosinophilia was present in a significant portion of subjects and was linked to increased exacerbations. The addition of inhaled glucocorticosteroids improved lung function in patients with eosinophilia.
10
#10
The Role of Eosinophils in Immunotherapy.
Review
11
This review discussed the role of eosinophils in atopic diseases and their potential as treatment response predictors. Researchers found that lower eosinophil counts are generally associated with better treatment outcomes. The study highlights the complexity of eosinophil biology and its implications for immunotherapy.
Publication Trend
Research publications about Eosinophile over time
10totalTrack your bloodwork in PepStack
Log lab results, track trends and optimize your biomarkers over time.
Legal Disclaimer
This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer