Lever
Lifestyle
- manage allergies
- reduce exposure to allergens
- practice stress-reduction techniques
Blutwerte · Marker
Eosinophile
Eosinophils · Eosinophile Granulozyten
BlutbildZeitabhängig
- Einheit:
- cells/µL
- Abbreviation
- EOS
Eosinophil count measures the number of eosinophils in the blood, reflecting immune activity and inflammation.
Reference Ranges
Reference
100–500cells/µL
100
500
LowNormalHigh
Reference
Unit · cells/µLReference ranges can vary slightly depending on the laboratory and population.
Overview
Übersicht
Eosinophils, abbreviated as EOS, are a type of white blood cell that play a crucial role in the body's immune response, particularly in combating parasitic infections and participating in allergic reactions. They are granulocytes, characterized by the presence of granules in their cytoplasm, which contain enzymes and proteins that contribute to their immune functions. Clinically, eosinophils are significant as they are involved in various inflammatory processes and are used as biomarkers for conditions such as asthma, chronic obstructive pulmonary disease (COPD), and eosinophilic disorders. Elevated eosinophil levels can indicate allergic reactions, parasitic infections, and certain autoimmune diseases, while low levels are less commonly of clinical concern. For athletes and biohackers, monitoring eosinophil levels might provide insights into immune function and inflammation status, which could influence recovery and performance. However, eosinophil counts can be affected by various factors, including time of day, recent infections, and medication use, which should be considered when interpreting results.
Klinische Bedeutung
Elevated eosinophil levels may indicate allergic reactions, parasitic infections, or eosinophilic disorders. Low levels are generally not clinically significant but may occur in certain conditions like acute infections or stress.
Dynamics
Trend Interpretation
Rising Values
Progressively rising eosinophil levels may suggest worsening of allergic or inflammatory conditions. Re-test in 4 weeks if levels are outside the optimal range.
Falling Values
Falling eosinophil levels may indicate resolution of an allergic or inflammatory condition.
Re-test Interval
4 weeks if outside optimal range
Etiology
Causes — High & Low
Cause
Elevated Levels
- allergic reactions
- parasitic infections
- autoimmune diseases
- certain cancers
- medication reactions
Cause
Low Levels
- acute infections
- stress
- Cushing's syndrome
- alcohol intoxication
- use of corticosteroids
Protocol
How to Optimize
Lever
Nutrition
- consume anti-inflammatory foods
- maintain a balanced diet
Lever
Supplementation
- Vitamin D
- Probiotics
Note:
Consult a healthcare provider for personalized advice, especially if considering changes due to abnormal eosinophil levels.
Testing Guidelines
✓Fasting Not Required
🕐Time-Sensitive
Eosinophil levels can vary throughout the day, typically peaking at night.
Testing Frequency
Annually for general health monitoring, more frequently if managing specific conditions.
Interfering Factors
- recent infections
- medication use
- stress levels
Open Research Questions
Current research suggests that the optimal eosinophil count thresholds for predicting treatment responses in COPD and asthma remain debated, with varying reference ranges complicating clinical application. Researchers have not yet established a unified consensus on the mechanisms underlying eosinophilic inflammation and its role as a treatable trait. Additionally, clinical questions regarding the long-term outcomes of eosinophil-targeted therapies and the impact of confounding factors on biomarker utility in diverse patient populations remain unanswered.
20 Research Publications
740
Total Citations
9
Human/RCT
3.6
Avg. Influence
2026
Latest
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Filter
01Top
#01
Eosinophils in COPD: just another biomarker?
ReviewInfluence5.0
208
This review explored the role of eosinophils as a biomarker in COPD. Researchers found that blood eosinophil counts are associated with exacerbation risk and treatment response, although their exact role in disease mechanisms remains unclear. The review calls for more research to clarify these associations.
02Top
#02
Eosinophilic inflammation in COPD: from an inflammatory marker to a treatable trait.
ReviewInfluence5.0
180
This study examined the role of blood eosinophil counts in chronic obstructive pulmonary disease (COPD). Researchers found that higher eosinophil levels may correlate with better responses to inhaled corticosteroids, although the underlying mechanisms remain unclear. The study emphasizes the need for further research to solidify eosinophils as a reliable biomarker for managing COPD.
03Top
#03
Association of sputum and blood eosinophil concentrations with clinical measures of COPD severity: an analysis of the SPIROMICS cohort.
HumanInfluence6.0
156
This study analyzed the association between blood and sputum eosinophil concentrations and COPD severity. Researchers found that high sputum eosinophil levels were linked to more severe disease and exacerbations, while blood eosinophil counts were less reliable as a biomarker for COPD severity. The findings highlight the importance of assessing sputum eosinophils in clinical practice.
04
#04
Cluster Analysis of Inflammatory Biomarker Expression in the International Severe Asthma Registry.
Denton Eve, et al. · The journal of allergy and clinical immunology. In practice · 2021
HumanInfluence6.0
79
This study characterized inflammatory biomarkers in adults with severe asthma. Researchers found that a significant proportion of patients exhibited elevated eosinophil counts, and distinct clusters of biomarker expression correlated with unique clinical characteristics. The findings suggest that eosinophils may play a role in the pathogenesis of severe asthma.
Key findings
- 01Researchers observed that 64% of the study participants were female, with an average age of 53 years.
- 02They identified significant overlap in the presence of inflammatory biomarkers among patients with severe asthma.
- 03Distinct clusters of biomarker expression were associated with unique clinical features, indicating different inflammatory pathways.
05
#05
Utility of eosinophil peroxidase as a biomarker of eosinophilic inflammation in asthma.
Tang Monica, et al. · The Journal of allergy and clinical immunology · 2024
HumanInfluence3.0
29
This study assessed eosinophil peroxidase as a biomarker in asthma. Researchers found that serum eosinophil peroxidase levels were elevated in a significant proportion of asthma patients, indicating systemic eosinophilic inflammation. The study suggests that this biomarker may be more sensitive than blood eosinophil counts for detecting airway inflammation.
Key findings
- 01EPX levels were elevated in 27% to 31% of serum samples and 36% to 53% of sputum samples from asthma patients.
- 02EPX in serum is a valid marker for systemic inflammation, while sputum EPX is more sensitive for detecting airway inflammation.
- 03Blood eosinophil counts often miss airway inflammation, and treatment with mepolizumab may not fully normalize airway inflammation despite normalizing systemic levels.
06
#06
Blood eosinophils and fractional exhaled nitric oxide are prognostic and predictive biomarkers in childhood asthma.
Bacharier Leonard B, et al. · The Journal of allergy and clinical immunology · 2024
HumanInfluence1.0
25
This study evaluated the relationship between blood eosinophil counts and treatment response in children with asthma. Researchers found that higher eosinophil levels were associated with an increased risk of asthma exacerbations and better responses to dupilumab treatment. The findings suggest that blood eosinophils are important biomarkers for predicting asthma severity and treatment outcomes.
Key findings
- 01Higher levels of blood eosinophils and Feno are linked to an increased risk of asthma exacerbations in children.
- 02Children with elevated biomarkers showed a greater response to the asthma medication dupilumab.
- 03These biomarkers can help identify which children may benefit most from specific asthma treatments.
07
#07
Eosinophil Inflammation and Hyperresponsiveness in the Airways as Phenotypes of COPD, and Usefulness of Inhaled Glucocorticosteroids.
Human
23
This study investigated the prevalence of airway eosinophilia in COPD patients without asthma symptoms. Researchers found that airway eosinophilia was present in a significant percentage of subjects and was associated with increased exacerbations. The addition of inhaled corticosteroids improved lung function in patients with eosinophilia.
08
#08
The Role of Eosinophils in Immunotherapy.
Review
11
Researchers reviewed the role of eosinophils in atopic diseases and their response to immunotherapy. They found that lower eosinophil counts are often associated with better treatment outcomes, but the relationship is complex. The study highlights the challenges of using eosinophils as a reliable biomarker.
09
#09
Workup for eosinophilia.
ReviewInfluence2.0
11
This article discussed the evaluation of eosinophilia in blood tests. Researchers found that eosinophilia is often linked to allergies but can also indicate other medical conditions. The study emphasizes the importance of a thorough medical history and further investigation when hypereosinophilia is detected.
10
#10
Severe Eosinophilic Asthma or Eosinophilic Granulomatosis With Polyangiitis: Potential Biomarkers for Novel Diagnostic Strategies.
Human
6
Researchers aimed to identify biomarkers that could differentiate severe eosinophilic asthma from eosinophilic granulomatosis with polyangiitis (EGPA). They found that sputum eosinophils and GM-CSF levels were significantly different between the two conditions, suggesting potential biomarkers for early diagnosis and treatment strategies.
Publication Trend
Research publications about Eosinophile over time
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