Lever
Lifestyle
- Regular exercise
- Smoking cessation
- Stress management
Blutwerte · Marker
Fibrinogen
Plasma Fibrinogen · Gerinnungsfaktor I
Entzündungsmarker
- Einheit:
- g/L
- Abbreviation
- Fib
Fibrinogen test quantifies the concentration of fibrinogen, a glycoprotein involved in blood clot formation.
Reference Ranges
Reference
2–4g/L
2
2.5
3.5
4
LowNormalHigh
Reference
Optimal
Unit · g/LReference ranges may vary slightly based on laboratory standards.
Overview
Übersicht
Fibrinogen, also known as Plasma Fibrinogen or Gerinnungsfaktor I, is a glycoprotein that plays a crucial role in blood coagulation. It is synthesized by the liver and circulates in the blood plasma. Upon vascular injury, fibrinogen is converted by thrombin into fibrin, which forms a mesh that helps in clot formation, thus preventing excessive bleeding. Researchers have observed that fibrinogen levels can be indicative of various physiological and pathological states. Clinically, fibrinogen is an important marker for inflammation and coagulation disorders. Elevated levels are associated with conditions such as cardiovascular disease, atherosclerosis, and acute phase reactions, while low levels may indicate bleeding disorders like disseminated intravascular coagulation (DIC) or liver dysfunction. In the context of athletic performance and biohacking, fibrinogen levels can reflect the body's inflammatory state and recovery capacity. Biohackers may monitor fibrinogen to optimize cardiovascular health and longevity. However, several factors can confound fibrinogen measurements, including acute infections, stress, and hormonal fluctuations. Time of day and fasting status do not significantly affect fibrinogen levels, but recent physical activity and certain medications can interfere with results. Researchers found that fibrinogen levels are generally stable, but it is important to consider these confounders when interpreting results.
Klinische Bedeutung
Elevated fibrinogen levels indicate increased risk of cardiovascular disease and inflammation, while reduced levels suggest bleeding disorders or liver dysfunction.
Dynamics
Trend Interpretation
Rising Values
Progressively rising fibrinogen levels suggest increased inflammation or cardiovascular risk. Re-test in 4 weeks if levels are outside the optimal range.
Falling Values
Progressively falling fibrinogen levels may indicate improved inflammation control or potential bleeding risk.
Re-test Interval
4 weeks if outside optimal range
Etiology
Causes — High & Low
Cause
Elevated Levels
- Inflammation
- Cardiovascular disease
- Acute phase reactions
- Pregnancy
- Smoking
Cause
Low Levels
- Liver disease
- Disseminated intravascular coagulation
- Severe malnutrition
- Genetic fibrinogen disorders
- Snake venom exposure
Protocol
How to Optimize
Lever
Nutrition
- Omega-3 fatty acids
- High-fiber diet
- Antioxidant-rich foods
Lever
Supplementation
- Omega-3 supplements
- Vitamin C
- Curcumin
Note:
Consult a healthcare provider before making significant lifestyle or dietary changes.
Testing Guidelines
✓Fasting Not Required
✓Not Time-Sensitive
Testing Frequency
Annually for adults with cardiovascular risk factors
Interfering Factors
- Recent intense exercise
- Hormonal medications
- Acute infections
Open Research Questions
Current research suggests that reference ranges for fibrinogen levels in various populations, particularly in neonates and those with dysfibrinogenemia, remain inadequately defined. Researchers have not yet established optimal fibrinogen-to-albumin ratio targets for predicting outcomes in neonatal sepsis or the specific confounders affecting fibrinogen levels in diverse clinical settings. Additionally, unanswered clinical questions include the precise role of fibrinogen in thrombus formation and its implications in managing disseminated intravascular coagulation.
26 Research Publications
614
Total Citations
10
Human/RCT
3.0
Avg. Influence
2025
Latest
Sort
Filter
01Top
#01
Laboratory diagnosis of dysfibrinogenemia.
ReviewInfluence6.0
120
Researchers reviewed the laboratory diagnosis of dysfibrinogenemia, a coagulation disorder linked to abnormal fibrinogen function. They outlined diagnostic tests and proposed an algorithm for identifying inherited and acquired forms of the disorder, emphasizing the importance of family testing.
02Top
#02
Plasma Fibrinogen as a Biomarker for Mortality and Hospitalized Exacerbations in People with COPD.
HumanInfluence8.0
109
Researchers analyzed data to assess plasma fibrinogen as a biomarker for mortality and exacerbations in COPD patients. They found that high fibrinogen levels were associated with increased risks of hospitalizations and death, suggesting its potential role in clinical trials.
03Top
#03
Laboratory and Genetic Investigation of Mutations Accounting for Congenital Fibrinogen Disorders.
ReviewInfluence4.0
98
This study reviewed congenital fibrinogen disorders, which can lead to bleeding issues. Researchers found that these disorders are caused by mutations in fibrinogen-encoding genes and can be classified into quantitative and qualitative deficiencies.
04
#04
Defibrinogenating enzymes.
AnimalInfluence2.0
62
Researchers found that snake venoms, specifically ancrod, batroxobin, and crotalase, can significantly reduce plasma fibrinogen levels by cleaving fibrinogen into its components. This reduction is accompanied by a rise in fibrinogen-fibrin degradation products. While these venoms have been studied in various medical conditions, further trials are needed to clarify their roles in treatment.
05
#05
Fibrinogen and aging.
Human
53
Researchers found that plasma fibrinogen levels increase with age, particularly in individuals over 65, which may elevate risks for cardiovascular diseases. This study highlights the age-dependent rise in fibrinogen compared to other blood components, suggesting its role in health monitoring.
06
#06
Laboratory testing for fibrinogen abnormalities.
ReviewInfluence1.0
48
This article summarized laboratory testing methods for diagnosing fibrinogen abnormalities. Researchers highlighted that both acquired and congenital fibrinogen disorders can lead to increased bleeding risk, emphasizing the importance of accurate laboratory assessments.
07
#07
Clotting factors: Clinical biochemistry and their roles as plasma enzymes.
ReviewInfluence2.0
35
Researchers reviewed the structure and function of coagulation factors, including fibrinogen, in the blood coagulation process. They highlighted the importance of fibrinogen in clot formation and discussed laboratory testing methods for coagulation disorders.
08
#08
Pretreatment plasma fibrinogen level as a prognostic biomarker for patients with lung cancer.
Meta-AnalysisInfluence1.0
28
This meta-analysis assessed the prognostic value of pretreatment plasma fibrinogen levels in lung cancer patients. Researchers found that higher fibrinogen levels were significantly associated with worse overall survival and advanced disease stage.
09
#09
Reference limits of plasma fibrinogen.
HumanInfluence2.0
25
This study established reference limits for plasma fibrinogen in healthy individuals and examined its relationship with various factors. Researchers found that fibrinogen levels increased with age and were influenced by body weight and smoking.
10
#10
Disseminated intravascular coagulation.
Review
11
Researchers noted that disseminated intravascular coagulation (DIC) in obstetrics is associated with high maternal and perinatal risks. They emphasized the importance of various laboratory tests, including plasma fibrinogen levels, for diagnosing DIC. Identifying the underlying causes of DIC is crucial for management.
Publication Trend
Research publications about Fibrinogen over time
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