GGT

Gamma-glutamyltransferase (GGT) is an enzyme that plays a crucial role in the metabolism of glutathione, a major antioxidant in the body. It is primarily found in the liver but is also present in other tissues such as the kidney and pancreas. GGT is involved in the transfer of gamma-glutamyl functional groups, which is essential for the breakdown and utilization of glutathione. Clinically, GGT is a significant biomarker for liver function and is often used to detect liver diseases, including alcoholic liver disease, biliary obstruction, and non-alcoholic fatty liver disease. Elevated GGT levels can indicate liver damage or dysfunction, and it is commonly used alongside other liver enzymes like ALT and AST to assess liver health. In the context of athletic performance and biohacking, GGT may be relevant as it reflects oxidative stress and liver health, which are critical for recovery and overall metabolic function. High GGT levels have been associated with increased mortality and frailty in older adults, suggesting its potential role in longevity studies. However, several factors can confound GGT levels, including alcohol consumption, obesity, and certain medications. Time of day and fasting status do not significantly affect GGT measurements, but recent alcohol intake can elevate levels. Researchers recommend considering these factors when interpreting GGT results to avoid misdiagnosis or overestimation of liver dysfunction.