Glutathion

Glutathione (GSH) is a tripeptide composed of glutamine, cysteine, and glycine, serving as a critical antioxidant in the human body. It plays a vital role in cellular redox reactions, detoxification of xenobiotics, and protection against oxidative stress by neutralizing reactive oxygen, nitrogen, and sulfur species. GSH is also involved in immune system regulation and protein synthesis. Clinically, GSH is significant as its dysregulation is associated with various conditions, including schizophrenia, neurological disorders, and age-related diseases. Researchers have found that altered GSH levels can indicate oxidative stress and immune dysfunction, making it a potential biomarker for these conditions. In the context of athletic performance and biohacking, GSH is valued for its ability to reduce oxidative stress, potentially enhancing recovery and performance. Its role in longevity is linked to its antioxidant properties, which may mitigate age-related cellular damage. However, GSH levels can be influenced by factors such as diet, supplementation, and overall health status. Researchers observed that oral supplementation can increase GSH levels, but these levels may return to baseline after discontinuation. Time-of-day and fasting do not significantly affect GSH levels, but factors like recent intense exercise or illness could interfere with measurements.