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Uric Acid · Urat · UA
Uric acid measures the concentration of uric acid in the blood, reflecting purine metabolism and renal excretion efficiency.
Reference ranges may vary slightly by age and sex.
Uric acid (UA) is a waste product formed from the natural breakdown of purines, which are found in certain foods and drinks. It is primarily excreted by the kidneys and serves as a marker for renal function and purine metabolism. Clinically, uric acid levels are significant as they can indicate conditions such as hyperuricemia and gout, where elevated levels lead to the formation of urate crystals in joints, causing pain and inflammation. Hyperuricemia is also associated with metabolic syndrome, obesity, and hypertension. Conversely, hypouricemia, or low uric acid levels, can occur due to certain medications or underlying health conditions affecting uric acid production or excretion. For athletes and biohackers, maintaining optimal uric acid levels is crucial as it may influence inflammation and recovery processes. Research has shown that lower uric acid levels are associated with longevity, suggesting a potential role in promoting a longer lifespan. However, uric acid levels can be influenced by various factors including diet, medications, and hydration status. Fasting and time-of-day variations may also affect test results, necessitating consistent testing conditions for accurate monitoring.
Klinische Bedeutung
Elevated uric acid levels can indicate hyperuricemia, gout, metabolic syndrome, or renal dysfunction. Low levels may suggest hypouricemia due to medications or renal tubular defects.
Progressively rising uric acid levels suggest worsening renal function or increased purine metabolism. Re-test in 4 weeks if outside optimal range.
Progressively falling levels may indicate effective management of hyperuricemia or overcorrection with urate-lowering therapy.
Re-test Interval
4 weeks if outside optimal range
Note:
Consult a healthcare provider before making significant dietary changes or starting new supplements.
Uric acid levels may vary throughout the day; morning tests are preferred.
Testing Frequency
Annually for healthy adults, more frequently if managing gout or hyperuricemia.
Correlated with
Current research suggests that reference ranges for uric acid levels, particularly in relation to age and gender, remain debated, with optimal targets for preventing conditions like hypertension and gout not yet established. Emerging research directions include the role of uric acid in obesity and its mechanistic pathways affecting gut microbiota. Clinical questions remain unanswered regarding the long-term effects of uric acid modulation on cardiovascular health and the potential for personalized treatment strategies based on individual biomarker profiles.
1,074
Total Citations
13
Human/RCT
4.6
Avg. Influence
2025
Latest
This review discusses the evolutionary significance of uric acid, suggesting it may have beneficial effects such as antioxidant properties and potential links to increased intelligence. Researchers argue that the higher uric acid levels in humans may have conferred advantages during evolution, despite its known harmful effects.
Researchers found that drug-induced hyperuricaemia is a growing concern in clinical practice, primarily caused by diuretics. The study highlights the mechanisms by which certain medications increase serum uric acid levels, leading to complications like gout. Increased awareness and monitoring of these drugs are essential for reducing related health issues.
Researchers found that elevated serum uric acid levels may predict the onset of hypertension. The study highlights mechanisms by which uric acid contributes to hypertension, including activation of the renin-angiotensin system. Ongoing clinical trials aim to clarify the role of uric acid in hypertension management.
This review discusses the connection between low uric acid levels and Parkinson's disease. Researchers observed that low uric acid may predispose individuals to oxidative stress, contributing to the disease's progression. The study calls for further research to clarify the relationship between uric acid and Parkinson's disease.
Researchers found that uric acid may serve as a biomarker for monitoring disease activity in multiple sclerosis. The study suggests that lower uric acid levels in MS patients could be a result of its role in scavenging reactive oxidants during inflammation, rather than a primary deficiency.
This review discussed the dual role of uric acid as both an antioxidant and a potential risk factor for cardiovascular disease. Researchers noted that high uric acid levels could indicate increased cardiovascular risk, particularly in women. The study emphasizes the need for further research to clarify the thresholds at which uric acid shifts from protective to harmful.
Researchers reviewed the clinical implications of uric acid in heart failure, noting its potential as a prognostic biomarker. The study highlighted that high serum uric acid levels are associated with increased mortality in heart failure patients. This suggests that uric acid may play a role in the pathophysiology of heart failure and could be a target for future therapies.
This study examined blood biomarker profiles in centenarians compared to shorter-lived individuals. Researchers found that centenarians had lower levels of uric acid and other biomarkers associated with aging, suggesting that these levels may play a role in exceptional longevity. The findings indicate potential lifestyle or genetic factors influencing these biomarker levels.
Researchers reviewed the potential of salivary uric acid as a noninvasive diagnostic tool for various diseases. The study found that elevated salivary uric acid levels are associated with conditions like cancer and hypertension, while lower levels may indicate neurological disorders. This suggests that salivary uric acid analysis could be a valuable addition to clinical diagnostics.
This review highlighted the potential of uric acid as a therapeutic target in neurodegenerative diseases. Researchers found that uric acid has neuroprotective properties and may help manage oxidative stress and neuroinflammation, although further research is needed to clarify its clinical applications.
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