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Blutwerte · Marker

Harnsäure

Uric Acid · Urat · UA

Nierenwerte
Einheit:
mg/dL
Abbreviation
UA

Uric acid measures the concentration of uric acid in the blood, reflecting renal excretion and purine metabolism.

Reference Ranges

Reference
3.57.2mg/dL
3.5
5.5
7.2
LowNormalHigh
Reference
Optimal
Unit · mg/dL

Ranges may vary slightly based on lab methods; generally higher in males.

Overview

Übersicht

Uric acid (UA) is a waste product formed from the breakdown of purines, which are found in certain foods and drinks. It is primarily excreted by the kidneys and measured in the blood to assess its concentration. The biological measurement of uric acid provides insight into renal function and purine metabolism. Clinically, uric acid levels are significant as they can indicate conditions such as gout, a form of inflammatory arthritis caused by uric acid crystal deposition in joints, and hyperuricemia, which is an elevated level of uric acid in the blood. Researchers have also found associations between high uric acid levels and hypertension, as well as potential links to subclinical hypothyroidism. In the context of longevity, lower uric acid levels have been observed in centenarians, suggesting a possible role in promoting a longer lifespan. For athletes and biohackers, maintaining optimal uric acid levels is important as it may influence inflammation and recovery. However, uric acid levels can be affected by various factors such as diet, medications, and renal function. Fasting is not typically required for testing, but certain drugs and conditions can interfere with accurate measurement.

Klinische Bedeutung

Elevated uric acid levels may indicate gout, hyperuricemia, or an increased risk of hypertension. Low levels can be associated with liver disease or over-treatment with urate-lowering medications.

Dynamics

Trend Interpretation

Rising Values

Progressively rising values suggest increased risk of gout or hypertension; retest in 4 weeks if elevated.

Falling Values

Falling values may indicate effective management of hyperuricemia or potential liver dysfunction.

Re-test Interval

4 weeks if outside optimal range

Etiology

Causes — High & Low

Cause

Elevated Levels

  • High purine diet
  • Renal insufficiency
  • Diuretic use
  • Alcohol consumption
  • Hypothyroidism
Cause

Low Levels

  • Liver disease
  • Over-treatment with urate-lowering drugs
  • Fanconi syndrome
  • SIADH (Syndrome of Inappropriate Antidiuretic Hormone secretion)
Protocol

How to Optimize

Lever

Lifestyle

  • Increase hydration
  • Limit alcohol intake
  • Maintain a healthy weight
Lever

Nutrition

  • Reduce intake of purine-rich foods
  • Increase consumption of cherries
  • Limit sugary beverages
Lever

Supplementation

  • Vitamin C
  • Cherries
  • Omega-3 fatty acids

Note:

Consult a healthcare provider before making significant dietary changes, especially if on medication.

Testing Guidelines

Fasting Not Required
Not Time-Sensitive

Uric acid levels may vary throughout the day; morning tests are preferred.

Testing Frequency

Annually for those with risk factors for gout or hypertension.

Interfering Factors

  • Diuretic medications
  • High-protein diet

Related Peptides & Hormones

hormone

Open Research Questions

Current research suggests that the relationship between uric acid levels and thyroid function, particularly in subclinical hypothyroidism, remains unclear, with no consensus on optimal reference ranges or targets. Researchers have not yet established the precise mechanisms by which uric acid influences hypertension and its role in aging processes. Additionally, clinical questions remain unanswered regarding the long-term effects of uric acid modulation on cardiovascular health and longevity.

26 Research Publications

1,010

Total Citations

11

Human/RCT

4.6

Avg. Influence

2025

Latest

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Filter
#01

Uric acid and evolution.

ReviewInfluence11.0
371
Researchers explored the evolutionary significance of uric acid, noting its role as an antioxidant and potential benefits for human health. They discussed various hypotheses regarding the advantages of higher uric acid levels, including implications for blood pressure regulation and neuroprotection. The study highlights both harmful and beneficial effects of uric acid.
View on PubMed
#02

Drug-induced hyperuricaemia and gout.

ReviewInfluence5.0
192
Researchers found that drug-induced hyperuricaemia is a growing concern in clinical practice, primarily caused by diuretics. They highlighted the mechanisms by which certain medications increase serum uric acid levels, leading to complications like gout. Increased awareness and monitoring of these drugs are essential for reducing related health issues.
View on PubMed
#03

Uric acid and hypertension.

HumanInfluence10.0
174
Researchers observed that elevated uric acid levels may predict the onset of essential hypertension, with significant findings in pediatric populations. They discussed mechanisms by which uric acid could contribute to hypertension, including effects on the renin-angiotensin system. Ongoing trials are expected to clarify uric acid's role in hypertension management.
View on PubMed
#04

Uric Acid in Parkinson's Disease: What Is the Connection?

ReviewInfluence3.0
62
Researchers examined the connection between low uric acid levels and Parkinson's disease, suggesting that low UA may predispose individuals to oxidative stress and neuronal degeneration. They discussed the complexities of this relationship, including the possibility of reverse causation. The study calls for further investigation into the mechanisms linking uric acid and Parkinson's disease.
View on PubMed
#05

Uric Acid for Cardiovascular Risk: Dr. Jekyll or Mr. Hide?

ReviewInfluence1.0
36
This review discussed the dual role of uric acid as both an antioxidant and a potential risk factor for cardiovascular disease. Researchers noted that high uric acid levels could indicate increased cardiovascular risk, particularly in women. The study emphasizes the need for further research to clarify the thresholds at which uric acid shifts from protective to harmful.
View on PubMed
#06

Clinical Implications of Uric Acid in Heart Failure: A Comprehensive Review.

Review
35
Researchers reviewed the clinical implications of uric acid in heart failure, noting its potential as a prognostic biomarker. The study highlighted that high serum uric acid levels are associated with increased mortality in heart failure patients. This suggests that uric acid may play a role in the pathophysiology of heart failure and could be a target for future therapies.
View on PubMed
#07

Blood biomarker profiles and exceptional longevity: comparison of centenarians and non-centenarians in a 35-year follow-up of the Swedish AMORIS cohort.

HumanInfluence3.0
31
Researchers examined blood biomarker profiles in centenarians compared to shorter-lived individuals, finding that lower uric acid levels were associated with reaching age 100. They noted that centenarians exhibited more favorable biomarker values from age 65 onwards. The study suggests that these biomarkers may reflect genetic or lifestyle factors influencing longevity.
View on PubMed
#08

Salivary Uric Acid: A Noninvasive Wonder for Clinicians?

ReviewInfluence2.0
30
Researchers reviewed the potential of salivary uric acid as a noninvasive diagnostic tool for various diseases. The study found that elevated salivary uric acid levels are associated with conditions like cancer and hypertension, while lower levels may indicate neurological disorders. This suggests that salivary uric acid analysis could be a valuable addition to clinical diagnostics.
View on PubMed
#09

Targeting uric acid: a promising intervention against oxidative stress and neuroinflammation in neurodegenerative diseases.

Review
29
This review highlighted the potential of uric acid as a therapeutic target in neurodegenerative diseases. Researchers found that uric acid has neuroprotective properties and may help manage oxidative stress and neuroinflammation, although further research is needed to clarify its clinical applications.
View on PubMed
#10

New markers in metabolic syndrome.

ReviewInfluence2.0
24
Researchers reviewed various biomarkers associated with metabolic syndrome, including uric acid, which correlates positively with the condition. They emphasized the significance of identifying reliable biomarkers for diagnosing metabolic syndrome, which is linked to serious health risks. The study aims to enhance laboratory analysis approaches for metabolic syndrome.
View on PubMed

Publication Trend

Research publications about Harnsäure over time

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