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Blutwerte · Marker

HDL-Cholesterin

High-Density Lipoprotein · HDL-C · HDL

Lipide & Herz-Kreislauf
Einheit:
mmol/L
Abbreviation
HDL-C

HDL-C quantifies the amount of cholesterol transported by high-density lipoproteins in the blood.

Reference Ranges

Reference
11.5mmol/L
1
1.3
1.6
1.5
LowNormalHigh
Reference
Optimal
Unit · mmol/L

Reference ranges may vary slightly by lab; generally, higher HDL-C is better.

Overview

Übersicht

High-Density Lipoprotein Cholesterol (HDL-C) is a type of cholesterol carried by high-density lipoproteins in the blood. It is often referred to as 'good' cholesterol because it helps transport cholesterol from other parts of the body back to the liver, where it can be processed and excreted. This process is crucial for maintaining lipid balance and preventing cholesterol accumulation in blood vessels. Clinically, HDL-C is important as it is inversely associated with the risk of atherosclerotic cardiovascular diseases (ASCVD), including coronary artery disease, peripheral vascular disease, and cerebrovascular disease. Low levels of HDL-C are linked to an increased risk of these conditions, while higher levels are generally protective. Additionally, researchers have found that HDL-C levels may also be inversely related to cancer incidence and progression, although the mechanisms are not fully understood. For athletes and biohackers, maintaining optimal HDL-C levels is important for cardiovascular health and longevity. HDL-C is involved in anti-inflammatory and antioxidant processes, which can support recovery and performance. However, it is important to note that HDL-C levels can be influenced by factors such as genetics, diet, physical activity, and certain medications. Fasting is not required for HDL-C testing, but levels can be affected by recent intense exercise or acute illness, which should be considered when interpreting results.

Klinische Bedeutung

Elevated HDL-C levels are generally protective against cardiovascular diseases, while low levels are associated with increased risk. HDL-C may also have a role in cancer prognosis.

Dynamics

Trend Interpretation

Rising Values

Progressively rising HDL-C values suggest improved cardiovascular protection. Re-test annually unless clinically indicated otherwise.

Falling Values

Progressively falling HDL-C values may indicate increased cardiovascular risk.

Re-test Interval

6 months if outside optimal range

Etiology

Causes — High & Low

Cause

Elevated Levels

  • Genetic factors
  • Regular physical activity
  • Moderate alcohol consumption
  • Estrogen therapy
  • Certain medications (e.g., niacin)
Cause

Low Levels

  • Sedentary lifestyle
  • Smoking
  • Obesity
  • High carbohydrate diet
  • Metabolic syndrome
Protocol

How to Optimize

Lever

Lifestyle

  • Increase physical activity
  • Quit smoking
  • Maintain healthy weight
Lever

Nutrition

  • Consume healthy fats (e.g., omega-3 fatty acids)
  • Increase fiber intake
Lever

Supplementation

  • Niacin
  • Omega-3 fatty acids

Note:

Consult a healthcare provider before starting new supplements, especially if on medication.

Testing Guidelines

Fasting Not Required
Not Time-Sensitive

Testing Frequency

Annually for adults, more frequently if managing cardiovascular risk.

Interfering Factors

  • Recent intense exercise
  • Acute illness

Open Research Questions

Current research suggests that the molecular mechanisms linking HDL-C to tumor incidence and prognosis remain understudied, with conflicting views on its role in cancer. Researchers have not yet established optimal reference ranges or targets for HDL-C in various populations, particularly concerning metabolic syndrome and cardiovascular disease risk. Additionally, clinical questions regarding the impact of HDL-C levels on outcomes in specific conditions like obstructive sleep apnea and gout remain unanswered.

21 Research Publications

530

Total Citations

7

Human/RCT

3.0

Avg. Influence

2021

Latest

Sort
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#01

The Triglyceride/High-Density Lipoprotein Cholesterol (TG/HDL-C) Ratio as a Risk Marker for Metabolic Syndrome and Cardiovascular Disease.

ReviewInfluence11.0
249
Researchers found that the ratio of triglycerides to high-density lipoprotein cholesterol (TG/HDL-C) is a promising biomarker for predicting the risk of metabolic syndrome and cardiovascular disease. The study highlights the importance of monitoring both triglycerides and HDL-C levels, even when low-density lipoprotein cholesterol is well-managed. This ratio may provide valuable insights into cardiovascular health.
View on PubMed
#02

Positive association between high-density lipoprotein cholesterol and bone mineral density in U.S. adults: the NHANES 2011-2018.

HumanInfluence3.0
78
Researchers found a positive correlation between high-density lipoprotein cholesterol (HDL-C) levels and lumbar bone mineral density (BMD) in adults aged 20-59. The study highlighted that this relationship varies by sex and race, suggesting that HDL-C could serve as a biomarker for early detection of osteoporosis.
View on PubMed
#03

Hypertriglyceridemia in Obese Children and Adolescents.

HumanInfluence2.0
34
This study investigated hypertriglyceridemia in obese children and adolescents, focusing on the TG/HDL-C ratio as a marker of cardiometabolic risk. Researchers found that elevated TG levels are common in this population and recommended lifestyle modifications to manage triglyceride levels.
View on PubMed
#04

Revealing the Role of High-Density Lipoprotein in Colorectal Cancer.

ReviewInfluence1.0
34
This review analyzed the role of high-density lipoprotein cholesterol (HDL-C) in colorectal cancer (CRC). Researchers found that HDL-C levels decrease in CRC patients, and emphasized the need for further studies on HDL functionality and its potential as a biomarker in CRC.
View on PubMed
#05

HDL in Endocrine Carcinomas: Biomarker, Drug Carrier, and Potential Therapeutic.

ReviewInfluence1.0
32
This review focused on the relationship between high-density lipoprotein (HDL) and cancer, particularly in endocrine carcinomas. Researchers observed that HDL-C levels may inversely correlate with cancer risk and suggested potential therapeutic applications of synthetic HDL in cancer treatment.
View on PubMed
#06

High-Density Lipoprotein Cholesterol in Age-Related Ocular Diseases.

Review
30
Researchers reviewed the role of high-density lipoprotein cholesterol (HDL-C) in age-related ocular diseases. The review summarizes current knowledge regarding HDL-C's potential involvement in conditions such as age-related macular degeneration and diabetic retinopathy, although specific mechanisms remain unclear.
View on PubMed
#07

Recombinant high-density lipoprotein formulations.

Review
18
Researchers reviewed novel recombinant high-density lipoprotein formulations as potential therapies for cardiovascular disease. The study highlights the need for further clinical trials to evaluate the effectiveness of these HDL-modifying therapies in reducing atherosclerotic events.
View on PubMed
#08

High-density lipoprotein cholesterol and carcinogenesis.

Review
16
Researchers examined the association between high-density lipoprotein cholesterol (HDL-C) levels and cancer outcomes. The findings suggest a negative correlation between HDL-C and tumor incidence, indicating that higher HDL-C levels may be linked to better cancer prognosis. However, the study calls for further investigation into the molecular mechanisms behind this relationship.
View on PubMed
#09

Non-linear association of the platelet/high-density lipoprotein cholesterol ratio with bone mineral density a cross-sectional study.

HumanInfluence2.0
12
Researchers explored the relationship between the platelet-to-high-density lipoprotein cholesterol ratio (PHR) and bone mineral density (BMD). The study identified a nonlinear, inverted U-shaped relationship, indicating that maintaining optimal PHR levels is important for supporting bone health, particularly in high-risk populations.
View on PubMed
#10

Association of non-high-density lipoprotein cholesterol-to-high-density lipoprotein cholesterol ratio (NHHR) with gout prevalence: a cross-sectional study.

HumanInfluence1.0
8
Researchers investigated the relationship between the non-high-density lipoprotein cholesterol-to-high-density lipoprotein cholesterol ratio (NHHR) and gout prevalence. The study revealed that higher NHHR levels are significantly associated with increased odds of developing gout, suggesting that NHHR may be a useful marker for assessing gout risk in adults.
View on PubMed

Publication Trend

Research publications about HDL-Cholesterin over time

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