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Blutwerte · Marker

HDL-Cholesterin

High-Density Lipoprotein · HDL-C · HDL

Lipide & Herz-KreislaufNüchtern erforderlich
Einheit:
mmol/L
Abbreviation
HDL-C

HDL-C measures the concentration of high-density lipoprotein cholesterol in the blood.

Reference Ranges

Reference
11.5mmol/L
1
1.3
1.6
1.5
LowNormalHigh
Reference
Optimal
Unit · mmol/L

Reference ranges may vary slightly by laboratory and population. Fasting is recommended for accurate measurement.

Overview

Übersicht

High-Density Lipoprotein Cholesterol (HDL-C) is a type of cholesterol carried in the blood by high-density lipoproteins. It is often referred to as 'good cholesterol' due to its role in transporting cholesterol from the arteries to the liver for excretion or re-utilization. HDL-C is a key component of lipid profiles used to assess cardiovascular health. Clinically, HDL-C levels are inversely associated with the risk of atherosclerotic cardiovascular disease (ASCVD), including coronary artery disease, peripheral vascular disease, and cerebrovascular disease. Low levels of HDL-C are linked to increased risk of metabolic syndrome and cardiovascular diseases, while very high levels may also pose risks. In the context of athletic performance and biohacking, maintaining optimal HDL-C levels is considered beneficial for cardiovascular health and longevity. However, researchers have noted that both extremely low and high HDL-C levels can be associated with genetic disorders or other health conditions. Confounders such as diet, exercise, and medication can influence HDL-C levels, and fasting is typically recommended before testing to ensure accurate results.

Klinische Bedeutung

Elevated HDL-C is generally considered protective against cardiovascular disease, while low HDL-C levels are associated with increased risk of ASCVD. However, extremely high HDL-C levels may indicate genetic disorders and could also pose health risks.

Dynamics

Trend Interpretation

Rising Values

Progressively rising HDL-C levels generally suggest improved cardiovascular health, but extremely high levels should be evaluated for potential genetic causes.

Falling Values

Progressively falling HDL-C levels may indicate increased cardiovascular risk and warrant lifestyle or medical intervention.

Re-test Interval

4 weeks if outside optimal range

Etiology

Causes — High & Low

Cause

Elevated Levels

  • Genetic factors
  • Regular physical activity
  • Moderate alcohol consumption
  • Certain medications (e.g., niacin)
Cause

Low Levels

  • Sedentary lifestyle
  • Smoking
  • Obesity
  • Type 2 diabetes
Protocol

How to Optimize

Lever

Lifestyle

  • Increase physical activity
  • Quit smoking
  • Maintain a healthy weight
Lever

Nutrition

  • Consume healthy fats (e.g., omega-3 fatty acids)
  • Increase fiber intake
  • Limit trans fats
Lever

Supplementation

  • Niacin
  • Omega-3 fatty acids

Note:

Consult a healthcare provider before starting any supplementation, especially if taking other medications.

Testing Guidelines

🍽️Fasting Required
Not Time-Sensitive

Testing Frequency

Annually for adults at risk of cardiovascular disease.

Interfering Factors

  • Recent intense exercise
  • Alcohol consumption
  • Acute illness

Open Research Questions

Current research suggests that the molecular mechanisms linking HDL-C to tumor incidence and prognosis remain understudied, with conflicting views on its role in cancer. Researchers have not yet established optimal HDL-C reference ranges or targets for various populations, particularly in the context of metabolic syndrome and cardiovascular disease. Additionally, clinical questions regarding the impact of genetic variations on HDL-C levels and their implications for personalized treatment strategies remain unanswered.

22 Research Publications

654

Total Citations

7

Human/RCT

3.5

Avg. Influence

2021

Latest

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#01

The Triglyceride/High-Density Lipoprotein Cholesterol (TG/HDL-C) Ratio as a Risk Marker for Metabolic Syndrome and Cardiovascular Disease.

ReviewInfluence12.0
280
This study examined the relationship between the triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio and the risk of metabolic syndrome and cardiovascular disease (CVD). Researchers found that increased TG levels and decreased HDL-C levels are associated with higher risks of these conditions, suggesting that the TG/HDL-C ratio could serve as a valuable predictor for CVD.
View on PubMed
#02

Diagnosis and treatment of high density lipoprotein deficiency.

ReviewInfluence5.0
82
Researchers observed that low levels of high-density lipoprotein cholesterol (HDL-C) are significant risk factors for cardiovascular disease (CVD). The study emphasizes the importance of genetic analysis in diagnosing HDL deficiency and its associated health risks.
View on PubMed
#03

Positive association between high-density lipoprotein cholesterol and bone mineral density in U.S. adults: the NHANES 2011-2018.

HumanInfluence4.0
82
This study explored the relationship between high-density lipoprotein cholesterol (HDL-C) and bone mineral density (BMD) in U.S. adults. Researchers found a positive association, particularly in women, suggesting HDL-C may serve as a biomarker for early osteoporosis detection.
View on PubMed
#04

Hypertriglyceridemia in Obese Children and Adolescents.

HumanInfluence2.0
34
This study investigated hypertriglyceridemia in obese children and adolescents, focusing on the TG/HDL-C ratio as a marker of cardiometabolic risk. Researchers found that elevated TG levels are common in this population and recommended lifestyle modifications to manage triglyceride levels.
View on PubMed
#05

Revealing the Role of High-Density Lipoprotein in Colorectal Cancer.

ReviewInfluence1.0
34
This review analyzed the role of high-density lipoprotein cholesterol (HDL-C) in colorectal cancer (CRC). Researchers found that HDL-C levels decrease in CRC patients, and emphasized the need for further studies on HDL functionality and its potential as a biomarker in CRC.
View on PubMed
#06

HDL in Endocrine Carcinomas: Biomarker, Drug Carrier, and Potential Therapeutic.

ReviewInfluence1.0
32
This review focused on the relationship between high-density lipoprotein (HDL) and cancer, particularly in endocrine carcinomas. Researchers observed that HDL-C levels may inversely correlate with cancer risk and suggested potential therapeutic applications of synthetic HDL in cancer treatment.
View on PubMed
#07

High-Density Lipoprotein Cholesterol in Age-Related Ocular Diseases.

Review
31
This literature review explored the role of high-density lipoprotein cholesterol (HDL-C) in age-related ocular diseases. Researchers found limited understanding of HDL-C's specific impact on conditions like age-related macular degeneration and diabetic retinopathy.
View on PubMed
#08

High-density lipoprotein cholesterol and carcinogenesis.

Review
19
Researchers found a negative association between high-density lipoprotein cholesterol (HDL-C) levels and tumor incidence, suggesting that measuring HDL-C could help assess cancer prognosis. However, the molecular mechanisms linking HDL-C to tumor development remain unclear.
View on PubMed
#09

Recombinant high-density lipoprotein formulations.

Review
18
Researchers reviewed novel recombinant high-density lipoprotein (HDL) formulations aimed at mitigating cardiovascular disease (CVD) risk. The study highlights the need for further clinical trials to evaluate the efficacy of these HDL-modifying therapies.
View on PubMed
#10

Non-linear association of the platelet/high-density lipoprotein cholesterol ratio with bone mineral density a cross-sectional study.

HumanInfluence2.0
13
This study explored the non-linear association between the platelet-to-high-density lipoprotein cholesterol (PHR) ratio and bone mineral density (BMD). Researchers found a complex, inverted U-shaped relationship, indicating that optimal PHR levels are important for maintaining bone health. The findings suggest that PHR may reflect inflammatory states affecting bone resorption.
View on PubMed

Publication Trend

Research publications about HDL-Cholesterin over time

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