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Blutwerte · Marker

Kalium

Potassium · K · Serum Potassium

Elektrolyte
Einheit:
mmol/L
Abbreviation
K+

Potassium test quantifies the concentration of potassium ions in the blood, reflecting cellular and fluid balance.

Reference Ranges

Reference
3.55mmol/L
2.5
3.5
5
6.5
LowNormalHigh
Reference
Critical
Unit · mmol/L

Reference ranges may vary slightly based on laboratory standards.

Overview

Übersicht

Potassium (K+), also known as kalium, is a vital electrolyte predominantly found inside cells. It plays a crucial role in maintaining cellular function, nerve signal transmission, muscle contraction, and fluid balance. Researchers have observed that potassium is essential for the proper functioning of the heart and kidneys, and it helps regulate blood pressure. Clinically, potassium levels reflect various conditions, including hyperkalaemia and hypokalaemia, which can lead to serious cardiac and neuromuscular complications. Elevated potassium levels, or hyperkalaemia, are often associated with conditions such as kidney dysfunction, while low levels, or hypokalaemia, can result from excessive losses due to diarrhea or diuretic use. In the context of athletic performance and biohacking, maintaining optimal potassium levels is crucial for muscle function and endurance. Athletes may experience potassium shifts due to intense exercise, which can affect performance and recovery. Biohackers often monitor potassium to optimize cellular health and longevity. Researchers have found that potassium levels can be influenced by factors such as diet, hydration status, and medication use. Time-of-day variations and recent food intake can also affect measurements, necessitating careful consideration when interpreting results. It is important to account for these confounders to ensure accurate assessment of potassium status.

Klinische Bedeutung

Elevated potassium levels can indicate kidney dysfunction, adrenal insufficiency, or tissue damage, while low levels may suggest diuretic use, diarrhea, or malnutrition. Both extremes can lead to cardiac and neuromuscular issues.

Dynamics

Trend Interpretation

Rising Values

Progressively rising potassium levels suggest potential kidney dysfunction or medication effects. Re-test within 2-4 weeks if levels exceed 5.0 mmol/L.

Falling Values

Progressively falling potassium levels may indicate excessive losses or insufficient intake.

Re-test Interval

4 weeks if outside optimal range

Etiology

Causes — High & Low

Cause

Elevated Levels

  • Kidney dysfunction
  • Adrenal insufficiency
  • Tissue damage
  • Excessive potassium intake
  • Certain medications
Cause

Low Levels

  • Diuretic use
  • Diarrhea
  • Malnutrition
  • Excessive sweating
  • Insufficient dietary intake
Protocol

How to Optimize

Lever

Lifestyle

  • Regular monitoring of potassium levels
  • Maintaining adequate hydration
  • Managing stress levels
Lever

Nutrition

  • Consuming potassium-rich foods like bananas and spinach
  • Reducing high-sodium foods
  • Ensuring balanced electrolyte intake
Lever

Supplementation

  • potassium supplements
  • magnesium supplements

Note:

Consult a healthcare provider before making significant dietary or lifestyle changes, especially if on medication affecting potassium levels.

Testing Guidelines

Fasting Not Required
Not Time-Sensitive

Potassium levels can vary throughout the day; testing at the same time ensures consistency.

Testing Frequency

Annually for healthy adults, more frequently if on medications affecting potassium.

Interfering Factors

  • Recent intense exercise
  • Certain medications
  • Dehydration

Related Peptides & Hormones

Aldosterone

May affect

hormone or peptide

Open Research Questions

Current research suggests that the interplay between potassium (K+) and other electrolytes, such as magnesium (Mg2+), remains understudied, particularly regarding optimal reference ranges and confounding factors affecting K+ measurements. Emerging research directions include investigating the role of K+ in endothelium-dependent hyperpolarizations and its clinical implications in vascular health. Additionally, researchers have not yet established definitive clinical guidelines for managing hyperkalaemia in diverse patient populations, leaving questions about individualized treatment strategies unanswered.

21 Research Publications

380

Total Citations

4

Human/RCT

3.1

Avg. Influence

2025

Latest

Sort
Filter
#01

Efficacy and safety of sodium zirconium cyclosilicate for hyperkalaemia: the randomized, placebo-controlled HARMONIZE-Global study.

HumanInfluence5.0
74
Researchers found that sodium zirconium cyclosilicate (SZC) effectively reduced potassium levels in patients with hyperkalaemia during a 28-day maintenance phase. The study showed that 77.3% of patients receiving SZC 10 g achieved normokalaemia compared to 24.0% in the placebo group. Common side effects included mild to moderate constipation and oedema.
View on PubMed
#02

Laboratory assessment of vitamin K status.

ReviewInfluence7.0
66
Researchers found that vitamin K is crucial for preventing bleeding and plays a role in bone metabolism. The study highlighted that common coagulation assays are not reliable indicators of vitamin K status, and measuring undercarboxylated proteins provides better insight into vitamin K utilization in patients.
View on PubMed
#03

What is the role of putrescine accumulated under potassium deficiency?

In VitroInfluence3.0
58
This study focused on putrescine as a potential biomarker for potassium (K+) deficiency in plants. Researchers observed that putrescine levels increase significantly under K+ starvation, suggesting its role in cellular adaptation to nutrient stress. The study highlighted the need for further research to clarify putrescine's specific functions in K+ deficiency.
View on PubMed
#04

Potassium and potassium clouds in endothelium-dependent hyperpolarizations.

ReviewInfluence4.0
54
Researchers observed that small increases in extracellular potassium act as regulators of blood flow in various tissues. The study discussed how potassium released from endothelial cells influences vascular relaxation and blood supply, highlighting its physiological importance in vascular health.
View on PubMed
#05

kEDTA Sample Contamination: A Reappraisal.

Human
19
This study highlighted the issue of potassium EDTA contamination in serum samples, which can lead to inaccurate potassium measurements. Researchers validated an EDTA assay that can detect low-level contamination, improving the reliability of potassium testing in clinical settings.
View on PubMed
#06

Interrelationships of magnesium and potassium homeostasis.

ReviewInfluence2.0
19
This review discussed the interrelationships between magnesium (Mg) and potassium (K) homeostasis. Researchers found that deficiencies in Mg and K often occur together, particularly due to renal losses. The study emphasized the importance of Mg in maintaining normal cellular K levels and its implications for cardiac health.
View on PubMed
#07

Minimizing tooth discoloration caused by topical silver diamine fluoride application: A systematic review.

Review
18
This systematic review examined methods to minimize discoloration caused by silver diamine fluoride (SDF) in dental treatments. Researchers identified three main techniques: masking with restorations, using chemicals, and substituting silver with nano-silver. Most studies focused on laboratory settings, indicating a need for more clinical trials.
View on PubMed
#08

Mitochondrial potassium channels - an overview.

Review
18
Researchers summarized the role of mitochondrial potassium channels in regulating cellular functions and their involvement in cytoprotection and cell death. The review focused on the regulatory mechanisms of these channels and their significance in various cell types.
View on PubMed
#09

The Laboratory and Clinical Perspectives of Magnesium Imbalance.

ReviewInfluence1.0
15
This study examined the significance of magnesium balance in relation to potassium levels and other electrolytes. Researchers highlighted that magnesium imbalance could coexist with potassium disorders, affecting clinical outcomes. The review emphasized the importance of accurate magnesium measurement in laboratory settings.
View on PubMed
#10

Dynamic duo: Kir6 and SUR in KATP channel structure and function.

ReviewInfluence1.0
13
Researchers reviewed the structure and function of KATP channels, which are essential for linking cellular energy status to membrane potential. The study emphasized the importance of understanding the interactions between Kir6 and SUR subunits for potential clinical applications.
View on PubMed

Clinical Trials (11)

11

Total Trials

3,537

Total Enrolled

Vonoprazan vs Proton Pump Inhibitor With Vitamin D or Probiotics Based Triple Therapy for Eradication of Helicobacter Pylori Infection

NCT07293910Phase 2RECRUITING
Sponsor

Tanta University

Enrollment

66

Started

2026

Primary outcome

Detection of H pylori eradication difference among the three groups through stool antigen test 4 weeks after completion of therapy.

HELICOBACTER PYLORI INFECTIONSHelicobacter InfectionHelicobacter Pylori Gastrointestinal Tract InfectionHelicobacter Pylori Infected Patients

Biomarker-estimated Flavanol Intake in Davis (FID)

NCT06086145ACTIVE_NOT_RECRUITING
Sponsor

University of California, Davis

Enrollment

200

Started

2023

Primary outcome

Biomarker-estimated (-)-epicatechin and flavanol intake

HealthyDietAdults

Nutrition Education Program in Spinal Cord Injury (SCI)

NCT05953597COMPLETED
Sponsor

University of Miami

Enrollment

10

Started

2023

Primary outcome

Change in Nutrition Knowledge

Spinal Cord Injuries

Markers of COPD Exacerbations

Sponsor

Center of Expertise for Chronic Organ Failure

Enrollment

150

Started

2022

Primary outcome

Respiratory symptoms: EXACT

COPDCOPD Exacerbation

2-Week Study In People With Nonalcoholic Fatty Liver Disease

NCT03513588Phase 1COMPLETED
Sponsor

Pfizer

Enrollment

48

Started

2018

Primary outcome

Relative Change From Baseline in Whole Liver Fat at Day 15 as Assessed by Magnetic Resonance Imaging (MRI) - Proton Density Fat Fraction (PDFF)

Non-alcoholic SteatohepatitisNon-alcoholic Fatty Liver Disease

A Study Evaluating the Safety and Pharmacokinetics of Orally Administered SM08502 in Subjects With Advanced Solid Tumors

NCT03355066Phase 1TERMINATED
Sponsor

Biosplice Therapeutics, Inc.

Enrollment

82

Started

2017

Primary outcome

Part 1A, Part 1B: Maximum tolerated dose (MTD) of SM08502 based on the frequency and severity of dose-limiting toxicities (DLTs)

Solid Tumor, Adult

A Study to Compare the Pharmacokinetics of Mepolizumab as a Liquid Drug in a Safety Syringe or an Autoinjector Versus Lyophilised Drug

NCT03014674Phase 3COMPLETED
Sponsor

GlaxoSmithKline

Enrollment

246

Started

2017

Primary outcome

Maximum Observed Plasma Concentration (Cmax) of Mepolizumab

Asthma

A Phase III Parallel Group Study, Comparing the Efficacy, Safety and Tolerability of the Fixed Dose Combination (FDC) of Fluticasone Furoate+Umeclidinium Bromide+Vilanterol (FF/UMEC/VI) With the FDC of FF/VI in Subjects With Inadequately Controlled Asthma

NCT02924688Phase 3COMPLETED
Sponsor

GlaxoSmithKline

Enrollment

2,436

Started

2016

Primary outcome

Mean Change From Baseline in Trough Forced Expiratory Volume in 1 Second (FEV1) at Week 24

Asthma

Effects of a 12-week Supervised Exercise Program Post Bariatric Surgery on Body Composition, Muscle Strength, and Insulin Resistance

NCT07651254COMPLETED
Sponsor

Laval University

Enrollment

61

Started

2012

Primary outcome

Change in abdominal adipose tissue (visceral) as measured by computed tomography (cm2)

Bariatric SurgeryExerciseBody Composition Changes

An Open-label Study of GSK1120212 Compared With Docetaxel in Stage IV KRAS-mutant Non-small Cell Lung Cancer

NCT01362296Phase 2COMPLETED
Sponsor

GlaxoSmithKline

Enrollment

134

Started

2011

Primary outcome

Progression-Free Survival (PFS) as Assessed by the Investigator (INV)

Lung Cancer, Non-Small Cell

Study To Evaluate Safety And Tolerability Of GSK256066 In Chronic Obstructive Pulmonary Disease (COPD) Patients

NCT00549679Phase 2COMPLETED
Sponsor

GlaxoSmithKline

Enrollment

104

Started

2007

Primary outcome

Number of participants with adverse events (AEs) and serious adverse events (SAEs)

Pulmonary Disease, Chronic Obstructive

Publication Trend

Research publications about Kalium over time

9total
1
'04
1
'18
2
'19
1
'20
2
'23
2
'24

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