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Blutwerte · Marker

Kupfer

Copper · Serum Copper · Cu

Elektrolyte
Einheit:
µmol/L
Abbreviation
Cu

The test quantifies the concentration of copper in the serum, reflecting copper status in the body.

Reference Ranges

Reference
1124µmol/L
11
24
LowNormalHigh
Reference
Unit · µmol/L

Reference ranges may vary slightly based on laboratory standards.

Overview

Übersicht

Copper (Cu) is a trace element that plays a crucial role in various biological processes, including iron metabolism, antioxidant defense, and neurotransmitter synthesis. It is primarily measured in serum to assess copper status in the body. Researchers have found that copper is essential for the function of several enzymes, such as cytochrome c oxidase and superoxide dismutase, which are vital for cellular respiration and protection against oxidative stress. Clinically, serum copper levels are important in diagnosing and monitoring conditions like Wilson's disease, a genetic disorder characterized by copper accumulation in tissues leading to hepatic and neurological symptoms. Elevated copper levels can also indicate other disorders such as Menkes disease and certain toxicities. In the context of athletic performance and biohacking, maintaining optimal copper levels is crucial for energy production and antioxidant defense, which can enhance endurance and recovery. However, researchers observed that copper levels can be influenced by various factors, including dietary intake, genetic disorders, and liver function. Time of day and fasting status are not significant confounders, but it is essential to consider potential interference from supplements or medications that affect copper metabolism.

Klinische Bedeutung

Elevated serum copper levels may indicate Wilson's disease, liver disease, or copper toxicity. Reduced levels can suggest Menkes disease or malnutrition.

Dynamics

Trend Interpretation

Rising Values

Progressively rising values may suggest worsening of copper overload conditions like Wilson's disease. Retest every 4 weeks if outside optimal range.

Falling Values

Progressively falling values could indicate effective treatment of copper overload or onset of deficiency.

Re-test Interval

4 weeks if outside optimal range

Etiology

Causes — High & Low

Cause

Elevated Levels

  • Wilson's disease
  • Copper toxicity
  • Cholestatic liver disease
  • Excessive copper supplementation
  • Inflammation
Cause

Low Levels

  • Menkes disease
  • Malnutrition
  • Malabsorption syndromes
  • Excessive zinc supplementation
  • Chronic diarrhea
Protocol

How to Optimize

Lever

Lifestyle

  • Regular health check-ups
  • Avoid exposure to copper-containing pesticides
  • Monitor liver health
Lever

Nutrition

  • Consume copper-rich foods like shellfish and nuts
  • Balance zinc and copper intake
  • Include whole grains in diet
Lever

Supplementation

  • Copper supplements if deficient
  • Zinc supplements to manage excess copper

Note:

Consult a healthcare provider before starting any supplementation, especially if you have a genetic disorder affecting copper metabolism.

Testing Guidelines

Fasting Not Required
Not Time-Sensitive

Testing Frequency

Annually for individuals with risk factors, more frequently if managing a condition like Wilson's disease

Interfering Factors

  • Recent copper supplementation
  • High vitamin C intake
  • Certain medications affecting liver function

Related Peptides & Hormones

Ceruloplasmin

Correlated with

hormone or peptide

Open Research Questions

Current research suggests that reference ranges for serum ceruloplasmin and urinary copper excretion in diagnosing Wilson's disease remain debated, particularly regarding their sensitivity and specificity. Researchers have not yet established optimal targets for managing copper levels in patients, especially concerning the role of non-ceruloplasmin-bound copper. Additionally, unanswered clinical questions include the effectiveness of novel therapeutic approaches in preventing neurological deterioration and the potential for incorporating new diagnostic assays into routine screening.

27 Research Publications

427

Total Citations

10

Human/RCT

2.1

Avg. Influence

2025

Latest

Sort
Filter
#01

New tools for Wilson's disease diagnosis: exchangeable copper fraction.

HumanInfluence5.0
80
Researchers found that relative exchangeable copper (REC) and exchangeable copper (CuEXC) are reliable biomarkers for diagnosing Wilson's disease. These tests provide rapid, non-invasive assessments of copper overload, facilitating early diagnosis and treatment without waiting for genetic test results.
View on PubMed
#02

Wilson's disease: A master of disguise.

ReviewInfluence3.0
65
Researchers discussed the challenges of diagnosing Wilson's disease, noting its nonspecific neurological symptoms. They found that laboratory abnormalities related to copper homeostasis are crucial for diagnosis, and timely treatment can prevent severe outcomes. The study also highlighted the importance of lifelong pharmacologic management.
View on PubMed
#03

Copper in depressive disorder: A systematic review and meta-analysis of observational studies.

Meta-AnalysisInfluence4.0
64
Researchers found that patients with depressive disorder had higher blood levels of copper compared to controls, suggesting a potential link between copper levels and mental health. The study conducted a meta-analysis of 21 studies, indicating that increased blood copper might be associated with depression, although hair copper levels showed no difference.
View on PubMed
#04

Interactions of trace elements: clinical significance.

UnknownInfluence1.0
52
Researchers examined the interactions between zinc, copper, and lead, noting that zinc deficiency can lead to copper overload. They proposed using zinc therapy to manage copper levels in Wilson's disease, highlighting the importance of trace element interactions in clinical settings.
View on PubMed
#05

Molecular imaging and therapy targeting copper metabolism in hepatocellular carcinoma.

HumanInfluence2.0
49
Researchers found that altered copper metabolism may serve as a new biomarker for hepatocellular carcinoma (HCC) detection. Increased copper accumulation was observed in HCC tissues, and copper-64 chloride showed potential in molecular imaging for HCC metastasis. The study suggests that targeting copper metabolism could enhance imaging and therapy for HCC.
View on PubMed
#06

ATP7A-related copper transport disorders: A systematic review and definition of the clinical subtypes.

ReviewInfluence1.0
26
Researchers conducted a systematic review on ATP7A-related copper transport disorders to identify clinical subtypes and management guidelines. They found that low ceruloplasmin is a sensitive biomarker for these disorders, outperforming serum copper levels. The study emphasized the need for clear clinical criteria to differentiate between subtypes.
View on PubMed
#07

Serum copper and the risk of cardiovascular disease death in Finnish men.

Human
24
This study examined the relationship between serum copper levels and cardiovascular disease (CVD) mortality in Finnish men. Researchers found that higher serum copper levels were associated with an increased risk of CVD death across different body mass index categories.
View on PubMed
#08

Biochemical diagnosis of Wilson's disease: an update.

Review
20
This paper reviewed the biochemical tests used to diagnose Wilson's disease, noting the limitations of current methods. Researchers found that serum ceruloplasmin and urinary copper excretion are key diagnostic indicators, while relative exchangeable copper shows high sensitivity and specificity.
View on PubMed
#09

Relative Exchangeable Copper, Exchangeable Copper and Total Copper in the Diagnosis of Wilson Disease.

HumanInfluence1.0
10
Researchers evaluated the diagnostic performance of different copper biomarkers in Wilson's disease. They found that relative exchangeable copper significantly differentiates patients with Wilson's disease from other liver conditions. The study suggests including this biomarker in future diagnostic criteria.
View on PubMed
#10

Iatrogenic copper deficiency: Risks and cautions with zinc prescribing.

Case ReportInfluence1.0
9
Researchers found that zinc-induced copper deficiency is often overlooked, with 50% of diagnosed cases previously undetected. The study emphasizes the need for better monitoring of serum zinc and copper levels in patients prescribed zinc to prevent this rare but significant condition.
View on PubMed

Clinical Trials (9)

9

Total Trials

836

Total Enrolled

Preemie Milk Analyser Validation Study

Sponsor

University Hospital Southampton NHS Foundation Trust

Enrollment

180

Started

2024

Primary outcome

Phase 1: Accuracy of the Preemie system against reference laboratory International Standards Organization (ISO) methods.

Pre-TermBreast Milk ExpressionNutrition Disorder, Infant

Comparison of Conventional and Cu-NiTi Archwires Regarding Clinical Efficiency and Pain Intensity Using Prostaglandin E2 Biomarker During Alignment and Leveling

NCT06653881COMPLETED
Sponsor

Postgraduate Institute of Dental Sciences Rohtak

Enrollment

30

Started

2024

Primary outcome

ARCH ALIGNMENT

Anterior Teeth Alignment EfficiencyPain PerceptionPGE2 Biomarker and Their Correlation

Safety and Superiority of Penicillamine in Radiosensitization of Recurrent Head and Neck Cancer

NCT06103617Phase 2UNKNOWN
Sponsor

Nanfang Hospital, Southern Medical University

Enrollment

10

Started

2023

Primary outcome

Objective response rate (ORR)

Head and Neck CancerRecurrent Cancer

Determination of Copper and Other Trace Elements in Serum Samples From Patients With Biliary Tract Cancers

NCT06060990RECRUITING
Sponsor

Institute of Oncology Ljubljana

Enrollment

20

Started

2023

Primary outcome

Serum copper (Cu) as a predictive biomarker of the response to systemic treatment of biliary tract cancer patients

Trace Element Deficiency

Role of Copper-Albumin Complex in Treatment of Knee Osteoarthritis in Human

Sponsor

Assiut University

Enrollment

60

Started

2019

Primary outcome

The mean difference of syndecan 4 expression and substance P before and after treatment

Osteo Arthritis Knee

Phase II Trial of Disulfiram With Copper in Metastatic Breast Cancer

NCT03323346Phase 2COMPLETED
Sponsor

The Institute of Molecular and Translational Medicine, Czech Republic

Enrollment

9

Started

2017

Primary outcome

Clinical response rate (RR)

Breast Neoplasm FemaleMetastatic Breast Cancer

Copper Cu-64 TP3805 PET/CT in Imaging Patients With Urothelial Cancer Undergoing Surgery or Biopsy

NCT03039413Early Phase 1COMPLETED
Sponsor

Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University

Enrollment

20

Started

2016

Primary outcome

Feasibility of Cu-64-TP3805 to detect UC as determined by post-surgical histology

Bladder Urothelial CarcinomaUrothelial Carcinoma

Evaluation of Micronutrients in Obese Patients

NCT04554082COMPLETED
Sponsor

Alexandria University

Enrollment

107

Started

2015

Primary outcome

Evaluation of zinc to copper ratio as biomarker of micro-nutrient deficiency

Nutritional Disorder

Lower Silesia Culotte Bifurcation Registry (LSCBR).

NCT06284057RECRUITING
Sponsor

Regional Cardiology Center, The Copper Health Centre (MCZ),

Enrollment

400

Started

2013

Primary outcome

Target lesion failure (TLF)

Safety IssuesEfficacy, Self

Publication Trend

Research publications about Kupfer over time

9total
1
'83
1
'13
1
'19
2
'22
2
'23
2
'25

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