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Blutwerte · Marker
LH
Luteinisierendes Hormon · Luteinizing Hormone · LH
Hormone — ReproduktionsachseZeitabhängig
- Einheit:
- IU/L
Luteinizing Hormone (LH) quantifies the concentration of LH in the blood, reflecting its role in the reproductive axis.
Reference Ranges
Reference
1–20IU/L
1
20
LowNormalHigh
Reference
Unit · IU/LReference ranges vary by sex and menstrual cycle phase. Typically higher in females during the mid-cycle surge.
Overview
Übersicht
Luteinizing Hormone (LH) is a glycoprotein hormone produced by the anterior pituitary gland. It plays a critical role in regulating the reproductive system by triggering ovulation in females and stimulating testosterone production in males. LH is part of the hypothalamic-pituitary-gonadal axis, which is essential for reproductive health. Clinically, LH is significant in diagnosing and managing conditions such as polycystic ovary syndrome (PCOS), infertility, and hypogonadism. Elevated LH levels can indicate conditions like PCOS or primary gonadal failure, while low levels may suggest secondary gonadal failure or hypothalamic disorders. For athletes and biohackers, LH levels can reflect the status of the reproductive axis, which may influence performance and recovery. However, LH levels can be affected by various factors, including the timing of the menstrual cycle, age, and body mass index. Researchers found that the timing of blood sampling is crucial, as LH levels fluctuate throughout the menstrual cycle and can be influenced by external factors like stress and diet. Accurate interpretation of LH levels requires consideration of these confounders to avoid misdiagnosis or inappropriate management.
Klinische Bedeutung
Elevated LH levels may indicate conditions such as polycystic ovary syndrome (PCOS) or primary gonadal failure. Reduced levels can suggest secondary gonadal failure or hypothalamic disorders.
Dynamics
Trend Interpretation
Rising Values
Progressively rising LH values may suggest worsening of conditions like PCOS or onset of menopause. Re-test in 4 weeks if outside the optimal range.
Falling Values
Progressively falling LH values may indicate improvement in conditions like PCOS or response to treatment for hypogonadism.
Re-test Interval
4 weeks if outside optimal range
Etiology
Causes — High & Low
Cause
Elevated Levels
- Polycystic ovary syndrome
- Primary ovarian insufficiency
- Menopause
- Testicular failure
- Klinefelter syndrome
Cause
Low Levels
- Hypothalamic dysfunction
- Pituitary insufficiency
- Hyperprolactinemia
- Severe stress
- Malnutrition
Protocol
How to Optimize
Lever
Nutrition
- Balanced diet
- Adequate protein intake
Lever
Supplementation
- Vitamin D
- Zinc
- Omega-3 fatty acids
Note:
Consult a healthcare provider for personalized interventions, especially if underlying conditions are suspected.
Testing Guidelines
✓Fasting Not Required
🕐Time-Sensitive
LH levels vary with the menstrual cycle; testing should be consistent with cycle timing.
Testing Frequency
As needed based on clinical symptoms or treatment monitoring.
Interfering Factors
- Recent intense exercise
- Stress
- Certain medications
Related Peptides & Hormones
Fsh
hormoneCorrelated with
Open Research Questions
Current research suggests that robust reference intervals for luteinizing hormone (LH) in women, particularly in the context of hormonal therapies and conditions like polycystic ovary syndrome (PCOS), remain incomplete. Researchers have not yet established optimal LH targets for different populations, especially considering ethnic differences and obesity status. Unanswered clinical questions include the precise timing for LH measurement to enhance diagnostic accuracy and the implications of elevated LH levels in various hormonal contexts.
16 Research Publications
95
Total Citations
6
Human/RCT
1.3
Avg. Influence
2024
Latest
Sort
Filter
01Top
#01
Ovulation timing. Concepts and controversies.
AnimalInfluence2.0
29
This study examined the identification of the luteinizing hormone (LH) surge in veterinary practice. Researchers found that recent developments in in-clinic assays allow for accurate prediction of ovulation timing by detecting the LH surge.
02Top
#02
Neurotransmitter regulation of luteinizing hormone-releasing hormone neuronal function.
AnimalInfluence1.0
11
This study reviewed neurotransmitter regulation of luteinizing hormone-releasing hormone (LHRH) neuronal function. Researchers found that increases in hypothalamic norepinephrine secretion are associated with preovulatory LH surges, indicating a complex regulatory mechanism.
03Top
#03
A Comprehensive Review of Estradiol, Progesterone, Luteinizing Hormone, and Follicle-Stimulating Hormone in the Context of Laboratory Medicine to Support Women's Health.
Review
9
This study reviewed the roles of estradiol, progesterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) in women's health. Researchers found that robust reference intervals for these hormones are lacking, and collaborative efforts are needed to better define therapeutic or reference intervals to enhance women's health globally.
04
#04
Efficacy and Clinical Significance of the Zuogui Pill on Premature Ovarian Failure via the GDF-9/Smad2 Pathway.
Animal
9
Researchers investigated the effects of the Zuogui pill on premature ovarian failure (POF) in rat models. They observed decreased levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in the treatment group, indicating a potential therapeutic effect.
05
#05
FSH, LH, lipid and adipokines in Polycystic Ovary Syndrome: Clinical biochemistry insights for diagnosis and management.
Review
9
This study reviewed the roles of FSH and LH in diagnosing and managing polycystic ovary syndrome (PCOS). Researchers observed that elevated LH levels relative to FSH are typical in PCOS patients, highlighting the importance of biochemical markers for diagnosis.
06
#06
Re-determination of upper reference range of follicular stimulating hormone in infertile men.
Ozkaya Muharrem, et al. · Systems biology in reproductive medicine · 2020
HumanInfluence1.0
8
Researchers examined the relationship between luteinizing hormone (LH) levels and male infertility, finding that LH levels above 4.8 IU/L were associated with abnormal sperm concentration. This suggests LH may serve as a useful indicator in infertility assessments.
Key findings
- 01Researchers observed that 62% of men with sperm concentration below 15 million/ml had FSH levels greater than 4.8 IU/L.
- 0259.7% of men with sperm counts below 39 million also had FSH levels above 4.8 IU/L.
- 03The study indicates that FSH values above 4.8 IU/L may signify abnormal conditions related to male infertility.
07
#07
Laboratory hematology in the history of Clinical Chemistry and Laboratory Medicine.
Review
7
This study provided a historical overview of laboratory hematology papers published in Clinical Chemistry and Laboratory Medicine. Researchers observed a significant increase in the number of papers published annually, particularly in the area of coagulation and fibrinolysis.
08
#08
Point-of-care impedimetric aptasensor to detect the luteinizing hormone.
In Vitro
6
Researchers developed a smartphone-enabled aptasensor for the rapid detection of luteinizing hormone (LH) in biological fluids. The sensor demonstrated high correlation with standard LH assays and could be stored at room temperature for 30 days without significant loss of function.
09
#09
Phenotypes and clinical laboratory data for polycystic ovary syndrome cases: A nationwide survey in Japan.
Human
4
This study described the phenotypes and clinical laboratory data of polycystic ovary syndrome (PCOS) cases in Japan. Researchers found that non-obese/overweight PCOS patients had significantly higher rates of elevated serum LH levels compared to obese/overweight patients.
10
#10
Male reproductive hormone disorders among copper smelter workers.
Human
3
Researchers assessed the impact of metal exposure on male reproductive hormone levels among copper smelter workers. They found significantly increased levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in exposed workers compared to controls.
Publication Trend
Research publications about LH over time
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