Skip to main content
PepStack
Blutwerte · Marker

Lymphozyten

Lymphocytes · T-cells · B-cells

BlutbildZeitabhängig
Einheit:
x10^9/L
Abbreviation
LYMPH

Lymphocyte count measures the number of lymphocytes in the blood, reflecting immune system activity.

Reference Ranges

Reference
13x10^9/L
1
3
LowNormalHigh
Reference
Unit · x10^9/L

Reference ranges may vary slightly by age and laboratory standards.

Overview

Übersicht

Lymphocytes, abbreviated as LYMPH, are a type of white blood cell pivotal to the immune system, primarily involved in the body's adaptive immune response. They include T-cells, B-cells, and natural killer cells, each playing distinct roles in pathogen recognition and elimination. Researchers have found that lymphocytes are critical in identifying and responding to foreign antigens, thus maintaining immune surveillance and homeostasis. Clinically, lymphocyte levels are significant indicators of immune function and can reflect various conditions. Elevated lymphocyte counts, or lymphocytosis, may indicate infections, certain cancers like lymphocytic leukemia, or autoimmune disorders. Conversely, low levels, or lymphocytopenia, can suggest immunodeficiency, bone marrow suppression, or chronic diseases. In the context of athletic performance and biohacking, lymphocyte levels can be indicative of immune system robustness, with potential implications for recovery and susceptibility to infections. However, researchers observed that factors such as stress, intense physical activity, and circadian rhythms can influence lymphocyte counts, necessitating careful interpretation of results. Time-of-day variations and fasting status may also affect measurements, as lymphocyte levels can fluctuate throughout the day and in response to dietary intake.

Klinische Bedeutung

Elevated lymphocyte levels can indicate infections, autoimmune disorders, or hematologic malignancies. Reduced levels may suggest immunodeficiency, bone marrow disorders, or chronic illness.

Dynamics

Trend Interpretation

Rising Values

Progressively rising lymphocyte counts may suggest an ongoing immune response or lymphoproliferative disorder. Re-test in 4 weeks if abnormal.

Falling Values

Falling lymphocyte counts could indicate immunosuppression or bone marrow dysfunction.

Re-test Interval

4 weeks if outside optimal range

Etiology

Causes — High & Low

Cause

Elevated Levels

  • Viral infections
  • Chronic inflammatory conditions
  • Lymphocytic leukemia
  • Autoimmune disorders
  • Stress response
Cause

Low Levels

  • HIV/AIDS
  • Bone marrow suppression
  • Chemotherapy
  • Chronic illness
  • Malnutrition
Protocol

How to Optimize

Lever

Lifestyle

  • Regular moderate exercise
  • Adequate sleep
  • Stress management
  • Avoiding smoking
Lever

Nutrition

  • Balanced diet rich in fruits and vegetables
  • Adequate protein intake
  • Omega-3 fatty acids
Lever

Supplementation

  • Vitamin C
  • Zinc
  • Vitamin D

Note:

Consult a healthcare provider before starting new supplements, especially if you have underlying health conditions.

Testing Guidelines

Fasting Not Required
🕐Time-Sensitive

Lymphocyte counts can vary with circadian rhythms; morning measurements are often preferred.

Testing Frequency

Annually for routine health check-ups, more frequently if monitoring a specific condition.

Interfering Factors

  • Recent intense exercise
  • Acute stress
  • Infections

Related Peptides & Hormones

Cortisol

May affect

hormone or peptide

Open Research Questions

Current research suggests that the optimal strategies for quantifying tumour-infiltrating lymphocytes (TILs) and understanding the specific roles of different TIL subpopulations remain debated, with a lack of standardized approaches. Researchers have not yet established the functional profiles, spatial distributions, and clonal diversity of TILs in various treatment contexts. Additionally, clinical questions regarding the predictive value of circulating neoantigen-specific lymphocytes and their relationship to tumor-resident lymphocytes remain unanswered.

22 Research Publications

1,269

Total Citations

8

Human/RCT

4.9

Avg. Influence

2022

Latest

Sort
Filter
#01

Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients.

HumanInfluence26.0
809
Researchers found that PD-1 expression on peripheral blood lymphocytes can identify neoantigen-specific T cells in melanoma patients. The study demonstrated that circulating CD8(+)PD-1(+) lymphocytes can target unique patient-specific neoantigens, suggesting a noninvasive method for developing personalized cancer therapies.
View on PubMed
#02

Role of T cells in cancer immunotherapy: Opportunities and challenges.

ReviewInfluence2.0
104
This study reviewed the role of T cells in cancer immunotherapy, focusing on their potential to target tumors. Researchers observed that various immunotherapy strategies aim to enhance T cell-mediated anti-tumor responses, indicating their clinical significance.
View on PubMed
#03

Biological and clinical significance of tumour-infiltrating lymphocytes in the era of immunotherapy: a multidimensional approach.

ReviewInfluence1.0
73
This study examined the role of tumour-infiltrating lymphocytes (TILs) in cancer immunotherapy. Researchers found that TILs are crucial for immune-mediated tumour elimination and highlighted the need for standardized quantification strategies to better understand their biological properties and clinical implications.
View on PubMed
#04

The Biogenesis, Biology, and Clinical Significance of Exosomal PD-L1 in Cancer.

Review
67
This study focused on exosomal PD-L1 in cancer, revealing its role in immunosuppression by inhibiting T cells. Researchers discussed the potential of exosomal PD-L1 as a tumor biomarker and its significance in immunotherapy.
View on PubMed
#05

Drug-induced lupus.

ReviewInfluence3.0
62
This study explored the mechanisms behind drug-induced lupus, which is associated with the accumulation of autoreactive lymphocytes. Researchers observed that oxidative metabolites of drugs may trigger autoimmunity, highlighting the role of lymphocytes in this condition.
View on PubMed
#06

Single-cell analyses identify dysfunctional CD16+ CD8 T cells in smokers.

Human
44
Researchers identified dysfunctional CD16+ CD8 T cells in smokers using single-cell analyses. They found that smoking is associated with an increase in differentiated T cells and a decrease in naïve T cells, indicating immune aging. This study suggests that smoking may lead to immune dysregulation, impacting overall health.
View on PubMed
#07

Autoimmune lymphoproliferative syndrome (ALPS).

ReviewInfluence3.0
42
Researchers studied autoimmune lymphoproliferative syndrome (ALPS) and found that it involves abnormal accumulation of lymphocytes and autoimmunity. The study emphasized the need for targeted therapies and further investigation into the underlying molecular mechanisms.
View on PubMed
#08

Characteristics and Clinical Significance of T-Cell Receptor Repertoire in Hepatocellular Carcinoma.

HumanInfluence2.0
16
This study analyzed the T-cell receptor (TCR) repertoire in hepatocellular carcinoma (HCC) patients. Researchers observed that peripheral blood TCR diversity is higher than that in tumor tissues, suggesting the potential of TCR sequences as non-invasive diagnostic biomarkers for HCC.
View on PubMed
#09

Nonmalignant disorders of lymphocytes.

Review
12
Researchers reviewed nonmalignant disorders of lymphocytes, noting that both lymphocytosis and lymphocytopenia can indicate various health conditions. The study highlighted the clinical laboratory's role in differentiating between reactive and malignant lymphoproliferative processes.
View on PubMed
#10

Dynamics and clinical significance of intestinal intraepithelial lymphocytes.

ReviewInfluence1.0
12
Researchers examined the dynamics of intestinal intraepithelial lymphocytes (IELs) and their role in immune defense against pathogens. The study indicated that IELs are involved in gut disorders, emphasizing their clinical significance and the need for further understanding of their functions.
View on PubMed

Publication Trend

Research publications about Lymphozyten over time

9total
1
'97
1
'03
1
'05
1
'16
1
'19
1
'20
2
'22
1
'25

Track your bloodwork in PepStack

Log lab results, track trends and optimize your biomarkers over time.

Legal Disclaimer

This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer