Skip to main content
PepStack
Blutwerte · Marker

Monozyten

Monocytes

BlutbildZeitabhängig
Einheit:
x10^9/L
Abbreviation
MONO

Monocytes measure the concentration of a specific type of white blood cell involved in immune response and inflammation.

Reference Ranges

Reference
0.20.8x10^9/L
0.2
0.8
LowNormalHigh
Reference
Unit · x10^9/L

Reference ranges may vary slightly based on age and laboratory standards.

Overview

Übersicht

Monocytes, abbreviated as MONO, are a type of white blood cell that plays a crucial role in the immune system by responding to infections and inflammation. They are part of the body's first line of defense and can differentiate into macrophages and dendritic cells, which are essential for phagocytosis and antigen presentation. Monocytes are measured as part of a complete blood count (CBC) to assess immune function and inflammatory status. Researchers have found that monocytes are involved in various pathological conditions, including autoimmune diseases, infections, and cancer. Elevated monocyte levels can indicate systemic inflammation, as observed in conditions like gout and sepsis, while reduced levels may suggest bone marrow suppression or chronic infections. In the context of Alzheimer's disease, researchers observed that monocytes play a role in the clearance of amyloid β, which is crucial for understanding disease progression. For athletes and biohackers, monocyte counts can reflect the body's response to physical stress and recovery. Elevated levels might indicate overtraining or an ongoing inflammatory response, while optimal levels are associated with effective immune surveillance and recovery. However, monocyte counts can be influenced by factors such as time of day, recent infections, and stress. Fasting is not required for testing, but consistent timing for blood draws is recommended to ensure comparability. Interfering factors include recent intense exercise and acute infections, which can transiently alter monocyte levels.

Klinische Bedeutung

Elevated monocyte levels can indicate systemic inflammation, infections, or autoimmune conditions. Reduced levels may suggest bone marrow suppression or chronic infections.

Dynamics

Trend Interpretation

Rising Values

Progressively rising values suggest increasing inflammation or infection. Retest in 4 weeks if outside optimal range.

Falling Values

Progressively falling values may indicate resolution of inflammation or potential bone marrow suppression.

Re-test Interval

4 weeks if outside optimal range

Etiology

Causes — High & Low

Cause

Elevated Levels

  • Infection
  • Inflammation
  • Autoimmune disease
  • Stress response
  • Cancer
Cause

Low Levels

  • Bone marrow suppression
  • Chronic infection
  • HIV/AIDS
  • Aplastic anemia
Protocol

How to Optimize

Lever

Lifestyle

  • Regular exercise
  • Adequate sleep
  • Stress management
Lever

Nutrition

  • Balanced diet rich in fruits and vegetables
  • Omega-3 fatty acids
Lever

Supplementation

  • Vitamin D
  • Omega-3 supplements

Note:

Consult a healthcare provider for personalized advice, especially if underlying conditions are suspected.

Testing Guidelines

Fasting Not Required
🕐Time-Sensitive

Monocyte levels can vary diurnally; consistent timing for blood draws is recommended.

Testing Frequency

Annually for healthy adults, more frequently if monitoring specific conditions.

Interfering Factors

  • Recent intense exercise
  • Acute infections
  • Stress

Open Research Questions

Current research suggests that the role of monocyte subsets, particularly CD38high monocytes, in sepsis and other inflammatory conditions remains debated, with unclear reference ranges and optimal targets for therapeutic intervention. Emerging research directions include the exploration of monocyte gene signatures in various diseases and their potential as biomarkers for diagnosis and monitoring. However, clinical questions remain unanswered regarding the precise mechanisms by which monocytes contribute to disease progression and their interactions with other immune cells.

21 Research Publications

735

Total Citations

14

Human/RCT

4.4

Avg. Influence

2026

Latest

Sort
Filter
#01

Monocyte Subsets: Phenotypes and Function in Tuberculosis Infection.

ReviewInfluence13.0
213
This review examined the role of monocyte subsets in tuberculosis infection. Researchers found alterations in the frequency of monocyte subsets during TB, suggesting their importance in the immune response and potential as biomarkers for disease progression.
View on PubMed
#02

Calprotectin in rheumatic diseases.

ReviewInfluence8.0
153
This review focused on calprotectin, a protein produced by activated monocytes, in rheumatic diseases. Researchers noted its potential as a biomarker for disease activity and treatment response, highlighting its sensitivity compared to traditional markers. The study also discussed calprotectin's role in the pathogenesis of autoimmune disorders.
View on PubMed
#03

Single cell RNA sequencing identifies an early monocyte gene signature in acute respiratory distress syndrome.

HumanInfluence2.0
83
This study investigated monocyte gene expression in patients with acute respiratory distress syndrome (ARDS) using single-cell RNA sequencing. Researchers identified a distinct gene signature in monocytes associated with inflammation and ARDS risk. Additionally, specific gene upregulations were linked to potential therapeutic targets for ARDS.
View on PubMed
#04

Heterogeneity of Bovine Peripheral Blood Monocytes.

ReviewInfluence5.0
63
This review focused on the heterogeneity of bovine peripheral blood monocytes and compared them to human monocytes. Researchers highlighted functional differences between bovine and human monocyte subsets, suggesting that bovine intermediate monocytes could serve as biomarkers for inflammatory responses postpartum.
View on PubMed
#05

Monocytes in Tumorigenesis and Tumor Immunotherapy.

ReviewInfluence3.0
50
This review discussed the heterogeneity and role of monocytes in tumorigenesis and immunotherapy. Researchers highlighted advances in understanding monocyte subsets and their functions in cancer development, emphasizing the need for systematic analysis to identify tumor biomarkers and improve anti-tumor therapies.
View on PubMed
#06

MSU crystal deposition contributes to inflammation and immune responses in gout remission.

Human
43
This study examined the role of monosodium urate (MSU) crystal deposition in immune inflammation during gout remission. Researchers found systemic inflammation characterized by activated inflammatory pathways and increased levels of specific monocyte subtypes in patients with advanced gout. The findings suggest distinctive immune responses in gout remission that warrant further investigation.
View on PubMed
#07

Monocyte and Macrophage miRNA: Potent Biomarker and Target for Host-Directed Therapy for Tuberculosis.

Review
40
This review examined the potential of monocyte and macrophage microRNA (miRNA) as biomarkers for tuberculosis. Researchers discussed how miRNA expression relates to disease progression and could serve as targets for host-directed therapy, emphasizing the importance of monocyte research in tuberculosis.
View on PubMed
#08

Monocyte distribution width (MDW) in sepsis.

HumanInfluence2.0
22
This study explored monocyte distribution width (MDW) as a biomarker for sepsis. Researchers found that MDW, calculated from monocyte characteristics, could indicate sepsis severity regardless of the causative pathogen. Further research is needed to validate its clinical utility.
View on PubMed
#09

Clearance and transport of amyloid β by peripheral monocytes correlate with Alzheimer's disease progression.

HumanInfluence1.0
19
Researchers explored the role of peripheral monocytes in the clearance of amyloid β (Aβ) in Alzheimer's disease. They found that Aβ-binding monocytes with high phagocytic potential were present in both blood and cerebrospinal fluid, and their levels correlated with disease progression. This suggests that these monocytes could serve as a potential biomarker for Alzheimer's diagnosis and monitoring.
View on PubMed
#10

Neutrophil extracellular trap-induced intermediate monocytes trigger macrophage activation syndrome in adult-onset Still's disease.

Human
16
Researchers investigated the role of intermediate monocytes in adult-onset Still's disease (AOSD) and their association with macrophage activation syndrome. They found elevated levels of these monocytes in active AOSD patients, which correlated with disease activity and cytokine production, suggesting their potential as biomarkers.
View on PubMed

Publication Trend

Research publications about Monozyten over time

10total
1
'17
1
'20
1
'21
4
'23
1
'24
2
'25

Track your bloodwork in PepStack

Log lab results, track trends and optimize your biomarkers over time.

Legal Disclaimer

This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer