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Blutwerte · Marker

Monozyten

Monocytes

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Einheit:
x10^9/L
Abbreviation
MONO

Monocytes measure the number of circulating monocytes in the blood, reflecting immune system activity.

Reference Ranges

Reference
0.20.8x10^9/L
0.2
0.8
LowNormalHigh
Reference
Unit · x10^9/L

Reference ranges may vary slightly based on age and laboratory standards.

Overview

Übersicht

Monocytes, abbreviated as MONO, are a type of white blood cell that plays a crucial role in the body's immune response. They are part of the mononuclear phagocyte system and are primarily responsible for phagocytosis, the process of engulfing and digesting cellular debris and pathogens. Monocytes circulate in the bloodstream and migrate into tissues where they differentiate into macrophages and dendritic cells, contributing to the body's defense mechanisms. Researchers have found that monocytes are involved in various inflammatory processes and immune responses, making them a significant focus in the study of diseases such as gout, acute respiratory distress syndrome (ARDS), Alzheimer's disease, myeloproliferative neoplasms, and sepsis. Clinically, elevated monocyte levels can indicate chronic inflammation, infection, or hematological disorders, while low levels may suggest bone marrow suppression or autoimmune conditions. In the context of athletic performance, biohacking, or longevity, monocytes are less directly studied, but their role in inflammation and immune function makes them relevant for understanding recovery and resilience. Researchers observed that factors like time of day, fasting status, and recent physical activity can influence monocyte levels, which should be considered when interpreting test results.

Klinische Bedeutung

Elevated monocyte levels can indicate chronic inflammation, infection, or hematological disorders. Reduced monocyte levels may suggest bone marrow suppression or autoimmune conditions.

Dynamics

Trend Interpretation

Rising Values

Progressively rising monocyte levels suggest increasing inflammation or infection; re-test in 4 weeks if outside optimal range.

Falling Values

Progressively falling monocyte levels may indicate resolving inflammation or potential bone marrow suppression.

Re-test Interval

4 weeks if outside optimal range

Etiology

Causes — High & Low

Cause

Elevated Levels

  • Chronic inflammation
  • Infection
  • Hematological disorders
  • Stress response
  • Autoimmune diseases
Cause

Low Levels

  • Bone marrow suppression
  • Autoimmune conditions
  • Certain infections
  • Chemotherapy
  • Aplastic anemia
Protocol

How to Optimize

Lever

Lifestyle

  • Regular exercise
  • Stress management
  • Adequate sleep
Lever

Nutrition

  • Anti-inflammatory diet
  • Omega-3 fatty acids
  • Fruits and vegetables
Lever

Supplementation

  • Vitamin D
  • Omega-3 supplements

Note:

Consult a healthcare provider before starting any new supplementation, especially if underlying health conditions exist.

Testing Guidelines

Fasting Not Required
🕐Time-Sensitive

Monocyte levels can fluctuate throughout the day; consistent timing is recommended for comparability.

Testing Frequency

Annually for healthy adults, more frequently if monitoring specific conditions.

Interfering Factors

  • Recent intense exercise
  • Acute stress
  • Infections

Open Research Questions

Current research suggests that the reference ranges and optimal targets for monocyte subsets, particularly CD38high monocytes, remain unclear, as their roles in various conditions like sepsis and myelofibrosis are still being debated. Emerging research directions include the exploration of monocyte gene signatures in inflammatory diseases and their potential as biomarkers for disease progression. However, clinical questions regarding the long-term implications of monocyte activation states and their therapeutic targeting in diverse patient populations remain unanswered.

23 Research Publications

950

Total Citations

14

Human/RCT

4.4

Avg. Influence

2026

Latest

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Filter
#01

Monocyte Subsets: Phenotypes and Function in Tuberculosis Infection.

ReviewInfluence13.0
213
This review examined the role of monocyte subsets in tuberculosis infection. Researchers found alterations in the frequency of monocyte subsets during TB, suggesting their importance in the immune response and potential as biomarkers for disease progression.
View on PubMed
#02

Clinical significance of monocyte heterogeneity.

ReviewInfluence4.0
175
Researchers reviewed the clinical significance of monocyte heterogeneity in human diseases. They emphasized the importance of identifying specific monocyte subpopulations as potential biomarkers for various health conditions, enhancing understanding of their roles in disease pathogenesis.
View on PubMed
#03

Calprotectin in rheumatic diseases.

ReviewInfluence8.0
160
Researchers reviewed the role of calprotectin, produced by activated monocytes, in rheumatic diseases. They found that calprotectin levels correlate with disease activity and may serve as a sensitive biomarker for monitoring inflammation in autoimmune disorders.
View on PubMed
#04

Single cell RNA sequencing identifies an early monocyte gene signature in acute respiratory distress syndrome.

HumanInfluence2.0
88
Researchers investigated monocyte gene signatures in patients with acute respiratory distress syndrome (ARDS) using single-cell RNA sequencing. They found that monocytes from ARDS patients exhibited a proinflammatory gene profile and identified 29 upregulated genes that could serve as potential biomarkers for ARDS risk assessment.
View on PubMed
#05

Heterogeneity of Bovine Peripheral Blood Monocytes.

ReviewInfluence5.0
63
This review compared the heterogeneity of bovine peripheral blood monocytes to their human counterparts. Researchers found functional differences between monocyte subsets in both species, suggesting that bovine intermediate monocytes may serve as biomarkers for inflammatory responses postpartum.
View on PubMed
#06

Monocytes in Tumorigenesis and Tumor Immunotherapy.

ReviewInfluence3.0
58
This review discussed the heterogeneity of monocytes in tumorigenesis and their role in cancer development. Researchers highlighted the potential of monocyte subsets as biomarkers for tumor progression and targets for immunotherapy.
View on PubMed
#07

MSU crystal deposition contributes to inflammation and immune responses in gout remission.

Human
47
This study examined the effects of monosodium urate (MSU) crystal deposition on immune responses in gout remission. Researchers found systemic inflammation characterized by activated inflammatory pathways and increased monocyte subtypes in patients with advanced gout. The findings suggest unique immune responses during gout remission that could inform future research.
View on PubMed
#08

Monocyte and Macrophage miRNA: Potent Biomarker and Target for Host-Directed Therapy for Tuberculosis.

Review
40
This review highlights the role of monocyte and macrophage microRNAs as biomarkers for tuberculosis. Researchers discuss how these miRNAs can inform disease progression and therapeutic strategies, emphasizing their potential in host-directed therapy.
View on PubMed
#09

Monocyte distribution width (MDW) in sepsis.

ReviewInfluence3.0
23
Researchers explored monocyte distribution width (MDW) as a biomarker for sepsis. They noted that MDW is calculated based on monocyte characteristics and may serve as an indicator of sepsis severity, independent of the causative pathogen.
View on PubMed
#10

Clearance and transport of amyloid β by peripheral monocytes correlate with Alzheimer's disease progression.

HumanInfluence1.0
21
This study explored the role of peripheral monocytes in the clearance of amyloid β in Alzheimer's disease. Researchers observed that Aβ-binding monocytes have high phagocytic potential and their levels correlate with disease progression, suggesting their potential as biomarkers for Alzheimer's diagnosis and monitoring.
View on PubMed

Publication Trend

Research publications about Monozyten over time

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