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- Regular physical activity
- Stress management
- Adequate sleep
Blutwerte · Marker
MPV
Mean Platelet Volume · Mittleres Plättchenvolumen
Blutbild
- Einheit:
- fL
MPV quantifies the average size of platelets in the blood, indicating platelet production and activation.
Reference Ranges
Reference
7.5–11.5fL
7.5
11.5
LowNormalHigh
Reference
Unit · fLReference ranges may vary slightly based on laboratory standards and population demographics.
Overview
Übersicht
Mean Platelet Volume (MPV) is a measure of the average size of platelets in the blood, reflecting platelet production and activation. It is determined using automated blood analyzers and is an indicator of platelet function and turnover. Clinically, MPV is significant in assessing various conditions, including cardiovascular diseases, autoimmune disorders, and inflammatory states. Research has shown that elevated MPV levels are associated with active disease states in systemic lupus erythematosus, particularly in certain ethnic groups, and can predict acute respiratory distress syndrome in influenza pneumonia. In preeclampsia, higher MPV values have been observed, suggesting its potential as a biomarker for this condition. For athletes and biohackers, MPV may offer insights into systemic inflammation and cardiovascular health, although its direct impact on performance or longevity is less clear. Caveats include potential confounders such as ethnicity, disease activity, and platelet count, which can influence MPV levels. Additionally, standardization of cutoff values remains a challenge, and factors like time of day or fasting status may affect results.
Klinische Bedeutung
Elevated MPV values can indicate active inflammatory or autoimmune conditions, such as systemic lupus erythematosus or preeclampsia. Lower MPV values have been associated with conditions like acute appendicitis.
Dynamics
Trend Interpretation
Rising Values
Progressively rising MPV values may suggest worsening inflammation or disease activity. Retesting in 4 weeks is recommended if values are outside the optimal range.
Falling Values
Falling MPV values may indicate resolution of an inflammatory state or effective treatment response.
Re-test Interval
4 weeks if outside optimal range
Etiology
Causes — High & Low
Cause
Elevated Levels
- Systemic lupus erythematosus
- Preeclampsia
- Influenza pneumonia
- Cardiovascular disease
- Diabetes mellitus
Cause
Low Levels
- Acute appendicitis
- Thrombocytopenia
- Bone marrow suppression
- Chronic liver disease
- Hypersplenism
Protocol
How to Optimize
Lever
Nutrition
- Anti-inflammatory diet
- Omega-3 fatty acids
- High-fiber foods
Lever
Supplementation
- Omega-3 supplements
- Vitamin D
- Curcumin
Note:
Consult a healthcare provider before making significant dietary or lifestyle changes, especially if underlying health conditions are present.
Testing Guidelines
✓Fasting Not Required
✓Not Time-Sensitive
MPV may vary slightly throughout the day; consistent timing is recommended for follow-up tests.
Testing Frequency
Annually for routine health check-ups, more frequently if monitoring specific conditions.
Interfering Factors
- Recent infection
- Medication use
- Acute stress
Open Research Questions
Current research suggests that the standardization of reference ranges and optimal cutoff values for mean platelet volume (MPV) in various autoimmune disorders and conditions like preeclampsia remains debated. Researchers have not yet established the impact of ethnic differences on MPV levels and their clinical significance. Additionally, unanswered clinical questions include the role of MPV in predicting disease progression in autoimmune disorders and its utility in risk stratification for conditions like acute respiratory distress syndrome.
28 Research Publications
785
Total Citations
12
Human/RCT
2.9
Avg. Influence
2026
Latest
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Filter
01Top
#01
Mean Platelet Volume (MPV): New Perspectives for an Old Marker in the Course and Prognosis of Inflammatory Conditions.
Korniluk Aleksandra, et al. · Mediators of inflammation · 2019
ReviewInfluence13.0
486
Researchers reviewed literature on mean platelet volume (MPV) as a biomarker in inflammatory and neoplastic diseases. They found that increased MPV is associated with various conditions, including cardiovascular diseases and cancers, while decreased MPV is noted in certain inflammatory states. The study emphasizes the potential of MPV in predicting disease progression and outcomes.
Key findings
- 01Researchers observed increased MPV in cardiovascular diseases, diabetes, and various cancers.
- 02They noted decreased MPV in conditions like tuberculosis and ulcerative colitis during flare-ups.
- 03The study suggests that MPV could provide insights into disease severity and patient prognosis, but more research is needed for clinical application.
02Top
#02
Mean Platelet Volume and Immature Platelet Fraction in Autoimmune Disorders.
ReviewInfluence2.0
70
This review focused on mean platelet volume (MPV) and immature platelet fraction (IPF) as potential biomarkers in autoimmune disorders. Researchers highlighted the need for standardization of cutoff values for both MPV and IPF, as current data on their applicability in autoimmune diseases remain limited and controversial.
03Top
#03
Mean platelet volume: a potential biomarker of the risk and prognosis of heart disease.
Review
55
This review highlighted mean platelet volume (MPV) as a potential biomarker for heart disease risk and prognosis. Researchers noted that MPV could predict outcomes in patients with atrial fibrillation and coronary artery disease, suggesting its utility in clinical decision-making.
04
#04
Platelet function in preeclampsia - a systematic review and meta-analysis.
Meta-AnalysisInfluence2.0
54
This study examined the role of platelet function markers in preeclampsia, focusing on mean platelet volume (MPV). Researchers found that women with preeclampsia had significantly higher MPV compared to those without the condition, suggesting MPV as a promising biomarker for evaluating platelet function in preeclampsia.
05
#05
Mean platelet volume values in preeclampsia: A systematic review and meta-analysis.
Meta-Analysis
36
This meta-analysis evaluated mean platelet volume (MPV) in preeclampsia. Researchers found that MPV was significantly higher in preeclamptic women compared to healthy controls, with the difference being more pronounced in severe cases. The study suggests that MPV may serve as a promising biomarker for preeclampsia detection.
06
#06
Association of decreased mean platelet volume with renal cell carcinoma.
HumanInfluence2.0
19
This study investigated the association of mean platelet volume (MPV) with renal cell carcinoma (RCC). Researchers found that RCC patients had significantly lower MPV compared to those with benign tumors and healthy controls, suggesting MPV could be a useful risk assessment tool.
07
#07
Acute Appendicitis and Mean Platelet Volume: A Systemic Review and Meta-analysis.
Meta-Analysis
15
This meta-analysis explored the relationship between mean platelet volume (MPV) and acute appendicitis. Researchers observed a significant decrease in MPV levels in patients with acute appendicitis compared to controls, supporting MPV as a potential biomarker for this condition.
08
#08
The relationship between mean platelet volume and resistant hypertension.
HumanInfluence1.0
12
This study evaluated the relationship between mean platelet volume (MPV) and resistant hypertension. Researchers found that MPV values were significantly higher in patients with resistant hypertension compared to those with controlled hypertension and normotensive individuals, indicating its potential role in predicting cardiovascular events.
09
#09
Low Mean Platelet Volume is Associated with Deep Vein Thrombosis in Older Patients with Hip Fracture.
HumanInfluence1.0
9
This study explored the association between mean platelet volume (MPV) and preoperative deep vein thrombosis (DVT) in older patients with hip fractures. Researchers found that lower MPV levels were significantly associated with an increased risk of DVT.
10
#10
Can mean platelet volume be a prognosis predictor in viral infections: An example of Covid-19.
Human
7
Researchers explored the utility of mean platelet volume (MPV) as a mortality marker in COVID-19 patients. The study found that MPV values correlated significantly with other inflammatory indicators and had greater specificity in predicting patient outcomes compared to traditional markers.
Publication Trend
Research publications about MPV over time
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