Skip to main content
PepStack
Blutwerte · Marker

Neutrophile

Neutrophils · PMN · Neutrophile Granulozyten

BlutbildZeitabhängig
Einheit:
x10^9/L
Abbreviation
NEUT

The test quantifies the number of neutrophils in the blood, reflecting the body's immune response capability.

Reference Ranges

Reference
27.5x10^9/L
2
7.5
LowNormalHigh
Reference
Unit · x10^9/L

Reference ranges may vary slightly based on laboratory standards and patient demographics.

Overview

Übersicht

Neutrophils, also known as neutrophile granulocytes, are a type of white blood cell pivotal in the body's defense against infections. They are a key component of the innate immune system, primarily responsible for phagocytosing pathogens and releasing enzymes that kill bacteria and fungi. Neutrophils are the most abundant type of white blood cells in the bloodstream and are produced in the bone marrow. Clinically, neutrophil counts are crucial in diagnosing and monitoring infections, inflammatory conditions, and hematological disorders. Elevated neutrophil levels, or neutrophilia, can indicate acute bacterial infections, inflammation, or stress, while low levels, or neutropenia, can suggest bone marrow disorders, severe infections, or the effects of chemotherapy. In the context of cancer, researchers have found that a high neutrophil-to-lymphocyte ratio is often associated with poor prognosis. For athletes and biohackers, maintaining optimal neutrophil levels is essential for immune function and recovery. However, excessive training can lead to transient changes in neutrophil counts, which may impact performance and recovery. Researchers observed that factors such as stress, circadian rhythms, and recent infections can influence neutrophil counts. Therefore, it is important to consider these variables when interpreting test results.

Klinische Bedeutung

Elevated neutrophil levels may indicate bacterial infections, inflammation, or stress, while reduced levels can suggest bone marrow disorders or the impact of chemotherapy.

Dynamics

Trend Interpretation

Rising Values

Progressively rising values may suggest worsening infection or inflammation. Re-test in 2-4 weeks if elevated.

Falling Values

Falling values can indicate recovery from infection or response to treatment.

Re-test Interval

4 weeks if outside optimal range

Etiology

Causes — High & Low

Cause

Elevated Levels

  • bacterial infections
  • inflammation
  • stress
  • smoking
  • corticosteroid use
Cause

Low Levels

  • bone marrow disorders
  • severe infections
  • chemotherapy
  • autoimmune diseases
  • aplastic anemia
Protocol

How to Optimize

Lever

Lifestyle

  • manage stress
  • adequate sleep
  • regular moderate exercise
Lever

Nutrition

  • balanced diet rich in vitamins
  • adequate protein intake
Lever

Supplementation

  • Vitamin B12
  • Folic acid

Note:

Consult a physician before making significant lifestyle or dietary changes, especially if neutrophil levels are abnormal.

Testing Guidelines

Fasting Not Required
🕐Time-Sensitive

Neutrophil levels can vary with circadian rhythms; consistent timing for tests is recommended.

Testing Frequency

Annually for healthy adults, more frequently if monitoring a specific condition.

Interfering Factors

  • recent intense exercise
  • stress
  • infection

Open Research Questions

Current research suggests that the predictive value of tumour-associated neutrophils (TANs) remains debated, with conflicting data across different cancer types and locations within tumors. Researchers have not yet established optimal reference ranges for neutrophil biomarkers in immunotherapy response, particularly regarding the role of interferon-stimulated neutrophils. Additionally, clinical questions regarding the mechanisms by which neutrophils influence therapeutic efficacy and their interactions with other immune cells remain unanswered.

23 Research Publications

1,959

Total Citations

8

Human/RCT

6.9

Avg. Influence

2025

Latest

Sort
Filter
#01

Tumour-associated neutrophils in patients with cancer.

ReviewInfluence34.0
894
Researchers found that neutrophils accumulate in the blood of cancer patients, particularly those with advanced disease. A high neutrophil-to-lymphocyte ratio is linked to poor outcomes across various cancers. The study also discusses the potential roles of tumor-associated neutrophils in cancer progression and treatment response.
View on PubMed
#02

Neutrophils in the Tumor Microenvironment.

ReviewInfluence10.0
498
Researchers discussed the dual role of neutrophils in cancer, noting their involvement in promoting tumor progression and serving as potential biomarkers for disease status. The study emphasized the need for understanding neutrophil behavior in the tumor microenvironment.
View on PubMed
#03

Interferon-stimulated neutrophils as a predictor of immunotherapy response.

HumanInfluence5.0
147
This study examined interferon-stimulated Ly6Ehi neutrophils as a predictive biomarker for immunotherapy response in cancer patients. Researchers found that these neutrophils can sensitize tumors to anti-PD1 therapy. The findings indicate a high accuracy in predicting treatment response in patients with non-small cell lung cancer and melanoma.
View on PubMed
#04

Mechanisms of Primary Membranous Nephropathy.

ReviewInfluence4.0
74
Researchers observed that the presence of specific autoantibodies is crucial for diagnosing membranous nephropathy (MN) and correlates with disease severity. The study highlights the importance of monitoring these biomarkers for assessing disease progression and treatment response.
View on PubMed
#05

Neutrophil extracellular traps: A novel target for the treatment of stroke.

ReviewInfluence1.0
73
This review highlighted the role of neutrophil extracellular traps (NETs) in stroke, noting their dual function in trapping pathogens and exacerbating inflammation. Researchers summarized mechanisms of NET formation and their contributions to stroke pathology, suggesting that targeting NETs could be a novel therapeutic approach.
View on PubMed
#06

Blood-brain crosstalk: the roles of neutrophils, platelets, and neutrophil extracellular traps in neuropathologies.

ReviewInfluence2.0
66
This review highlights the roles of neutrophils and platelets in neuroinflammatory diseases. Researchers found that these cells contribute to thromboinflammation and neuroinflammation, emphasizing the need for further research into their mechanisms in neurological disorders.
View on PubMed
#07

Neutrophils, a candidate biomarker and target for radiation therapy?

Review
58
Researchers discussed the potential of neutrophils as biomarkers and therapeutic targets in radiation therapy for cancer. The study emphasized the complex interplay between neutrophils and the tumor microenvironment, suggesting that neutrophil evaluation could enhance treatment outcomes.
View on PubMed
#08

Tumor-neutrophil cross talk orchestrates the tumor microenvironment to determine the bladder cancer progression.

Human
45
This study examined the interaction between bladder cancer cells and neutrophils, revealing that IL-8 secretion recruits neutrophils, which then influence tumor progression. Researchers found that urine IL-8 is a better biomarker for prognosis than serum IL-8.
View on PubMed
#09

Anti-neutrophil cytoplasmic antibodies and their clinical significance.

ReviewInfluence3.0
45
Researchers reviewed anti-neutrophil cytoplasmic antibodies (ANCA) and their role as biomarkers for ANCA-associated vasculitis. The study outlines the different staining patterns of ANCA and their clinical significance in diagnosing various forms of systemic small-vessel vasculitis.
View on PubMed
#10

Neutrophil dynamics in pulmonary fibrosis: pathophysiological and therapeutic perspectives.

ReviewInfluence2.0
31
This review examined the role of neutrophils in pulmonary fibrosis, noting their increased presence in patients with interstitial lung diseases. Researchers highlighted the potential of neutrophils as biomarkers for disease severity and emphasized the need for further investigation into their dual roles in lung tissue.
View on PubMed

Clinical Trials (11)

11

Total Trials

1,749

Total Enrolled

Biomarkers of Acute Organ Injury in Pediatric Newly Diagnosed Type 1 Diabetes

NCT07483879RECRUITING
Sponsor

Aristotle University Of Thessaloniki

Enrollment

45

Started

2025

Primary outcome

Neutrophil Gelatinase-Associated Lipocalin

Type 1 Diabetes MellitusDiabetic Ketoacidosis

Use of Reticulocyte Ratio and Neutrophil / Lymphocyte Ratio in the Diagnosis of Ventilator-associated Pneumonia

NCT04620941COMPLETED
Sponsor

Muğla Sıtkı Koçman University

Enrollment

35

Started

2022

Primary outcome

Early inflammation markers for VAP

Ventilator-associated Pneumonia (VAP)

Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio to Predict Carotid Intima-Media Thickness in Chronic Kidney Disease Patients

NCT05472805COMPLETED
Sponsor

Universitas Sebelas Maret

Enrollment

72

Started

2022

Primary outcome

Neutrophil-lymphocyte ratio (NLR)

Chronic Kidney DiseasesDialysis; ComplicationsCoronary Heart Disease

Renal Tubular Injury and Transplant Outcomes in Cardiac Recipients Converting From IR Tacrolimus to XR Tacrolimus

NCT04917718Phase 4UNKNOWN
Sponsor

Loyola University

Enrollment

42

Started

2021

Primary outcome

Urinary neutrophil gelatinase-associated lipocalin (NGAL)

Chronic Kidney DiseasesHeart Transplant

Comparison of Two Different Preload Targets of Stroke Volume Variation During Kidney Transplantation

NCT03949036COMPLETED
Sponsor

Seoul National University Hospital

Enrollment

60

Started

2019

Primary outcome

serum neutrophil-gelatinase-associated lipocalin (NGAL)

Kidney Transplant; ComplicationsRenal Failure Chronic

Implementing a Combination of Clinical Parameters, Biomarkers and SoCs for the Etiology Diagnoses of Pneumonia in Pediatric Patients

NCT03366454COMPLETED
Sponsor

INA-RESPOND Secretariat

Enrollment

188

Started

2017

Primary outcome

White Blood Cells and Absolute Neutrophil Count Cut-off Levels for Distinguishing of Viral and Bacterial/Mixed Pathogens

Pneumonia

Use of 6% Hydroxyethylstarch (130/0.4) in Cardiac Surgical Patients

NCT02192502Phase 3COMPLETED
Sponsor

The Cleveland Clinic

Enrollment

149

Started

2015

Primary outcome

Urine Neutrophil Gelatinase-associated Lipocalin (NGAL) [Time Frame: 24 Hours After Surgery] [Designated as Safety Issue: Yes]

Postoperative Kidney Injury

Urinary Neutrophil Gelatinase-Associated Lipocalin (uNGAL) in Invasive Cardiology

NCT01612117COMPLETED
Sponsor

University of Freiburg

Enrollment

244

Started

2011

Primary outcome

to assess the value of uNGAL measurement 4 to 6 hours after PCP as a possible early detector of CIN

Renal Failure

Plasma Exchange and Glucocorticoids for Treatment of Anti-Neutrophil Cytoplasm Antibody (ANCA) - Associated Vasculitis

NCT00987389Phase 3COMPLETED
Sponsor

University of Pennsylvania

Enrollment

704

Started

2010

Primary outcome

Composite of i) All-cause Mortality or ii) End-stage Renal Disease

Granulomatosis With Polyangiitis (Wegener's) (GPA)Microscopic Polyangiitis (MPA)

Double Blinded Randomized Clinical Trial of the Effect of Open Versus Laparoscopic Colectomy on Neutrophils in Patients With Colon Cancer

Sponsor

University Hospital Dubrava

Enrollment

60

Started

2008

Primary outcome

Neutrophil activity before and after the open or laparoscopic surgery - Serum concentrations of sFas, sFasL and IL - 17.

Colonic Neoplasms

Neutrophil Gelatinase-Associated Lipocalin: Biomarker of Acute Kidney Injury After Cardiac Surgery

Sponsor

Hospital de Base

Enrollment

150

Started

2007

Primary outcome

Evaluate the urinary excretion of NGAL as a marker of early development of acute kidney injury in patients undergoing cardiac surgery

Early Acute Kidney Injury

Publication Trend

Research publications about Neutrophile over time

7total
1
'18
1
'19
1
'21
2
'23
1
'24
1
'25

Track your bloodwork in PepStack

Log lab results, track trends and optimize your biomarkers over time.

Legal Disclaimer

This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer