Lifestyle
- manage stress
- adequate sleep
- regular moderate exercise
Neutrophils · PMN · Neutrophile Granulozyten
The test quantifies the number of neutrophils in the blood, reflecting the body's immune response capability.
Reference ranges may vary slightly based on laboratory standards and patient demographics.
Neutrophils, also known as neutrophile granulocytes, are a type of white blood cell pivotal in the body's defense against infections. They are a key component of the innate immune system, primarily responsible for phagocytosing pathogens and releasing enzymes that kill bacteria and fungi. Neutrophils are the most abundant type of white blood cells in the bloodstream and are produced in the bone marrow. Clinically, neutrophil counts are crucial in diagnosing and monitoring infections, inflammatory conditions, and hematological disorders. Elevated neutrophil levels, or neutrophilia, can indicate acute bacterial infections, inflammation, or stress, while low levels, or neutropenia, can suggest bone marrow disorders, severe infections, or the effects of chemotherapy. In the context of cancer, researchers have found that a high neutrophil-to-lymphocyte ratio is often associated with poor prognosis. For athletes and biohackers, maintaining optimal neutrophil levels is essential for immune function and recovery. However, excessive training can lead to transient changes in neutrophil counts, which may impact performance and recovery. Researchers observed that factors such as stress, circadian rhythms, and recent infections can influence neutrophil counts. Therefore, it is important to consider these variables when interpreting test results.
Klinische Bedeutung
Elevated neutrophil levels may indicate bacterial infections, inflammation, or stress, while reduced levels can suggest bone marrow disorders or the impact of chemotherapy.
Progressively rising values may suggest worsening infection or inflammation. Re-test in 2-4 weeks if elevated.
Falling values can indicate recovery from infection or response to treatment.
Re-test Interval
4 weeks if outside optimal range
Note:
Consult a physician before making significant lifestyle or dietary changes, especially if neutrophil levels are abnormal.
Neutrophil levels can vary with circadian rhythms; consistent timing for tests is recommended.
Testing Frequency
Annually for healthy adults, more frequently if monitoring a specific condition.
Current research suggests that the predictive value of tumour-associated neutrophils (TANs) remains debated, with conflicting data across different cancer types and locations within tumors. Researchers have not yet established optimal reference ranges for neutrophil biomarkers in immunotherapy response, particularly regarding the role of interferon-stimulated neutrophils. Additionally, clinical questions regarding the mechanisms by which neutrophils influence therapeutic efficacy and their interactions with other immune cells remain unanswered.
1,959
Total Citations
8
Human/RCT
6.9
Avg. Influence
2025
Latest
Researchers found that neutrophils accumulate in the blood of cancer patients, particularly those with advanced disease. A high neutrophil-to-lymphocyte ratio is linked to poor outcomes across various cancers. The study also discusses the potential roles of tumor-associated neutrophils in cancer progression and treatment response.
Researchers discussed the dual role of neutrophils in cancer, noting their involvement in promoting tumor progression and serving as potential biomarkers for disease status. The study emphasized the need for understanding neutrophil behavior in the tumor microenvironment.
This study examined interferon-stimulated Ly6Ehi neutrophils as a predictive biomarker for immunotherapy response in cancer patients. Researchers found that these neutrophils can sensitize tumors to anti-PD1 therapy. The findings indicate a high accuracy in predicting treatment response in patients with non-small cell lung cancer and melanoma.
Researchers observed that the presence of specific autoantibodies is crucial for diagnosing membranous nephropathy (MN) and correlates with disease severity. The study highlights the importance of monitoring these biomarkers for assessing disease progression and treatment response.
This review highlighted the role of neutrophil extracellular traps (NETs) in stroke, noting their dual function in trapping pathogens and exacerbating inflammation. Researchers summarized mechanisms of NET formation and their contributions to stroke pathology, suggesting that targeting NETs could be a novel therapeutic approach.
This review highlights the roles of neutrophils and platelets in neuroinflammatory diseases. Researchers found that these cells contribute to thromboinflammation and neuroinflammation, emphasizing the need for further research into their mechanisms in neurological disorders.
Researchers discussed the potential of neutrophils as biomarkers and therapeutic targets in radiation therapy for cancer. The study emphasized the complex interplay between neutrophils and the tumor microenvironment, suggesting that neutrophil evaluation could enhance treatment outcomes.
This study examined the interaction between bladder cancer cells and neutrophils, revealing that IL-8 secretion recruits neutrophils, which then influence tumor progression. Researchers found that urine IL-8 is a better biomarker for prognosis than serum IL-8.
Researchers reviewed anti-neutrophil cytoplasmic antibodies (ANCA) and their role as biomarkers for ANCA-associated vasculitis. The study outlines the different staining patterns of ANCA and their clinical significance in diagnosing various forms of systemic small-vessel vasculitis.
This review examined the role of neutrophils in pulmonary fibrosis, noting their increased presence in patients with interstitial lung diseases. Researchers highlighted the potential of neutrophils as biomarkers for disease severity and emphasized the need for further investigation into their dual roles in lung tissue.
11
Total Trials
1,749
Total Enrolled
Aristotle University Of Thessaloniki
45
2025
Neutrophil Gelatinase-Associated Lipocalin
Muğla Sıtkı Koçman University
35
2022
Early inflammation markers for VAP
Universitas Sebelas Maret
72
2022
Neutrophil-lymphocyte ratio (NLR)
Loyola University
42
2021
Urinary neutrophil gelatinase-associated lipocalin (NGAL)
Seoul National University Hospital
60
2019
serum neutrophil-gelatinase-associated lipocalin (NGAL)
INA-RESPOND Secretariat
188
2017
White Blood Cells and Absolute Neutrophil Count Cut-off Levels for Distinguishing of Viral and Bacterial/Mixed Pathogens
The Cleveland Clinic
149
2015
Urine Neutrophil Gelatinase-associated Lipocalin (NGAL) [Time Frame: 24 Hours After Surgery] [Designated as Safety Issue: Yes]
University of Freiburg
244
2011
to assess the value of uNGAL measurement 4 to 6 hours after PCP as a possible early detector of CIN
University of Pennsylvania
704
2010
Composite of i) All-cause Mortality or ii) End-stage Renal Disease
University Hospital Dubrava
60
2008
Neutrophil activity before and after the open or laparoscopic surgery - Serum concentrations of sFas, sFasL and IL - 17.
Hospital de Base
150
2007
Evaluate the urinary excretion of NGAL as a marker of early development of acute kidney injury in patients undergoing cardiac surgery
Research publications about Neutrophile over time
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