Lever
Lifestyle
- Increase physical activity
- Avoid smoking
- Manage stress
- Maintain healthy weight
Blutwerte · Marker
Oxidiertes LDL
Oxidized LDL · oxLDL · ox-LDL
Lipide & Herz-Kreislauf
- Einheit:
- mg/dL
- Abbreviation
- oxLDL
Oxidiertes LDL measures the amount of oxidized low-density lipoprotein in the blood, indicating oxidative modification of LDL cholesterol.
Reference Ranges
Reference
0.5–1.5mg/dL
0.5
1.5
LowNormalHigh
Reference
Unit · mg/dLReference ranges may vary based on population and laboratory methods.
Overview
Übersicht
Oxidiertes LDL (oxLDL), or oxidized low-density lipoprotein, is a modified form of LDL cholesterol that has undergone oxidative modification. It is a biomarker of oxidative stress and plays a crucial role in the pathogenesis of atherosclerosis. Researchers have found that oxLDL is taken up by macrophages, leading to foam cell formation and atherosclerotic plaque development. Clinically, elevated oxLDL levels are associated with increased risk of cardiovascular diseases, including coronary artery disease and stroke. It reflects endothelial dysfunction and is considered a proatherogenic factor. In the context of athletic performance and biohacking, oxLDL is of interest due to its role in vascular health and potential impact on longevity. High levels may indicate increased oxidative stress, which could affect recovery and performance. However, the interpretation of oxLDL levels can be confounded by factors such as diet, smoking, and metabolic syndrome. Fasting is not required for testing, but levels may vary with time of day and other physiological conditions.
Klinische Bedeutung
Elevated oxLDL levels indicate increased oxidative stress and are associated with a higher risk of atherosclerosis and cardiovascular diseases. Low levels are generally considered favorable, reflecting lower oxidative stress and reduced cardiovascular risk.
Dynamics
Trend Interpretation
Rising Values
Progressively rising oxLDL levels suggest worsening oxidative stress and increased cardiovascular risk. Retesting is recommended every 3-6 months if levels are elevated.
Falling Values
Progressively falling oxLDL levels indicate improved oxidative stress status and reduced cardiovascular risk.
Re-test Interval
6 months if outside optimal range
Etiology
Causes — High & Low
Cause
Elevated Levels
- High dietary intake of oxidized fats
- Smoking
- Metabolic syndrome
- Chronic inflammation
- Diabetes
Cause
Low Levels
- Low oxidative stress
- Healthy diet rich in antioxidants
- Regular physical activity
- Effective lipid-lowering therapy
- Non-smoking status
Protocol
How to Optimize
Lever
Nutrition
- Consume antioxidants-rich foods
- Reduce intake of trans fats
- Increase omega-3 fatty acids
- Eat more fruits and vegetables
Lever
Supplementation
- Vitamin E
- Coenzyme Q10
- Omega-3 fatty acids
Note:
Consult a healthcare provider before starting any supplementation, especially if you have underlying health conditions.
Testing Guidelines
✓Fasting Not Required
✓Not Time-Sensitive
Testing Frequency
Annually for individuals at risk of cardiovascular disease
Interfering Factors
- Recent high-fat meal
- Acute illness
- Intense physical activity
Related Peptides & Hormones
Interleukin 6
hormone or peptideCorrelated with
Open Research Questions
Current research suggests that reference ranges and optimal targets for oxidized LDL (oxLDL) remain inadequately defined, particularly regarding confounding factors such as metabolic syndrome and inflammation. Researchers have not yet established the precise role of soluble LOX-1 as a reliable biomarker for early diagnosis of acute coronary syndrome across diverse populations. Additionally, clinical questions regarding the long-term efficacy of targeting the oxLDL-LOX-1 axis in therapeutic interventions for atherosclerosis remain unanswered.
20 Research Publications
971
Total Citations
4
Human/RCT
4.1
Avg. Influence
2025
Latest
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Filter
01Top
#01
Scavenger receptors, oxidized LDL, and atherosclerosis.
In VitroInfluence13.0
347
Researchers investigated the binding mechanisms of oxidized LDL (oxLDL) to macrophages, revealing that oxidized phospholipids play a significant role in this process. They found that oxLDL competes with apoptotic cells for macrophage binding, which has implications for atherogenesis. The study highlights the importance of these interactions in cardiovascular disease.
02Top
#02
Oxidation of LDL and its clinical implication.
ReviewInfluence6.0
229
Researchers reviewed the clinical implications of oxidized LDL (oxLDL) in atherosclerosis, finding that oxLDL promotes inflammatory responses and foam cell formation. They noted that autoantibodies against oxLDL complexes may be linked to arterial thrombosis, highlighting the complex role of oxLDL in cardiovascular disease.
03Top
#03
Oxidized LDL and NO synthesis--Biomarkers of endothelial dysfunction and ageing.
Gradinaru Daniela, et al. · Mechanisms of ageing and development · 2015
ReviewInfluence6.0
159
Researchers explored the relationship between oxidized LDL (oxLDL) and nitric oxide (NO) in the context of endothelial dysfunction and aging. They found that both oxLDL and NO are indicative of oxidative stress and could serve as biomarkers for cardiovascular diseases. The study highlights the importance of these parameters in evaluating vascular aging.
Key findings
- 01Researchers observed that metabolic health affects the levels of oxidized LDL and nitric oxide, which are linked to oxidative stress.
- 02The study indicates that oxidized LDL and nitric oxide can be used as biomarkers to predict cardiovascular outcomes in humans.
- 03Evidence suggests that these biomarkers are significant in understanding vascular aging and related diseases.
04
#04
Challenges and advances in the management of inflammation in atherosclerosis.
Review
79
This review examined the role of inflammation in atherosclerosis, highlighting how oxidized LDL (oxLDL) contributes to plaque formation by being ingested by macrophages. Researchers found that macrophages can take on different roles within plaques, influencing disease progression. The study also discussed advancements in imaging and biomarker technology for better understanding and managing atherosclerosis.
05
#05
LOX-1 in atherosclerotic disease.
HumanInfluence1.0
48
This study investigated the role of LOX-1, a receptor for oxidized LDL (oxLDL), in atherosclerosis. Researchers found that LOX-1 levels correlate with carotid intima-media thickness and cardiovascular disease incidence. The study suggests that measuring soluble LOX-1 could improve early diagnosis of acute coronary syndrome.
06
#06
LOX-1 and atherosclerotic-related diseases.
Review
47
Researchers reviewed the role of LOX-1 in atherosclerosis, noting its contribution to plaque formation and rupture. They found that circulating levels of soluble LOX-1 are linked to acute coronary syndrome and stroke risk. The study emphasizes the potential of LOX-1 as a biomarker for cardiovascular diseases.
07
#07
Clinical and Preclinical Use of LOX-1-Specific Antibodies in Diagnostics and Therapeutics.
ReviewInfluence1.0
13
Researchers reviewed the clinical applications of LOX-1-specific antibodies in diagnostics and therapeutics related to diseases like atherosclerosis. The study emphasized the need for further clinical studies to translate LOX-1 findings into effective patient care strategies.
08
#08
Controversy over the atherogenicity of lipoprotein-X.
ReviewInfluence1.0
12
This review discussed the controversial role of lipoprotein-X (Lp-X) in atherosclerosis, noting its association with cholestasis and its potential atherogenic properties. Researchers found that Lp-X may cause more lipid accumulation than oxidized LDL in macrophages. The study calls for further research to clarify Lp-X's clinical significance in cardiovascular disease.
09
#09
Oxidized LDL receptors: a recent update.
ReviewInfluence1.0
9
Researchers reviewed recent findings on oxidized LDL (oxLDL) receptors, particularly LOX-1, and their impact on lipid metabolism and inflammation in atherosclerosis. They found that soluble LOX-1 could serve as a valuable biomarker for cardiovascular disease diagnosis and prognosis. The study emphasizes the potential for targeting the oxLDL-LOX-1 axis in future therapeutic developments.
10
#10
Modified LDL Immune Complexes and Cardiovascular Disease.
Clinical
7
Researchers explored the immunogenicity of modified LDL, particularly oxidized LDL (oxLDL), and its association with cardiovascular disease (CVD). They found that immune complexes formed with oxLDL can predict atherosclerosis progression. The study highlights the differing effects of various LDL modifications on cardiovascular risk.
Publication Trend
Research publications about Oxidiertes LDL over time
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