Lever
Lifestyle
- Regular physical activity
- Weight management
- Stress reduction
Blutwerte · Marker
Resistin
Resistin · FIZZ3
Adipokine & Metabolische HormoneNüchtern erforderlichZeitabhängig
- Einheit:
- ng/mL
Resistin quantifies the level of a hormone secreted by adipose tissue that is involved in insulin resistance and inflammation.
Reference Ranges
Reference
7–22ng/mL
7
22
LowNormalHigh
Reference
Unit · ng/mLReference ranges may vary based on sex, age, and fasting state.
Overview
Übersicht
Resistin is an adipokine primarily secreted by adipose tissue, playing a significant role in metabolic processes. It is involved in the regulation of glucose metabolism and insulin resistance. Researchers have observed that resistin levels correlate with inflammatory states and metabolic disorders. Clinically, resistin is associated with obesity, type 2 diabetes, and cardiovascular diseases. Elevated resistin levels have been linked to increased risk of coronary artery disease and peripheral artery disease, making it a potential biomarker for cardiovascular health. In the context of athletic performance and biohacking, resistin's role in inflammation and insulin resistance may impact recovery and metabolic efficiency. Longevity research also considers resistin due to its involvement in age-related metabolic decline. However, resistin levels can be influenced by various factors such as circadian rhythms, fasting state, and inflammatory conditions, which may confound its interpretation as a biomarker. Further research is needed to establish standardized reference ranges and to clarify its role in disease prediction.
Klinische Bedeutung
Elevated resistin levels indicate increased risk for metabolic disorders such as type 2 diabetes and cardiovascular diseases. It is also associated with chronic inflammation and may serve as a marker for obesity-related complications.
Dynamics
Trend Interpretation
Rising Values
Progressively rising resistin levels suggest worsening insulin resistance or increased inflammation. Retest in 3-6 months if levels are elevated.
Falling Values
Falling resistin levels may indicate improved metabolic health and reduced inflammation.
Re-test Interval
6 months if outside optimal range
Etiology
Causes — High & Low
Cause
Elevated Levels
- Obesity
- Type 2 diabetes
- Chronic inflammation
- Cardiovascular disease
- Circadian misalignment
Cause
Low Levels
- Improved insulin sensitivity
- Weight loss
- Anti-inflammatory interventions
- Healthy metabolic state
Protocol
How to Optimize
Lever
Nutrition
- High-fiber diet
- Omega-3 fatty acids
- Low glycemic index foods
Lever
Supplementation
- Omega-3 supplements
- Curcumin
- Resveratrol
Note:
Consult with a healthcare provider before making significant lifestyle changes.
Testing Guidelines
🍽️Fasting Required
🕐Time-Sensitive
Resistin levels may vary throughout the day; morning samples are recommended for consistency.
Testing Frequency
Annually for individuals with metabolic syndrome or cardiovascular risk factors.
Interfering Factors
- Recent intense exercise
- Acute infections
- Inflammatory conditions
Related Peptides & Hormones
C Reactive Protein
hormoneCorrelated with
Open Research Questions
Current research suggests that the independence of resistin as a biomarker for cardiovascular disease is complicated by confounders such as C-reactive protein, and reference ranges for resistin levels remain poorly defined. Researchers have not yet established optimal targets for resistin in clinical practice, particularly in relation to its role in obesity and cancer. Unanswered clinical questions include the precise mechanisms by which resistin contributes to various disease states and its potential as a therapeutic target.
20 Research Publications
3,439
Total Citations
5
Human/RCT
10.2
Avg. Influence
2021
Latest
Sort
Filter
01Top
#01
Obesity and cancer risk: Emerging biological mechanisms and perspectives.
ReviewInfluence38.0
1241
This study examined the rising trends in obesity-related cancers, finding that excess body weight is linked to an increased risk for at least 13 types of cancer. Researchers summarized biological mechanisms connecting obesity to cancer, including insulin resistance and chronic inflammation. They also discussed future perspectives on prevention and treatment.
02Top
#02
Circadian misalignment increases cardiovascular disease risk factors in humans.
HumanInfluence15.0
590
This study examined the effects of circadian misalignment on cardiovascular disease risk factors, finding that it increases blood pressure and inflammatory markers, including resistin. Researchers observed significant changes in blood pressure during sleep and wake periods, suggesting that misalignment may contribute to hypertension and inflammation.
03Top
#03
Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases.
ReviewInfluence13.0
427
Researchers aimed to identify potential frailty biomarkers related to aging, including resistin. They evaluated 44 markers across various aging pathways and proposed a core panel of biomarkers that could enhance the understanding of frailty in older adults. The study emphasized the need for further research on these biomarkers.
04
#04
Adipokines, Hepatokines and Myokines: Focus on Their Role and Molecular Mechanisms in Adipose Tissue Inflammation.
ReviewInfluence6.0
217
Researchers found that chronic low-grade inflammation in adipose tissue is a key feature of obesity, influenced by various adipokines, including resistin. The study highlighted the roles of these proteins in regulating inflammation and their potential as therapeutic targets for obesity-related metabolic disorders. It provided insights into the molecular mechanisms underlying adipokine functions.
05
#05
Resistin- and Obesity-associated metabolic diseases.
ReviewInfluence18.0
198
This study discussed the relationship between resistin, obesity, and metabolic diseases, highlighting resistin's role as a potential biomarker for inflammation and metabolic disorders. Researchers noted the complex interplay between resistin levels and insulin sensitivity in humans and rodents.
06
#06
Resistin in metabolism, inflammation, and disease.
Tripathi Deeksha, et al. · The FEBS journal · 2020
ReviewInfluence5.0
186
This study explored the multifaceted role of resistin in metabolism and inflammation, noting its significance as a biomarker in diagnostics. Researchers found that resistin is involved in stress response mechanisms and plays a role in obesity and inflammation-related diseases.
Key findings
- 01Resistin has different functions in mice and humans, affecting metabolism and inflammation.
- 02In mice, resistin is associated with insulin resistance and type 2 diabetes.
- 03In humans, resistin is linked to inflammation and may serve as a biomarker for disease evaluation.
07
#07
Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions.
ReviewInfluence2.0
153
This study reviewed the interactions between adipokines, myokines, and hepatokines, including resistin, in metabolic disorders. Researchers found that these biomarkers can have both harmful and beneficial effects on health outcomes.
08
#08
Resistin: insulin resistance to malignancy.
ReviewInfluence8.0
142
This review highlighted resistin as an inflammatory biomarker linking obesity to various diseases, including cardiovascular conditions and cancer. Researchers discussed its potential role in mediating metabolic disturbances and its implications for diagnostics.
09
#09
Adipokines: Biomarkers for osteoarthritis?
ReviewInfluence9.0
111
Researchers summarized the role of adipokines, including resistin, in osteoarthritis, noting that obesity contributes to the disease's progression. The study highlighted altered levels of adipokines in osteoarthritis patients and their potential as biomarkers for diagnosis and monitoring disease progression.
10
#10
Resistin: Potential biomarker and therapeutic target in atherosclerosis.
Zhou Li, et al. · Clinica chimica acta; international journal of clinical chemistry · 2021
ReviewInfluence3.0
65
Researchers reviewed the pro-atherosclerotic effects of resistin, noting its role in vascular inflammation and lipid accumulation. They highlighted resistin's potential as a therapeutic and diagnostic target for cardiovascular diseases, emphasizing its impact on various cell types in the cardiovascular system.
Key findings
- 01Resistin can trigger inflammation and lipid accumulation in blood vessels.
- 02It affects various cell types, contributing to cardiovascular problems like atherosclerosis.
- 03The study highlights resistin as a potential target for future cardiovascular disease therapies and diagnostics.
Clinical Trials (2)
2
Total Trials
140
Total Enrolled
Relationship Between Serum Resistin Levels and Reduction in Visceral Fat in Patients Undergoing Sleeve Gastrectomy Due to Morbid Obesity
NCT07564986COMPLETED
Sponsor
Sercan YUKSEL, MD
Enrollment
80
Started
2025
Primary outcome
Change in body mass index at 8 months
Morbid Obesity Requiring Bariatric Surgery
Beta-glucan-chitin-chitosan Polymer Supplement in Overweight/Obese Subjects: Cardiovascular Risk Biomarkers (QUITOVASC)
NCT06622447COMPLETED
Sponsor
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Enrollment
60
Started
2017
Primary outcome
Adipokines Plasma Levels (Adiponectin, Leptin, Resistin) at Week 12
Dietary Exposure
Publication Trend
Research publications about Resistin over time
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