Lever
Lifestyle
- Regular physical activity
- Weight management
- Stress reduction
- Adequate sleep
Blutwerte · Marker
Resistin
Resistin · FIZZ3
Adipokine & Metabolische HormoneNüchtern erforderlichZeitabhängig
- Einheit:
- ng/mL
Resistin quantifies the level of a hormone involved in glucose metabolism and inflammation.
Reference Ranges
Reference
7–22ng/mL
7
22
LowNormalHigh
Reference
Unit · ng/mLReference ranges may vary based on age, sex, and health status.
Overview
Übersicht
Resistin is an adipokine primarily secreted by adipose tissue, involved in the regulation of glucose metabolism and insulin sensitivity. It is a cysteine-rich protein that plays a role in inflammatory processes and is associated with obesity and metabolic syndrome. Researchers have observed that resistin levels are elevated in obesity, contributing to insulin resistance and inflammation. Clinically, elevated resistin levels are linked to increased risk of type 2 diabetes, cardiovascular diseases, and certain cancers. Resistin is also implicated in the pathophysiology of obesity-related disorders, serving as a biomarker for metabolic dysfunction. In the context of athletic performance and biohacking, resistin may influence energy metabolism and inflammatory responses, potentially affecting recovery and adaptation to exercise. However, its role in longevity is less clear, with ongoing research needed to elucidate its impact. Caveats include potential confounders such as circadian rhythm variations and fasting status, which can influence resistin levels. Researchers found that resistin levels may vary throughout the day, and fasting conditions are recommended for accurate assessment.
Klinische Bedeutung
Elevated resistin levels indicate increased risk of insulin resistance, type 2 diabetes, and cardiovascular diseases. Low levels are less commonly associated with specific clinical conditions.
Dynamics
Trend Interpretation
Rising Values
Progressively rising resistin levels suggest worsening insulin resistance and increased inflammation. Re-test in 4 weeks if outside optimal range.
Falling Values
Falling resistin levels may indicate improved metabolic health and reduced inflammation.
Re-test Interval
4 weeks if outside optimal range
Etiology
Causes — High & Low
Cause
Elevated Levels
- Obesity
- Insulin resistance
- Chronic inflammation
- Type 2 diabetes
- Cardiovascular disease
- Circadian misalignment
Cause
Low Levels
- Healthy weight
- Improved insulin sensitivity
- Anti-inflammatory interventions
- Weight loss
- Exercise
- Balanced diet
Protocol
How to Optimize
Lever
Nutrition
- Balanced diet rich in fruits and vegetables
- Reduced intake of processed foods
- Omega-3 fatty acids
- High-fiber foods
Lever
Supplementation
- Omega-3 supplements
- Curcumin
- Resveratrol
Note:
Consult with a healthcare provider before making significant lifestyle changes.
Testing Guidelines
🍽️Fasting Required
🕐Time-Sensitive
Resistin levels may vary; morning fasting samples are recommended.
Testing Frequency
Annually for individuals with metabolic risk factors.
Interfering Factors
- Recent meal intake
- Circadian rhythm disruptions
- Acute stress
Related Peptides & Hormones
Adiponectin
hormone or peptideCorrelated with
Open Research Questions
Current research suggests that reference ranges for resistin levels in various populations, particularly in children and adolescents, remain poorly defined, and the optimal targets for therapeutic interventions are still debated. Researchers have not yet established the precise role of resistin in mediating obesity-related inflammation and its interactions with other adipokines. Additionally, clinical questions remain unanswered regarding the long-term implications of resistin levels on cardiovascular disease risk and metabolic syndrome progression in diverse demographics.
42 Research Publications
4,632
Total Citations
16
Human/RCT
7.3
Avg. Influence
2021
Latest
Sort
Filter
01Top
#01
Obesity and cancer risk: Emerging biological mechanisms and perspectives.
ReviewInfluence39.0
1283
This review examined the relationship between obesity and cancer risk, highlighting that excess body weight is linked to an increased risk of various cancers. Researchers found multiple biological mechanisms that connect obesity to cancer, including insulin resistance and inflammation.
02Top
#02
Circadian misalignment increases cardiovascular disease risk factors in humans.
HumanInfluence16.0
633
This study investigated the effects of circadian misalignment on cardiovascular risk factors. Researchers observed that misalignment increased levels of inflammatory markers, including resistin, and elevated blood pressure in healthy adults.
03Top
#03
Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases.
ReviewInfluence13.0
432
This study aimed to identify potential frailty biomarkers, including resistin, associated with aging and age-related diseases. Researchers proposed a biomarker panel that includes resistin as a candidate for assessing frailty in older adults.
04
#04
Human resistin: found in translation from mouse to man.
ReviewInfluence9.0
312
Researchers examined the link between human resistin and metabolic diseases, noting its secretion by macrophages. They found that resistin serves as an inflammatory biomarker and may mediate diabetes and cardiovascular disease.
05
#05
Adipokines, Hepatokines and Myokines: Focus on Their Role and Molecular Mechanisms in Adipose Tissue Inflammation.
ReviewInfluence6.0
234
Researchers investigated the role of adipokines, including resistin, in adipose tissue inflammation associated with obesity. They found that obesity leads to increased levels of pro-inflammatory adipokines, which may contribute to metabolic disorders.
06
#06
Pomegranate and type 2 diabetes.
ReviewInfluence7.0
231
Researchers reviewed the effects of pomegranate on type 2 diabetes, noting that certain components can reduce resistin formation and improve metabolic variables. They highlighted the need for further clinical studies to validate these findings.
07
#07
Resistin- and Obesity-associated metabolic diseases.
ReviewInfluence18.0
199
Researchers examined the relationship between resistin and metabolic diseases, noting that resistin is produced by macrophages in humans and may serve as a biomarker for inflammation and metabolic disorders.
08
#08
Resistin in metabolism, inflammation, and disease.
Tripathi Deeksha, et al. · The FEBS journal · 2020
ReviewInfluence5.0
194
Researchers summarized the diverse roles of resistin in metabolism and inflammation, noting its involvement in insulin resistance and stress response. They highlighted resistin's potential as a biomarker for evaluating disease status.
Key findings
- 01Resistin has different functions in mice and humans, affecting metabolism and inflammation.
- 02In mice, resistin is associated with insulin resistance and type 2 diabetes.
- 03In humans, resistin is linked to inflammation and may serve as a biomarker for disease evaluation.
09
#09
Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions.
ReviewInfluence2.0
169
Researchers reviewed the interactions between adipokines, myokines, and hepatokines, emphasizing their roles in metabolic disorders. They found that pro-inflammatory adipokines, including resistin, are secreted more by overweight individuals, potentially contributing to diseases like type 2 diabetes and cardiovascular diseases.
10
#10
Resistin: insulin resistance to malignancy.
ReviewInfluence8.0
142
This review highlighted resistin as an inflammatory biomarker linking obesity to various diseases, including cardiovascular conditions and cancer. Researchers discussed its potential role in mediating metabolic disturbances and its implications for diagnostics.
Clinical Trials (4)
4
Total Trials
264
Total Enrolled
Metabolic and Hormonal Parameters in Women With Polyendocrine Metabolic Ovarian Syndrome
NCT07844785NOT_YET_RECRUITING
Sponsor
Istinye University
Enrollment
80
Started
2026
Primary outcome
Correlation Between Serum and Salivary Fetuin-A and Resistin Levels
Polycystic Ovary SyndromePolycystic Ovary Syndrome (PCOS) WomenFetuin-ASerum BiomarkersInsulin Resistance
Relationship Between Serum Resistin Levels and Reduction in Visceral Fat in Patients Undergoing Sleeve Gastrectomy Due to Morbid Obesity
NCT07564986COMPLETED
Sponsor
Sercan YUKSEL, MD
Enrollment
80
Started
2025
Primary outcome
Change in body mass index at 8 months
Morbid Obesity Requiring Bariatric Surgery
Beta-glucan-chitin-chitosan Polymer Supplement in Overweight/Obese Subjects: Cardiovascular Risk Biomarkers (QUITOVASC)
NCT06622447COMPLETED
Sponsor
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Enrollment
60
Started
2017
Primary outcome
Adipokines Plasma Levels (Adiponectin, Leptin, Resistin) at Week 12
Dietary Exposure
Levels of Serum Resistin in Asthmatics as a Potential Marker of Systemic Inflammation and Disease State.
NCT00339703COMPLETED
Sponsor
59th Medical Wing
Enrollment
44
Started
2004
Asthma
Publication Trend
Research publications about Resistin over time
10totalTrack your bloodwork in PepStack
Log lab results, track trends and optimize your biomarkers over time.
Legal Disclaimer
This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer