Lifestyle
- Regular physical activity
- Weight management
- Stress reduction
Resistin · FIZZ3
Resistin quantifies the level of a pro-inflammatory adipokine involved in metabolic and inflammatory processes.
Reference ranges may vary based on sex, age, and fasting status.
Resistin is a small secretory protein primarily associated with adipose tissue in rodents and inflammatory cells in humans. It is part of the adipokine family and plays a role in modulating inflammation and insulin resistance. Researchers have found that resistin is involved in the pathophysiology of metabolic disorders such as obesity and type 2 diabetes. Clinically, elevated resistin levels are linked to increased inflammation and may contribute to cardiovascular diseases and other obesity-related conditions. Resistin's role in inflammation makes it a potential biomarker for assessing disease status and treatment outcomes. In the context of athletic performance and biohacking, resistin's influence on inflammation and metabolic processes may impact recovery and metabolic efficiency. However, its specific role in longevity is still under investigation. Researchers observed that resistin levels can be influenced by factors such as circadian rhythms and fasting status, which should be considered when interpreting test results. Additionally, resistin's secretion source varies between species, which may affect its biological activity and relevance in human studies.
Klinische Bedeutung
Elevated resistin levels indicate increased inflammation and are associated with obesity, type 2 diabetes, and cardiovascular diseases. Reduced levels may suggest lower inflammatory activity.
Progressively rising resistin levels suggest worsening inflammation and metabolic dysfunction. Retest in 4 weeks if levels continue to rise.
Progressively falling resistin levels may indicate improved inflammatory status and metabolic health.
Re-test Interval
4 weeks if outside optimal range
Note:
Consult a healthcare provider for personalized advice, especially if considering significant lifestyle changes.
Resistin levels may vary with circadian rhythms; consistent timing for tests is recommended.
Testing Frequency
Annually for those with metabolic disorders, more frequently if monitoring treatment response.
Correlated with
Current research suggests that reference ranges for resistin levels in different populations and the optimal targets for therapeutic interventions remain unclear, with confounding factors such as obesity and inflammation complicating interpretations. Researchers have not yet established the precise role of resistin in various metabolic disorders and its potential as a frailty biomarker. Additionally, clinical questions regarding the longitudinal impact of resistin levels on disease progression and treatment outcomes remain unanswered.
2,997
Total Citations
5
Human/RCT
8.3
Avg. Influence
2021
Latest
This study examined the relationship between obesity and cancer risk, finding that excess body weight is linked to an increased risk for at least 13 types of cancer. Researchers summarized biological mechanisms connecting obesity to cancer, including insulin resistance and inflammation. They discussed future perspectives for prevention and treatment.
Researchers found that short-term circadian misalignment in healthy adults increased blood pressure and inflammatory markers, including resistin. The study showed that this misalignment adversely affected cardiovascular risk factors. These findings may explain the heightened cardiovascular disease risk associated with shift work.
Researchers aimed to identify potential biomarkers for frailty, finding resistin among other candidates. The study evaluated 44 markers related to aging and disease, proposing a core panel for frailty assessment. The findings suggest that biomarker panels may be more effective than single markers in clinical settings.
This review examined the role of adipokines, including resistin, in chronic low-grade inflammation in adipose tissue associated with obesity. Researchers highlighted the importance of these proteins in regulating inflammation and their potential implications for metabolic disorders. The study suggests that understanding these mechanisms could lead to new therapeutic targets.
Tripathi Deeksha, et al. · The FEBS journal · 2020
This review summarized recent developments in resistin biology, noting its roles in metabolism, inflammation, and stress response. Researchers highlighted resistin's potential as a biomarker for disease status and treatment outcomes. The study emphasizes the importance of understanding resistin's diverse functions in health.
Key findings
This study reviewed the interactions between adipokines, myokines, and hepatokines, including resistin, in metabolic disorders. Researchers found that these biomarkers can have both harmful and beneficial effects on health outcomes.
This review focused on the role of adipokines, including resistin, in osteoarthritis (OA). Researchers noted that resistin levels were increased in OA patients, suggesting its potential as a biomarker for diagnosis and monitoring. The study emphasizes the need for further research on adipokines in OA.
Zhou Li, et al. · Clinica chimica acta; international journal of clinical chemistry · 2021
Researchers highlighted resistin's role in atherosclerosis, noting its effects on vascular inflammation and lipid accumulation. The study proposed resistin as a potential therapeutic or diagnostic target for cardiovascular disease. Evidence suggests resistin's involvement in various cardiovascular pathologies.
Key findings
Ding Qinxue, et al. · Trends in cardiovascular medicine · 2011
Researchers discussed resistin's association with cardiovascular diseases, including coronary artery disease and heart failure. The study highlighted resistin's potential as a diagnostic and prognostic marker, although its role is complicated by confounding factors. Further research is needed to clarify resistin's biomarker function.
Key findings
This study examined the relationship between obesity-related biomarkers, including resistin, and heart failure with preserved ejection fraction (HFpEF). Researchers found that higher levels of certain biomarkers were associated with impaired exercise capacity and increased odds of HFpEF. The findings suggest inflammation and adipokine signaling may underlie these associations.
Research publications about Resistin over time
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