Lever
Lifestyle
- Regular physical activity
- Weight management
- Stress reduction
Blutwerte · Marker
Resistin
Resistin · FIZZ3
Adipokine & Metabolische HormoneNüchtern erforderlichZeitabhängig
- Einheit:
- ng/mL
Resistin quantifies the level of a secretory protein involved in inflammation and metabolic regulation.
Reference Ranges
Reference
7–22ng/mL
7
22
LowNormalHigh
Reference
Unit · ng/mLReference ranges may vary based on sex, age, and fasting status.
Overview
Übersicht
Resistin is a small secretory protein categorized as an adipokine and metabolic hormone. It is primarily involved in the regulation of inflammation and metabolic processes. In humans, resistin is secreted by immune cells and is associated with inflammatory responses, while in rodents, it is secreted by adipocytes and linked to insulin resistance. Clinically, resistin is significant as it is associated with obesity, type 2 diabetes, and cardiovascular diseases. Elevated levels of resistin have been observed in conditions characterized by chronic inflammation, such as obesity and metabolic syndrome, and may serve as a biomarker for these conditions. Researchers have found that resistin is involved in the pathophysiology of these diseases by promoting inflammatory pathways and contributing to insulin resistance. In the context of athletic performance, biohacking, or longevity, resistin's role in inflammation and metabolism may influence recovery and adaptation to physical stress. However, its direct impact on athletic performance or longevity is less clear and requires further investigation. Caveats in measuring resistin include potential confounding factors such as obesity, inflammatory status, and circadian rhythms. Time-of-day and fasting status may influence resistin levels, and researchers recommend standardizing these conditions during testing to ensure accurate and comparable results.
Klinische Bedeutung
Elevated resistin levels indicate increased inflammation and are associated with obesity, type 2 diabetes, and cardiovascular diseases. Low resistin levels are less commonly discussed but may indicate reduced inflammatory activity.
Dynamics
Trend Interpretation
Rising Values
Progressively rising resistin levels suggest worsening inflammation or metabolic dysfunction. Retesting in 3-6 months is recommended.
Falling Values
Progressively falling resistin levels may indicate improved inflammation or metabolic health.
Re-test Interval
6 months if outside optimal range
Etiology
Causes — High & Low
Cause
Elevated Levels
- Obesity
- Chronic inflammation
- Type 2 diabetes
- Cardiovascular disease
- Metabolic syndrome
Cause
Low Levels
- Reduced inflammatory activity
- Weight loss
- Improved metabolic health
- Anti-inflammatory interventions
Protocol
How to Optimize
Lever
Nutrition
- Anti-inflammatory diet
- High-fiber foods
- Omega-3 fatty acids
Lever
Supplementation
- Omega-3 supplements
- Curcumin
- Resveratrol
Note:
Consult a healthcare provider before starting any supplementation, especially if you have underlying health conditions.
Testing Guidelines
🍽️Fasting Required
🕐Time-Sensitive
Resistin levels may vary throughout the day; morning measurements are recommended.
Testing Frequency
Annually for individuals with metabolic syndrome or obesity.
Interfering Factors
- Recent intense exercise
- Acute infections
- Chronic inflammatory conditions
Related Peptides & Hormones
Leptin
hormoneCorrelated with
Open Research Questions
Current research suggests that reference ranges and optimal targets for resistin levels remain poorly defined, particularly in diverse populations and clinical contexts. Researchers have not yet established the confounding effects of factors such as circadian misalignment and obesity on resistin's role as a biomarker. Additionally, unanswered clinical questions include the precise mechanisms by which resistin influences inflammation and metabolic disorders, as well as its potential as a therapeutic target in obesity-related diseases.
18 Research Publications
3,033
Total Citations
5
Human/RCT
8.8
Avg. Influence
2021
Latest
Sort
Filter
01Top
#01
Obesity and cancer risk: Emerging biological mechanisms and perspectives.
ReviewInfluence34.0
1219
This study examined the relationship between obesity and cancer risk, finding that excess body weight is linked to an increased risk of at least 13 types of cancer. Researchers highlighted emerging biological mechanisms, including insulin resistance and chronic inflammation, that connect obesity to cancer development.
02Top
#02
Circadian misalignment increases cardiovascular disease risk factors in humans.
HumanInfluence13.0
577
Researchers found that short-term circadian misalignment significantly increases cardiovascular disease risk factors, including elevated blood pressure and inflammatory markers like resistin. The study demonstrated that these changes occur during both sleep and wake periods.
03Top
#03
Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases.
ReviewInfluence13.0
423
Researchers aimed to identify potential frailty biomarkers related to aging, highlighting resistin among others. The study proposed a core panel of biomarkers that could help assess frailty and related health risks in older adults.
04
#04
Adipokines, Hepatokines and Myokines: Focus on Their Role and Molecular Mechanisms in Adipose Tissue Inflammation.
ReviewInfluence5.0
204
This review focused on the role of adipokines, including resistin, in chronic low-grade inflammation in adipose tissue, which is linked to obesity and metabolic disorders. Researchers discussed how these proteins influence inflammation and metabolic abnormalities.
05
#05
Resistin in metabolism, inflammation, and disease.
Tripathi Deeksha, et al. · The FEBS journal · 2020
ReviewInfluence5.0
182
This study summarized the diverse roles of resistin in metabolism and inflammation, noting its association with obesity and stress response mechanisms. Researchers emphasized its potential as a biomarker for disease diagnostics.
Key findings
- 01Resistin has different functions in mice and humans, affecting metabolism and inflammation.
- 02In mice, resistin is associated with insulin resistance and type 2 diabetes.
- 03In humans, resistin is linked to inflammation and may serve as a biomarker for disease evaluation.
06
#06
Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions.
ReviewInfluence2.0
153
This study reviewed the interactions between adipokines, myokines, and hepatokines, including resistin, in metabolic disorders. Researchers found that these biomarkers can have both harmful and beneficial effects on health outcomes.
07
#07
Adipokines: Biomarkers for osteoarthritis?
ReviewInfluence9.0
110
Researchers reviewed the role of adipokines, including resistin, in osteoarthritis (OA), suggesting that these molecules may serve as biomarkers for disease diagnosis and monitoring. The study highlighted altered levels of resistin in OA patients.
08
#08
Resistin: Potential biomarker and therapeutic target in atherosclerosis.
Zhou Li, et al. · Clinica chimica acta; international journal of clinical chemistry · 2021
ReviewInfluence3.0
60
This study highlighted resistin's role in atherosclerosis, noting its involvement in vascular inflammation and plaque vulnerability. Researchers suggested that resistin could serve as a therapeutic or diagnostic target for cardiovascular diseases.
Key findings
- 01Resistin can trigger inflammation and lipid accumulation in blood vessels.
- 02It affects various cell types, contributing to cardiovascular problems like atherosclerosis.
- 03The study highlights resistin as a potential target for future cardiovascular disease therapies and diagnostics.
09
#09
Resistin and cardiovascular disease.
Ding Qinxue, et al. · Trends in cardiovascular medicine · 2011
ReviewInfluence3.0
40
This review examined the association of resistin with cardiovascular diseases, including coronary artery disease and heart failure. Researchers noted its potential as a diagnostic and prognostic marker, although further studies are needed to clarify its role.
Key findings
- 01Resistin is associated with coronary and peripheral artery diseases, including ischemic stroke.
- 02Its role as a diagnostic and prognostic marker for cardiovascular disease is complicated by other inflammatory markers.
- 03Further large-scale studies are necessary to better understand resistin's function in heart disease.
10
#10
Obesity-Related Biomarkers Are Associated With Exercise Intolerance and HFpEF.
HumanInfluence1.0
30
Researchers investigated the relationship between obesity-related biomarkers, including resistin, and heart failure with preserved ejection fraction (HFpEF). The study found that higher levels of certain biomarkers were associated with impaired exercise capacity and HFpEF status.
Publication Trend
Research publications about Resistin over time
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