Lifestyle
- Regular physical activity
- Weight management
- Stress reduction
Resistin · FIZZ3
Resistin quantifies the level of a secretory protein involved in inflammation and metabolic regulation.
Reference ranges may vary based on sex, age, and fasting status.
Resistin is a small secretory protein categorized as an adipokine and metabolic hormone. It is primarily involved in the regulation of inflammation and metabolic processes. In humans, resistin is secreted by immune cells and is associated with inflammatory responses, while in rodents, it is secreted by adipocytes and linked to insulin resistance. Clinically, resistin is significant as it is associated with obesity, type 2 diabetes, and cardiovascular diseases. Elevated levels of resistin have been observed in conditions characterized by chronic inflammation, such as obesity and metabolic syndrome, and may serve as a biomarker for these conditions. Researchers have found that resistin is involved in the pathophysiology of these diseases by promoting inflammatory pathways and contributing to insulin resistance. In the context of athletic performance, biohacking, or longevity, resistin's role in inflammation and metabolism may influence recovery and adaptation to physical stress. However, its direct impact on athletic performance or longevity is less clear and requires further investigation. Caveats in measuring resistin include potential confounding factors such as obesity, inflammatory status, and circadian rhythms. Time-of-day and fasting status may influence resistin levels, and researchers recommend standardizing these conditions during testing to ensure accurate and comparable results.
Klinische Bedeutung
Elevated resistin levels indicate increased inflammation and are associated with obesity, type 2 diabetes, and cardiovascular diseases. Low resistin levels are less commonly discussed but may indicate reduced inflammatory activity.
Progressively rising resistin levels suggest worsening inflammation or metabolic dysfunction. Retesting in 3-6 months is recommended.
Progressively falling resistin levels may indicate improved inflammation or metabolic health.
Re-test Interval
6 months if outside optimal range
Note:
Consult a healthcare provider before starting any supplementation, especially if you have underlying health conditions.
Resistin levels may vary throughout the day; morning measurements are recommended.
Testing Frequency
Annually for individuals with metabolic syndrome or obesity.
Correlated with
Current research suggests that reference ranges and optimal targets for resistin levels remain poorly defined, particularly in diverse populations and clinical contexts. Researchers have not yet established the confounding effects of factors such as circadian misalignment and obesity on resistin's role as a biomarker. Additionally, unanswered clinical questions include the precise mechanisms by which resistin influences inflammation and metabolic disorders, as well as its potential as a therapeutic target in obesity-related diseases.
3,033
Total Citations
5
Human/RCT
8.8
Avg. Influence
2021
Latest
This study examined the relationship between obesity and cancer risk, finding that excess body weight is linked to an increased risk of at least 13 types of cancer. Researchers highlighted emerging biological mechanisms, including insulin resistance and chronic inflammation, that connect obesity to cancer development.
Researchers found that short-term circadian misalignment significantly increases cardiovascular disease risk factors, including elevated blood pressure and inflammatory markers like resistin. The study demonstrated that these changes occur during both sleep and wake periods.
Researchers aimed to identify potential frailty biomarkers related to aging, highlighting resistin among others. The study proposed a core panel of biomarkers that could help assess frailty and related health risks in older adults.
This review focused on the role of adipokines, including resistin, in chronic low-grade inflammation in adipose tissue, which is linked to obesity and metabolic disorders. Researchers discussed how these proteins influence inflammation and metabolic abnormalities.
Tripathi Deeksha, et al. · The FEBS journal · 2020
This study summarized the diverse roles of resistin in metabolism and inflammation, noting its association with obesity and stress response mechanisms. Researchers emphasized its potential as a biomarker for disease diagnostics.
Key findings
This study reviewed the interactions between adipokines, myokines, and hepatokines, including resistin, in metabolic disorders. Researchers found that these biomarkers can have both harmful and beneficial effects on health outcomes.
Researchers reviewed the role of adipokines, including resistin, in osteoarthritis (OA), suggesting that these molecules may serve as biomarkers for disease diagnosis and monitoring. The study highlighted altered levels of resistin in OA patients.
Zhou Li, et al. · Clinica chimica acta; international journal of clinical chemistry · 2021
This study highlighted resistin's role in atherosclerosis, noting its involvement in vascular inflammation and plaque vulnerability. Researchers suggested that resistin could serve as a therapeutic or diagnostic target for cardiovascular diseases.
Key findings
Ding Qinxue, et al. · Trends in cardiovascular medicine · 2011
This review examined the association of resistin with cardiovascular diseases, including coronary artery disease and heart failure. Researchers noted its potential as a diagnostic and prognostic marker, although further studies are needed to clarify its role.
Key findings
Researchers investigated the relationship between obesity-related biomarkers, including resistin, and heart failure with preserved ejection fraction (HFpEF). The study found that higher levels of certain biomarkers were associated with impaired exercise capacity and HFpEF status.
Research publications about Resistin over time
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