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Lifestyle
- Regular physical activity
- Weight management
- Stress reduction
Blutwerte · Marker
Resistin
Resistin · FIZZ3
Adipokine & Metabolische HormoneNüchtern erforderlichZeitabhängig
- Einheit:
- ng/mL
Resistin quantifies the level of a pro-inflammatory adipokine involved in metabolic and inflammatory processes.
Reference Ranges
Reference
7–22ng/mL
7
22
LowNormalHigh
Reference
Unit · ng/mLReference ranges may vary based on sex, age, and fasting status.
Overview
Übersicht
Resistin is a small secretory protein primarily associated with adipose tissue in rodents and inflammatory cells in humans. It is part of the adipokine family and plays a role in modulating inflammation and insulin resistance. Researchers have found that resistin is involved in the pathophysiology of metabolic disorders such as obesity and type 2 diabetes. Clinically, elevated resistin levels are linked to increased inflammation and may contribute to cardiovascular diseases and other obesity-related conditions. Resistin's role in inflammation makes it a potential biomarker for assessing disease status and treatment outcomes. In the context of athletic performance and biohacking, resistin's influence on inflammation and metabolic processes may impact recovery and metabolic efficiency. However, its specific role in longevity is still under investigation. Researchers observed that resistin levels can be influenced by factors such as circadian rhythms and fasting status, which should be considered when interpreting test results. Additionally, resistin's secretion source varies between species, which may affect its biological activity and relevance in human studies.
Klinische Bedeutung
Elevated resistin levels indicate increased inflammation and are associated with obesity, type 2 diabetes, and cardiovascular diseases. Reduced levels may suggest lower inflammatory activity.
Dynamics
Trend Interpretation
Rising Values
Progressively rising resistin levels suggest worsening inflammation and metabolic dysfunction. Retest in 4 weeks if levels continue to rise.
Falling Values
Progressively falling resistin levels may indicate improved inflammatory status and metabolic health.
Re-test Interval
4 weeks if outside optimal range
Etiology
Causes — High & Low
Cause
Elevated Levels
- Obesity
- Type 2 diabetes
- Chronic inflammation
- Cardiovascular disease
- Circadian misalignment
Cause
Low Levels
- Reduced inflammatory activity
- Weight loss
- Improved insulin sensitivity
- Anti-inflammatory treatments
Protocol
How to Optimize
Lever
Nutrition
- Anti-inflammatory diet
- High fiber intake
- Omega-3 fatty acids
Lever
Supplementation
- Omega-3 supplements
- Curcumin
- Resveratrol
Note:
Consult a healthcare provider for personalized advice, especially if considering significant lifestyle changes.
Testing Guidelines
🍽️Fasting Required
🕐Time-Sensitive
Resistin levels may vary with circadian rhythms; consistent timing for tests is recommended.
Testing Frequency
Annually for those with metabolic disorders, more frequently if monitoring treatment response.
Interfering Factors
- Recent intense exercise
- Acute stress
- Medication use
Related Peptides & Hormones
Adiponectin
hormoneCorrelated with
Open Research Questions
Current research suggests that reference ranges for resistin levels in different populations and the optimal targets for therapeutic interventions remain unclear, with confounding factors such as obesity and inflammation complicating interpretations. Researchers have not yet established the precise role of resistin in various metabolic disorders and its potential as a frailty biomarker. Additionally, clinical questions regarding the longitudinal impact of resistin levels on disease progression and treatment outcomes remain unanswered.
18 Research Publications
2,997
Total Citations
5
Human/RCT
8.3
Avg. Influence
2021
Latest
Sort
Filter
01Top
#01
Obesity and cancer risk: Emerging biological mechanisms and perspectives.
ReviewInfluence31.0
1205
This study examined the relationship between obesity and cancer risk, finding that excess body weight is linked to an increased risk for at least 13 types of cancer. Researchers summarized biological mechanisms connecting obesity to cancer, including insulin resistance and inflammation. They discussed future perspectives for prevention and treatment.
02Top
#02
Circadian misalignment increases cardiovascular disease risk factors in humans.
HumanInfluence12.0
574
Researchers found that short-term circadian misalignment in healthy adults increased blood pressure and inflammatory markers, including resistin. The study showed that this misalignment adversely affected cardiovascular risk factors. These findings may explain the heightened cardiovascular disease risk associated with shift work.
03Top
#03
Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases.
ReviewInfluence12.0
418
Researchers aimed to identify potential biomarkers for frailty, finding resistin among other candidates. The study evaluated 44 markers related to aging and disease, proposing a core panel for frailty assessment. The findings suggest that biomarker panels may be more effective than single markers in clinical settings.
04
#04
Adipokines, Hepatokines and Myokines: Focus on Their Role and Molecular Mechanisms in Adipose Tissue Inflammation.
ReviewInfluence5.0
197
This review examined the role of adipokines, including resistin, in chronic low-grade inflammation in adipose tissue associated with obesity. Researchers highlighted the importance of these proteins in regulating inflammation and their potential implications for metabolic disorders. The study suggests that understanding these mechanisms could lead to new therapeutic targets.
05
#05
Resistin in metabolism, inflammation, and disease.
Tripathi Deeksha, et al. · The FEBS journal · 2020
ReviewInfluence5.0
179
This review summarized recent developments in resistin biology, noting its roles in metabolism, inflammation, and stress response. Researchers highlighted resistin's potential as a biomarker for disease status and treatment outcomes. The study emphasizes the importance of understanding resistin's diverse functions in health.
Key findings
- 01Resistin has different functions in mice and humans, affecting metabolism and inflammation.
- 02In mice, resistin is associated with insulin resistance and type 2 diabetes.
- 03In humans, resistin is linked to inflammation and may serve as a biomarker for disease evaluation.
06
#06
Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions.
ReviewInfluence2.0
153
This study reviewed the interactions between adipokines, myokines, and hepatokines, including resistin, in metabolic disorders. Researchers found that these biomarkers can have both harmful and beneficial effects on health outcomes.
07
#07
Adipokines: Biomarkers for osteoarthritis?
ReviewInfluence9.0
108
This review focused on the role of adipokines, including resistin, in osteoarthritis (OA). Researchers noted that resistin levels were increased in OA patients, suggesting its potential as a biomarker for diagnosis and monitoring. The study emphasizes the need for further research on adipokines in OA.
08
#08
Resistin: Potential biomarker and therapeutic target in atherosclerosis.
Zhou Li, et al. · Clinica chimica acta; international journal of clinical chemistry · 2021
ReviewInfluence3.0
59
Researchers highlighted resistin's role in atherosclerosis, noting its effects on vascular inflammation and lipid accumulation. The study proposed resistin as a potential therapeutic or diagnostic target for cardiovascular disease. Evidence suggests resistin's involvement in various cardiovascular pathologies.
Key findings
- 01Resistin can trigger inflammation and lipid accumulation in blood vessels.
- 02It affects various cell types, contributing to cardiovascular problems like atherosclerosis.
- 03The study highlights resistin as a potential target for future cardiovascular disease therapies and diagnostics.
09
#09
Resistin and cardiovascular disease.
Ding Qinxue, et al. · Trends in cardiovascular medicine · 2011
ReviewInfluence3.0
40
Researchers discussed resistin's association with cardiovascular diseases, including coronary artery disease and heart failure. The study highlighted resistin's potential as a diagnostic and prognostic marker, although its role is complicated by confounding factors. Further research is needed to clarify resistin's biomarker function.
Key findings
- 01Resistin is associated with coronary and peripheral artery diseases, including ischemic stroke.
- 02Its role as a diagnostic and prognostic marker for cardiovascular disease is complicated by other inflammatory markers.
- 03Further large-scale studies are necessary to better understand resistin's function in heart disease.
10
#10
Obesity-Related Biomarkers Are Associated With Exercise Intolerance and HFpEF.
HumanInfluence1.0
29
This study examined the relationship between obesity-related biomarkers, including resistin, and heart failure with preserved ejection fraction (HFpEF). Researchers found that higher levels of certain biomarkers were associated with impaired exercise capacity and increased odds of HFpEF. The findings suggest inflammation and adipokine signaling may underlie these associations.
Publication Trend
Research publications about Resistin over time
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