Lever
Lifestyle
- Regular physical activity
- Weight management
- Stress reduction
- Adequate sleep
Blutwerte · Marker
Resistin
Resistin · FIZZ3
Adipokine & Metabolische HormoneZeitabhängig
- Einheit:
- ng/mL
Resistin quantifies the level of a pro-inflammatory adipokine involved in inflammation and insulin resistance.
Reference Ranges
Reference
7–22ng/mL
7
22
LowNormalHigh
Reference
Unit · ng/mLReference ranges may vary based on sex, age, and metabolic health status.
Overview
Übersicht
Resistin is a small secretory protein primarily associated with adipose tissue in rodents and inflammatory cells in humans. It plays a significant role in modulating inflammation and insulin resistance, acting as a link between obesity and metabolic disorders. Researchers have found that resistin levels are elevated in conditions characterized by chronic inflammation, such as obesity, type 2 diabetes, and cardiovascular diseases. Clinically, resistin is considered a biomarker for inflammation and metabolic dysfunction, reflecting the body's inflammatory state and its potential impact on metabolic pathways. Elevated resistin levels have been linked to increased risk of conditions such as type 2 diabetes, cardiovascular diseases, and certain cancers. In the context of athletic performance and biohacking, resistin's role in inflammation and metabolic regulation may influence recovery times and energy metabolism, although its direct impact on performance is less clear. Longevity research has identified resistin as part of a broader panel of biomarkers related to aging and age-related diseases, suggesting its potential role in assessing frailty and metabolic health. However, resistin levels can be influenced by various factors including circadian rhythms, obesity, and inflammatory states, which may confound its interpretation. Time-of-day variations and fasting status can affect resistin measurements, necessitating standardized testing conditions for accurate assessment.
Klinische Bedeutung
Elevated resistin levels indicate increased inflammation and are associated with obesity, type 2 diabetes, and cardiovascular diseases. Low levels are less commonly discussed but may reflect reduced inflammatory activity.
Dynamics
Trend Interpretation
Rising Values
Progressively rising resistin levels suggest worsening inflammation and metabolic dysfunction. Retesting is recommended in 4-6 weeks.
Falling Values
Decreasing resistin levels may indicate improved inflammatory status and metabolic health.
Re-test Interval
4-6 weeks if outside optimal range
Etiology
Causes — High & Low
Cause
Elevated Levels
- Obesity
- Chronic inflammation
- Type 2 diabetes
- Cardiovascular disease
- Cancer
- Circadian misalignment
Cause
Low Levels
- Reduced inflammation
- Improved metabolic health
- Weight loss
- Anti-inflammatory treatments
- Healthy lifestyle changes
Protocol
How to Optimize
Lever
Nutrition
- Anti-inflammatory diet
- Increased fiber intake
- Reduced sugar consumption
- Omega-3 fatty acids
Lever
Supplementation
- Omega-3 supplements
- Curcumin
- Resveratrol
Note:
Consult a healthcare provider before making significant lifestyle or dietary changes.
Testing Guidelines
✓Fasting Not Required
🕐Time-Sensitive
Resistin levels may vary with circadian rhythms; consistent timing for tests is recommended.
Testing Frequency
Annually for individuals with metabolic syndrome or obesity.
Interfering Factors
- Acute illness
- Recent intense exercise
- Inflammatory conditions
Related Peptides & Hormones
Leptin
hormone or peptideCorrelated with
Open Research Questions
Current research suggests that reference ranges and optimal targets for resistin levels in various populations remain poorly defined, complicating its use as a reliable biomarker. Researchers have not yet established the impact of confounding factors such as circadian misalignment and obesity on resistin levels. Additionally, clinical questions regarding the precise role of resistin in disease progression and its potential as a therapeutic target in metabolic disorders remain unanswered.
21 Research Publications
3,714
Total Citations
5
Human/RCT
9.8
Avg. Influence
2021
Latest
Sort
Filter
01Top
#01
Obesity and cancer risk: Emerging biological mechanisms and perspectives.
ReviewInfluence38.0
1253
This study examined the relationship between obesity and cancer risk, finding that excess body weight is linked to an increased risk of various cancers. Researchers highlighted emerging biological mechanisms, including inflammation and hormonal changes, that connect obesity to cancer development.
02Top
#02
Circadian misalignment increases cardiovascular disease risk factors in humans.
HumanInfluence15.0
604
This study examined the effects of circadian misalignment on cardiovascular risk factors, finding that it increased blood pressure and inflammatory markers, including resistin. Researchers observed that such misalignment may contribute to heightened risks of hypertension and cardiovascular disease.
03Top
#03
Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases.
ReviewInfluence13.0
431
Researchers conducted a systematic search for potential frailty biomarkers, identifying resistin among others as a candidate. The study suggests that biomarker panels could improve the assessment of frailty in elderly populations, highlighting resistin's relevance in age-related health issues.
04
#04
Pomegranate and type 2 diabetes.
ReviewInfluence6.0
231
This review explored the effects of pomegranate on type 2 diabetes, highlighting that certain components can reduce resistin formation and improve metabolic variables. Researchers found evidence for the anti-diabetic activity of pomegranate, though further studies are needed.
05
#05
Adipokines, Hepatokines and Myokines: Focus on Their Role and Molecular Mechanisms in Adipose Tissue Inflammation.
ReviewInfluence6.0
225
Researchers found that chronic low-grade inflammation in adipose tissue is a hallmark of obesity, influenced by various adipokines, including resistin. The study emphasizes the role of these proteins in regulating inflammation and their potential as therapeutic targets for obesity-related metabolic disorders.
06
#06
Resistin- and Obesity-associated metabolic diseases.
ReviewInfluence18.0
199
Researchers examined the relationship between resistin and metabolic diseases, noting that resistin is produced by macrophages in humans and may serve as a biomarker for inflammation and metabolic disorders.
07
#07
Resistin in metabolism, inflammation, and disease.
Tripathi Deeksha, et al. · The FEBS journal · 2020
ReviewInfluence5.0
189
This review summarized the multifaceted role of resistin in metabolism, inflammation, and disease. Researchers observed that resistin is linked to obesity and inflammation, and its potential as a biomarker for disease status and treatment outcomes is being actively researched.
Key findings
- 01Resistin has different functions in mice and humans, affecting metabolism and inflammation.
- 02In mice, resistin is associated with insulin resistance and type 2 diabetes.
- 03In humans, resistin is linked to inflammation and may serve as a biomarker for disease evaluation.
08
#08
Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions.
ReviewInfluence2.0
153
This study reviewed the interactions between adipokines, myokines, and hepatokines, including resistin, in metabolic disorders. Researchers found that these biomarkers can have both harmful and beneficial effects on health outcomes.
09
#09
Resistin: insulin resistance to malignancy.
ReviewInfluence8.0
142
This review highlighted resistin as an inflammatory biomarker linking obesity to various diseases, including cardiovascular conditions and cancer. Researchers discussed its potential role in mediating metabolic disturbances and its implications for diagnostics.
10
#10
Adipokines: Biomarkers for osteoarthritis?
ReviewInfluence9.0
111
This study explored the role of adipokines, including resistin, in osteoarthritis, noting that increased levels of resistin are associated with the disease. Researchers suggest that adipokines could serve as biomarkers for diagnosis and monitoring of osteoarthritis.
Clinical Trials (3)
3
Total Trials
184
Total Enrolled
Relationship Between Serum Resistin Levels and Reduction in Visceral Fat in Patients Undergoing Sleeve Gastrectomy Due to Morbid Obesity
NCT07564986COMPLETED
Sponsor
Sercan YUKSEL, MD
Enrollment
80
Started
2025
Primary outcome
Change in body mass index at 8 months
Morbid Obesity Requiring Bariatric Surgery
Beta-glucan-chitin-chitosan Polymer Supplement in Overweight/Obese Subjects: Cardiovascular Risk Biomarkers (QUITOVASC)
NCT06622447COMPLETED
Sponsor
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Enrollment
60
Started
2017
Primary outcome
Adipokines Plasma Levels (Adiponectin, Leptin, Resistin) at Week 12
Dietary Exposure
Levels of Serum Resistin in Asthmatics as a Potential Marker of Systemic Inflammation and Disease State.
NCT00339703COMPLETED
Sponsor
59th Medical Wing
Enrollment
44
Started
2004
Asthma
Publication Trend
Research publications about Resistin over time
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