Lever
Lifestyle
- Regular exercise
- Stress management
- Adequate sleep
Blutwerte · Marker
TPO-Antikörper
Anti-TPO · TPO-Antikörper · Thyreoglobulin-Antikörper · Anti-Thyroid Antibodies
Hormone — Schilddrüse
- Einheit:
- IU/mL
- Abbreviation
- TPO-AK
TPO-AK quantifies the presence of antibodies against thyroid peroxidase, an enzyme crucial for thyroid hormone synthesis.
Reference Ranges
Reference
0–34IU/mL
0
34
LowNormalHigh
Reference
Unit · IU/mLReference ranges may vary slightly between laboratories.
Overview
Übersicht
Thyroid peroxidase antibodies (TPO-AK) are autoantibodies directed against the thyroid peroxidase enzyme, which plays a crucial role in the synthesis of thyroid hormones. These antibodies are a key marker in diagnosing autoimmune thyroid diseases, particularly Hashimoto's thyroiditis and Graves' disease. Researchers found that elevated levels of TPO-AK indicate an autoimmune response against the thyroid gland, leading to inflammation and potential thyroid dysfunction. Clinically, TPO-AK is significant for diagnosing and managing autoimmune thyroid conditions. Elevated TPO-AK levels are commonly associated with Hashimoto's thyroiditis, where they contribute to thyroid gland destruction and hypothyroidism. In Graves' disease, these antibodies may coexist with other thyroid-stimulating antibodies, exacerbating hyperthyroidism. For athletes and biohackers, monitoring TPO-AK can be relevant in understanding unexplained fatigue or metabolic changes, as thyroid function is integral to energy metabolism and overall performance. However, TPO-AK levels alone do not directly correlate with disease severity or thyroid function, necessitating comprehensive thyroid function testing. Caveats include potential interference from other autoimmune conditions, and the presence of TPO-AK in euthyroid individuals, which may not indicate active disease. Testing does not require fasting, but consistent timing can improve result comparability.
Klinische Bedeutung
Elevated TPO-AK levels suggest autoimmune thyroiditis, such as Hashimoto's thyroiditis or Graves' disease. They indicate an autoimmune attack on the thyroid gland, potentially leading to hypothyroidism or hyperthyroidism.
Dynamics
Trend Interpretation
Rising Values
Progressively rising TPO-AK levels suggest worsening autoimmune activity. Re-test in 6 months if levels are rising.
Falling Values
Falling TPO-AK levels may indicate effective treatment or remission of autoimmune thyroiditis.
Re-test Interval
6 months if outside optimal range
Etiology
Causes — High & Low
Cause
Elevated Levels
- Hashimoto's thyroiditis
- Graves' disease
- Subacute thyroiditis
- Postpartum thyroiditis
- Autoimmune polyendocrine syndromes
Cause
Low Levels
- Effective treatment of autoimmune thyroiditis
- Remission of autoimmune thyroid disease
- Laboratory error
- Non-autoimmune thyroid dysfunction
- Healthy thyroid function
Protocol
How to Optimize
Lever
Nutrition
- Balanced diet with sufficient iodine
- Selenium-rich foods
- Avoidance of goitrogens in excess
Lever
Supplementation
- Selenium
- Vitamin D
- Omega-3 fatty acids
Note:
Consult a healthcare provider before starting any supplementation, especially if thyroid disease is suspected.
Testing Guidelines
✓Fasting Not Required
✓Not Time-Sensitive
Testing Frequency
Annually for those with thyroid disease, or as directed by a healthcare provider.
Interfering Factors
- Recent infection
- Pregnancy
- Other autoimmune diseases
Related Peptides & Hormones
Thyroid Stimulating Hormone
hormoneCorrelated with
Open Research Questions
Current research suggests that the optimal reference ranges and targets for anti-TPO antibody levels in various autoimmune conditions, including Hashimoto's encephalopathy, remain debated. Researchers have not yet established the impact of confounding factors, such as micronutrient deficiencies, on anti-TPO levels. Additionally, clinical questions remain unanswered regarding the correlation between anti-TPO antibody titers and disease severity or treatment response in autoimmune thyroiditis.
54 Research Publications
468
Total Citations
34
Human/RCT
1.6
Avg. Influence
2024
Latest
Sort
Filter
01Top
#01
Causal Relationship Between Anti-TPO IgE and Chronic Urticaria by In Vitro and In Vivo Tests.
HumanInfluence2.0
93
Researchers investigated the role of anti-TPO IgE in chronic spontaneous urticaria (CSU). They found that anti-TPO IgE levels were higher in CSU patients compared to healthy subjects, suggesting a potential pathogenic role in urticaria exacerbation, although it is not a specific biomarker.
02Top
#02
Autoimmune Chronic Spontaneous Urticaria Detection with IgG Anti-TPO and Total IgE.
HumanInfluence1.0
64
Researchers investigated the association between elevated IgG anti-TPO and low total IgE levels in autoimmune chronic spontaneous urticaria. They found that these markers were linked to features of the disease and treatment responses. The presence of high anti-TPO and low IgE was associated with poorer treatment outcomes.
03Top
#03
Color Doppler sonography in hypothyroidism.
HumanInfluence2.0
44
This study assessed color Doppler sonography in 89 hypothyroid patients. Researchers found a correlation between color Doppler patterns and anti-TPO antibody levels, indicating that color flow appearance may reflect autoimmune activity rather than thyroid hormone production. The findings suggest a potential diagnostic role for sonography in hypothyroidism.
04
05
#05
Effect of Micronutrients on Thyroid Parameters.
HumanInfluence2.0
34
Researchers investigated the correlation between serum levels of micronutrients and thyroid parameters in a group of 387 healthy individuals. They found that deficiencies in certain vitamins significantly affected thyroid functioning, and specific amino acids showed strong positive correlations with TSH levels. This study highlights the importance of micronutrient levels in thyroid health.
06
#06
Anti-Thyroid Peroxidase and Anti-Thyroglobulin Autoantibodies in the Cerebrospinal Fluid of Patients with Unipolar Depression.
Human
25
This study explored the presence of anti-TPO antibodies in the cerebrospinal fluid of patients with unipolar depression. Researchers found elevated levels of anti-TPO antibodies in a subgroup of patients, indicating potential central autoimmunity and the need for further research on its implications.
07
#07
Role of antithyroid autoimmunity as a predictive biomarker of chronic immune thrombocytopenia.
HumanInfluence2.0
24
08
#08
Inflammatory and autoimmune predictive markers of response to anti-PD-1/PD-L1 therapy in NSCLC and melanoma.
UnknownInfluence2.0
16
09
#09
Laboratory tests for thyroid disorders.
Review
16
Researchers reviewed the evolution of thyroid function tests, emphasizing the importance of TSH and anti-TPO antibody levels in diagnosing thyroid disorders. They found that measuring TSH provides early detection of thyroid dysfunction, while including anti-TPO enhances diagnostic accuracy. The study highlights the role of clinical judgment in interpreting test results.
10
#10
IgE and IgG Anti-Thyroid Autoantibodies in Chinese Patients With Chronic Spontaneous Urticaria and a Literature Review.
HumanInfluence1.0
16
This study explored the prevalence of IgE and IgG anti-thyroid autoantibodies in Chinese patients with chronic spontaneous urticaria. Researchers found significantly higher rates of these antibodies compared to controls. The study indicates that these autoantibodies may be linked to antihistamine-refractory cases.
Publication Trend
Research publications about TPO-Antikörper over time
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