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Lifestyle
- Regular exercise
- Stress management
- Adequate sleep
- Avoiding smoking
Blutwerte · Marker
TPO-Antikörper
Anti-TPO · TPO-Antikörper · Thyreoglobulin-Antikörper · Anti-Thyroid Antibodies
Hormone — Schilddrüse
- Einheit:
- IU/mL
- Abbreviation
- TPO-AK
Anti-thyroid peroxidase antibodies, which target the thyroid peroxidase enzyme involved in thyroid hormone synthesis.
Reference Ranges
Reference
0–34IU/mL
0
34
LowNormalHigh
Reference
Unit · IU/mLReference ranges may vary slightly between laboratories. Typically higher in females and older adults.
Overview
Übersicht
Anti-thyroid peroxidase antibodies (TPO-AK) are autoantibodies directed against thyroid peroxidase, an enzyme crucial for thyroid hormone synthesis. These antibodies are commonly measured to assess autoimmune thyroid conditions, such as Hashimoto's thyroiditis and Graves' disease. Researchers have found that elevated levels of TPO-AK are indicative of autoimmune thyroiditis, even in the absence of overt thyroid dysfunction. Clinically, TPO-AK is significant in diagnosing and managing autoimmune thyroid disorders, with elevated levels often seen in Hashimoto's encephalopathy and chronic spontaneous urticaria. In biohacking and longevity contexts, monitoring TPO-AK can provide insights into autoimmune activity and thyroid health, which are crucial for metabolic regulation and overall well-being. However, the presence of TPO-AK does not always correlate with thyroid function test results or disease severity, and levels can be influenced by factors such as age, sex, and other autoimmune conditions. Researchers emphasize the importance of considering these confounders when interpreting TPO-AK levels.
Klinische Bedeutung
Elevated TPO-AK levels suggest autoimmune thyroiditis, such as Hashimoto's thyroiditis or Graves' disease. They may also be elevated in other autoimmune conditions and are used to assess the risk of thyroid dysfunction.
Dynamics
Trend Interpretation
Rising Values
Progressively rising TPO-AK levels suggest increasing autoimmune activity, warranting further investigation and potential adjustment in treatment. Retest every 3-6 months if levels are rising.
Falling Values
Falling TPO-AK levels may indicate effective management of autoimmune thyroiditis or reduced autoimmune activity.
Re-test Interval
6 months if outside optimal range
Etiology
Causes — High & Low
Cause
Elevated Levels
- Hashimoto's thyroiditis
- Graves' disease
- Chronic spontaneous urticaria
- Autoimmune disorders
- Polycystic ovary syndrome
Cause
Low Levels
- Effective treatment of autoimmune thyroiditis
- Immunosuppressive therapy
- Low autoimmune activity
- Normal thyroid function
- Absence of thyroid disease
Protocol
How to Optimize
Lever
Nutrition
- Selenium-rich foods
- Iodine intake
- Anti-inflammatory diet
- Omega-3 fatty acids
Lever
Supplementation
- Selenium
- Vitamin D
- Omega-3 supplements
Note:
Consult a healthcare provider before starting supplements, especially if you have thyroid or autoimmune conditions.
Testing Guidelines
✓Fasting Not Required
✓Not Time-Sensitive
Testing Frequency
Annually for those with autoimmune thyroid conditions, or as recommended by a healthcare provider.
Interfering Factors
- Recent infections
- Pregnancy
- Hormonal fluctuations
- Certain medications
Related Peptides & Hormones
Thyroid Stimulating Hormone
hormoneCorrelated with
Open Research Questions
Current research suggests that reference ranges and optimal thresholds for anti-TPO antibodies remain debated, particularly in diverse populations, as highlighted by the high prevalence found in specific cohorts. Researchers have not yet established the impact of confounding factors, such as coexisting autoimmune conditions, on anti-TPO levels. Furthermore, clinical questions remain unanswered regarding the predictive value of anti-TPO antibodies in treatment responses across various autoimmune disorders, particularly in chronic spontaneous urticaria.
22 Research Publications
152
Total Citations
11
Human/RCT
1.0
Avg. Influence
2024
Latest
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Filter
01Top
#01
Autoimmune Chronic Spontaneous Urticaria Detection with IgG Anti-TPO and Total IgE.
HumanInfluence1.0
64
Researchers investigated the association between elevated IgG anti-TPO and low total IgE levels in autoimmune chronic spontaneous urticaria. They found that these markers were linked to features of the disease and treatment responses. The presence of high anti-TPO and low IgE was associated with poorer treatment outcomes.
02Top
#02
Anti-Thyroid Peroxidase and Anti-Thyroglobulin Autoantibodies in the Cerebrospinal Fluid of Patients with Unipolar Depression.
Human
23
Researchers investigated the presence of anti-TPO antibodies in the cerebrospinal fluid of patients with unipolar depression. They found that a subgroup of patients had elevated levels of anti-TPO, suggesting potential central autoimmunity. The findings indicate a need for further studies to confirm these results.
03Top
#03
IgE and IgG Anti-Thyroid Autoantibodies in Chinese Patients With Chronic Spontaneous Urticaria and a Literature Review.
HumanInfluence1.0
16
This study explored the prevalence of IgE and IgG anti-thyroid autoantibodies in Chinese patients with chronic spontaneous urticaria. Researchers found significantly higher rates of these antibodies compared to controls. The study indicates that these autoantibodies may be linked to antihistamine-refractory cases.
04
#04
Anti-TPO IgG/Total IgE Ratio: Biomarker for Omalizumab Response Prediction in Chronic Spontaneous Urticaria.
Brás Rita, et al. · International archives of allergy and immunology · 2023
Retrospective Study
13
In a study of chronic spontaneous urticaria patients, researchers found that a high IgG-anti-TPO/total IgE ratio was associated with poorer response to omalizumab treatment. This suggests that anti-TPO antibodies may serve as a biomarker for treatment prediction.
Key findings
- 01A higher IgG-anti-TPO/total IgE ratio was significantly associated with a poorer response to omalizumab.
- 02Patients with a ratio above 0.154 had ten times the odds of a poor treatment response.
- 03Other inflammatory biomarkers did not show significant differences between responders and non-responders.
05
#05
Distinct Clinical Profiles of IgE and IgG Autoantibodies to Thyroid Peroxidase in Chronic Spontaneous Urticaria.
HumanInfluence1.0
12
Researchers found that 46% of patients with chronic spontaneous urticaria (CSU) had elevated levels of anti-thyroid peroxidase (TPO) antibodies. They observed distinct clinical profiles associated with anti-TPO IgE and IgG, including differences in disease activity and treatment responses. Most patients had either IgE or IgG antibodies, but not both.
06
#06
Association of raised levels of IL-4 and anti-TPO with hyperprolactinemia.
Case-Control Study
7
Researchers found significantly high levels of IL-4 and anti-TPO antibodies in various cases of hyperprolactinemia. This suggests a potential association between hyperprolactinemia and autoimmune conditions, warranting further investigation.
07
#07
A Case of Steroid-Responsive Encephalopathy.
Case ReportInfluence1.0
4
Researchers examined a case of steroid-responsive encephalopathy linked to autoimmune thyroiditis, characterized by symptoms like confusion and impaired memory. Elevated anti-TPO antibodies were crucial for diagnosis, while thyroid function tests did not correlate with disease severity.
08
#08
Hashimoto's encephalopathy.
Case ReportInfluence1.0
3
Researchers reported a case of Hashimoto's encephalopathy in a 65-year-old female who presented with sudden deep coma. Despite normal thyroid function tests, anti-TPO antibodies were highly elevated. After treatment with steroids, the patient gradually regained consciousness over a month.
09
#09
Vitamin D Status and Its Association With Disease Severity in Hashimoto's Thyroiditis.
Human
3
Researchers examined the association between vitamin D levels and the severity of Hashimoto's thyroiditis. They found an inverse correlation between vitamin D deficiency and anti-TPO antibody titers. The study suggests that lower vitamin D levels may be linked to increased autoimmune activity in Hashimoto's thyroiditis.
10
#10
Clinical characteristics of dry eye patients with thyroid disorders: a cross-sectional study.
Cross-Sectional Study
2
In a study of dry eye disease patients with thyroid disorders, researchers found a correlation between elevated anti-TPO antibody levels and reduced tear film stability. This suggests that anti-TPO levels may serve as a predictive biomarker for thyroid-related dry eye symptoms.
Publication Trend
Research publications about TPO-Antikörper over time
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