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Vitamin A

Retinol · Vitamin A · Retinyl Palmitate

Vitamine & Nährstoffe
Einheit:
µmol/L
Abbreviation
Retinol

Vitamin A tests measure the concentration of retinol in the blood, reflecting the body's vitamin A status.

Reference Ranges

Reference
0.7–1.5µmol/L
0.7
1.5
LowNormalHigh
Reference
Unit · µmol/L

Reference ranges may vary slightly based on age and laboratory standards.

Overview

Übersicht

Vitamin A, also known as retinol, is a fat-soluble vitamin essential for various biological functions, including vision, immune function, and cellular communication. It exists in several forms, with retinol being the most biologically active. Retinoic acid, a derivative of vitamin A, plays a crucial role in gene expression and cellular differentiation. Vitamin A can be obtained from animal-derived foods as retinol or from plant-based foods as provitamin A carotenoids, which are converted into retinol in the body. Clinically, vitamin A is significant for maintaining healthy vision, skin, and immune function. Deficiency can lead to conditions such as night blindness and increased susceptibility to infections, while excess intake may result in toxicity, characterized by symptoms like liver damage and central nervous system disorders. In the context of athletic performance and biohacking, vitamin A is crucial for maintaining optimal vision and immune function, which can indirectly influence performance and recovery. However, excessive supplementation without medical supervision can lead to toxicity. Researchers have found that vitamin A levels can be influenced by factors such as dietary intake, liver function, and genetic variations. Testing for vitamin A levels typically does not require fasting, but it is important to consider potential confounders such as recent dietary intake and liver health when interpreting results.

Klinische Bedeutung

Elevated vitamin A levels may indicate excessive supplementation or liver disease, while low levels suggest dietary deficiency or malabsorption issues. Both extremes can lead to significant health problems.

Dynamics

Trend Interpretation

Rising Values

Progressively rising values may suggest excessive supplementation or liver dysfunction. Re-test in 4 weeks if outside optimal range.

Falling Values

Progressively falling values may indicate dietary deficiency or malabsorption.

Re-test Interval

4 weeks if outside optimal range

Etiology

Causes — High & Low

Cause

Elevated Levels

  • Excessive supplementation
  • Liver disease
  • Hypervitaminosis A
  • Certain genetic disorders
Cause

Low Levels

  • Dietary deficiency
  • Malabsorption syndromes
  • Chronic alcoholism
  • Liver disease
Protocol

How to Optimize

Lever

Lifestyle

  • Regular monitoring of vitamin A intake
  • Avoid excessive alcohol consumption
Lever

Nutrition

  • Consume foods rich in beta-carotene like carrots and sweet potatoes
  • Include liver and fish in diet
Lever

Supplementation

  • Retinol supplements
  • Beta-carotene supplements

Note:

Consult a healthcare provider before starting supplements, especially if you have liver disease.

Testing Guidelines

✓Fasting Not Required
✓Not Time-Sensitive

Testing Frequency

Annually for those at risk of deficiency or excess.

Interfering Factors

  • Recent high-fat meal
  • Liver function abnormalities

Related Peptides & Hormones

Transthyretin

Correlated with

hormone or peptide

Open Research Questions

Current research suggests that the relationship between vitamin A levels and type 2 diabetes remains uncertain, particularly regarding optimal targets and reference ranges for vitamin A in metabolic contexts. Researchers have not yet established the confounding factors that influence vitamin A metabolism in diabetic patients. Additionally, clinical questions remain unanswered regarding the efficacy of retinoids in treating colorectal cancer, especially in cases where retinoic acid receptor expression is lost.

48 Research Publications

2,283

Total Citations

9

Human/RCT

5.1

Avg. Influence

2025

Latest

Sort
Filter
#01

The clinical significance of measles: a review.

ReviewInfluence26.0
602
Researchers highlighted the ongoing public health issue of measles and its complications, particularly in the context of vitamin A deficiency. The study found that vitamin A deficiency can exacerbate the severity of measles complications, especially in malnourished children.
View on PubMed
#02

Carotenoids and the immune response.

ReviewInfluence13.0
465
This review highlighted the immunomodulatory effects of beta-carotene, a precursor to vitamin A, in enhancing immune responses and potentially reducing tumor burden in animal studies. Researchers noted that while vitamin A itself is a poor antioxidant, beta-carotene may play a more significant role in health.
View on PubMed
#03

Vitamin a deficiency and clinical disease: an historical overview.

ReviewInfluence8.0
305
Researchers provided a historical overview of vitamin A deficiency and its clinical manifestations. They noted that symptoms range from eye-related issues to growth disturbances and increased infection susceptibility. The study highlighted the evolution of understanding vitamin A deficiency and its global health implications.
View on PubMed
#04

Assessing vitamin A status: past, present and future.

ReviewInfluence5.0
184
This review discussed methods for assessing vitamin A status, noting that traditional classifications are evolving. Researchers found that serum retinol concentrations are homeostatically controlled and may not reflect deficiency until liver reserves are low. The study emphasizes the importance of using multiple assessment methods to accurately evaluate vitamin A status.
View on PubMed
#05

Retinoids in biological control and cancer.

ReviewInfluence5.0
116
Researchers reviewed the relationship between vitamin A deficiency and cancer, establishing a link between retinoids and tumor prevention. The study emphasized the need for continued research on retinoid signaling pathways for therapeutic applications.
View on PubMed
#06

Vitamin A deficiency disorders: international efforts to control a preventable "pox".

ReviewInfluence2.0
111
This review addressed global efforts to control vitamin A deficiency disorders (VADD), which affect millions. Researchers noted that while progress has been made through supplementation and food fortification, sustainable strategies are essential for long-term success.
View on PubMed
#07

Vitamin A deficiency and xerophthalmia in children of a developed country.

UnknownInfluence1.0
59
This study characterized vitamin A deficiency in Australian children, finding a prevalence of 35.6% among those assessed. Researchers observed significant associations between vitamin A deficiency and conditions such as anemia and systemic health issues, indicating a need for ophthalmic review.
View on PubMed
#08

Lipophilic antioxidants in neurodegenerative diseases.

ReviewInfluence2.0
48
This study reviewed the potential of lipophilic antioxidants, including vitamin A, in neurodegenerative diseases. Researchers found that while there is no clear clinical evidence of benefit, some studies suggest that these antioxidants may provide neuroprotection in cellular and animal models.
View on PubMed
#09

Vitamin A and bone health: the balancing act.

ReviewInfluence1.0
44
This review examined the complex relationship between vitamin A and bone health, noting that high intake of preformed vitamin A may increase osteoporosis risk. Researchers found that carotenoids, vitamin A precursors, are associated with better bone health. The study calls for further research to clarify the impact of different forms of vitamin A on bone health.
View on PubMed
#10

Changes in micronutrient and inflammation serum biomarker concentrations after a norovirus human challenge.

Human
38
In a study involving healthy adults exposed to norovirus, researchers observed that inflammation affected serum concentrations of several micronutrient biomarkers, including vitamin A. Specifically, retinol levels were found to be depressed during the inflammatory response following infection.
View on PubMed

Clinical Trials (2)

2

Total Trials

100,027

Total Enrolled

Establishing Reference Ranges for Fat-Soluble Vitamins in Healthy Chinese Adults

Sponsor

First Affiliated Hospital of Zhejiang University

Enrollment

100,000

Started

2024

Primary outcome

serum vitamin A

Fat Soluble Vitamin Deficiencies and Disorders

Vitamin A Liver Reserves and Serum Markers of Vitamin A in US Adults at Time of Death

NCT03305042COMPLETED
Sponsor

University of Wisconsin, Madison

Enrollment

27

Started

2012

Primary outcome

Serum retinyl esters, nmol/L

Vitamin A DeficiencyVitamin A Toxicity

Publication Trend

Research publications about Vitamin A over time

9total
1
'79
1
'83
1
'85
1
'04
1
'06
2
'20
1
'22
1
'25

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