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Vitamin A

Retinol · Vitamin A · Retinyl Palmitate

Vitamine & Nährstoffe
Einheit:
µmol/L
Abbreviation
Retinol

Vitamin A tests measure the levels of retinol in the blood, reflecting the body's vitamin A status.

Reference Ranges

Reference
1.052.8µmol/L
1.05
2.8
LowNormalHigh
Reference
Unit · µmol/L

Reference ranges may vary slightly based on laboratory standards.

Overview

Übersicht

Vitamin A, also known as retinol, is a fat-soluble vitamin essential for various biological functions. It plays a critical role in vision, particularly in the conversion of light into electrical signals in the retina. Additionally, vitamin A is crucial for cellular differentiation, immune function, and reproduction. It exists in several forms, including retinol, retinoic acid, and retinyl palmitate, with retinoic acid being particularly important for epithelial cell differentiation. Clinically, vitamin A is significant due to its involvement in preventing deficiency-related conditions such as night blindness and xerophthalmia. Deficiency can also lead to impaired immune function and increased susceptibility to infections. Conversely, excessive intake can result in hypervitaminosis A, characterized by symptoms such as liver damage, bone pain, and neurological issues. In the context of athletic performance and biohacking, vitamin A's antioxidant properties are of interest, as they may contribute to reducing oxidative stress and supporting recovery. However, the evidence for its direct impact on performance is limited. When interpreting vitamin A levels, researchers observed that factors such as liver function, dietary intake, and metabolic conditions like diabetes can influence its metabolism. Testing for vitamin A does not typically require fasting, but it is important to consider potential confounders such as recent dietary intake or supplementation.

Klinische Bedeutung

Elevated vitamin A levels can indicate excessive supplementation or liver dysfunction, while low levels may suggest dietary deficiency or malabsorption issues. Both extremes can lead to significant health problems.

Dynamics

Trend Interpretation

Rising Values

Progressively rising values may suggest excessive intake or liver dysfunction. Re-test in 4 weeks if levels are outside the optimal range.

Falling Values

Falling values could indicate dietary deficiency or increased metabolic demand.

Re-test Interval

4 weeks if outside optimal range

Etiology

Causes — High & Low

Cause

Elevated Levels

  • Excessive supplementation
  • Liver disease
  • Hyperlipidemia
  • Chronic kidney disease
  • Certain genetic disorders
Cause

Low Levels

  • Dietary deficiency
  • Malabsorption syndromes
  • Chronic alcoholism
  • Liver disease
  • Certain medications
Protocol

How to Optimize

Lever

Lifestyle

  • Avoid excessive alcohol consumption
  • Regular health check-ups
  • Maintain a balanced diet
Lever

Nutrition

  • Consume liver
  • Include carrots
  • Eat sweet potatoes
  • Add leafy greens
Lever

Supplementation

  • Retinol supplements
  • Beta-carotene supplements

Note:

Consult a healthcare provider before starting supplements, especially in the presence of liver disease.

Testing Guidelines

Fasting Not Required
Not Time-Sensitive

Testing Frequency

Annually for individuals at risk of deficiency or excess.

Interfering Factors

  • Recent high-fat meal
  • Alcohol consumption
  • Certain medications

Related Peptides & Hormones

Insulin

May affect

hormone or peptide

Open Research Questions

Current research suggests that the relationship between vitamin A levels and type 2 diabetes remains uncertain, particularly regarding optimal targets and confounding factors influencing metabolism. Researchers have not yet established clear reference ranges for vitamin A in the context of neurodegenerative diseases, despite its potential neuroprotective effects. Additionally, clinical questions regarding the precise role of vitamin A in diabetes management and its therapeutic applications in neurodegenerative conditions remain unanswered.

29 Research Publications

1,416

Total Citations

5

Human/RCT

4.4

Avg. Influence

2025

Latest

Sort
Filter
#01

Carotenoids and the immune response.

ReviewInfluence13.0
465
This review highlighted the immunomodulatory effects of beta-carotene, a precursor to vitamin A, in enhancing immune responses and potentially reducing tumor burden in animal studies. Researchers noted that while vitamin A itself is a poor antioxidant, beta-carotene may play a more significant role in health.
View on PubMed
#02

Vitamin a deficiency and clinical disease: an historical overview.

ReviewInfluence8.0
305
Researchers provided a historical overview of vitamin A deficiency and its clinical manifestations. They noted that symptoms range from eye-related issues to growth disturbances and increased infection susceptibility. The study highlighted the evolution of understanding vitamin A deficiency and its global health implications.
View on PubMed
#03

Assessing vitamin A status: past, present and future.

ReviewInfluence5.0
183
Researchers discussed various methods for assessing Vitamin A status, including serum retinol concentrations and new response tests. They found that traditional methods may not adequately reflect Vitamin A reserves in healthy individuals. The study emphasizes the need for improved assessment techniques to evaluate Vitamin A deficiency.
View on PubMed
#04

Retinoids in biological control and cancer.

ReviewInfluence5.0
116
Researchers reviewed the relationship between vitamin A deficiency and cancer, establishing a link between retinoids and tumor prevention. The study emphasized the need for continued research on retinoid signaling pathways for therapeutic applications.
View on PubMed
#05

Vitamin A deficiency disorders: international efforts to control a preventable "pox".

ReviewInfluence2.0
111
This review addressed global efforts to control vitamin A deficiency disorders (VADD), which affect millions. Researchers noted that while progress has been made through supplementation and food fortification, sustainable strategies are essential for long-term success.
View on PubMed
#06

Lipophilic antioxidants in neurodegenerative diseases.

ReviewInfluence2.0
48
Researchers reviewed the role of lipophilic antioxidants, including Vitamin A, in neurodegenerative diseases. They found that while clinical evidence is lacking, laboratory studies suggest a potential neuroprotective effect of these antioxidants. The study calls for future research to optimize treatment strategies involving lipophilic antioxidants.
View on PubMed
#07

Changes in micronutrient and inflammation serum biomarker concentrations after a norovirus human challenge.

Human
38
In a study involving healthy adults exposed to norovirus, researchers observed that inflammation affected serum concentrations of several micronutrient biomarkers, including vitamin A. Specifically, retinol levels were found to be depressed during the inflammatory response following infection.
View on PubMed
#08

Oral contraceptives and vitamins: a review.

ReviewInfluence1.0
33
This review examined the effects of oral contraceptives on vitamin levels, noting that elevated vitamin A levels may not have clinical significance. Researchers found connections between hormonal contraception and disturbances in vitamin B6 metabolism, but hematologic abnormalities are rare.
View on PubMed
#09

Vitamin A derivatives in the prevention and treatment of human cancer.

Review
32
This report discussed the role of vitamin A and its derivatives in cancer prevention and treatment. Researchers found that while natural vitamin A has limited activity against cancer, synthetic retinoids show promise in treating various malignancies.
View on PubMed
#10

Vitamin A and Diabetes.

Review
26
Researchers summarized the relationship between Vitamin A and diabetes, noting that type 1 diabetes is associated with reduced blood Vitamin A levels. They observed that the effects of type 2 diabetes on Vitamin A metabolism remain uncertain. The study highlights the need for further research to clarify these interactions.
View on PubMed

Publication Trend

Research publications about Vitamin A over time

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'23
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'25

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This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer