Lever
Lifestyle
- Regular physical activity
- Avoid smoking
- Limit alcohol consumption
Blutwerte · Marker
Vitamin E
Alpha-Tocopherol · Tocopherol · Vitamin E
Vitamine & Nährstoffe
- Einheit:
- µmol/L
- Abbreviation
- a-Tocopherol
The test quantifies the concentration of alpha-tocopherol, the most active form of vitamin E, in the blood.
Reference Ranges
Reference
11.6–46.4µmol/L
11.6
20
30
46.4
LowNormalHigh
Reference
Optimal
Unit · µmol/LRanges may vary slightly based on age and sex.
Overview
Übersicht
Vitamin E, primarily in the form of alpha-tocopherol, is a fat-soluble antioxidant that plays a crucial role in protecting cell membranes from oxidative damage by scavenging free radicals. Researchers have developed assays like the FRAP to measure its antioxidant capacity, indicating its reducing potential in biological fluids. Clinically, vitamin E is significant for its role in preventing oxidative stress-related conditions and is often studied in the context of cancer chemoprevention and cardiovascular health. It is also relevant in the context of renal health, where high doses can have adverse effects. For athletes and biohackers, vitamin E's antioxidant properties are thought to support recovery and reduce oxidative stress, potentially enhancing performance and longevity. However, researchers have noted that the benefits and risks of supplementation can vary based on dosage and individual health status. Caveats include potential interactions with other antioxidants, the influence of dietary sources, and the need for careful consideration of dosage to avoid adverse effects, particularly on renal function.
Klinische Bedeutung
Elevated levels of vitamin E may indicate excessive supplementation, which can lead to adverse effects such as renal stress. Reduced levels might suggest inadequate dietary intake or malabsorption issues, potentially leading to increased oxidative stress and associated health risks.
Dynamics
Trend Interpretation
Rising Values
Progressively rising values may suggest excessive supplementation or dietary intake. Re-test in 4-6 weeks if levels are significantly above the reference range.
Falling Values
Progressively falling values may indicate dietary insufficiency or malabsorption issues.
Re-test Interval
4 weeks if outside optimal range
Etiology
Causes — High & Low
Cause
Elevated Levels
- Excessive supplementation
- High dietary intake
- Liver disease
- Hyperlipidemia
- Obesity
Cause
Low Levels
- Poor dietary intake
- Malabsorption syndromes
- Chronic liver disease
- Cystic fibrosis
- Abetalipoproteinemia
Protocol
How to Optimize
Lever
Nutrition
- Increase intake of nuts and seeds
- Consume more leafy greens
- Include vegetable oils in diet
Lever
Supplementation
- Vitamin E supplements
- Mixed tocopherol supplements
Note:
Consult a healthcare provider before starting any supplementation, especially if you have underlying health conditions.
Testing Guidelines
✓Fasting Not Required
✓Not Time-Sensitive
Testing Frequency
Annually for general health monitoring, more frequently if managing specific health conditions.
Interfering Factors
- Recent high-fat meal
- Alcohol consumption
- Use of certain medications like anticoagulants
Related Peptides & Hormones
Cortisol
hormoneCorrelated with
Open Research Questions
Current research suggests that the varying bioavailability and metabolic conversion between gamma- and alpha-tocopherol remain understudied, particularly regarding their respective roles as biomarkers for cancer and cardiovascular risk. Researchers have not yet established optimal plasma levels for these tocopherols, nor the impact of high-dose vitamin E on renal health and inflammation. Unanswered clinical questions include the long-term effects of vitamin E supplementation on oxidative stress markers and its efficacy in cancer chemoprevention.
26 Research Publications
23,481
Total Citations
7
Human/RCT
100.0
Avg. Influence
2025
Latest
Sort
Filter
01Top
#01
The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay.
HumanInfluence966.0
22299
This study examined the FRAP assay, a novel method for assessing antioxidant power in biological fluids. Researchers found that the FRAP assay is inexpensive, highly reproducible, and provides a putative index of antioxidant potential in plasma samples from healthy adults.
02Top
#02
Gamma-tocopherol--an underestimated vitamin?
ReviewInfluence6.0
290
Researchers reviewed the biological activities of gamma-tocopherol, a major form of vitamin E in the diet. They found that gamma-tocopherol has distinct antioxidant properties and serves as a biomarker for cancer and cardiovascular risk, differing from alpha-tocopherol.
03Top
#03
Vitamin E inadequacy in humans: causes and consequences.
ReviewInfluence13.0
231
Researchers reviewed the consequences of inadequate dietary vitamin E intake. They found that low plasma α-tocopherol levels are associated with increased health risks, suggesting the need for additional biomarkers to assess vitamin E status.
04
#04
Hepatoprotective effect of curcumin and alpha-tocopherol against cisplatin-induced oxidative stress.
AnimalInfluence2.0
135
Researchers investigated the protective role of curcumin and alpha-tocopherol against cisplatin-induced oxidative stress in rats. They found that pre-treatment with these compounds improved liver function and reduced oxidative stress markers. The study suggests that the combination may help mitigate hepatotoxicity associated with cisplatin treatment.
05
#05
Fat-Soluble Vitamins: Clinical Indications and Current Challenges for Chromatographic Measurement.
ReviewInfluence2.0
106
Researchers outlined the challenges in measuring fat-soluble vitamins, including vitamin E, in blood. They noted that deficiencies in these vitamins are linked to increased disease risks. The study emphasizes the need for improved measurement techniques to accurately assess vitamin E status.
06
#06
Lipid oxidation that is, and is not, inhibited by vitamin E: Consideration about physiological functions of vitamin E.
In VitroInfluence2.0
90
Researchers examined the role of vitamin E in inhibiting lipid oxidation. They found that while vitamin E effectively scavenges certain radicals, it is less efficient against others, indicating that its antioxidant effects depend on the type of oxidants involved.
07
#07
Vitamin E, immune response, and disease resistance.
ReviewInfluence5.0
88
Researchers observed that vitamin E supplementation enhances immune response and disease resistance in various populations. They noted that vitamin E protects immune cells from oxidative damage and improves phagocytosis. The study emphasizes the greater effectiveness of vitamin E as an adjuvant in vaccines compared to dietary supplementation.
08
#08
The role of vitamin E in immune response and disease resistance.
ReviewInfluence2.0
84
Researchers found that vitamin E supplementation enhances immune response and disease resistance, particularly when combined with other antioxidants. They noted that the effectiveness of vitamin E depends on its delivery system, with targeted delivery to immune cells being more effective than general dietary intake. The study emphasizes the importance of optimal dosing.
09
#09
Vitamin E and Alzheimer's disease: what do we know so far?
Review
83
Researchers explored the potential of vitamin E as an intervention for Alzheimer's disease. They found diminished vitamin E levels in individuals with AD and noted that while dietary intake may reduce disease progression, evidence for supplementation remains inconclusive.
10
#10
Cancer chemoprevention.
ReviewInfluence1.0
34
This review highlighted recent advances in cancer chemoprevention, focusing on the role of biomarkers in clinical trials. Researchers observed significant activity in reversing premalignancy and preventing cancer, emphasizing the importance of ongoing trials involving various agents.
Publication Trend
Research publications about Vitamin E over time
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