Norepinephrine

Postoperative Acute Kidney Injury

remission of acute phase

pH

28-day survival

Incidence of acute kidney injury after surgery

All cause in-hospital mortality

Area under a mean arterial pressure (MAP) of 65 mmHg (mmHg x min)

Changes in myocardial function

PostESD bleeding

Hypotension during anesthetic induction

incidence of PRS and VS

Improvement as Measured by Change in Clinical Global Impression of Severity (CGI-S) Rating From Baseline

Ranking score and mortality

Postoperative delirium and cognitive function in patients with high-risk stroke.

incidence of post-spinal hemodynamic instability

systolic blood pressure

Cardiovascular collapse (composite outcome)

The incidence of hypotension

The incidence of post-spinal anesthesia hypotension

Need of postoperative vasoactive support after LUTX

Development of pressure injury

The incidence of bradycardia

Incidence of spinal anesthesia induced Hypotension

Bradycardia: Heart rate less than 50 bpm

number of injections

Mortality

Frequency of Intermediate Phenotypes in Subjects with Diabetes Mellitus versus Hypertension

Maternal systolic blood pressure

Occurrence of Acute Kidney Injury

The frequency of post-spinal hypotension

The incidence of post-spinal anesthesia hypotension

Nepean Dyspepsia Index

Myocardial ischemia measures by transesophageal echocardiography and ST segment analyses

Incidence of Hypotension During the First 20 Minutes After Spinal Anesthesia

mean arterial pressure

The Hemodynamic improvement as defined as mean arterial pressure > 65 mmHg.

Incidence of post induction hypotension in both groups

incidence of hypotension

ED50 and ED90

The dose that would be effective in preventing postspinal anesthesia hypotension in 50% (effective dose, ED 50) and 90% (ED90) of patients

ED50 and ED90

Correlation between Peripheral Perfusion Index and ( Central venous oxygen saturation , and lactate clearance).

The dose that would be effective in preventing postspinal anesthesia hypotension in 50% (effective dose, ED 50) and 90% (ED90) of patients

Incidence of hypotension

All cause mortality

Cardiac output (CO)

the percentage (%) of the time when the target blood pressure falls outside of 90-110%, 80-120%, and 70-130% of the target blood pressure during the total anesthesia duration

incidence of hypotension

the haemodynamical effects of norepinephrine and phenylephrine during ophthalmic surgery

Regional Cerebral Blood Flow

Renal insult

ED50 and ED90

Mortality

Change of noradrenalin plasma levels between group A and group B

Assess use of noradrenaline in the experimental group (postural mobilization) vs control group (NA only) for hemodynamic management during open-heart coronary bypass graft surgery.

Preload responsiveness defined as stroke volume increase > 10%, measured by continuous arterial waveform analysis.

Systolic blood pressure

The effect of Noradrenaline on change of cardiac output .

Locally induced changes in red blood cell concentration and movement due to iontophoresis of vasoactive substances.

Changes in ventriculo-arterial coupling

Changes of Pulse pressure variation during the operation and the post-operative 24 hours

Stability of treatment response as defined as change in self-report PHQ-9 total scores during the observational period from Baseline/Day 0 to End of Study (EOS)/Day 365.

The change of plasma volume measured by 125I-HSA before anesthesia induction until 50 minutes after anesthesia induction.

Arterial oxygen saturation measured via arterial blood gas sample (Sa02)

Change in Glomerular filtration rate (ml/min)

Acute Kidney Injury (AKI)

Number of Participants with a Composite of Major Perfusion-Related Complications

PTSD Symptoms

Change in inotropic function assessed by cardiac output between T0 and T1

postspinal hypotension

incidence of postspinal hypotension

30% or more reduction in terms of the use of renal function replacement

Incidence of post-spinal hypotension

Difference between the 2 groups in cardiac output at 10 minutes after intrathecal injection

Incidence of post-induction hypotension

Incidence of intraoperative maternal hypotension

Cumulative dose of inopressors (norepinephrine and epinephrine) per kg bodyweight/hour during the perioperative period

Fetal Base excess

Umbilical artery pH

Systolic Blood Pressure (SBP)

systolic blood pressure variation before delivery

Cardiac output maintenance (measured in L/min by bioreactance).

Incidence of post-spinal anesthesia hypotension.

Maternal Blood Pressure

Intravenous norepinephrine to maintain maternal systolic blood pressure 80% above baseline before fetal delivery.

Rate of successful management of maternal hypotension

Number of Rescue Boluses to Maintain SBP

right ventricular ejection fraction

mean heart rate

Mean intaroperative heart rate (beats /minute) during vasopressor infusion measured by continous electrocardiogrammonitoring

Hypotension

Cumulative duration of MAP below 65 mmHg during induction

Neonatal concentration of HCO3 from a sample of umbilical cord as a surrogate of neonatal outcome

Compared effects of investigated drugs on cardiac index

change in hepatic blood flow during goal-directed hemodynamic therapy with norepinphrine

throracic volume variations change from baseline

Microcirculatory flow index (MIF) measured by sidestream darkfield after rising the mean arterial pressure with norepinephrine

pulse pressure variation

Incidence of Acute kidney Injury

Changes in LV systolic strain

Evidence of clinically definite ischemia in a flap confirmed by changes in tissue oxygen pressure level and microdialysates metabolites

Absolute change in transfer function (flap vascular resistance) after pressor infusion.

dose norepinephrine used in group A

Liver blood flow

Occurrence of a renal complication or death

Perioperative hypotension

Number of Postoperative Organ failure

The primary outcome is the proportion of patients achieving either SBP >100 mmHg or MAP > 65 mmHg or a target blood pressure set by the treating physician at 90 (±15) minutes after inclusion.

Composite endpoint of major morbidity according to Society of Thoracic Surgery

Efficacy and Safety of Dopamine Versus Norepinephrine in Septic Shock

mPAP-to-MAP Ratio

the tissue oxygenation

Obtention of a optimal cardiac output

MOD (Multiple Organ Dysfunction) Score

Mean flow index

The main study parameter will be the number of SAH patients with a diagnosis of DCI who were randomised to one of the intervention groups, in whom the intervention was adequately performed, during the duration of the trial.

28 Day mortality

Time to All-Cause Discontinuation of Study Drug

mPAP in millimeter of mercury (mmHg) measured by the Swan-Ganz catheter in the operating room.

Number of bolus required

Systemic and regional hemodynamics

Gastric mucosal blood flow assessed using a laser-Doppler flowmeter

24-hour mortality

Genetic Variation at the Caveolin-1 Locus

To estimate the degree of DAT occupancy in brain regions of interest (ROIs)following oral doses of GSK1360707 in healthy male subjects-To estimate the degree of SERT occupancy in brain ROIs following total oral doses of GSK1360707 in healthy male subject

Safety of daily topical application of norepinephrine to the radiation field.

cardiac output

Change in forearm vascular conductance with intra-arterial drug infusion

Primary Feasibility Outcome: Ability to achieve and maintain systolic blood pressure goals