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Platelet-Rich Plasma

PRP · Platelet-Rich Plasma Therapy

Growth FactorsApproved
MW
390.07g/mol
Formula
C5H13O14P3

Platelet-rich plasma (PRP) is an autologous blood-derived product characterized by a concentration of platelets that is significantly higher than that found in normal whole blood. Researchers primarily study PRP for its potential regenerative effects and therapeutic applications across various medical fields, including orthopedics, dermatology, and sports medicine. Key findings from the literature indicate that PRP contains growth factors that may promote tissue repair and regeneration, with studies suggesting its efficacy in enhancing healing processes in musculoskeletal injuries and improving aesthetic outcomes in dermatological applications. Current research highlights the need for standardized treatment protocols and larger randomized clinical trials to better understand the full scope of PRP's clinical relevance and effectiveness. Despite the promising nature of PRP therapy, the variability in preparation methods and outcomes necessitates further investigation to establish comprehensive guidelines for its use.

Overview

Übersicht

Platelet-rich plasma (PRP) is an endogenous therapeutic preparation derived from autologous blood, characterized by a concentration of platelets significantly above baseline levels. It is not a single chemical entity but a complex mixture of platelets and growth factors. PRP is produced by centrifuging whole blood to separate and concentrate the platelets. It belongs to the category of growth factors due to its high content of biologically active proteins that promote tissue regeneration. Researchers have found that PRP plays a crucial role in various physiological processes, including tissue repair and regeneration. It has been extensively studied in fields such as dermatology, orthopedics, and sports medicine. PRP is used in hair restoration, skin rejuvenation, and the treatment of musculoskeletal injuries, among other applications. Researchers have observed that PRP exerts its effects through several mechanisms of action. It promotes cellular proliferation, matrix formation, and collagen synthesis, while also regulating inflammation and angiogenesis. PRP's regenerative effects are attributed to the release of growth factors from activated platelets, which stimulate these biological processes. The pharmacokinetic properties of PRP are not well-defined due to its nature as a biological preparation. The half-life and metabolism of PRP are not applicable in the traditional sense, as it is not a single compound but a mixture of cellular components. Researchers have found that PRP is used clinically in a variety of settings, including dermatology and orthopedics. It is generally considered safe, though its efficacy can vary depending on the specific indication and preparation method. Regulatory standing varies by region, with PRP often used off-label in many countries. Large-scale clinical trials are needed to further establish its therapeutic potential and standardize treatment protocols.

Chemical profile

Chemische Struktur

Chemical structure of Platelet-Rich Plasma
FormelC5H13O14P3
Molekulargewicht390.07g/mol
CAS-Nummer7540-64-9
PubChem CID7339
Mechanism

Wirkmechanismus

PRP acts by releasing growth factors such as platelet-derived growth factor (PDGF) and transforming growth factor-beta (TGF-β) upon platelet activation. These factors engage in signaling pathways that promote cellular proliferation, angiogenesis, and tissue regeneration, leading to enhanced healing and repair processes.

Mechanism

Signalweg

Platelet-rich plasma (PRP) exerts its effects primarily through the binding of growth factors, such as platelet-derived growth factor (PDGF) and transforming growth factor-beta (TGF-β), to their respective receptors on target cells, activating signaling pathways like the PI3K/Akt and MAPK/ERK pathways. These pathways promote biological processes including cellular proliferation, angiogenesis, collagen synthesis, and tissue remodeling. While the mechanisms are increasingly understood, the full spectrum of PRP's actions and the specific receptors involved remain to be fully elucidated.

Half-Life & Pharmacokinetics

PRP is a biological preparation, and traditional pharmacokinetic parameters like half-life are not applicable.

Storage

Temperature

Refrigerate at 2-8C

Light

Protect from light

Form

Aqueous solution: use within a few hours after preparation

Notes

PRP should be used shortly after preparation to maintain its efficacy.

Solubility

Löslichkeit

PRP is an aqueous preparation and is not applicable to solubility in oil or ethanol.

Legal Status

🇩🇪DE

Data limited

🇺🇸US

Data limited

🇦🇺AU

Data limited

🇬🇧UK

Data limited

Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.

Open Questions

Offene Forschungsfragen

Current evidence is limited regarding the optimal preparation protocols for platelet-rich plasma (PRP), as the heterogeneity in PRP formulations complicates the interpretation of existing literature and hinders the establishment of standardized treatment guidelines. Further research is needed through larger randomized controlled trials (RCTs) that assess the efficacy of PRP across specific medical conditions, particularly in dermatology and musculoskeletal applications, while also exploring long-term outcomes and effects in diverse populations. Additionally, investigations into the molecular mechanisms underlying PRP's therapeutic effects and the potential for synergistic applications with other treatments are necessary to fully understand its clinical relevance.

150 Research Publications

6,139

Total Citations

30

Human/RCT

4.0

Avg. Influence

2024

Latest

Sort
Filter
#01

Principles and Methods of Preparation of Platelet-Rich Plasma: A Review and Author's Perspective.

ReviewInfluence56.0
959
The review highlighted that there is significant confusion regarding the terminology and preparation methods of platelet-rich plasma (PRP), which complicates its clinical application across various medical fields.
#02

A Review of Platelet-Rich Plasma: History, Biology, Mechanism of Action, and Classification.

Alves Rubina & Grimalt Ramon · Skin appendage disorders · 2018

ReviewInfluence31.0
652
The review emphasized the need for better understanding and standardization of platelet-rich plasma (PRP) preparation methods to optimize its therapeutic applications in various medical fields.

Key findings

  1. 01PRP is derived from a patient's own blood and has a higher concentration of platelets.
  2. 02It is used for tissue regeneration, scar revision, and treating hair loss.
  3. 03Understanding PRP's biology and classification can improve its clinical use.
#03

Current Clinical Recommendations for Use of Platelet-Rich Plasma.

Le Adrian D K, et al. · Current reviews in musculoskeletal medicine · 2018

ReviewInfluence11.0
352
Researchers observed that current evidence supports the use of leukocyte-rich platelet-rich plasma (LR-PRP) for lateral epicondylitis and leukocyte-poor PRP (LP-PRP) for knee osteoarthritis, though efficacy varies by condition.

Key findings

  1. 01LR-PRP is effective for lateral epicondylitis.
  2. 02LP-PRP shows promise for knee osteoarthritis.
  3. 03Insufficient evidence exists for PRP in rotator cuff injuries and Achilles tendinopathy.
#04

Platelet-rich plasma therapy - future or trend?

ReviewInfluence11.0
285
The review described that platelet-rich plasma (PRP) has potential as a promising therapeutic approach for enhancing musculoskeletal healing, although significant knowledge gaps regarding its mechanisms of action remain.
#05

The use of platelet-rich plasma in bone reconstruction therapy.

ReviewInfluence14.0
251
Researchers concluded that the efficacy of platelet-rich plasma in bone reconstruction therapy remains controversial, with varying results depending on preparation methods and application protocols.
#06

Applications of the regenerative capacity of platelets in modern medicine.

ReviewInfluence1.0
195
Researchers observed that platelet-rich plasma (PRP) contains essential growth factors that regulate wound healing processes, making it a promising alternative treatment across multiple medical disciplines.
#07

Platelet-Rich Plasma.

Wu Peter I-Kung, et al. · Physical medicine and rehabilitation clinics of North America · 2016

ReviewInfluence4.0
180
The review indicated that platelet-rich plasma (PRP) has therapeutic potential in musculoskeletal medicine due to its ability to deliver high concentrations of growth factors that promote tissue repair.

Key findings

  1. 01PRP contains a higher concentration of platelets than normal blood, which may aid in healing.
  2. 02It shows promise in treating musculoskeletal injuries.
  3. 03There are still limitations in understanding its full effectiveness and areas for future study.
#08

Platelet-rich plasma (PRP): methodological aspects and clinical applications.

ReviewInfluence4.0
180
The review highlighted the need for standardized techniques in the preparation of platelet-rich plasma (PRP) to maximize its therapeutic potential in clinical applications.
#09

Evidence-based indications of platelet-rich plasma therapy.

ReviewInfluence3.0
167
The review demonstrated that platelet-rich plasma (PRP) is a versatile therapeutic option with evidence supporting its safety and effectiveness across various medical conditions, although large randomized clinical trials are limited.
#10

Platelet-rich plasma therapy and reproductive medicine.

HumanInfluence5.0
139
Researchers observed that platelet-rich plasma (PRP) may enhance endometrial receptivity and follicular growth in assisted reproduction cycles, although the underlying mechanisms remain largely unverified.

Clinical Trials (154)

Preclinical
Phase I
Phase II
Phase III
Approved

154

Total Trials

16,981

Total Enrolled

Evaluation of Platelet-Rich Plasma (PRP) Treatment in Tendinopathies

NCT07558564RECRUITING
Sponsor

ReSport Clinic

Enrollment

2,000

Started

2026

Primary outcome

Visual Analog Scale

Patellar TendinopathyAchilles Tendinopathy (AT)Epicondylitis, LateralPlantar Fasciitis, Chronic

Use of Platelet-Rich Plasma (PRP) and Platelet-Poor Plasma (PPP) to Prevent Infection and Delayed Wound Healing

NCT01639144COMPLETED
Sponsor

Gary M. Kiebzak, Ph.D.

Enrollment

515

Started

2012

Primary outcome

Postoperative Infection and Delayed Wound Healing.

Elective Foot and Ankle Surgery.

Combined Use of PRP and Hyaluronic Acid for Infiltrative Treatment of Patients With Knee Osteoarthritis

NCT06685120RECRUITING
Sponsor

Istituto Ortopedico Rizzoli

Enrollment

288

Started

2025

Primary outcome

Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)

Osteo Arthritis Knee

The Efficacy and Safety of Pulsed Radiofrequency Combined With Platelet-rich Plasma for the Trigeminal Neuralgia

NCT06472323RECRUITING
Sponsor

Beijing Tiantan Hospital

Enrollment

270

Started

2024

Primary outcome

The response rate of treatment

Trigeminal Neuralgia, IdiopathicPRP

Comparative Study for the Optimal Treatment Method of Lateral Epicondylosis

NCT02052089COMPLETED
Sponsor

CM Chungmu Hospital

Enrollment

231

Started

2009

Primary outcome

DASH scoring system to measure the changes in the upper extremity function

Tennis Elbow

Platelet-Rich and Concentrated Platelet-Poor Plasma to Reduce Air Leak Post-Lobectomy: A Randomized Controlled Trial

NCT00665912COMPLETED
Sponsor

Zimmer Biomet

Enrollment

204

Started

2008

Primary outcome

Duration of postoperative air leak

Lung Cancer

Platelet-Rich Plasma Versus Standard Care for Episiotomy Wound Healing in Postpartum Women

NCT07669285NOT_YET_RECRUITING
Sponsor

Saint Andrew Hospital Constanta

Enrollment

200

Started

2026

Primary outcome

REEDA Score (Redness, Edema, Ecchymosis, Discharge, Approximation)

EpisiotomyPlatelet Rich Plasma (PRP)Wound HealingObstetric

Ovarian PRP Injections for Improved Embryo Quality Using Embryo Quality Score

NCT07020546RECRUITING
Sponsor

Generation Next Fertility

Enrollment

180

Started

2025

Primary outcome

Blastocyst formation and embryo quality

InfertilityPoor Ovarian ReserveEmbryo Growth Disorderin Vitro Fertilization

PRP Versus HA IN OSTEOARTHRITIS OF THE PATELLOFEMORAL JOINT

NCT04937998RECRUITING
Sponsor

Istituto Ortopedico Rizzoli

Enrollment

166

Started

2022

Primary outcome

KOOS-Pain Score

Patellofemoral Osteoarthritis

Comparison of Platelet-Rich Plasma Dressing and Normal Saline Dressing for Wound Healing in Patients With Chronic Diabetic Wounds

NCT06867328COMPLETED
Sponsor

Gulab Devi Hospital

Enrollment

156

Started

2024

Primary outcome

Wound Healing

Diabetic WoundsDiabetic Ulcers

A Comparative Study of Platelet-Rich Plasma and Normal Saline Dressings in the Treatment of Chronic Wounds (PRP-NS Wound T)

NCT06849232COMPLETED
Sponsor

Quaid-e-Azam Medical College

Enrollment

156

Started

2024

Primary outcome

Wound Healing Rate

Wound Healing

Evaluation of Treatment of Osteoarthritis of the Knee in the Form of Chondromalacia of the Articular Cartilage Treated in the Arthroscopic Technique With the Use of:Autogenous Transplantation of Fragmented Adipose Tissue,PRP GF,Mesenchymal Cells,Hyaluronic Acid-low Molecular Weight and Cross-linked

NCT07110402COMPLETED
Sponsor

eMKa MED Medical Center

Enrollment

150

Started

2022

Primary outcome

Tegner Activity Level Scale (TAS)

Osteoarthritis, KneeChondral DefectChondromalacia, Left KneeChondromalacia, Right KneeArticular Cartilage Disorder of Knee

Efficacy of Therapy With PRP Injections Versus HA in Patients With Advanced Grade of GONArthrosis

NCT07016672RECRUITING
Sponsor

Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer

Enrollment

150

Started

2025

Primary outcome

Functional impact

Knee Osteoarthritis

Effects of Platelet Rich Plasma on Endometrium

NCT04424160COMPLETED
Sponsor

Acibadem University

Enrollment

150

Started

2020

Primary outcome

Endometrial thickness during hormone replacement therapy

Asherman Syndrome

PRP in Recurrent Implantation Failure

NCT04085783COMPLETED
Sponsor

Dr. Kamal Rageh

Enrollment

150

Started

2017

Primary outcome

Number of Participants with positive pregnancy test

Recurrent Implantation Failure

Full-Thickness Macular Hole Surgery: A Comparison of Ten Techniques

NCT07606404RECRUITING
Sponsor

Kazakh Eye Research Institute

Enrollment

120

Started

2026

Primary outcome

Macular Hole Closure at 7 days

Macular Holes

Tunnel Widening in Augmented ACL Integration Via PrP Enriched Collected Autologous Bone vs Standard ACL Technique

NCT05953051RECRUITING
Sponsor

Schulthess Klinik

Enrollment

107

Started

2024

Primary outcome

Tibial tunnel diameter change

Anterior Cruciate Ligament Tear

Immuno-based Profiling of knEe OA Patients to Predict reSponse to Regenerative Treatment

Sponsor

Istituto Clinico Humanitas

Enrollment

105

Started

2021

Primary outcome

knee OA patients focusing on changes in Wnt and IL1-ß signalling and PTX3 expression

Osteoarthritis, Knee

Comparison Between Ultrasound Guided Ozone, Platelet-Rich Plasma or Steroid Injection in the Treatment of Sacroiliitis; a Randomized Double Blinded Controlled Study

Sponsor

Tanta University

Enrollment

105

Started

2023

Primary outcome

Assessment of pain intensity using visual analog scale (VAS)

the Efficacy of Ultrasound Guided Sacroiliac Injection of Ozone, Platelet Rich Plasma (PRP) or Steroid for Treatment of Sacroiliitis

Comparison of Efficacy of Carbon Dioxide Laser With Subcision Versus Platelet-Rich Plasma Bio-Fillers With Subcision for the Treatment of Atrophic Acne

NCT07752186COMPLETED
Sponsor

Lahore General Hospital

Enrollment

100

Started

2025

Primary outcome

Change in Patient and Observer Scar Assessment Scale Score

Atrophic Acne Scars

Combined Photo-Biomodulation At Acupuncture Points, Autologous PRP, and Umbilical Cord-Derived Exosome Therapy in Autism Spectrum Disorder

Sponsor

Iffat Anwar Medical Complex

Enrollment

100

Started

2024

Primary outcome

Change in Childhood Autism Rating Scale (CARS) Score (15-60)

Autism Spectrum Disorder

PRP vs HA Intra-articular Knee Injections for Cartilage Defects

Sponsor

Shetty-Kim Research Foundation

Enrollment

100

Started

2014

Primary outcome

Clinical outcome

Osteoarthritis

Use of Platelet-Rich Plasma to Reduce Sternal Wound Complications After CABG With Median Sternotomy

NCT07352020COMPLETED
Sponsor

Shaheed Zulfiqar Ali Bhutto Medical University

Enrollment

98

Started

2022

Primary outcome

Superficial & Deep Sternal Wound Infections, Delayed Wound Healing and readmission.

Surgical Site Infection (SSI)MediastinitisDelayed Wound Healing

A Study on the Effect of High-concentrated Platelet Rich Plasma (PRP) on Osteoarthritis in the Thumb Base.

NCT06193499ACTIVE_NOT_RECRUITING
Sponsor

Karolinska Institutet

Enrollment

90

Started

2024

Primary outcome

Pain on load in thumb

Osteoarthritis Thumb

Platelet-rich Plasma and Synovial Cytokines in Knee Osteoarthritis

NCT04754685COMPLETED
Sponsor

South Valley University

Enrollment

90

Started

2019

Primary outcome

Changes in Pain Scores in patients with various severities of knee OA following intra-articular injection of PRP at 0, and 2 weeks from the second injection (0,4 weeks).

Knee Osteoarthritis

Ovarian Function Following Intraovarian Injection of PRP

NCT04278313ACTIVE_NOT_RECRUITING
Sponsor

Center for Human Reproduction

Enrollment

90

Started

2020

Primary outcome

Embryo Transfer

Diminished Ovarian ReserveDiminished Ovarian Reserve Due to Advanced Maternal Age

In Vivo Clinical and Radiological Effects of Platelet-rich Plasma on Interstitial Supraspinatus Lesion: Randomized Study

Sponsor

La Tour Hospital

Enrollment

84

Started

2015

Primary outcome

Lesion healing

Supraspinatis Interstitial Partial-thickness TearsPlatelet-rich Plasma (PRP)

Platelet-Rich Plasma in the Treatment of Patients With Idiopathic Carpal Tunnel Syndrome

NCT03863873COMPLETED
Sponsor

Mansoura University

Enrollment

80

Started

2017

Primary outcome

Pain improvement

Carpal Tunnel Syndrome

Study of PRP in Women With Evidence of Diminished Ovarian Reserve

NCT04275700COMPLETED
Sponsor

Center for Human Reproduction

Enrollment

80

Started

2018

Primary outcome

Emergence of new ovarian follicles with evidence of estradiol production

Diminished Ovarian ReserveOvarian Failure

Comparative Efficacy of Platelet Rich Plasma and Dry Needling in Management of Anterior Disc Displacement of Temporomandibular Joint

Sponsor

Postgraduate Institute of Dental Sciences Rohtak

Enrollment

78

Started

2021

Primary outcome

Pain intensity

Temporomandibular Joint Disc Displacement

Evaluation of Arthrocentesis With and Without PRP Injection in Patients With Disc Displacement With Reduction.

NCT05983653COMPLETED
Sponsor

Cairo University

Enrollment

74

Started

2023

Primary outcome

TMJ pain

TMJ Disc Disorder

Effectiveness of PRP Pharmacopuncture for Chronic Neck Pain in Cervical Myofascial Syndrome of the Upper Trapezius

NCT07119255RECRUITING
Sponsor

Indonesia University

Enrollment

72

Started

2025

Primary outcome

Biomarker parameters

Neck PainMyofascial Pain Syndrome

Genicular Nerve and Intra-articular Radiofrequency Versus Platelet Rich Plasma Injection for Knee Osteoarthritis

Sponsor

Mansoura University

Enrollment

70

Started

2017

Primary outcome

Pain score

Chronic Knee Osteoarthritis

Carpal Tunnel Syndrome Treatment: Surgery Vs. Injections

NCT06852131COMPLETED
Sponsor

Ankara University

Enrollment

68

Started

2022

Primary outcome

Electrophysiological studies

Carpal Tunnel Syndrome (CTS)

Autologous Intraovarian Platelet Rich Plasma Treatment in Women With Poor Ovarian Response

NCT04797377COMPLETED
Sponsor

Nadezhda Women's Health Hospital

Enrollment

66

Started

2021

Primary outcome

Oocyte number

Poor Ovarian Reserve

Effect of PRP Injection on Voice Recovery After Benign Vocal Fold Surgery

NCT07300800RECRUITING
Sponsor

Beni-Suef University

Enrollment

64

Started

2025

Primary outcome

Shimmer (Local, dB)

Benign Vocal Fold Lesions

Meniscal Repair Augmented With Leukocyte-Poor Platelet-Rich Plasma: A Prospective Comparative Clinical Study

NCT07815743NOT_YET_RECRUITING
Sponsor

Universidad Autonoma de Nuevo Leon

Enrollment

62

Started

2026

Primary outcome

Change in Knee Function Assessed by the IKDC Subjective Knee Form

Meniscal Tears

The Efficiency and Safety of PRP Treatment After Anterior Cruciate Ligament Reconstruction.

NCT06442319RECRUITING
Sponsor

Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz

Enrollment

60

Started

2024

Primary outcome

Pain and cartilage volume

ACL InjuryKnee OsteoarthritisKnee Injuries

GO PRP: Assessing the Efficacy of Intra Articular Injection of Platelets Rich Plasma for Gonarthrosis Treatment in Routine Care

Sponsor

Hospital St. Joseph, Marseille, France

Enrollment

60

Started

2017

Primary outcome

to monitor and follow the evolution of pain

Knee Osteoarthritis

Subacromial Injection of Allogeneic Platelet Rich Plasma (PRP) for Shoulder Impingement Syndrome

NCT02019537COMPLETED
Sponsor

Seoul National University Hospital

Enrollment

60

Started

2014

Primary outcome

Safety determined with symptoms & signs of infection and immune response and adverse events evaluated with NCI-CTCAE v3.0

Shoulder Impingement Syndrome

Comparative Efficacy and Safety if Intravesical Botulinum Toxin A Versus Platelet-Rich Plasma in the Management of Refractory Overactive Bladder : A 2 Year Study

NCT07693192ACTIVE_NOT_RECRUITING
Sponsor

Mahmoud Mohamed Farag Ali

Enrollment

60

Started

2026

Primary outcome

Reduction in Urgency Urinary Incontinence Episodes

Overactive Bladder

Biocellular-Cellular Regenerative Treatment Scaring Alopecia and Alopecia Areata

Sponsor

Regeneris Medical

Enrollment

60

Started

2017

Primary outcome

Safety of Intervention

Alopecia AreataScarring Alopecia

Comparison of Platelet-rich Plasma and Activated Cytokine-rich Serum Injection Treatments in Patients With Knee Osteoarthritis. (KOA PRP ACS)

NCT07473232RECRUITING
Sponsor

Pamukkale University

Enrollment

60

Started

2026

Primary outcome

Visual pain scale score

Knee Arthritis OsteoarthritisPlatelet Rich Plasma InjectionConditioned Serum

Efficacy of Intralesional PRP +/- Topical Silymarin in the Treatment of Melasma

Sponsor

Sohag University

Enrollment

60

Started

2022

Primary outcome

Improvement in mMASI SCORE

Melasma

Platelet Rich Plasma (PRP) as Terapeutical Option in Erectil Disfunction (DE)

NCT06768177ENROLLING_BY_INVITATION
Sponsor

Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari

Enrollment

60

Started

2023

Primary outcome

Change in erectile function

Erectile Dysfunction Due to General Medical ConditionErectile Dysfunction Following Radical ProstatectomyErectile Dysfunction Associated With Type 2 Diabetes MellitusErectile Dysfunctions

Corticosteroid Versus PRP Injections for Shoulder Tendinopathy

NCT07094178RECRUITING
Sponsor

Hopital Charles Nicolle

Enrollment

60

Started

2025

Primary outcome

Change in pain intensity measured by Visual Analog Scale (VAS)

Tendinopathy of Rotator Cuff

Clinical Outcomes of Intraarticular Platelet-Rich Plasma Injection in Knee Osteoarthritis

NCT07828561COMPLETED
Sponsor

KIST Medical and Teaching Hospital

Enrollment

59

Started

2022

Primary outcome

Pain intensity

Knee OsteoarthritisOsteoarthritis (OA)Degenerative Joint Disease of KneeKnee Pain

Comparison of Leucocyte-rich PRP and Leucocyte-poor PRP in Treating Mild to Moderate Knee Osteoarthritis

NCT07857954COMPLETED
Sponsor

St. Catherine Specialty Hospital

Enrollment

59

Started

2023

Primary outcome

Knee injury and Osteoarthritis Outcome Score

Knee Osteoarthritis (Kellgren-Lawrence Grade 1-3)Knee OsteoarthritisPRPPlatelet-rich Plasma (PRP)

ECRB Tendinopathy: Needling ± PRP After Failure of Rehabilitation

Sponsor

Adrien Schwitzguebel

Enrollment

58

Started

2020

Primary outcome

Pain during isometric contraction of the ECRB

Tennis ElbowPRPTendinopathyTendinosisExtracorporal Shockwave Therapy (ESWT)Tendon Needling (Peppering)Extensor Carpi Radialis Brevis (ECRB)

Platelet Rich Plasma (PRP) One-Shot Injection For Supraspinatus Tendinosis

NCT04851951COMPLETED
Sponsor

Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari

Enrollment

48

Started

2018

Primary outcome

Change in Visual Analogic Scale

Supraspinatus Tendinitis

Arthroscopic Rotator Cuff Repair With Platelet-Rich Plasma(PRP) in Large to Massive Tears

NCT01238302COMPLETED
Sponsor

Seoul National University Hospital

Enrollment

48

Started

2009

Primary outcome

structural integrity of repaired rotator cuff tendon

Rotator Cuff Tear

Treatment of Vulvar Lichen Sclerosus With Corticosteroid Ointment, Calcineurin Inhibitor Ointment, and Platelet-Rich Plasma (PRP) Therapy.

NCT07240389NOT_YET_RECRUITING
Sponsor

Milosz Pietrus

Enrollment

45

Started

2025

Primary outcome

Change in DLQI (Dermatology Life Quality Index) Score

Vulvar Lichen Sclerosus

The Effects of Intra-articular and Peri-articular Platelet-rich Plasma (PRP) Injections ın Chronic Knee Osteoarthritis

NCT07339137RECRUITING
Sponsor

Ankara City Hospital Bilkent

Enrollment

42

Started

2025

Primary outcome

VAS (Visual Analog Scale)

Platelet Rich Plasma InjectionUltrasonographyGonarthrosis

Efficacy of Mesotherapy Added to Intra-articular Platelet-rich Plasma (PRP) in Patients With Knee Osteoarthritis

Sponsor

Necmettin Yildiz

Enrollment

42

Started

2022

Primary outcome

Visual Analogue Scale (VAS)

Osteo Arthritis Knee

Trial for Treating Painful Degenerative Disc Disease

NCT05287867RECRUITING
Sponsor

Regenexx, LLC

Enrollment

42

Started

2022

Primary outcome

Numeric Pain Scale (NPS)

Degenerative Disc Disease

PRP Regenerative Endodontics vs. Root Canal Treatment for Post-Op Pain and Healing in Mature Teeth

NCT07124962COMPLETED
Sponsor

HITEC-Institute of Medical Sciences

Enrollment

41

Started

2024

Primary outcome

Post-operative Pain Score

Irreversible Pulpitis With Apical Periodontitis

CO₂ Laser With or Without Platelet-Rich Plasma for Genitourinary Syndrome of Menopause

NCT07863739COMPLETED
Sponsor

National and Kapodistrian University of Athens

Enrollment

40

Started

2023

Primary outcome

Change in Vaginal Dryness Severity

Genitourinary Syndrome of Menopause (GSM)

Comparison of Hyaluronic Acid and Platelet-rich Plasma Injections

NCT03761472COMPLETED
Sponsor

Bezmialem Vakif University

Enrollment

40

Started

2019

Primary outcome

Change of numeric rating scale (rest, movement)

Knee Osteoarthritis

Platelet-rich Plasma in the Sacroiliac Joint

NCT03744234COMPLETED
Sponsor

Columbia University

Enrollment

40

Started

2016

Primary outcome

Change in Visual Analogue Pain (VAS) Score

Sacroiliac Joint Arthritis

Efficacy of Injectable Platelet-rich Fibrin Versus Platelet-Rich Plasma As Adjunctive to Scaling and Root Planning in Non-surgical Periodontal Therapy of Periodontitis Patients

NCT06685393COMPLETED
Sponsor

ELsabbahy Ahmed Mohamed Youssef

Enrollment

40

Started

2023

Primary outcome

clinical measurement of plaque index (PI).

Peridontal Disease

Percutaneous Needle Tenotomy (PNT) Versus Platelet Rich Plasma (PRP) With PNT in the Treatment of Chronic Tendinosis

NCT01833598COMPLETED
Sponsor

Hospital for Special Surgery, New York

Enrollment

40

Started

2012

Primary outcome

Improvement in pain based on a visual analog score

Chronic Tendinopathy

Platelet Rich Plasma vs Hyaluronic-Acid in Hip OA (Osteoarthritis)

NCT01920152COMPLETED
Sponsor

University of Colorado, Denver

Enrollment

38

Started

2013

Primary outcome

Survivorship, as Measured by the Frequency of Patient Withdrawal of Their Treated Hip to Undergo Surgery (Total Hip Arthroplasty [THA] or Hip Resurfacing Procedure).

Hip Osteoarthritis

Atrophic Age-related Macular Degeneration Treated With Intravitreal Injections of Umbilical Cord Blood Platelet-rich Plasma

NCT05706896RECRUITING
Sponsor

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Enrollment

36

Started

2022

Primary outcome

Autofluorescence atrophy area changes in treated eyes compared with sham group

Dry Age-related Macular Degeneration

Injections of Autologous PRP in Women With Primary Ovarian Insufficiency

NCT03542708COMPLETED
Sponsor

Center for Human Reproduction

Enrollment

34

Started

2018

Primary outcome

Ovarian Follicles

Primary Ovarian InsufficiencyPremature Menopause

Investigating Orthobiologics After PRP and Photobiomodulation for Knee Osteoarthritis

NCT06122116TERMINATED
Sponsor

Musculoskeletal Injury Rehabilitation Research for Operational Readiness

Enrollment

33

Started

2023

Primary outcome

Kellgren Lawrence Classification System (KL)

Knee Osteoarthritis

PANDORA: Evaluation of Platelet-rich Plasma in Non-tumoural Odour Disorders: a Descriptive Pilot Study.

NCT07473830NOT_YET_RECRUITING
Sponsor

Hospices Civils de Lyon

Enrollment

30

Started

2026

Primary outcome

Proportion of participants with clinically meaningful improvement in olfactory function (Sniffin' Sticks Test TDI score)

Olfactory DysfunctionPost-traumatic Olfactory DysfunctionAge-related Degenerative Olfactory Dysfunction

Platelet Rich Plasma in Healing of Through and Through Periradicular Lesions

Sponsor

Postgraduate Institute of Dental Sciences Rohtak

Enrollment

30

Started

2016

Primary outcome

CHANGE IN PERIAPICAL RADIOLUCENCY ON RADIOGRAPH

Periapical Lesions

Treatment of Acute and Chronic Ligament and Tendon Injuries With Platelet Rich Plasma

NCT01406821COMPLETED
Sponsor

Stanford University

Enrollment

30

Started

2009

Primary outcome

Patient-reported improvement in symptoms at 12 weeks

Tendinopathy

Platelet-rich Plasma(PRP) Injection in ED

Sponsor

National Taiwan University Hospital

Enrollment

30

Started

2021

Primary outcome

International Index of Erectile Function(IIEF-5)

Erectile DysfunctionPRP

Assessment of Endometrial and Sub-endometrial Vascularity Before and After PRP Infusion in Frozen Embryo Transfer Cycles

Sponsor

Hatem AbuHashim

Enrollment

30

Started

2020

Primary outcome

Vascularization index of the endometrial region

Frozen Embryo Transfer

Platelet-rich Plasma Injection for Ulnar Neuropathy at Elbow

NCT04264000COMPLETED
Sponsor

Yung-Tsan Wu

Enrollment

30

Started

2020

Primary outcome

Visual analog scale (VAS)

Ulnar Neuropathy at Elbow

Homologus PRP in the Infiltrative Treatment of Knee Osteoarthritis in Young Athletic Patients

NCT06483269RECRUITING
Sponsor

Istituto Ortopedico Rizzoli

Enrollment

30

Started

2023

Primary outcome

International Knee Documentation Committee score

Knee Osteoarthritis

Intra-Articular PRP Versus Dexamethasone for TMJ Internal Derangement

NCT07691684COMPLETED
Sponsor

University Of Anbar

Enrollment

30

Started

2025

Primary outcome

Change in Pain Intensity (VAS)

Temporomandibular Joint DisordersTemporomandibular Joint Internal DerangementTemporomandibular Joint Dysfunction Syndrome

Intra-articular Platelet-Rich Plasma for Acetabular Labral Tears

NCT06332352COMPLETED
Sponsor

University of Utah

Enrollment

30

Started

2024

Primary outcome

Global Assessment Score

Acetabular Labrum Tear

Lyophilized Platelet-Rich Plasma Lysate vs Dextrose Prolotherapy for Partial Rotator Cuff Tears

NCT07789951ACTIVE_NOT_RECRUITING
Sponsor

Taichung Veterans General Hospital

Enrollment

28

Started

2022

Primary outcome

Sonographic Rotator Cuff Tear Size

Rotator Cuff TearRotator Cuff SyndromeRotator Cuff Arthropathy of Right ShoulderRotator Cuff Arthropathy of Left ShoulderRotator Cuff Arthropathy of Bilateral Shoulders

The Efficacy of LPPRP in the Treatment of Chondromalacia Patella

NCT06020794COMPLETED
Sponsor

Kayseri City Hospital

Enrollment

28

Started

2021

Primary outcome

Western Ontario & McMaster Universities Osteoarthritis Index (WOMAC)

Chondromalacia Patellae

Performance-Enhancing Effects of Platelet-Rich Plasma (PRP) Injections

NCT01200875COMPLETED
Sponsor

Stanford University

Enrollment

25

Started

2010

Primary outcome

Blood Growth Factor Concentrations

TendinopathyRheumatic Diseases

Clinical Study on Autologous Platelet-rich Plasma (PRP) Treatment for Refractory Benign Airway Stenosis

Sponsor

Guangzhou Institute of Respiratory Disease

Enrollment

24

Started

2019

Primary outcome

Cure rate for benign stenosis

Benign Airway Stenosis

Comparative Evaluation of the Regenerative Capacity of Two Platelet Concentrates

Sponsor

Cairo University

Enrollment

24

Started

2018

Primary outcome

Increase in root length

Necrotic Pulp

A Randomized Trial on Platelet Rich Plasma Versus Saline Dressing of Diabetic Foot Ulcers

NCT04090008COMPLETED
Sponsor

Mansoura University

Enrollment

24

Started

2017

Primary outcome

Percent reduction in the ulcer size

Diabetic Foot

Platelet-Rich Plasma Intra-Articular Injection in Treating Hemophilic Arthropathy

NCT02601170COMPLETED
Sponsor

Tri-Service General Hospital (TSGH)

Enrollment

22

Started

2014

Primary outcome

Pain (Visual Analogue Scale) and Change From Baseline at 1, 2, 3 &6 Months

HemophiliaHemophilic Arthropathy

Microdrilling Surgery for Full Thickness Chondral Lesions of the Knee Augmented With Concentrated Bone Marrow Aspirate, Platelet Rich Plasma and Hyaluronic Acid

NCT02285725COMPLETED
Sponsor

Joseph E. Broyles

Enrollment

21

Started

2011

Primary outcome

Change in International Knee Documentation Committee (IKDC) score

Unilateral Primary Osteoarthritis of KneeOsteoarthritis KneeDegeneration; Articular Cartilage, KneeDegenerative Lesion of Articular Cartilage of Knee

Efficacy and Safety of Platelet Rich Plasma in Androgenetic Alopecia

Sponsor

Vancouver General Hospital

Enrollment

20

Started

2014

Primary outcome

The degree of hair regrowth based on the hair regrowth score (RGS) for each side of scalp.

Androgenetic Alopecia

Validation of a Low-cost Platelet-Rich Plasma (PRP)

NCT06184048COMPLETED
Sponsor

University of Utah

Enrollment

20

Started

2023

Primary outcome

The primary goal of this study is to validate our easy-to replicate LC-PRP preparation technique

Platelet-Rich Plasma (PRP)Knee Osteoarthritis (OA)

Percutaneous Needle Tenotomy Associated With Platelet-rich Plasma Injection Platelet-rich Plasma in the Treatment of Refractory Plantar Fasciitis: a Pilot Study of the Effect on Pain and Tolerance

NCT05622279COMPLETED
Sponsor

Nantes University Hospital

Enrollment

19

Started

2023

Primary outcome

To evaluate the evolution of plantar pain after treatment combining needle tenotomy and PRP injection in refractory plantar fasciitis.

Plantar Fascitis

PRP Efficacy and Safety in BPF

NCT05304897COMPLETED
Sponsor

Guangzhou Institute of Respiratory Disease

Enrollment

16

Started

2022

Primary outcome

Cure rate for bronchopleural fistula

Bronchopleural Fistula

PRP as Adjuvant Treatment to CTR for Severe CTS Tunnel Syndrome

NCT04811287TERMINATED
Sponsor

Michael Fredericson, MD

Enrollment

15

Started

2021

Primary outcome

Number of Participants With Severe or Very Severe Symtoms as Measured by the Boston Carpal Tunnel Questionnaire

Carpal Tunnel SyndromePRP

Effect of Platelet-Rich Plasma Biomembrane on Enhancing Bone Regeneration Following Endodontic Surgery

NCT04109417COMPLETED
Sponsor

Alexandria University

Enrollment

15

Started

2014

Primary outcome

degree of periapical inflammation using periapical index (PAI)

Endodontic Disease

Platelet Rich Plasma Injection in Pilon Fractures

NCT02481869COMPLETED
Sponsor

University of Missouri-Columbia

Enrollment

11

Started

2015

Primary outcome

Intra-articular Inflammatory Biomarkers at the Time of Definitive Fixation

Fracture

A Trial Comparing Three Orthobiologic Therapies on Atrophied Multifidus Muscles in Patients With Low Back Pain

NCT03618979TERMINATED
Sponsor

Regenexx, LLC

Enrollment

8

Started

2019

Primary outcome

Post-treatment MRI

Low Back Pain

Botulinum-assisted Orbital Fat Augmentation With PRP (Platelet-rich-plasma)

NCT02244671COMPLETED
Sponsor

Fox, Donald Munro, M.D., P.C.

Enrollment

6

Started

2014

Primary outcome

Orbital volume

Orbital Atrophy

Autologous Fat Grafting With PRP (Platelet Rich Plasma) to Anophthalmic Sockets

NCT01712555COMPLETED
Sponsor

Fox, Donald Munro, M.D., P.C.

Enrollment

5

Started

2011

Primary outcome

Improved retention of autologous fat injected into anophthalmic sockets

Orbital Atrophy

Leukocyte-rich PRP vs Leukocyte-poor PRP for the Treatment of Knee Cartilage Degeneration: a Randomized Controlled Trial

NCT02923700Phase 4COMPLETED
Sponsor

Istituto Ortopedico Rizzoli

Enrollment

192

Started

2016

Primary outcome

IKDC (International knee documentation committee) score trend over time

Osteoarthritis

The Impact of Procedural Awareness of Knee Injections for Osteoarthritis on Patient Perceptions of Effectiveness

NCT04111718Phase 4ACTIVE_NOT_RECRUITING
Sponsor

ArthroBiologix Inc.

Enrollment

158

Started

2019

Primary outcome

VAS Pain

Osteoarthritis, Knee

PRP vs PRP+Betamethasone vs Betamethasone Injection for Upper Trapezius Myofascial Pain

NCT07547605Phase 4RECRUITING
Sponsor

University of Kyrenia

Enrollment

150

Started

2026

Primary outcome

Change in Visual Analog Scale (VAS) Pain Score

Myofascial Pain Dysfunction SyndromeTrigger Points, MyofascialTrigger Point in Trapezius Muscle

Comparison of Effectiveness Between PL and PRP on Knee Osteoarthritis: a Prospective,Randomized,Placebo-controlled Trial

NCT03734900Phase 4UNKNOWN
Sponsor

National Taiwan University Hospital

Enrollment

150

Started

2018

Primary outcome

Pain score of the patient

Osteoarthritis (OA) of the Knee

Effectiveness of Extracorporeal Shockwave Therapy Combined With Platelet-rich Plasma in the Treatment of Chronic Insertional Achilles Tendinopathy

NCT06384859Phase 4NOT_YET_RECRUITING
Sponsor

Mahidol University

Enrollment

94

Started

2024

Primary outcome

VAS

Insertional Achilles Tendinopathy

PRP vs HA Intra-articular Injections in TMDs

NCT06530745Phase 4COMPLETED
Sponsor

Hospital of the Ministry of Interior, Kielce, Poland

Enrollment

81

Started

2024

Primary outcome

Mandibular abduction

Temporomandibular Joint DisordersTemporomandibular Joint Pain

The Effect of Proprioception of Platelet Rich Plasma for Patients With Ankle Sprain

NCT03808454Phase 4UNKNOWN
Sponsor

National Defense Medical Center, Taiwan

Enrollment

60

Started

2019

Primary outcome

mean of the distance of ankle movement by the force plate system

Ankle Sprain 2Nd DegreeAnkle Sprain 3Rd Degree

Platelet-rich Plasma, Corticosteroid, or Lidocaine for Acromioclavicular Joint Pain

NCT05161468Phase 4TERMINATED
Sponsor

Brooke Army Medical Center

Enrollment

34

Started

2021

Primary outcome

Patient Reported Outcomes Measurement Information Systems (PROMIS) - Physical Function Scale Computer Adapted Test (PF-CAT)

Acromioclavicular Sprain

Temporomandibular Joint Arthrocentesis With Infiltration of PRP + Ropivacaine Versus PRP

NCT05817162Phase 4UNKNOWN
Sponsor

Instituto Portugues da Face

Enrollment

30

Started

2023

Primary outcome

TMJ Pain

Temporomandibular Joint Disorders

The Analysis of Efficacy Factors for Autologous Platelet-Rich Plasma Therapy in the Treatment of Elbow Tendinopathy

NCT06815042Phase 4NOT_YET_RECRUITING
Sponsor

CHA University

Enrollment

30

Started

2025

Primary outcome

Change in Patient-Rated Tennis Elbow Evaluation (PRTEE) Score

Elbow Tendinopathy

Patellar Tendon Regeneration With Platelet-rich Plasma

NCT01111747Phase 4COMPLETED
Sponsor

University of Sao Paulo General Hospital

Enrollment

27

Started

2008

Primary outcome

Evaluation of the patellar tendon regeneration with magnetic resonance imaging.

Knee Instability

Platelet-rich Plasma Versus Corticosteroid Injection for the Treatment of Femoroacetabular Impingement

NCT02920177Phase 4TERMINATED
Sponsor

University of Michigan

Enrollment

4

Started

2016

Primary outcome

Change From Baseline in Pain Score on the Visual Analog Scale

Femoroacetabular Impingement

Platelet-rich Plasma vs. Whole Blood for Gluteus Medius Tendinopathy

NCT02978833Phase 4TERMINATED
Sponsor

Hospital for Special Surgery, New York

Enrollment

2

Started

2013

Primary outcome

Improvement in Pain

TendinopathyHip Pain

Comparison Between Intra-articular Infiltrations of PRP, MFAT, and PRP-MFAT in the Treatment of Symptomatic Knee Osteoarthritis.

NCT06084637Phase 3NOT_YET_RECRUITING
Sponsor

Assistance Publique Hopitaux De Marseille

Enrollment

180

Started

2024

Primary outcome

KOOS score at 6 months

Osteo Arthritis Knee

The Effect of Platelet-rich Plasma in Patients With Osteoarthritis of the Knee

NCT01926327Phase 3COMPLETED
Sponsor

Royan Institute

Enrollment

150

Started

2013

Primary outcome

pain

Osteoarthritis

Knee Osteoarthritis Treatment With Platelet-rich Plasma

NCT05824806Phase 3UNKNOWN
Sponsor

Instituto Nacional de Traumatologia e Ortopedia

Enrollment

90

Started

2024

Primary outcome

Evolution of Western Ontario and McMaster Universities Arthritis Index over time

Osteoarthritis, Knee

Platelet-rich Plasma Intra-articular Knee Injections for Knee Osteoarthritis

NCT01381081Phase 3COMPLETED
Sponsor

Hospital Universitari Vall d'Hebron Research Institute

Enrollment

74

Started

2011

Primary outcome

The value of the visual analogue scale pain (VAS)

Knee Osteoarthritis

PRP in ACLR to Prevent PTOA

NCT05412381Phase 3RECRUITING
Sponsor

Hospital for Special Surgery, New York

Enrollment

56

Started

2022

Primary outcome

Platelet count (Thousand/uL)

Anterior Cruciate Ligament InjuriesPost-traumatic OsteoarthritisPRP

Platelet-Rich Plasma for Stress Urinary Incontinence

NCT05390970Phase 3COMPLETED
Sponsor

Annah J. Vollstedt

Enrollment

50

Started

2022

Primary outcome

Number of Participants With Negative Urinary Stress Test (no Leakage Noted on Examination During Cough or Valsalva Maneuvers at a Standardized Bladder Volume of 300 mL)

Urinary Incontinence,StressUrinary Incontinence

Umbilical Cord Blood Mononuclear Cell Gel in the Treatment of Refractory Diabetic Foot Ulcer

NCT04689425Phase 3UNKNOWN
Sponsor

Peking University Third Hospital

Enrollment

40

Started

2021

Primary outcome

Wound area reduction rate

Diabetic Foot Ulcer

Comparative Efficacy of PRP and Dry Needling in Management of Trigger Points in Masseter Muscle in MPS Patients

NCT04286880Phase 3UNKNOWN
Sponsor

Postgraduate Institute of Dental Sciences Rohtak

Enrollment

30

Started

2020

Primary outcome

assessment of pain improvement upto 3 months

Myofascial Pain Syndrome

CB-PRP in Retinitis Pigmentosa and Dry Age-related Macular Degeneration

NCT04636853Phase 3COMPLETED
Sponsor

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Enrollment

20

Started

2020

Primary outcome

Optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) morphological changes

Retinitis PigmentosaDry Age-related Macular Degeneration

The Combination Therapy of Fractional Laser and PRP Compared With Nanofat Grafting and PRP Synergy in Treating Striae Gravidarum.

NCT03328871Phase 3UNKNOWN
Sponsor

First Affiliated Hospital of Jinan University

Enrollment

10

Started

2017

Primary outcome

Immunohistochemical analysis

Treatments of Striae Gravidarum

PRP-HA Versus HA in Knee Osteoarthritis

NCT05076526Phase 2/3UNKNOWN
Sponsor

Singapore General Hospital

Enrollment

132

Started

2021

Primary outcome

Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score

Osteoarthritis, Knee

Autologous Platelet-Rich Plasma Intra-ovarian Infusion in Poor Responders

NCT03937661Phase 2/3RECRUITING
Sponsor

Genesis Athens Clinic

Enrollment

100

Started

2019

Primary outcome

Number of oocytes retrieved

Ovary; AnomalyInfertility, Female

Intraarticular Leukocyte-rich and Leukocyte-poor PRP for Osteoarthritis of the Knee

NCT05737173Phase 2/3COMPLETED
Sponsor

Queen Savang Vadhana Memorial Hospital, Thailand

Enrollment

93

Started

2020

Primary outcome

The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)

Osteo Arthritis Knee

Effectiveness of iPRF Injections in Temporomandibular Joints Degeneration Management

NCT05214924Phase 2/3ENROLLING_BY_INVITATION
Sponsor

Wroclaw Medical University

Enrollment

42

Started

2022

Primary outcome

The effectiveness of intra-articular platelet-rich fibrin (iPRF) injections on TMD symptoms reduction assessed by clinical examination in accordance to Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) protocol with DC/TMD examination form.

Temporomandibular DisorderTemporomandibular Joint DisordersTemporomandibular ArthritisTemporomandibular Joint Osteoarthritis

Elimination of Odor and Treatment of Malodorous Recalcitrant Wounds by Using Supraz and PRP-FG Versus Standard of Care

NCT05983302Phase 2/3UNKNOWN
Sponsor

Mashhad University of Medical Sciences

Enrollment

40

Started

2023

Primary outcome

Wound Odor Change

Wounds and Injuries

Autologous Platelet-rich Plasma for Clomiphene Citrate-induced Thin Endometrium

NCT03770026Phase 2/3COMPLETED
Sponsor

Benha University

Enrollment

30

Started

2018

Primary outcome

Endometrial thickness

Infertility, Female, Associated With Anovulation

Safety & Effectiveness of Autologous Regenerative Cell Therapy on Pain & Inflammation of Osteoarthritis of the Hip

NCT02844764Phase 2RECRUITING
Sponsor

VivaTech International, Inc.

Enrollment

4,000

Started

2015

Primary outcome

Change is being assessed for the HOOS survey (Hip Osteoarthritis Outcome Scores)

Osteoarthritis

Comparison of Recurrence Rate of Keloid After Excision Between Intra-operative Steroid Injection and Steroid With Platelet-rich Plasma Injection Combination Therapy

NCT06965088Phase 2ACTIVE_NOT_RECRUITING
Sponsor

Ramathibodi Hospital

Enrollment

212

Started

2025

Primary outcome

Recurrence rate of keloid

Patients With Keloid Scar

Effectiveness of Apheresis Platelet-Rich Plasma Injection for Androgenic Alopecia

NCT07348315Phase 2COMPLETED
Sponsor

zhang li

Enrollment

201

Started

2023

Primary outcome

Response Based on the Basic and Specific (BASP) classification

Androgenic Alopecia

G-CSF and PRP in Patients With Recurrent Implantation Failure

NCT04411212Phase 2UNKNOWN
Sponsor

Riyadh Fertility and Reproductive Health center

Enrollment

112

Started

2020

Primary outcome

Clinical pregnancy rate

Infertility,Female

Effectiveness of Platelet-rich Plasma Treatment of Knee Osteoarthritis

NCT05825105Phase 2COMPLETED
Sponsor

Universidad Nacional de Entre Rios

Enrollment

111

Started

2024

Primary outcome

Change in the Western Ontario and McMaster Universities (WOMAC) Ostearthritis Index

Knee Osteoarthritis

Intra-articular Platelet-Rich Plasma Compared With Viscosupplementation in the Treatment of Knee Osteoarthritis

NCT03491761Phase 2RECRUITING
Sponsor

Endeavor Health

Enrollment

100

Started

2018

Primary outcome

Cartilage Thickness on MRI

Knee Osteoarthritis

Association of Photobiomodulation With Platelet Rich Plasma Intradermal Injection for Facial Rejuvenation

NCT04145999Phase 2UNKNOWN
Sponsor

University of Nove de Julho

Enrollment

96

Started

2020

Primary outcome

Change in Photographic Analysis

Wrinkle

Use of Platelet Rich Plasma in the Management of Acute Hamstring Muscle Strain Injury

NCT01812564Phase 2COMPLETED
Sponsor

Aspetar

Enrollment

90

Started

2009

Primary outcome

Time to Return to Play

Acute Hamstring Muscle Strain Injury

A RCT on the Effect of Platelets Rich Plasma in ICSI Patients With Recurrent Implantation Failure

NCT04434547Phase 2UNKNOWN
Sponsor

Dr. Osman Hospital

Enrollment

86

Started

2020

Primary outcome

Clinical pregnancy rate

Pregnancy Outcome

Evaluation of Platelet Rich Plasma (PRP) for Knee Osteoarthritis

NCT03138317Phase 2UNKNOWN
Sponsor

University of Sao Paulo

Enrollment

60

Started

2017

Primary outcome

Knee pain score measured by Visual Analogue Scale (VAS)

Osteoarthritis, Knee

Platelet Rich Plasma Injections In Young And Old Human Subjects

NCT06451120Phase 2ACTIVE_NOT_RECRUITING
Sponsor

University of California, San Francisco

Enrollment

60

Started

2024

Primary outcome

Identify Protein Changes in Platelet Rich Plasma (PRP)

OsteoarthritisArticular CartilageMusculoskeletal Disorders

Comparison of Functional Outcomes Following Arthroscopic ACL Reconstruction With Peroneus Longus Autograft With and Without Intra-articular Platelet-Rich Plasma Injection.

NCT07470359Phase 2RECRUITING
Sponsor

Lahore General Hospital

Enrollment

60

Started

2026

Primary outcome

KOOS4 score

ACL ReconstructionIntraarticular InjectionPRP

Comparative Assessment of Intra-articular Knee Injections of Platelet-rich Plasma (PRP) and Hyaluronic Acid in the Treatment of Knee Osteoarthritis

NCT01697423Phase 2COMPLETED
Sponsor

Assistance Publique Hopitaux De Marseille

Enrollment

58

Started

2012

Primary outcome

Variation of the functional score of WOMAC

the Treatment of Knee Osteoarthritis

Autologous Platelet-rich Plasma to Improve Responsiveness and Embryo Quality in Patients With Poor Ovarian Response

NCT05105724Phase 2UNKNOWN
Sponsor

Nanjing University

Enrollment

50

Started

2019

Primary outcome

number of oocytes retrieved

Infertility

Investigation of Mesenchymal Stem Cell Therapy for the Treatment of Osteoarthritis of the Knee

NCT02958267Phase 2COMPLETED
Sponsor

OhioHealth

Enrollment

32

Started

2016

Primary outcome

Knee Injury and Osteoarthritis Outcome Score

Knee Osteoarthritis

Evaluation of Vulvar Lichen Sclerosus Treatment Using Adipose Tissue Associated With Autologous Platelet-rich Plasma.

NCT03961126Phase 2COMPLETED
Sponsor

Instituto de Investigacion Sanitaria La Fe

Enrollment

20

Started

2017

Primary outcome

Vulvar elasticity measured by the cutometer-dualmpa®

Vulvar Lichen Sclerosus

Persistent Pleural Effusion Treatment Following Cardiothoracic Surgery by Platelet-Fibrin Glue

NCT06449131Phase 2COMPLETED
Sponsor

Daryoush Hamidi Alamdari, PhD

Enrollment

19

Started

2017

Primary outcome

The rate of air leak that is assessed by Cerfolio classification of the air leak by a single observer

Pleural Effusion

Use of Platelet Rich Plasma from Cord Blood Vs Placebo in the Treatment of Vulvar Lichen Sclerosus

NCT06661382Phase 1/2RECRUITING
Sponsor

Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico

Enrollment

100

Started

2023

Primary outcome

Patient satisfaction in treatment group vs placebo group

Vulvar Lichen Sclerosus

Regenerative Medicine for Joint Hypermobility and Instability

NCT07688096Phase 1/2NOT_YET_RECRUITING
Sponsor

Manhattan Pain Medicine, PLLC

Enrollment

100

Started

2026

Primary outcome

Global Percentage of Improvement (GPI) Responder Rate After Dextrose Prolotherapy

Ehlers-Danlos Syndrome Hypermobility Type (hEDS)Ehlers-Danlos Syndrome (EDS)Joint HypermobilityJoint InstabilityHypermobility Spectrum DisorderChronic Pain SyndromeMusculoskeletal PainSprainSubluxationDislocationCraniocervical Disfunction

Prospective Evaluation of PRP and BMC Treatment to Accelerate Healing After ACL Reconstruction

NCT04205656Phase 1/2ACTIVE_NOT_RECRUITING
Sponsor

Steadman Philippon Research Institute

Enrollment

45

Started

2020

Primary outcome

Incidence of Treatment-Emergent Adverse Events

Osteoarthritis, Knee

Effectiveness of PRP, Conditioned Medium UC-MSCs Secretome and Hyaluronic Acid for the Treatment of Knee Osteoarthritis

NCT05579665Phase 1/2COMPLETED
Sponsor

Universitas Sriwijaya

Enrollment

45

Started

2022

Primary outcome

Visual Analog Scale (VAS)

Knee Osteoarthritis

Acceleration of Tooth Movement Using PRP and Photobiomodulation With Clear Aligners

NCT07795073Phase 1/2NOT_YET_RECRUITING
Sponsor

Sana'a University

Enrollment

42

Started

2026

Primary outcome

Rate of clinical tooth movement via intraoral digital scans

Orthodontic Tooth Movement

Subtenon Autologous Platelet-Rich Plasma in Inherited and Degenerative Retinal Diseases

NCT07341919Phase 1/2ACTIVE_NOT_RECRUITING
Sponsor

Rubens Camargo Siqueira

Enrollment

30

Started

2025

Primary outcome

Change in Field Preservation Deviation Index (FPDI)

Extensive Macular Atrophy With Pseudodrusen (EMAP)Retinitis Pigmentosa (RP)

A Study to Evaluate Platelet Rich Plasma to Treat Vulvar Lichen Sclerosus

NCT04967170Phase 1/2COMPLETED
Sponsor

Jennifer R. Arthurs

Enrollment

30

Started

2022

Primary outcome

Incidence of adverse events

Vulvar Lichen Sclerosus

Mesenchymal Stem Cells Enhanced With PRP Versus PRP In OA Knee

NCT01985633Phase 1/2UNKNOWN
Sponsor

Aditya K Aggarwal

Enrollment

24

Started

2013

Primary outcome

Pain relief

Osteoarthritis, Knee

Mesenchymal Stem Cell Therapy for Type 1 Diabetes Mellitus Patients

NCT03484741Phase 1/2UNKNOWN
Sponsor

Van Hanh General Hospital

Enrollment

15

Started

2017

Primary outcome

Fasting blood glucose

Type 1 Diabetes Mellitus

Combining Shockwave Therapy and Platelet Rich Plasma to Treat Erectile Dysfunction in Diabetic Men (COCKTAIL-DM)

NCT05525572Phase 1/2TERMINATED
Sponsor

University of Miami

Enrollment

2

Started

2024

Primary outcome

Markers of Vasodilation

Erectile Dysfunction With Diabetes Mellitus

Radiofrequency, Perineural Injection, Idiopathic Carpal Tunnel Syndrome

NCT05053477Phase 1UNKNOWN
Sponsor

Alexandria University

Enrollment

75

Started

2018

Primary outcome

Evaluate the role of pulsed radiofrequency versus platelet rich plasma injection in treatment of idiopathic mild to moderate carpal tunnel syndrome

Carpal Tunnel Syndrome

Treatment Outcome of Autologous PRP Versus Conventional Therapy Among Patients With Chronic Venous Leg Ulcers

NCT05974982Phase 1COMPLETED
Sponsor

Jinnah Postgraduate Medical Centre

Enrollment

48

Started

2022

Primary outcome

Complete healing

Venous Leg Ulcer

Intra-discal Injection of Platelet-rich Plasma (PRP) Enriched With Exosomes in Chronic Low Back Pain

NCT04849429Phase 1COMPLETED
Sponsor

Dr. Himanshu Bansal Foundation

Enrollment

30

Started

2021

Primary outcome

Visual analog scale (VAS)

Chronic Low Back PainDegenerative Disc Disease

Platelet Rich Plasma vs. Corticosteroid Injection in the Treatment of Partial Rotator Cuff Tears

NCT01688362Phase 1TERMINATED
Sponsor

University of North Carolina, Chapel Hill

Enrollment

12

Started

2012

Primary outcome

Percent change in Disabilities of the Arm, Shoulder, and Hand score. (DASH)

Rotator Cuff Tear

Use of PRP in Treatment of Mandibular Traumatic Bone Cyst

NCT01944410Phase 1COMPLETED
Sponsor

Shiraz University of Medical Sciences

Enrollment

12

Started

2013

Primary outcome

Fulfill bone cyst defect

Traumatic Bone Cyst

The Effect of Combination Therapy of Oral MB and PRP-FG in Patients With Non-healing Diabetic Foot Ulcer

NCT05850611Early Phase 1UNKNOWN
Sponsor

Mashhad University of Medical Sciences

Enrollment

20

Started

2023

Primary outcome

The healing rate of the ulcer

Diabetic Foot UlcersDiabetic Wound

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