Estrone

Naunyn-Schmiedeberg's archives of pharmacology · 2024

Researchers observed that estrone (E1), a form of estrogen, improved blood vessel function and reduced oxidative stress in ovariectomized rats, which mimic postmenopausal conditions. E1 treatment also helped lower body weight and cholesterol levels, suggesting potential benefits for cardiovascular health in postmenopausal women.

• E1 treatment decreased body weight and fat in ovariectomized rats.
• E1 improved blood vessel function and reduced oxidative stress.
• E1 helped lower cholesterol levels in the treated rats.

Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024

Researchers found that higher levels of estradiol (E2) and estrone (E1) are linked to lower volumes of white matter hyperintensities in the brains of midlife women, while higher levels of follicle-stimulating hormone (FSH) are associated with greater volumes. These findings highlight the significant role of reproductive hormones in women's brain health during midlife.

• Higher E2 and E1 levels are associated with lower white matter hyperintensity volumes.
• Higher FSH levels are linked to greater white matter hyperintensity volumes.
• The relationships between E1 and FSH with white matter hyperintensity volumes persist even when considering cardiovascular disease risk factors.

Ecotoxicology and environmental safety · 2024

Researchers found that a specific bacterium, Novosphingobium sp. ES2-1, can break down estriol, a natural estrogen that can pollute water and soil. They identified the products formed during this process using advanced laboratory techniques, contributing to our understanding of how bacteria can help in the degradation of potentially harmful substances in the environment.

• Novosphingobium sp. ES2-1 can metabolize estriol.
• The study identified the breakdown products of estriol.
• This research enhances knowledge of bacterial roles in environmental cleanup.

Aquatic toxicology (Amsterdam, Netherlands) · 2023

Researchers observed that exposure to estrone, a natural estrogen, significantly disrupted the endocrine system of western mosquitofish. High levels of estrone led to a complete female population and inhibited female growth, while lower levels caused male fish to develop female-like traits. Additionally, changes were noted in reproductive cell development and gene expression related to sex differentiation.

• High estrone exposure resulted in 100% female mosquitofish and stunted growth in females.
• Lower estrone levels caused males to develop female-like physical traits.
• Estrone exposure altered reproductive cell development and gene expression related to sex differentiation.

Applied and environmental microbiology · 2023

Researchers found that a specific bacterium, Microbacterium oxydans ML-6, can effectively break down estrone, a harmful chemical contaminating soil and water due to animal manure use. They identified a new set of genes involved in this degradation process, which could help develop better methods for cleaning up contaminated environments.

• Microbacterium oxydans ML-6 can efficiently degrade estrone.
• A new gene cluster related to estrone breakdown was discovered.
• This research could lead to improved bioremediation strategies for contaminated soils.

Environmental geochemistry and health · 2022

Researchers observed that estrone-3-sulfate (E1-3S) moves through soil more easily than estrone (E1), which raises concerns about its potential impact on groundwater. They also found that E1-3S can transform into other estrogen compounds in soil, highlighting the need to understand how these substances behave in the environment.

• E1-3S migrates more readily through soil compared to E1.
• E1-3S has a high potential to leach into groundwater.
• E1-3S can transform into other estrogen compounds in sterilized soil.

Anti-cancer agents in medicinal chemistry · 2009

Researchers observed that about 40% of breast cancers rely on the hormone estradiol, which is produced from estrone. They found that while current treatments target one enzyme to reduce estradiol, another enzyme, estrone sulfatase, also contributes to its production in tumors. This has led to the development of new inhibitors that could help in treating hormone-dependent breast cancer more effectively.

• Approximately 40% of breast cancers are hormone-dependent.
• Current treatments do not fully prevent estradiol production in tumors.
• New inhibitors targeting estrone sulfatase are being developed to improve treatment.

Breast cancer (Tokyo, Japan) · 2006

Researchers observed that certain enzymes in breast tumors, particularly 17beta-HSD type 1, play a crucial role in producing estrogens that can fuel cancer growth. They found that targeting these enzymes, along with aromatase, may offer new treatment options for breast cancer patients, especially postmenopausal women. The study highlights the variability of these enzymes in different patients, suggesting personalized approaches to therapy.

• 17beta-HSD type 1 is linked to increased estrogen levels in breast tumors.
• Inhibiting 17beta-HSD type 1 could reduce tumor growth by lowering estrogen.
• The presence of estrogen sulfotransferase (EST) is associated with better prognosis in breast cancer.

Domestic animal endocrinology · 1994

Researchers observed that when 17 beta-estradiol (E2) was introduced into the stomach of pigs, it was quickly converted into other forms before entering the bloodstream. They found that most of the E2 was metabolized in the stomach and liver, with significant levels of its metabolites detected in the blood. Additionally, the presence of gut bacteria influenced the absorption and metabolism of estrogens from bile.

• Most E2 was converted to other forms before entering the bloodstream.
• The stomach and liver play key roles in metabolizing estrogens.
• Gut bacteria affect the absorption and metabolism of estrogens from bile.

Maturitas · 1990

Researchers observed significant variations in hormone levels from both natural and synthetic steroids, influenced by how they are taken. They found that oral steroids affect liver metabolism more than other methods, and that different forms of estrogen and progestin have varying impacts on hormone activity and effectiveness.

• Oral steroids have a stronger effect on liver metabolism than other administration routes.
• Oestrone and oestradiol can convert into each other, but oestrone is a weaker estrogen.
• Different progestogens affect liver metabolism differently, with some being more potent at lower doses.