Skip to main content
PepStack

Finasteride

Hormone Management
PropeciaProscar5-alpha reductase inhibitor

Overview

Finasteride is a synthetic compound classified as a 5-alpha reductase inhibitor. It is not produced endogenously but is manufactured for medical use. Chemically, it belongs to the class of azasteroids and is primarily used in the management of conditions related to dihydrotestosterone (DHT) levels. Researchers have extensively studied its effects in the context of hormone management, particularly in conditions like benign prostatic hyperplasia (BPH) and androgenetic alopecia (male pattern baldness). Finasteride's primary physiological role is to inhibit the conversion of testosterone to dihydrotestosterone (DHT), a potent androgen involved in the development of male characteristics and conditions like prostate enlargement and hair loss. Researchers have found it effective in reducing prostate size and promoting hair regrowth in affected individuals. The mechanism of action of finasteride involves the selective inhibition of the type II 5-alpha reductase enzyme. This enzyme is responsible for converting testosterone into DHT, and its inhibition leads to decreased levels of DHT, thereby mitigating its effects on target tissues such as the prostate and hair follicles. Pharmacokinetically, finasteride has a half-life of approximately 5-6 hours. It is metabolized primarily in the liver and has an oral bioavailability of around 65%. Researchers have noted that its absorption is not significantly affected by food intake. Clinically, finasteride is used in the treatment of BPH and male pattern baldness. It is approved by regulatory agencies such as the FDA for these indications. The drug is generally well-tolerated, but researchers have observed potential side effects, including sexual dysfunction and mood changes. Its use is regulated and requires a prescription in many countries.

Mechanism of Action

Finasteride acts by inhibiting the type II 5-alpha reductase enzyme, which is responsible for converting testosterone into dihydrotestosterone (DHT). This inhibition leads to a decrease in DHT levels, reducing its effects on tissues such as the prostate and hair follicles, thereby alleviating symptoms of conditions like BPH and androgenetic alopecia.

Molecular Data

FormulaC23H36N2O2
Molecular Weight372.5 g/mol
CAS Number98319-26-7
PubChem CID57363

Half-Life & Pharmacokinetics

OralApproximately 5-6 hours

Finasteride is primarily administered orally, and its pharmacokinetics are not significantly affected by food intake.

Storage

Temperature

Store at room temperature (15-30°C)

Light

Protect from light

Form

Stable in tablet form

Notes

Keep in a dry place and ensure the container is tightly closed.

Solubility

Finasteride is poorly soluble in water but more soluble in organic solvents like ethanol.

Legal Status

🇩🇪DE

In Germany, finasteride is classified as a prescription medication (verschreibungspflichtig) and is not a controlled substance under BtMG.

🇺🇸US

In the USA, finasteride is FDA-approved for BPH and androgenetic alopecia and requires a prescription.

🇦🇺AU

In Australia, finasteride is classified as a Schedule 4 (S4) prescription-only medicine by the TGA.

🇬🇧UK

In the UK, finasteride is a prescription-only medicine (POM) regulated by the MHRA.

Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.

7 Research Publications

Risk of Depression Associated With Finasteride Treatment.

Meta-Analysis

Journal of clinical psychopharmacology

Researchers found that finasteride, a medication used for hair loss and prostate issues, may be linked to an increased risk of depression and suicidal thoughts. The study revealed that individuals taking finasteride experienced higher rates of depressive symptoms and sexual dysfunction, which could persist even after stopping the medication.

  • Depressive symptoms were reported in 3.33% of finasteride users compared to 2.54% of non-users.
  • The risk of suicidal thoughts was higher in finasteride users at 21.2% versus 14.0% in non-users.
  • About 60.1% of users experienced sustained sexual dysfunction.
PubMed

Topical Finasteride: A Comprehensive Review of Androgenetic Alopecia Management for Men and Women.

Review

Cureus · 2023

Researchers observed that androgenetic alopecia, or pattern hair loss, is common in both men and women and becomes more frequent with age. They found that topical finasteride may be a promising treatment option, showing early signs of safety and effectiveness, though more research is needed to fully understand its potential benefits and side effects.

  • Androgenetic alopecia affects many individuals and is challenging to treat.
  • Topical finasteride shows promise as a treatment option with early positive results.
  • More research is needed to determine optimal usage and potential side effects.
PubMed

Finasteride for hair loss: a review.

Review

The Journal of dermatological treatment · 2022

Researchers found that taking finasteride 1 mg daily can significantly increase hair count in men with male pattern baldness after 24 weeks compared to a placebo. The study also reviewed how finasteride works, its effects on the body, and potential side effects.

  • Finasteride 1 mg/day significantly increases total hair count after 24 weeks.
  • The review covers how finasteride functions and is processed in the body.
  • Potential side effects and post-marketing reports were also discussed.
PubMed

Topical finasteride for male and female pattern hair loss: Is it a safe and effective alternative?

Review

Journal of cosmetic dermatology · 2022

Researchers observed that topical finasteride, although not FDA-approved, may be a safe and effective alternative for treating male and female pattern hair loss. In a study, the results showed that topical finasteride spray was as effective as the oral version, with similar increases in hair growth over 24 weeks. This option could be beneficial for individuals worried about potential side effects from taking finasteride orally.

  • Topical finasteride may be a safer alternative to oral finasteride due to fewer systemic side effects.
  • In a study, topical finasteride spray showed similar effectiveness to oral finasteride in promoting hair growth.
  • The research included 32 relevant articles, indicating a growing interest in topical treatments for hair loss.
PubMed

Efficacy and safety of topical finasteride spray solution for male androgenetic alopecia: a phase III, randomized, controlled clinical trial.

Human

Journal of the European Academy of Dermatology and Venereology : JEADV · 2022

Researchers found that a topical finasteride spray significantly improved hair count in men with androgenetic alopecia compared to a placebo. The treatment was well tolerated and had lower systemic exposure compared to oral finasteride, reducing the likelihood of side effects related to sexual health.

  • Topical finasteride increased hair count more than placebo after 24 weeks.
  • The side effects of topical finasteride were similar to those of the placebo.
  • Topical finasteride had much lower levels of systemic exposure than oral finasteride.
PubMed

Comparitive effectiveness of finasteride vs Serenoa repens in male androgenetic alopecia: a two-year study.

Human

International journal of immunopathology and pharmacology · 2012

Researchers found that after two years, only 38% of men taking Serenoa repens experienced hair growth, compared to 68% of those taking finasteride. They observed that finasteride was more effective for men with moderate hair loss, particularly in both the front and top of the head, while Serenoa repens mainly improved hair growth at the top. Further research is needed to understand why these treatments have different effects.

  • 38% of patients on Serenoa repens saw hair growth.
  • 68% of patients on finasteride experienced improvement.
  • Finasteride was more effective for moderate alopecia, affecting both front and vertex areas.
PubMed

Finasteride in the treatment of men with androgenetic alopecia. Finasteride Male Pattern Hair Loss Study Group.

Human

Journal of the American Academy of Dermatology · 1998

Researchers found that finasteride, a medication taken daily, significantly improved hair growth and slowed hair loss in men with male pattern baldness over two years. The study involved 1,553 men, and results showed that those taking finasteride had a notable increase in hair count compared to those on a placebo.

  • Finasteride treatment led to a significant increase in hair count after one and two years.
  • Men taking finasteride reported improvements in hair growth and appearance.
  • Minimal adverse effects were noted during the study.
PubMed

Track your hormone research in PepStack

Log cycles, set reminders and visualize serum levels.

This page is for informational and research purposes only. All information is based on published scientific literature. Nothing on this page constitutes medical advice or replaces consultation with a qualified healthcare professional.