Insulin-like Growth Factor 1

Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024

Researchers observed that combining neural stem cells with a special gel containing insulin-like growth factor-1 (IGF-1) enhances the survival and growth of these cells after spinal cord injuries. This treatment not only promotes the regeneration of nerve fibers but also supports the healing of damaged areas in the spinal cord, suggesting a promising approach for improving recovery from such injuries.

• The IGF-1 gel helps prevent the death of neural stem cells and encourages their growth.
• This combination promotes the repair of nerve fibers and myelin in injured spinal cord areas.
• Extracellular vesicles from stem cells may aid in further regeneration and healing.

Biochemistry and cell biology = Biochimie et biologie cellulaire · 2023

Researchers observed that insulin-like growth factor-1 (IGF-1) plays a crucial role in bone growth after birth. They found that disruptions in IGF-1 signaling can lead to stunted growth in conditions like juvenile arthritis, while childhood obesity can cause accelerated growth but poorer bone quality.

• Dysregulated IGF-1 signaling can lead to growth stunting in autoimmune diseases.
• Childhood obesity accelerates growth but results in lower bone quality.
• Understanding IGF-1 signaling is important for addressing chronic diseases.

Revista clinica espanola · 2023

Researchers observed that various banned substances, including growth hormone and erythropoietin, are used by some professional athletes and gym-goers to enhance performance. The review highlights the prevalence, methods of use, and potential side effects of these substances, as well as the detection methods employed by anti-doping agencies.

• Growth hormone and related substances are commonly used to improve athletic performance.
• There are specific dosing practices and forms of use among athletes.
• The review discusses the side effects and detection methods for these banned substances.

JCI insight · 2023

Researchers observed that insulin-like growth factor 1 (IGF-1) significantly reduced coronary artery plaque in pigs with a genetic condition that raises cholesterol levels. The treatment not only decreased the size of the plaques but also made them more stable, which could be beneficial for heart health.

• IGF-1 decreased the amount of coronary atheroma in pigs.
• IGF-1 increased the thickness of the fibrous cap of plaques, making them more stable.
• IGF-1 reduced levels of triglycerides and markers of oxidative stress in the bloodstream.

Experimental and therapeutic medicine · 2022

Researchers observed that insulin-like growth factor-1 (IGF-1) may play a significant role in the development and treatment of bronchopulmonary dysplasia (BPD), a common lung condition in premature infants. They found that IGF-1 could help reduce lung inflammation and improve lung development in affected children, suggesting it as a potential new treatment target for BPD.

• IGF-1 promotes lung cell growth and development.
• IGF-1 can reduce inflammation and cell death in the lungs.
• There are no specific treatments for BPD currently, making IGF-1 a promising option.

Arthritis research & therapy · 2021

Researchers observed that insulin-like growth factor-1 (IGF-1) plays a significant role in repairing articular cartilage, which is important for treating osteoarthritis. They highlighted recent advancements in methods to deliver IGF-1 effectively, which could enhance its use in cartilage repair and improve treatment outcomes for osteoarthritis.

• IGF-1 promotes the growth and maintenance of cartilage cells.
• It helps in the production of cartilage matrix and prevents cell death.
• Optimized delivery systems for IGF-1 could improve treatment effectiveness for osteoarthritis.

Immunity · 2021

Researchers found that immune cells, specifically resident macrophages, play a crucial role in helping the heart adapt to stress caused by high blood pressure. They observed that the loss of insulin-like growth factor-1 (IGF-1) from these macrophages prevented the heart from growing and adapting properly, leading to dysfunction. This highlights the importance of macrophages in maintaining heart health under stress conditions.

• Resident macrophages are essential for heart adaptation to hypertension.
• Loss of IGF-1 from macrophages disrupts heart growth and function.
• A similar macrophage population expressing IGF-1 was identified in human heart disease.

International journal of molecular sciences · 2021

Researchers observed that insulin-like growth factor 1 (IGF-1) plays a significant role in how colorectal cancer cells process glucose, which may be linked to increased cancer risk in patients with metabolic syndrome. They highlighted the need for more understanding of the mechanisms involved and discussed potential treatments targeting glucose metabolism in colorectal cancer.

• Colorectal cancer risk is higher in patients with metabolic syndrome.
• High glycemic index diets may increase colon cancer risk through IGF-1 signaling.
• Current therapies are exploring ways to correct impaired glucose metabolism in colorectal cancer.

Cells · 2020

Researchers observed that insulin-like growth factor-1 (IGF-1) plays a crucial role in building and maintaining skeletal muscle by promoting protein synthesis and inhibiting muscle breakdown. They found that IGF-1 helps muscle regeneration and is affected by chronic diseases, which can lead to muscle loss.

• IGF-1 increases muscle protein synthesis through specific cellular pathways.
• IGF-1 can inhibit factors that contribute to muscle breakdown.
• Chronic diseases can lower IGF-1 levels, leading to muscle atrophy.

Journal of clinical medicine research · 2017

Researchers observed that cirrhosis, a severe liver condition, often leads to a deficiency of insulin-like growth factor-1 (IGF-1), which can worsen malnutrition and liver damage. They found that restoring IGF-1 levels may help improve the health of cirrhotic patients, suggesting a potential new treatment approach.

• Cirrhosis is a major global health issue and can be caused by various factors.
• IGF-1 deficiency is common in patients with cirrhosis and contributes to their worsening condition.
• Studies indicate that IGF-1 replacement may offer therapeutic benefits for cirrhotic patients.