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5-Amino-1MQ

Metabolic & Weight
5-Amino-1-methylquinolinium

Overview

5-Amino-1MQ, also known as 5-Amino-1-methylquinolinium, is a synthetic compound that belongs to the quinolinium class of chemicals. It is characterized by the presence of an amino group and a methyl group attached to a quinolinium core. The synthesis of 5-Amino-1MQ typically involves the methylation of quinoline derivatives, followed by the introduction of an amino group. This compound has gained attention in scientific research due to its potential metabolic effects. Researchers have primarily investigated 5-Amino-1MQ in the context of metabolic regulation and weight management. Studies have observed that it may influence metabolic pathways, potentially affecting energy expenditure and fat metabolism. These effects have prompted further exploration into its role in obesity and related metabolic disorders. The mechanism of action of 5-Amino-1MQ is thought to involve modulation of specific metabolic pathways. Researchers have found that it may interact with enzymes involved in cellular energy regulation, potentially influencing the activity of pathways related to fat metabolism. However, the precise molecular targets and pathways remain under investigation. Pharmacokinetic data on 5-Amino-1MQ is limited. Researchers have noted that its stability and bioavailability can vary depending on the route of administration. The compound's half-life and absorption characteristics are still being studied, with some reports suggesting variable bioavailability. Currently, 5-Amino-1MQ is primarily a subject of preclinical research. It has not been approved for therapeutic use by major regulatory agencies, and its safety profile in humans is not well-established. As such, it remains a compound of interest in the research community, with ongoing studies aimed at elucidating its potential applications and safety profile.

Mechanism of Action

5-Amino-1MQ is believed to modulate metabolic pathways by interacting with enzymes involved in cellular energy regulation. Researchers have suggested that it may influence the activity of pathways related to fat metabolism, although the exact molecular targets are still under investigation.

Half-Life

IntranasalNot applicable
OralPoor bioavailability

Pharmacokinetic data is limited and under investigation.

Storage

Lyophilized

Stable for 2+ years at -20°C, 12 months at 4°C

Reconstituted

Use within 14 days when refrigerated at 4°C

Avoid

Avoid repeated freeze-thaw cycles, direct light

Solvent

Bacteriostatic water or sterile saline recommended

Solubility

5-Amino-1MQ is soluble in DMSO and water, with varying solubility in other solvents.

Legal Status

🇩🇪DE

Not approved as a medicinal product. Not a controlled substance. Sale as research chemical is a legal grey area.

🇺🇸US

Not approved by the FDA. Not scheduled by the DEA.

🇦🇺AU

Not listed in the TGA scheduling.

🇬🇧UK

Not approved by the MHRA. Not a controlled substance.

Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.

3 Research Publications

NAD

Human

Journal for immunotherapy of cancer · 2024

Researchers investigated the role of a protein called NNMT in bladder cancer and how it affects tumor growth and response to treatment. They found that higher levels of NNMT are linked to worse outcomes for patients with bladder cancer, suggesting it plays a significant role in the disease's progression.

  • Researchers observed that elevated NNMT expression is associated with poorer clinical outcomes in bladder cancer patients.
  • The study found that NNMT in cancer-associated fibroblasts influences tumor progression.
  • Researchers demonstrated that NNMT may contribute to resistance against immunotherapy in bladder cancer.
PubMed

Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice.

Animal

Scientific reports · 2022

Researchers found that a low-calorie diet combined with a specific treatment altered the gut microbiome of obese mice, leading to significant weight loss and changes in fat composition. This combination was more effective than diet alone in normalizing these measures to those of lean mice.

  • DIO mice on a low-fat diet with NNMT inhibition lost weight and fat more effectively than those on a diet alone.
  • The gut microbiomes of treated obese mice showed distinct patterns compared to both untreated obese mice and lean controls.
  • Specific gut bacteria, such as Lactobacillus and Erysipelatoclostridium, were linked to changes in body weight and metabolism.
PubMed

Small molecule inhibitor of nicotinamide N-methyltransferase shows anti-proliferative activity in HeLa cells.

In Vitro

Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology · 2021

Researchers investigated the effects of a compound called 5-methylquinolinium (5MQ) on cervical cancer cells. They found that 5MQ, which inhibits a specific enzyme linked to tumor growth, reduced the viability of HeLa cells, suggesting potential anti-cancer properties.

  • Researchers observed that 5MQ inhibits the enzyme nicotinamide N-methyltransferase (NNMT), which is associated with cancer progression.
  • The study tested various concentrations of 5MQ on HeLa cervical cancer cells.
  • Results indicated that 5MQ has anti-proliferative effects, reducing the growth of these cancer cells.
PubMed

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This page is for informational and research purposes only. All information is based on published scientific literature. Nothing on this page constitutes medical advice or replaces consultation with a qualified healthcare professional.