Enclomiphene

Archives of endocrinology and metabolism · 2025

Researchers evaluated the effectiveness of clomiphene and enclomiphene, medications known as selective estrogen receptor modulators (SERMs), in men with low testosterone levels. They found that SERM therapy significantly increased testosterone, luteinizing hormone, and follicle-stimulating hormone levels compared to a placebo, suggesting it could be a viable alternative to testosterone gel.

• SERM therapy led to a significant increase in total testosterone levels compared to placebo.
• SERM therapy also improved luteinizing hormone and follicle-stimulating hormone levels compared to placebo.
• There was no significant difference in testosterone levels between SERM therapy and testosterone gel.

Translational andrology and urology · 2024

Researchers studied the effects of two medications, clomiphene and its isomer enclomiphene, on testosterone levels in men with low testosterone. They found that enclomiphene significantly increased testosterone levels while also having fewer reported side effects compared to clomiphene.

• Enclomiphene resulted in a median testosterone increase of 166.
• Enclomiphene was associated with a lower rate of adverse events compared to clomiphene.
• The study suggests enclomiphene as a viable treatment option for men with hypogonadism.

Andrology · 2023

Researchers found that selective estrogen receptor modulators, specifically clomiphene and enclomiphene citrate, can significantly increase testosterone levels in obese men with androgen deficiency. This study suggests these medications may be a safe alternative to traditional testosterone replacement therapy. However, further long-term research is needed to better understand their effects and safety.

• Researchers observed a significant increase in testosterone levels among men treated with clomiphene and enclomiphene citrate.
• The study included data from seven studies involving 292 men with obesity-related functional androgen deficiency.
• Further long-term studies are needed to clarify the safety profile and clinical implications of these treatments.

Cureus · 2023

Researchers compared the effects of two medications, clomiphene citrate (CC) and enclomiphene citrate (EC), on testosterone levels and semen quality in men facing infertility and low testosterone. The study aimed to identify which medication might be more effective for improving these conditions.

• Researchers observed that both CC and EC were used to manage male infertility and hypogonadism.
• The study analyzed hormone levels and semen parameters in men treated with either medication over a three-month period.
• Findings indicated differences in the effectiveness of CC and EC, although specific results were not detailed in the abstract.

Expert review of endocrinology & metabolism · 2019

Researchers studied enclomiphene citrate, a selective estrogen receptor modulator, as a potential treatment for men with secondary hypogonadism. They found that enclomiphene can increase testosterone levels while preserving fertility, unlike traditional testosterone treatments that may suppress fertility.

• Researchers observed that enclomiphene increases testosterone levels in men with secondary hypogonadism.
• The study highlighted that enclomiphene stimulates the production of hormones FSH and LH, which are important for fertility.
• Initial findings suggest that enclomiphene provides the benefits of clomiphene citrate without the negative effects associated with its other isomer, zuclomiphene.

Expert opinion on pharmacotherapy · 2016

Researchers observed that enclomiphene citrate, a medication traditionally used for women's fertility issues, may effectively increase testosterone levels in men with secondary hypogonadism. This treatment raises hormones that stimulate testosterone production without harming fertility, making it a potential alternative for men who cannot use traditional testosterone therapy.

• Enclomiphene citrate raises testosterone levels by increasing luteinizing hormone (LH) and follicle stimulating hormone (FSH).
• The treatment does not negatively affect semen quality, preserving male fertility.
• This study suggests enclomiphene citrate could be a viable option for men with testosterone deficiency who are concerned about fertility.

BJU international · 2013

Researchers studied the effects of enclomiphene citrate, an oral medication, on testosterone levels in men with secondary hypogonadism, comparing it to transdermal testosterone. They found that enclomiphene citrate significantly increased testosterone and luteinizing hormone levels, maintaining these effects even after treatment stopped.

• Enclomiphene citrate consistently raised testosterone levels into the normal range after six weeks of use.
• Both enclomiphene citrate and transdermal testosterone increased testosterone levels, but they affected other hormones differently.
• The effects of enclomiphene citrate on testosterone and luteinizing hormone persisted for at least one week after stopping treatment.

IDrugs : the investigational drugs journal · 2009

Researchers studied enclomiphene, a drug that may help increase testosterone levels in men with low testosterone due to secondary hypogonadism. They found that enclomiphene effectively restores testosterone levels while maintaining testicular health and may also improve blood sugar levels.

• Enclomiphene significantly increased testosterone levels in men with secondary hypogonadism during clinical trials.
• The drug showed a favorable effect on fasting plasma glucose levels.
• Short-term safety data for enclomiphene were comparable to testosterone gels and placebo.