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Epithalon

Anti-Aging & Longevity
EpitalonEpithalaminAla-Glu-Asp-Gly

Overview

Epithalon, also known as Epitalon, Epithalamin, or Ala-Glu-Asp-Gly, is a synthetic tetrapeptide derived from the naturally occurring pineal gland peptide epithalamin. It consists of four amino acids: alanine, glutamic acid, aspartic acid, and glycine. Researchers synthesize Epithalon to mimic the effects of epithalamin, which is believed to play a role in regulating the body's aging processes. The compound is categorized under anti-aging and longevity research due to its potential effects on cellular aging and lifespan extension. Researchers have primarily investigated Epithalon in the context of its potential to modulate telomerase activity, which is an enzyme responsible for maintaining telomere length. Telomeres are protective caps on the ends of chromosomes that shorten with age, and their maintenance is associated with cellular longevity. Studies have also explored its effects on oxidative stress, immune function, and circadian rhythm regulation. The mechanism of action of Epithalon is thought to involve the upregulation of telomerase activity, thereby promoting telomere elongation and cellular longevity. It may also interact with various signaling pathways involved in stress response and cellular repair. However, the precise molecular targets and pathways remain under investigation. Pharmacokinetic data on Epithalon is limited, but researchers have noted its relatively short half-life, suggesting rapid metabolism and clearance from the body. Its stability and bioavailability may vary depending on the route of administration, with subcutaneous and intramuscular routes being more commonly studied. Current research on Epithalon is ongoing, with studies primarily in preclinical or early clinical stages. It is not approved as a medicinal product in many regions, and its use is largely confined to research settings. Regulatory standing varies by country, and it is often considered a research chemical rather than a therapeutic agent.

Mechanism of Action

Epithalon is believed to exert its effects primarily through the upregulation of telomerase activity, which helps maintain telomere length and promote cellular longevity. It may also interact with signaling pathways involved in oxidative stress response and circadian rhythm regulation, although these mechanisms are still under investigation.

Molecular Data

FormulaC14H22N4O9
Molecular Weight390.35 g/mol
CAS Number307297-39-8
PubChem CID219042

Half-Life

OralPoor bioavailability

Pharmacokinetic data is limited, and the compound is rapidly metabolized.

Storage

Lyophilized

Stable for 2+ years at -20°C, 12 months at 4°C

Reconstituted

Use within 14 days when refrigerated at 4°C

Avoid

Avoid repeated freeze-thaw cycles, direct light

Solvent

Bacteriostatic water or sterile saline recommended

Solubility

Epithalon is soluble in water and aqueous solutions.

Legal Status

🇩🇪DE

Not approved as a medicinal product. Not a controlled substance. Sale as research chemical is a legal grey area.

🇺🇸US

Not approved by the FDA as a medicinal product. Not scheduled by the DEA.

🇦🇺AU

Not approved by the TGA. Considered a research chemical.

🇬🇧UK

Not approved by the MHRA. Considered a research chemical.

Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.

6 Research Publications

Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity.

In Vitro

Biogerontology · 2025

Researchers found that Epitalon, a natural peptide, can increase telomere length in human cells, which is linked to aging and longevity. The study observed that this effect occurs through the activation of telomerase in normal cells and through a different mechanism in cancer cells.

  • Epitalon increases telomere length in normal human cells by promoting telomerase enzyme activity.
  • In breast cancer cells, telomere length is extended through a process called Alternative Lengthening of Telomeres (ALT).
  • The study highlights the potential of Epitalon as a tool for studying telomere dynamics in various cell types.
PubMed

The Antioxidant Tetrapeptide Epitalon Enhances Delayed Wound Healing in an in Vitro Model of Diabetic Retinopathy.

In Vitro

Stem cell reviews and reports · 2025

Researchers observed that the antioxidant tetrapeptide Epitalon can improve delayed wound healing in cells affected by high glucose levels, which is relevant for diabetic retinopathy. The study suggests that Epitalon may counteract harmful changes in retinal cells caused by diabetes.

  • High glucose levels delayed wound healing in retinal cells and increased harmful reactive oxygen species.
  • Epitalon improved wound healing by inhibiting changes associated with fibrosis and cell transition linked to diabetes.
  • The findings indicate that Epitalon could be a promising treatment strategy for enhancing retinal healing in diabetic retinopathy.
PubMed

Epitalon protects against post-ovulatory aging-related damage of mouse oocytes

Unknown

Aging · 2022

Researchers studied the effects of a substance called Epitalon on mouse oocytes, which are the cells involved in reproduction. They found that Epitalon may protect these cells from damage that occurs after ovulation, potentially preserving their ability to develop over time.

  • Researchers observed that the developmental potential of oocytes decreases after ovulation.
  • The study found that Epitalon may help protect against this aging-related damage.
  • These findings suggest a possible way to maintain oocyte health in the context of reproductive aging.
PubMed

Epithalon decelerates aging and suppresses development of breast adenocarcinomas in transgenic her-2/neu mice.

Animal

Bulletin of experimental biology and medicine · 2002

Researchers found that a peptide called Epithalon can extend the lifespan of mice genetically predisposed to breast cancer. The study observed that Epithalon not only slowed down the aging process but also significantly reduced the development of breast tumors and metastases in these mice.

  • Epithalon increased the average lifespan of the mice by 13.5%.
  • The incidence of breast adenocarcinomas was reduced by 1.6 times, and the number of mice without breast tumors increased by 3.7 times.
  • Mice with breast tumors lived 1.4 times longer when treated with Epithalon.
PubMed

[Aging of the pineal gland].

Animal

Advances in gerontology = Uspekhi gerontologii · 2002

Researchers studied the aging of the pineal gland in animals and found that changes are more functional than structural, suggesting they can be corrected. They observed that dietary restrictions and certain compounds could improve melatonin production and other functions of the gland in older animals.

  • Researchers found that age-related changes in the pineal gland can be functionally improved rather than being permanent.
  • The synthetic peptide Epithalon significantly increased melatonin levels in older rhesus monkeys.
  • Epithalon also showed potential benefits in extending lifespan and delaying vision loss in other animal models.
PubMed

Modulating effects of epithalamin and epithalon on the functional morphology of the spleen in old pinealectomized rats.

Animal

Bulletin of experimental biology and medicine · 2001

Researchers observed the effects of two peptides, epithalamin and epithalon, on the spleen's structure and function in older rats that had their pineal glands removed. The study found that both peptides helped maintain normal spleen function by preventing excessive growth of certain immune cells and reducing blood cell production outside the bone marrow.

  • Researchers found that epithalamin and epithalon prevented the overgrowth of lymphoid cells in the spleen.
  • The study observed a reduction in extramedullary hemopoiesis, which is the production of blood cells outside the bone marrow.
  • These findings highlight the relationship between the pineal gland and the immune system in older rats.
PubMed

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This page is for informational and research purposes only. All information is based on published scientific literature. Nothing on this page constitutes medical advice or replaces consultation with a qualified healthcare professional.