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Pinealon

Nootropic & CNS
Ala-Glu-AspEDR tripeptide

Overview

Pinealon, also known as Ala-Glu-Asp or EDR tripeptide, is a synthetic peptide composed of three amino acids: alanine, glutamic acid, and aspartic acid. It is categorized as a nootropic compound, primarily investigated for its potential effects on the central nervous system (CNS). Pinealon is synthesized through standard peptide synthesis techniques, which involve the sequential addition of protected amino acids to form the desired tripeptide structure. Researchers have shown interest in Pinealon due to its potential neuroprotective and cognitive-enhancing properties. Studies have explored its effects on memory, learning, and overall brain function. Pinealon has been observed to exhibit antioxidant properties, which may contribute to its neuroprotective effects. Additionally, it has been investigated for its potential role in reducing oxidative stress and modulating neuronal activity. The mechanism of action of Pinealon is not fully understood, but it is believed to interact with cellular pathways involved in oxidative stress and apoptosis. Researchers have suggested that Pinealon may influence the expression of genes related to cell survival and neuroprotection. Its effects on mitochondrial function and cellular energy metabolism have also been subjects of investigation. Pharmacokinetic data on Pinealon is limited. Researchers have noted that its stability and bioavailability can vary depending on the route of administration. The half-life of Pinealon is not well-documented, and further studies are needed to elucidate its pharmacokinetic profile. Currently, Pinealon is primarily a subject of preclinical research, with limited clinical trials conducted. It is not approved as a medicinal product in most jurisdictions, and its regulatory status varies by country. Researchers continue to investigate its potential therapeutic applications, but it remains largely experimental at this stage.

Mechanism of Action

Pinealon is thought to exert its effects by modulating pathways related to oxidative stress and apoptosis. It may influence mitochondrial function and gene expression associated with cell survival, contributing to its neuroprotective properties.

Molecular Data

FormulaC15H26N6O8
Molecular Weight418.4 g/mol
CAS Number175175-23-2
PubChem CID10273502

Half-Life

OralPoor bioavailability

Pharmacokinetic data on Pinealon is limited, and further research is needed to determine its half-life and bioavailability across different administration routes.

Storage

Lyophilized

Stable for 2+ years at -20°C, 12 months at 4°C

Reconstituted

Use within 14 days when refrigerated at 4°C

Avoid

Avoid repeated freeze-thaw cycles, direct light

Solvent

Bacteriostatic water or sterile saline recommended

Solubility

Pinealon is soluble in water and aqueous solutions.

Legal Status

🇩🇪DE

Not approved as a medicinal product. Not a controlled substance. Sale as research chemical is a legal grey area.

🇺🇸US

Not approved by the FDA. Not scheduled by the DEA.

🇦🇺AU

Not listed in the TGA schedules.

🇬🇧UK

Not approved as a medicinal product by the MHRA.

Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.

6 Research Publications

[Comparative analysis of different methods of geroprotective].

Human

Advances in gerontology = Uspekhi gerontologii · 2016

Researchers studied the effects of various anti-aging methods on 110 people of different ages. They found that combining two specific oligopeptide treatments had the most significant positive impact on biological age, while therapeutic massage and oligopeptides were the safest options. However, dry carbon dioxide baths and hyperbaric oxygen therapy, although beneficial, had certain safety limitations.

  • The combined use of two oligopeptide complexes showed the most pronounced positive effects on biological age.
  • Therapeutic massage and oligopeptide drugs were found to be the safest methods regarding biochemical and clinical parameters.
  • Dry carbon dioxide baths and hyperbaric oxygen therapy had positive effects but also presented safety concerns and limitations.
PubMed

[EFFECT OF SYNTHETIC PEPTIDES ON AGING OF PATIENTS WITH CHRONIC POLYMORBIDITY AND ORGANIC BRAIN SYNDROME OF THE CENTRAL NERVOUS SYSTEM IN REMISSION].

Human

Advances in gerontology = Uspekhi gerontologii · 2015

Researchers studied the effects of two synthetic peptides, Vesugen and Pinealon, on aging in older adults with complex health issues. They found that these peptides improved central nervous system activity and slowed biological aging, with Vesugen showing more significant effects than Pinealon.

  • Both Vesugen and Pinealon demonstrated significant positive effects on the central nervous system and vital organs.
  • Vesugen was found to have a more pronounced effect on slowing biological aging compared to Pinealon.
  • The peptides did not impact the genetic material in cells, suggesting they are safe for use at the nuclear level.
PubMed

Pinealon protects the rat offspring from prenatal hyperhomocysteinemia.

Animal

International journal of clinical and experimental medicine · 2012

Researchers studied the effects of a compound called pinealon on the offspring of pregnant rats exposed to high levels of homocysteine. They found that pinealon improved cognitive function and made brain cells more resilient to stress, suggesting potential protective benefits for brain development in challenging prenatal conditions.

  • Pinealon significantly improved cognitive function in rat offspring exposed to prenatal hyperhomocysteinemia.
  • The compound enhanced the resilience of cerebellum neurons to oxidative stress.
  • Offspring showed better spatial orientation and learning abilities, along with reduced cell damage in the brain.
PubMed

[Analysis of some parameters of biological age and adaptation possibilities of workers of locomotive brigades].

Unknown

Advances in gerontology = Uspekhi gerontologii · 2012

Researchers studied the effects of the peptide bioregulator Pinealon on the biological age and adaptability of locomotive brigade workers. They found that using Pinealon for two weeks improved workers' biological age parameters and their ability to adapt to the demands of their job.

  • Pinealon positively influenced the biological age of locomotive brigade workers.
  • The use of Pinealon enhanced the effectiveness of adaptive reactions in these workers.
  • The study suggests that Pinealon may help maintain professional reliability among locomotive brigade workers.
PubMed

Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA.

Unknown

Biochemistry. Biokhimiia · 2011

Researchers observed that certain short peptides can enter animal cells and their nuclei, potentially interacting with DNA and RNA. The study found that these peptides specifically bind to different DNA sequences, indicating their role in regulating gene activity.

  • Peptides labeled with fluorescence were able to penetrate HeLa cells, highlighting their ability to enter cell nuclei.
  • Different peptides showed varying effects on the fluorescence of DNA, suggesting specific interactions with nucleic acids.
  • Some peptides preferentially bind to DNA sequences associated with cytosine methylation, which may influence gene regulation.
PubMed

Pinealon increases cell viability by suppression of free radical levels and activating proliferative processes.

Unknown

Rejuvenation research · 2011

Researchers found that the synthetic tripeptide pinealon can reduce harmful free radicals in certain brain and immune cells, leading to increased cell survival. Additionally, they observed that pinealon influences the cell cycle, suggesting it interacts with genetic material. This study highlights pinealon's potential protective effects against oxidative stress.

  • Pinealon reduces the accumulation of reactive oxygen species (ROS) in various cell types.
  • The compound decreases necrotic cell death in tested cells.
  • Pinealon affects the cell cycle, indicating a direct interaction with the cell genome.
PubMed

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This page is for informational and research purposes only. All information is based on published scientific literature. Nothing on this page constitutes medical advice or replaces consultation with a qualified healthcare professional.