Selank

Cardiovascular research · 2023

Researchers studied how atrial fibrillation (AF) affects heart cell function using human heart cells created from stem cells. They found that mimicking AF conditions led to significant changes in electrical activity and heart cell behavior, which could help in developing new treatments for AF.

• Researchers observed that electrical pacing mimicking AF conditions caused decreased calcium current and impaired potassium current in heart cells.
• The study found that long-term pacing resulted in changes such as increased potassium current and altered heart cell contractility.
• Researchers successfully modeled AF-associated changes in heart cells, providing a new platform for discovering potential antiarrhythmic therapies.

Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2020

Researchers studied the effects of two substances, Selank and Semax, on brain connectivity in healthy individuals. They found that these substances influenced how different regions of the brain communicate, particularly between areas involved in anxiety regulation and executive functions.

• Researchers observed changes in brain connectivity between the right amygdala and several regions in the right temporal cortex after administration of Selank and Semax.
• The study identified both general and specific effects of Selank and Semax on brain connectivity for the first time.
• Functional connectivity was assessed using resting-state fMRI before and after injections of the substances.

Bulletin of experimental biology and medicine · 2019

Researchers studied the effects of Selank on liver changes in rats exposed to chronic stress. They found that Selank reduced the harmful effects of stress on liver cells, particularly at a specific dose, helping to restore normal cell structure.

• Chronic foot-shock stress caused significant damage to liver cells in rats.
• Selank reduced the severity of stress-induced liver damage across all tested doses.
• The most effective dose of Selank for protecting liver cells was 300 μg/kg.

Dalton transactions (Cambridge, England : 2003) · 2019

Researchers studied the reactions of a specific molybdenum compound with various metal complexes to create new isoselenocarbonyl compounds. They successfully produced and characterized several new derivatives, including those involving ruthenium and iron. This research contributes to the understanding of complex metal interactions and their potential applications in chemistry.

• Researchers found that reactions with ruthenium complexes led to the formation of new molybdenum-ruthenium derivatives.
• The study successfully characterized a new hydrido-isoselenocarbonyl complex involving molybdenum and ruthenium.
• A molybdenum-iron derivative was obtained, although its formulation is based on spectroscopic data.

Current medicinal chemistry · 2017

Researchers reviewed the properties of tuftsin, a peptide that can modulate the immune system, and its derivatives. They found that these substances have potential anti-tumor, anti-inflammatory, and antimicrobial effects, with many showing promise for use in vaccines.

• The review included 86 documents, highlighting tuftsin's significant biological activities.
• Thirty-two studies focused on tuftsin's effects in humans, while others explored its analogs' properties.
• Many tuftsin derivatives demonstrated potential in cancer treatment and as components of vaccines.

Frontiers in pharmacology · 2017

Researchers studied the effects of GABA, Selank, and Olanzapine on gene expression related to GABA neurotransmission in human cells. They found that Selank has an anxiolytic effect similar to traditional anti-anxiety medications by enhancing GABA's inhibitory action.

• Selank showed an anxiolytic effect comparable to classical benzodiazepines.
• GABA and Selank influence gene expression related to GABAergic neurotransmission.
• Olanzapine also affects the expression of these genes in the studied cells.

Frontiers in pharmacology · 2016

Researchers studied the effects of Selank, a compound similar to benzodiazepines, on gene expression related to neurotransmission in rats. They found that Selank significantly altered the expression of several genes involved in brain signaling, indicating its complex effects on nerve cells.

• Researchers observed significant changes in the expression of 45 genes one hour after administering Selank or GABA.
• Three hours post-administration, 22 genes showed altered expression.
• The study found a positive correlation in gene expression changes between Selank and GABA within the first hour.

Bioorganicheskaia khimiia · 2008

Researchers studied how two peptides, Pro-Gly-Pro and Selanc, distribute in rat organs when administered through different methods. They found that intranasal delivery was the most effective for reaching the central nervous system, while all methods showed a strong accumulation of these peptides in gastric tissues.

• Intranasal administration was the most effective route for delivering glyproline peptides to the central nervous system.
• All administration methods resulted in high concentrations of glyprolines in gastric tissues.
• The accumulation of glyprolines in the stomach may contribute to their effectiveness in influencing gastric health.

Vestnik Rossiiskoi akademii meditsinskikh nauk · 2007

Researchers studied how opioids, which are known to affect anxiety levels, work differently for individuals. They found that variations in opioid receptors and the balance of natural opioid peptides in the body contribute to this difference. This research suggests that adjusting the opioid system with specific peptide drugs could offer new ways to address certain anxiety disorders.

• Researchers observed that the effectiveness of synthetic opioids on anxiety varies based on the desensitization of opioid receptors in the brain.
• The study found that the anxiolytic effects of the peptide Selanc are more pronounced in individuals with higher levels of enzymes that break down natural opioids.
• The research indicates that fine-tuning the opioid system may provide a new approach for treating anxiety disorders, especially generalized anxiety disorder.