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Blutwerte · Marker

Wachstumshormon

Growth Hormone · HGH · GH · Somatotropin

Hormone — GH/IGF-AchseNüchtern erforderlichZeitabhängig
Einheit:
ng/mL
Abbreviation
GH / HGH

Growth Hormone test quantifies the level of growth hormone in the blood, reflecting pituitary gland function and overall growth regulation.

Reference Ranges

Reference
0.410ng/mL
0.4
10
LowNormalHigh
Reference
Unit · ng/mL

GH levels vary with age, sex, and time of day. Levels are typically higher in children and adolescents.

Overview

Übersicht

Growth Hormone (GH), also known as Human Growth Hormone (HGH), is a peptide hormone that stimulates growth, cell reproduction, and regeneration in humans. It is synthesized and secreted by the somatotropic cells of the anterior pituitary gland and plays a crucial role in promoting linear growth in children and adolescents. GH exerts its effects directly and indirectly through the production of insulin-like growth factor 1 (IGF-1) in the liver and other tissues. Clinically, GH is important for diagnosing and managing growth disorders in children, such as idiopathic short stature and growth hormone deficiency. In adults, GH levels can reflect pituitary function and are involved in metabolic processes, including the regulation of body composition, bone density, and lipid metabolism. Abnormal GH levels can indicate pituitary tumors, acromegaly, or GH deficiency. In the context of athletic performance and biohacking, GH is often discussed for its potential to enhance muscle mass and reduce fat. However, its use is controversial due to potential side effects and legal restrictions. In longevity research, reduced GH signaling has been associated with increased lifespan in animal models, though the implications for humans are less clear. Measurement of GH can be confounded by factors such as time of day, fasting status, and exercise. GH secretion follows a pulsatile pattern, with peaks occurring during sleep, making timing crucial for accurate assessment. Fasting is generally required to minimize variability, and interfering factors such as stress and acute illness can skew results.

Klinische Bedeutung

Elevated GH levels may indicate acromegaly or pituitary adenomas, while reduced levels can suggest growth hormone deficiency or hypopituitarism. GH levels are also assessed in the context of growth disorders in children.

Dynamics

Trend Interpretation

Rising Values

Progressively rising GH levels may indicate pituitary adenoma or acromegaly. Re-test in 4-6 weeks if levels are unexpectedly high.

Falling Values

Progressively falling GH levels could suggest pituitary dysfunction or aging.

Re-test Interval

4 weeks if outside optimal range

Etiology

Causes — High & Low

Cause

Elevated Levels

  • Acromegaly
  • Pituitary adenoma
  • Stress
  • Exercise
  • Hypoglycemia
  • Renal failure
Cause

Low Levels

  • Growth hormone deficiency
  • Hypopituitarism
  • Chronic kidney disease
  • Malnutrition
  • Aging
  • Hypothyroidism
Protocol

How to Optimize

Lever

Lifestyle

  • Regular exercise
  • Adequate sleep
  • Stress management
Lever

Nutrition

  • Balanced diet
  • Adequate protein intake
Lever

Supplementation

  • Arginine
  • Glutamine

Note:

Consult a healthcare provider before making significant changes to GH levels, especially if considering supplementation.

Testing Guidelines

🍽️Fasting Required
🕐Time-Sensitive

GH is secreted in pulses, with peaks during sleep; morning fasting levels are often used for assessment.

Testing Frequency

Annually if monitoring growth disorders; more frequently if under treatment.

Interfering Factors

  • Recent intense exercise
  • Acute illness
  • Stress

Related Markers

Related Peptides & Hormones

Igf 1

Correlated with

hormone

Open Research Questions

Current research suggests that the optimal timing and dosing of growth hormone therapy in various genetic contexts, particularly in RASopathies, remain debated, with unclear effects on final height. Researchers have not yet established standardized reference ranges for growth hormone measurements due to assay discrepancies and confounding factors like GH binding proteins. Additionally, clinical questions regarding the long-term impacts of GH therapy on quality of life and health outcomes in aging populations remain unanswered.

24 Research Publications

1,622

Total Citations

4.5

Avg. Influence

2023

Latest

Sort
#01

Evaluation of pretest clinical score (4 T's) for the diagnosis of heparin-induced thrombocytopenia in two clinical settings.

UnknownInfluence31.0
955
This study evaluated a clinical scoring system for diagnosing heparin-induced thrombocytopenia (HIT). Researchers found that low scores were effective in ruling out HIT, while higher scores correlated with positive HIT antibody tests in different clinical settings.
View on PubMed
#02

Growth Hormone and Aging: Updated Review.

ReviewInfluence4.0
110
This review explored the role of growth hormone in aging. Researchers found that the decline in growth hormone levels is associated with various aging symptoms and that its absence can extend longevity in laboratory mice. However, the potential of growth hormone as an anti-aging agent has shown limited benefits and significant side effects.
View on PubMed
#03

Laboratory measurement of growth hormone.

ReviewInfluence7.0
98
This review addressed the complexities of measuring growth hormone in clinical settings. Researchers found that different assays can yield varying results due to the heterogeneous nature of growth hormone, emphasizing the need for standardized measurement strategies to improve diagnostic accuracy.
View on PubMed
#04

Ghrelin and cancer progression.

ReviewInfluence4.0
78
This review discussed the multifaceted role of ghrelin in cancer progression. Researchers observed that ghrelin regulates various physiological processes and may influence cancer metastasis and proliferation. The study highlights the potential pathological implications of ghrelin in cancer outcomes.
View on PubMed
#05

Iatrogenic Alzheimer's disease in recipients of cadaveric pituitary-derived growth hormone.

Case ReportInfluence2.0
77
This study reported on the potential link between cadaver-derived growth hormone and Alzheimer's disease. Researchers found evidence suggesting that recipients of this hormone may develop dementia and biomarker changes associated with Alzheimer's, highlighting the need for preventive measures.
View on PubMed
#06

Insulin and Growth Hormone Balance: Implications for Obesity.

ReviewInfluence1.0
70
This review summarized the hormonal balance between insulin and growth hormone in obesity. Researchers found that disruptions in this balance can affect metabolism and energy storage, proposing the insulin-to-growth hormone ratio as a potential biomarker for obesity risk.
View on PubMed
#07

Growth hormone deficiency in children.

ReviewInfluence1.0
46
This study focused on diagnosing growth hormone deficiency in children. Researchers found that assessing growth patterns against established norms is crucial, and highlighted the variability in growth hormone assay results, which can impact diagnosis.
View on PubMed
#08

The Use and Abuse of Human Growth Hormone in Sports.

ReviewInfluence2.0
43
This review addressed the use of recombinant human growth hormone in sports. Researchers found that while it has therapeutic benefits for those with growth hormone deficiency, its use in healthy athletes raises concerns about health risks and fairness in competition.
View on PubMed
#09

Growth hormone replacement in adults - current standards and new perspectives.

ReviewInfluence1.0
37
This review discussed the current standards and perspectives on growth hormone replacement in adults with growth hormone deficiency (GHD). Researchers found that GH treatment can improve body composition and quality of life, though long-term effects on mortality and cardiovascular events remain to be established.
View on PubMed
#10

Growth Hormone Therapy in Heart Failure.

Review
22
This article examined the impact of growth hormone deficiency in chronic heart failure. Researchers found that while animal studies show potential benefits of growth hormone therapy, clinical results have been inconsistent, warranting further investigation.
View on PubMed

Publication Trend

Research publications about Wachstumshormon over time

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This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer