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Argireline

Acetyl Hexapeptide-3 · Acetyl Hexapeptide-8

Anti-Aging & SkinPhase III
From$1.01/mgCompare prices
MW
887g/mol
Formula
C35H62N14O11S

Argireline, also known as acetyl hexapeptide-8, is a synthetic peptide derived from the N-terminal sequence of the protein SNAP-25, classified as a cosmeceutical agent. Researchers primarily study it for its anti-wrinkle effects, positioning it as a non-toxic alternative to botulinum neurotoxin (Botox). Key findings from various studies indicate that Argireline can significantly reduce wrinkle depth and improve skin histology by enhancing collagen production while inhibiting neurotransmitter release at the neuromuscular junction. Current research status shows a growing interest in Argireline, with evidence supporting its efficacy and safety in cosmetic applications, leading to its increasing popularity among consumers seeking accessible anti-aging solutions.

Chemical Profile

Chemical Profile

Chemical structure
Chemical Structure
FormulaC35H62N14O11S
Molecular Weight887 g/mol
CAS Number616204-22-9
PubChem CID71587772

Half-Life

INIntranasal

Not applicable

POOral

Poor bioavailability

Primarily used topically; systemic pharmacokinetics are not well-documented.

Mechanism

Mechanism of Action

Argireline, a synthetic hexapeptide, mimics the action of botulinum neurotoxin by inhibiting the release of neurotransmitters at the neuromuscular junction, primarily through interference with the SNARE complex involved in Ca²⁺-dependent exocytosis. This inhibition affects synaptic signaling, leading to reduced muscle contraction and wrinkle formation. The exact receptors and downstream signaling pathways involved in Argireline's action remain to be fully elucidated.

Research

22 Research Publications

515

Total Citations

10

Human/RCT

2.2

Avg. Influence

2025

Latest

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#01

A synthetic hexapeptide (Argireline) with antiwrinkle activity.

Blanes-Mira C, et al. · International journal of cosmetic science · 2002

UnknownInfluence6.0
180
Researchers observed that Argireline significantly reduced wrinkle depth by up to 30% in healthy women after 30 days of treatment, mimicking the action of botulinum neurotoxin without toxicity.

Key findings

  1. 01Argireline reduced wrinkle depth by up to 30% after 30 days of use.
  2. 02The peptide inhibits neurotransmitter release, mimicking the action of botulinum toxins.
  3. 03Argireline showed no oral toxicity or skin irritation at high doses.
10%topical(human)30 daystwice dailytopical(human)4 weeks10%topical(human)not mentioned1 mLtopical(not mentioned)not mentioned0.125%topical(zebrafish)not mentioned
PubMed
#02

Enhanced Skin Permeation of Anti-wrinkle Peptides via Molecular Modification.

HumanInfluence3.0
57
Researchers observed that modifications to Argireline enhanced its skin permeation and wrinkle reduction efficacy, with Arg3 showing the most effectiveness.
10%topical(human)30 daystwice dailytopical(human)4 weeks10%topical(human)not mentioned1 mLtopical(not mentioned)not mentioned0.125%topical(zebrafish)not mentioned
PubMed
#03

The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study.

Wang Yuan, et al. · American journal of clinical dermatology · 2013

HumanInfluence1.0
57
The study demonstrated that Argireline significantly reduced peri-orbital wrinkles in Chinese subjects, achieving a 48.9% efficacy compared to placebo.

Key findings

  1. 01The anti-wrinkle efficacy of argireline was 48.9% in the treatment group, while the placebo group showed no improvement.
  2. 02Objective measurements indicated a significant decrease in skin roughness in the argireline group.
  3. 03This study highlights the effectiveness of argireline in reducing wrinkles specifically in Chinese subjects.
10%topical(human)30 daystwice dailytopical(human)4 weeks10%topical(human)not mentioned1 mLtopical(not mentioned)not mentioned0.125%topical(zebrafish)not mentioned
PubMed
#04

Preparation and stability of cosmetic formulations with an anti-aging peptide.

Human
42
Researchers observed that the stability of cosmetic formulations containing Argireline varies between emulsion and gel forms, which were evaluated through laboratory analyses and in vitro release assays.
10%topical(human)30 daystwice dailytopical(human)4 weeks10%topical(human)not mentioned1 mLtopical(not mentioned)not mentioned0.125%topical(zebrafish)not mentioned
PubMed
#05

The anti-wrinkle efficacy of Argireline.

AnimalInfluence1.0
33
Researchers observed that Argireline improved the histological structure of aged mouse skin, increasing type I collagen and decreasing type III collagen after 6 weeks of treatment.
10%topical(human)30 daystwice dailytopical(human)4 weeks10%topical(human)not mentioned1 mLtopical(not mentioned)not mentioned0.125%topical(zebrafish)not mentioned
PubMed
#06

Iontophoretic skin permeation of peptides: an investigation into the influence of molecular properties, iontophoretic conditions and formulation parameters.

UnknownInfluence1.0
30
The study demonstrated that iontophoresis can enhance the transdermal permeation of Argireline and other peptides by up to 30 times compared to passive delivery, influenced by various molecular and formulation parameters.
10%topical(human)30 daystwice dailytopical(human)4 weeks10%topical(human)not mentioned1 mLtopical(not mentioned)not mentioned0.125%topical(zebrafish)not mentioned
PubMed
#07

The study of cellular cytotoxicity of argireline - an anti-aging peptide.

Human
28
Researchers observed dose-dependent anti-proliferation effects of Argireline on human cell lines, with significant cytotoxicity at concentrations much higher than doxorubicin.
10%topical(human)30 daystwice dailytopical(human)4 weeks10%topical(human)not mentioned1 mLtopical(not mentioned)not mentioned0.125%topical(zebrafish)not mentioned
PubMed
#08

3D-bioengineered model of human skeletal muscle tissue with phenotypic features of aging for drug testing purposes.

Human
23
Researchers observed that Argireline amplified the effects of aging in a 3D bioengineered muscle model, demonstrating its potential applications in cosmetics and biomedicine.
10%topical(human)30 daystwice dailytopical(human)4 weeks10%topical(human)not mentioned1 mLtopical(not mentioned)not mentioned0.125%topical(zebrafish)not mentioned
PubMed
#09

Cosmeceuticals in photoaging: A review.

Chan Lisa Kwin Wah, et al. · Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024

Review
20
The study demonstrated that topical cosmeceuticals, particularly peptides like Argireline, show strong efficacy in treating photodamaged skin.

Key findings

  1. 01The evidence supporting the effectiveness of these cosmeceuticals is generally high, with most studies rated between Level I and Level II.
  2. 02Peptides showed the strongest evidence, with many studies achieving Level Ib status.
  3. 03Common ingredients like azelaic acid, green tea, and aloe vera were included in the review as effective options for photodamaged skin.
10%topical(human)30 daystwice dailytopical(human)4 weeks10%topical(human)not mentioned1 mLtopical(not mentioned)not mentioned0.125%topical(zebrafish)not mentioned
PubMed
#10

Public Interest in Acetyl Hexapeptide-8: Longitudinal Analysis.

Olsson Sofia Eva, et al. · JMIR dermatology · 2024

Unknown
10
The study demonstrated a significant increase in public interest for Argireline, particularly in 2022, highlighting its appeal as a cost-effective alternative to Botox.

Key findings

  1. 01Search interest in Argireline surged in 2022, indicating growing public awareness.
  2. 02Despite the increase, Argireline remains less searched than Botox, which has consistently high interest.
  3. 03The rise in interest may be attributed to Argireline's affordability and ease of use as an alternative to Botox.
10%topical(human)30 daystwice dailytopical(human)4 weeks10%topical(human)not mentioned1 mLtopical(not mentioned)not mentioned0.125%topical(zebrafish)not mentioned
PubMed
Safety

Safety & Handling

Research Gaps

No long-term human trials have been conducted to assess the sustained efficacy and safety of Argireline beyond the initial treatment periods reported. Additionally, the precise molecular mechanisms by which Argireline influences collagen synthesis and skin histology remain unclear, particularly regarding its effects on different skin types and conditions.

Solubility

Argireline is soluble in water and shows limited solubility in organic solvents like DMSO.

Storage & Handling

Lyophilized

Stable for 2+ years at -20°C, 12 months at 4°C

Reconstituted

Use within 14 days when refrigerated at 4°C

Avoid

Avoid repeated freeze-thaw cycles, direct light

Solvent

Bacteriostatic water or sterile saline recommended

Safety information is derived from published research and may not reflect all known risks. This is not medical advice.

Legal Status

Legal Status

🇩🇪DE

Not approved as a medicinal product. Not a controlled substance. Sale as a cosmetic ingredient is permitted.

🇺🇸US

Not approved by the FDA as a drug. Used in cosmetics under the regulation of the FDA.

🇦🇺AU

Not scheduled by the TGA. Used in cosmetics.

🇬🇧UK

Not classified as a medicinal product by the MHRA. Permitted in cosmetic formulations.

Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.

Community Insights

Community Insights

Publications per Year

18 total
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Pricing

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Mechanism

Tools

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Mechanism

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Legal Disclaimer

This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer