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Argireline

Acetyl Hexapeptide-3 · Acetyl Hexapeptide-8

Anti-Aging & SkinPhase III
From$0.22/mgCompare prices
MW
887g/mol
Formula
C35H62N14O11S

Argireline, also known as acetyl hexapeptide-8, is a synthetic peptide derived from the N-terminal end of the protein SNAP-25, classified as a neuromodulating agent. Researchers primarily study it for its potential anti-wrinkle effects, positioning it as a non-invasive alternative to botulinum neurotoxin treatments. Key findings from various studies indicate that Argireline can significantly reduce the appearance of facial wrinkles and improve the histological structure of skin by enhancing collagen production. Additionally, preclinical evidence suggests that Argireline possesses a strong affinity for copper ions, which may influence its efficacy in cosmetic applications. Current research continues to explore its mechanisms of action and potential derivatives to enhance its properties in skincare formulations.

Chemical Profile

Chemical Profile

Chemical structure
Chemical Structure
FormulaC35H62N14O11S
Molecular Weight887 g/mol
CAS Number616204-22-9
PubChem CID71587772

Half-Life

INIntranasal

Not applicable

POOral

Poor bioavailability

Primarily used topically; systemic pharmacokinetics are not well-documented.

Mechanism

Mechanism of Action

Argireline (Acetyl Hexapeptide-8) mimics a fragment of SNAP-25, inhibiting the release of neurotransmitters at the neuromuscular junction, thereby reducing muscle contractions and producing a botulinum toxin-like effect. This action likely involves modulation of the SNARE complex, impacting synaptic vesicle fusion and neurotransmitter release, although the precise receptors and downstream signaling pathways remain to be fully elucidated. Additionally, Argireline has been shown to enhance collagen synthesis and improve skin histology, indicating its role in promoting skin rejuvenation and potentially influencing pathways related to extracellular matrix remodeling.

Research

20 Research Publications

481

Total Citations

9

Human/RCT

2.0

Avg. Influence

2025

Latest

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#01

A synthetic hexapeptide (Argireline) with antiwrinkle activity.

Blanes-Mira C, et al. · International journal of cosmetic science · 2002

In VitroInfluence6.0
171
Researchers observed that Argireline reduced wrinkle depth by up to 30% after 30 days of treatment, demonstrating its efficacy as a non-toxic alternative to botulinum toxins.

Key findings

  1. 01Argireline reduced wrinkle depth by up to 30% after 30 days of use.
  2. 02The peptide inhibits neurotransmitter release, mimicking the action of botulinum toxins.
  3. 03Argireline showed no oral toxicity or skin irritation at high doses.
PubMed
#02

The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study.

Wang Yuan, et al. · American journal of clinical dermatology · 2013

HumanInfluence1.0
54
Researchers observed a 48.9% reduction in peri-orbital wrinkles in Chinese subjects treated with Argireline compared to no improvement in the placebo group.

Key findings

  1. 01The anti-wrinkle efficacy of argireline was 48.9% in the treatment group, while the placebo group showed no improvement.
  2. 02Objective measurements indicated a significant decrease in skin roughness in the argireline group.
  3. 03This study highlights the effectiveness of argireline in reducing wrinkles specifically in Chinese subjects.
PubMed
#03

Enhanced Skin Permeation of Anti-wrinkle Peptides via Molecular Modification.

In VitroInfluence2.0
53
Researchers observed enhanced skin permeation and wrinkle reduction efficacy of modified Argireline analogues compared to the original peptide.
PubMed
#04

Preparation and stability of cosmetic formulations with an anti-aging peptide.

In Vitro
42
Researchers observed the stability of cosmetic formulations containing Argireline, confirming its potential for effective anti-aging treatments.
PubMed
#05

The anti-wrinkle efficacy of Argireline.

AnimalInfluence1.0
31
Researchers observed that Argireline significantly improved the histological structure of skin tissue in aged mice, increasing type I collagen while decreasing type III collagen.
PubMed
#06

Iontophoretic skin permeation of peptides: an investigation into the influence of molecular properties, iontophoretic conditions and formulation parameters.

In VitroInfluence1.0
28
The study demonstrated that iontophoresis can significantly enhance the transdermal permeation of peptides, including Argireline, by up to 30 times compared to passive methods, influenced by various molecular and formulation parameters.
PubMed
#07

The study of cellular cytotoxicity of argireline - an anti-aging peptide.

In Vitro
27
Researchers observed dose-dependent anti-proliferation effects of Argireline on various human cell lines, indicating its potential cytotoxicity at high concentrations.
PubMed
#08

3D-bioengineered model of human skeletal muscle tissue with phenotypic features of aging for drug testing purposes.

In Vitro
19
Researchers observed that the 3D-bioengineered human muscle model could effectively assess the effects of Argireline on muscle relaxation in aging tissue.
PubMed
#09

Cosmeceuticals in photoaging: A review.

Chan Lisa Kwin Wah, et al. · Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024

Review
17
Researchers observed that topical cosmeceuticals, particularly peptides like Argireline, have strong evidence supporting their efficacy in treating photodamaged skin.

Key findings

  1. 01The evidence supporting the effectiveness of these cosmeceuticals is generally high, with most studies rated between Level I and Level II.
  2. 02Peptides showed the strongest evidence, with many studies achieving Level Ib status.
  3. 03Common ingredients like azelaic acid, green tea, and aloe vera were included in the review as effective options for photodamaged skin.
PubMed
#10

Public Interest in Acetyl Hexapeptide-8: Longitudinal Analysis.

Olsson Sofia Eva, et al. · JMIR dermatology · 2024

In Vitro
8
Researchers observed a significant increase in public interest for Argireline, particularly in 2022, indicating its potential as a cost-effective alternative to Botox.

Key findings

  1. 01Search interest in Argireline surged in 2022, indicating growing public awareness.
  2. 02Despite the increase, Argireline remains less searched than Botox, which has consistently high interest.
  3. 03The rise in interest may be attributed to Argireline's affordability and ease of use as an alternative to Botox.
PubMed
Safety

Safety & Handling

Research Gaps

No extensive randomized controlled trials in diverse human populations have been published to validate the efficacy and safety of Argireline over the long term. Additionally, the precise molecular mechanisms by which Argireline exerts its anti-wrinkle effects, particularly in relation to neurotransmitter release and skin collagen dynamics, remain inadequately understood.

Solubility

Argireline is soluble in water and shows limited solubility in organic solvents like DMSO.

Storage & Handling

Lyophilized

Stable for 2+ years at -20°C, 12 months at 4°C

Reconstituted

Use within 14 days when refrigerated at 4°C

Avoid

Avoid repeated freeze-thaw cycles, direct light

Solvent

Bacteriostatic water or sterile saline recommended

Safety information is derived from published research and may not reflect all known risks. This is not medical advice.

Legal Status

Legal Status

🇩🇪DE

Not approved as a medicinal product. Not a controlled substance. Sale as a cosmetic ingredient is permitted.

🇺🇸US

Not approved by the FDA as a drug. Used in cosmetics under the regulation of the FDA.

🇦🇺AU

Not scheduled by the TGA. Used in cosmetics.

🇬🇧UK

Not classified as a medicinal product by the MHRA. Permitted in cosmetic formulations.

Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.

Community Insights

Community Insights

Publications per Year

16 total
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Pricing

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Mechanism

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Mechanism

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Legal Disclaimer

This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer