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Argireline

Acetyl Hexapeptide-3 · Acetyl Hexapeptide-8

Anti-Aging & SkinPhase III
From$1.01/mgCompare prices
MW
887g/mol
Formula
C35H62N14O11S

Argireline, also known as acetyl hexapeptide-8, is a synthetic peptide derived from the N-terminal end of the protein SNAP-25. Researchers primarily study it for its potential antiwrinkle effects, particularly as a non-toxic alternative to botulinum neurotoxin (Botox). Key findings from various studies indicate that Argireline can significantly reduce wrinkle depth and improve skin histology by enhancing collagen structure in aged skin. Additionally, studies suggest that it functions by inhibiting neurotransmitter release at the neuromuscular junction, mimicking the effects of Botox without the associated risks. Current research continues to explore its efficacy and stability in cosmetic formulations, highlighting its growing popularity in the field of dermatology.

Chemical Profile

Chemical Profile

Chemical structure
Chemical Structure
FormulaC35H62N14O11S
Molecular Weight887 g/mol
CAS Number616204-22-9
PubChem CID71587772

Half-Life

INIntranasal

Not applicable

POOral

Poor bioavailability

Primarily used topically; systemic pharmacokinetics are not well-documented.

Mechanism

Mechanism of Action

Argireline, a synthetic hexapeptide, mimics the action of botulinum neurotoxin by inhibiting the release of neurotransmitters at the neuromuscular junction, primarily through interference with the SNARE complex involved in Ca²⁺-dependent exocytosis. This inhibition leads to a reduction in muscle contraction, thereby decreasing wrinkle formation and promoting skin rejuvenation. While the precise signaling pathways remain to be fully elucidated, the peptide's effects on collagen synthesis and skin histology suggest involvement in pathways related to extracellular matrix remodeling and cellular signaling associated with skin aging.

Research

21 Research Publications

491

Total Citations

9

Human/RCT

2.2

Avg. Influence

2025

Latest

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#01

A synthetic hexapeptide (Argireline) with antiwrinkle activity.

Blanes-Mira C, et al. · International journal of cosmetic science · 2002

In VitroInfluence6.0
175
Researchers observed that the synthetic hexapeptide Argireline significantly reduced wrinkle depth by up to 30% over 30 days, mimicking the action of botulinum neurotoxin without the associated toxicity.

Key findings

  1. 01Argireline reduced wrinkle depth by up to 30% after 30 days of use.
  2. 02The peptide inhibits neurotransmitter release, mimicking the action of botulinum toxins.
  3. 03Argireline showed no oral toxicity or skin irritation at high doses.
PubMed
#02

The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study.

Wang Yuan, et al. · American journal of clinical dermatology · 2013

HumanInfluence1.0
55
The study demonstrated that Argireline significantly reduced peri-orbital wrinkles in Chinese subjects, achieving a 48.9% improvement compared to placebo.

Key findings

  1. 01The anti-wrinkle efficacy of argireline was 48.9% in the treatment group, while the placebo group showed no improvement.
  2. 02Objective measurements indicated a significant decrease in skin roughness in the argireline group.
  3. 03This study highlights the effectiveness of argireline in reducing wrinkles specifically in Chinese subjects.
PubMed
#03

Enhanced Skin Permeation of Anti-wrinkle Peptides via Molecular Modification.

In VitroInfluence3.0
54
The study demonstrated that modifications to Argireline enhanced its skin permeation and anti-wrinkle efficacy, with Arg3 showing the highest effectiveness in reducing wrinkle formation.
PubMed
#04

Preparation and stability of cosmetic formulations with an anti-aging peptide.

In Vitro
42
Researchers observed that two stable cosmetic formulations containing Argireline were developed, demonstrating the potential of acetyl hexapeptide-8 for anti-aging applications in skin care.
PubMed
#05

The anti-wrinkle efficacy of Argireline.

AnimalInfluence1.0
31
The study demonstrated that Argireline improved the histological structure of aged mouse skin, increasing type I collagen fibers and decreasing type III collagen fibers.
PubMed
#06

Iontophoretic skin permeation of peptides: an investigation into the influence of molecular properties, iontophoretic conditions and formulation parameters.

In VitroInfluence1.0
28
The study demonstrated that iontophoresis significantly enhanced the transdermal permeation of Argireline and other peptides, with up to a 30-fold increase compared to passive permeation in human skin.
PubMed
#07

The study of cellular cytotoxicity of argireline - an anti-aging peptide.

In Vitro
27
Researchers observed dose-dependent anti-proliferation effects of Argireline in various human cell lines, indicating significant cytotoxicity at higher concentrations compared to doxorubicin.
PubMed
#08

3D-bioengineered model of human skeletal muscle tissue with phenotypic features of aging for drug testing purposes.

In Vitro
21
Researchers observed that Argireline amplified peptide effects in a 3D-bioengineered human muscle model, indicating its potential for cosmetic applications in aging muscle tissue.
PubMed
#09

Cosmeceuticals in photoaging: A review.

Chan Lisa Kwin Wah, et al. · Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024

Review
17
The study demonstrated that topical cosmeceuticals, particularly peptides like Argireline, show strong efficacy in treating photodamaged skin based on high-quality evidence.

Key findings

  1. 01The evidence supporting the effectiveness of these cosmeceuticals is generally high, with most studies rated between Level I and Level II.
  2. 02Peptides showed the strongest evidence, with many studies achieving Level Ib status.
  3. 03Common ingredients like azelaic acid, green tea, and aloe vera were included in the review as effective options for photodamaged skin.
PubMed
#10

Public Interest in Acetyl Hexapeptide-8: Longitudinal Analysis.

Olsson Sofia Eva, et al. · JMIR dermatology · 2024

In Vitro
8
The study demonstrated a significant increase in public interest in Argireline, particularly in 2022, indicating its growing popularity as a cost-effective alternative to Botox.

Key findings

  1. 01Search interest in Argireline surged in 2022, indicating growing public awareness.
  2. 02Despite the increase, Argireline remains less searched than Botox, which has consistently high interest.
  3. 03The rise in interest may be attributed to Argireline's affordability and ease of use as an alternative to Botox.
PubMed
Safety

Safety & Handling

Research Gaps

No long-term human trials have been conducted to assess the sustained efficacy and safety of Argireline beyond the initial treatment periods. Additionally, the precise molecular mechanisms by which Argireline influences collagen synthesis and skin histology remain inadequately defined, particularly in diverse populations outside of the studied cohorts.

Solubility

Argireline is soluble in water and shows limited solubility in organic solvents like DMSO.

Storage & Handling

Lyophilized

Stable for 2+ years at -20°C, 12 months at 4°C

Reconstituted

Use within 14 days when refrigerated at 4°C

Avoid

Avoid repeated freeze-thaw cycles, direct light

Solvent

Bacteriostatic water or sterile saline recommended

Safety information is derived from published research and may not reflect all known risks. This is not medical advice.

Legal Status

Legal Status

🇩🇪DE

Not approved as a medicinal product. Not a controlled substance. Sale as a cosmetic ingredient is permitted.

🇺🇸US

Not approved by the FDA as a drug. Used in cosmetics under the regulation of the FDA.

🇦🇺AU

Not scheduled by the TGA. Used in cosmetics.

🇬🇧UK

Not classified as a medicinal product by the MHRA. Permitted in cosmetic formulations.

Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.

Community Insights

Community Insights

Publications per Year

17 total
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Pricing

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Mechanism

Tools

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Mechanism

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Legal Disclaimer

This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer