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Collagen Peptides

Hydrolyzed Collagen · Collagen Hydrolysate

Anti-Aging & SkinPreclinical
From$2.28/mgCompare prices

Collagen peptides are bioactive fragments derived from collagen, the most abundant protein in the human body, primarily sourced from animal connective tissues. Researchers primarily study these peptides for their potential benefits in skin health, bone density, muscle recovery, and joint function. Key findings from clinical studies indicate that specific collagen peptides can significantly reduce skin wrinkles and enhance dermal matrix synthesis, as well as improve bone mineral density in postmenopausal women. Additionally, evidence suggests that collagen peptide supplementation may aid in muscle recovery and reduce pain in active adults. Current research continues to explore the diverse applications and mechanisms of collagen peptides in various health contexts.

Chemical Profile

Chemical Profile

Half-Life

INIntranasal

Not applicable

POOral

Moderate bioavailability

Oral administration is the most common route, with peptides rapidly absorbed and distributed.

Mechanism

Mechanism of Action

Collagen peptides are believed to exert their effects through the activation of specific receptors on fibroblasts and osteoblasts, leading to the stimulation of signaling pathways such as the TGF-β and Wnt/β-catenin pathways, which promote collagen and elastin synthesis in the dermis and bone formation, respectively. Additionally, collagen peptides may enhance the production of glycosaminoglycans and improve skin hydration by modulating the extracellular matrix. However, the precise molecular mechanisms and receptor interactions remain to be fully elucidated.

Research

83 Research Publications

3,227

Total Citations

27

Human/RCT

4.3

Avg. Influence

2023

Latest

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#01

Identification of food-derived collagen peptides in human blood after oral ingestion of gelatin hydrolysates.

In VitroInfluence19.0
383
The study demonstrated that food-derived collagen peptides were identified in human blood after oral ingestion of gelatin hydrolysates, indicating their bioavailability.
2.5 goral(human)8 weeks5 goral(human)12 months10 g/doral(human)3-9 months20 g/doral(human)3-9 months2.5 goral(human)8 weeks5 goral(human)84 days5 goral(human)12 weeks500 mg/kgoral(mouse)6 weeks1000 mg/kgoral(mouse)6 weeks1,650 mg/dayoral(human)8 weeks
PubMed
#02

Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study.

Proksch E, et al. · Skin pharmacology and physiology · 2014

HumanInfluence19.0
232
The study demonstrated that oral supplementation of collagen hydrolysate improved skin elasticity and moisture in human participants aged 35-55 years.

Key findings

  1. 01Skin elasticity improved significantly in women taking collagen peptides compared to those on a placebo.
  2. 02Positive effects on skin moisture and evaporation were noted, although they were not statistically significant.
  3. 03No side effects were reported during the study.
2.5 goral(human)8 weeks5 goral(human)12 months10 g/doral(human)3-9 months20 g/doral(human)3-9 months2.5 goral(human)8 weeks5 goral(human)84 days5 goral(human)12 weeks500 mg/kgoral(mouse)6 weeks1000 mg/kgoral(mouse)6 weeks1,650 mg/dayoral(human)8 weeks
PubMed
#03

The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials.

HumanInfluence10.0
231
The study demonstrated that oral collagen peptide supplementation significantly improved skin hydration and reduced collagen network fragmentation in human participants.
2.5 goral(human)8 weeks5 goral(human)12 months10 g/doral(human)3-9 months20 g/doral(human)3-9 months2.5 goral(human)8 weeks5 goral(human)84 days5 goral(human)12 weeks500 mg/kgoral(mouse)6 weeks1000 mg/kgoral(mouse)6 weeks1,650 mg/dayoral(human)8 weeks
PubMed
#04

Preparation of low-molecular-weight, collagen hydrolysates (peptides): Current progress, challenges, and future perspectives.

ReviewInfluence8.0
206
The review summarized that low-molecular-weight collagen hydrolysates derived from food processing byproducts have significant bioactivities but face challenges in preparation due to their structural properties.
2.5 goral(human)8 weeks5 goral(human)12 months10 g/doral(human)3-9 months20 g/doral(human)3-9 months2.5 goral(human)8 weeks5 goral(human)84 days5 goral(human)12 weeks500 mg/kgoral(mouse)6 weeks1000 mg/kgoral(mouse)6 weeks1,650 mg/dayoral(human)8 weeks
PubMed
#05

Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis.

HumanInfluence10.0
172
The study demonstrated that oral intake of specific bioactive collagen peptides significantly reduced eye wrinkle volume and increased dermal matrix synthesis in human participants aged 45-65 years.
2.5 goral(human)8 weeks5 goral(human)12 months10 g/doral(human)3-9 months20 g/doral(human)3-9 months2.5 goral(human)8 weeks5 goral(human)84 days5 goral(human)12 weeks500 mg/kgoral(mouse)6 weeks1000 mg/kgoral(mouse)6 weeks1,650 mg/dayoral(human)8 weeks
PubMed
#06

What is the role of peptide fragments of collagen I and IV in health and disease?

ReviewInfluence6.0
139
The review discussed the regulatory roles of collagen peptides in cellular processes and their impact on health and disease through ECM remodeling.
2.5 goral(human)8 weeks5 goral(human)12 months10 g/doral(human)3-9 months20 g/doral(human)3-9 months2.5 goral(human)8 weeks5 goral(human)84 days5 goral(human)12 weeks500 mg/kgoral(mouse)6 weeks1000 mg/kgoral(mouse)6 weeks1,650 mg/dayoral(human)8 weeks
PubMed
#07

Exploration of collagen recovered from animal by-products as a precursor of bioactive peptides: Successes and challenges.

ReviewInfluence8.0
136
The review discussed the potential of collagen peptides derived from animal by-products as bioactive ingredients with various health benefits, while also addressing the challenges in their development for functional foods.
2.5 goral(human)8 weeks5 goral(human)12 months10 g/doral(human)3-9 months20 g/doral(human)3-9 months2.5 goral(human)8 weeks5 goral(human)84 days5 goral(human)12 weeks500 mg/kgoral(mouse)6 weeks1000 mg/kgoral(mouse)6 weeks1,650 mg/dayoral(human)8 weeks
PubMed
#08

Specific Collagen Peptides Improve Bone Mineral Density and Bone Markers in Postmenopausal Women-A Randomized Controlled Study.

HumanInfluence3.0
129
Researchers observed that daily oral administration of specific collagen peptides increased bone mineral density and positively shifted bone markers in postmenopausal women.
2.5 goral(human)8 weeks5 goral(human)12 months10 g/doral(human)3-9 months20 g/doral(human)3-9 months2.5 goral(human)8 weeks5 goral(human)84 days5 goral(human)12 weeks500 mg/kgoral(mouse)6 weeks1000 mg/kgoral(mouse)6 weeks1,650 mg/dayoral(human)8 weeks
PubMed
#09

Ingestion of bioactive collagen hydrolysates enhance facial skin moisture and elasticity and reduce facial ageing signs in a randomised double-blind placebo-controlled clinical study.

HumanInfluence3.0
112
Researchers observed that collagen hydrolysate with higher bioactive peptide content significantly improved facial skin moisture, elasticity, and reduced wrinkles compared to a placebo.
2.5 goral(human)8 weeks5 goral(human)12 months10 g/doral(human)3-9 months20 g/doral(human)3-9 months2.5 goral(human)8 weeks5 goral(human)84 days5 goral(human)12 weeks500 mg/kgoral(mouse)6 weeks1000 mg/kgoral(mouse)6 weeks1,650 mg/dayoral(human)8 weeks
PubMed
#10

Recognition and catabolism of synthetic heterotrimeric collagen peptides by matrix metalloproteinases.

In VitroInfluence5.0
104
Researchers observed that synthetic heterotrimeric collagen peptides effectively mimic natural collagen and gelatin, revealing distinct proteolytic mechanisms of matrix metalloproteinases during digestion.
2.5 goral(human)8 weeks10 g/doral(human)6 months2.5 goral(human)8 weeks5 goral(human)84 days1,650 mg/dayoral(human)8 weeks500 mg/kgoral(mouse)6 weeks1,000 mg/kgoral(mouse)6 weeks
PubMed
Safety

Safety & Handling

Research Gaps

While several studies have demonstrated the short-term benefits of collagen peptide supplementation on skin health, bone density, and muscle recovery, there is a lack of long-term clinical trials specifically examining the sustained effects and safety of these supplements in diverse populations. Additionally, the precise biological mechanisms by which collagen peptides exert their effects on muscle recovery and pain management remain unclear, warranting further investigation to elucidate these pathways.

Solubility

Collagen peptides are highly soluble in water.

Storage & Handling

Lyophilized

Stable for 2+ years at -20°C, 12 months at 4°C

Reconstituted

Use within 14 days when refrigerated at 4°C

Avoid

Avoid repeated freeze-thaw cycles, direct light

Solvent

Bacteriostatic water or sterile saline recommended

Safety information is derived from published research and may not reflect all known risks. This is not medical advice.

Legal Status

Legal Status

🇩🇪DE

Not approved as a medicinal product. Not a controlled substance. Sale as a dietary supplement is permitted.

🇺🇸US

Recognized as a dietary supplement by the FDA. Not a controlled substance.

🇦🇺AU

Listed as a complementary medicine by the TGA. Not a controlled substance.

🇬🇧UK

Recognized as a food supplement by the MHRA. Not a controlled substance.

Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.

Community Insights

Community Insights

Publications per Year

50 total
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Pricing

Price Comparison

  • BESTcrownwellresearch.comUS
    20mg
    $45.60
    Price/mg
    $2.28/mg
    View
  • Verified PeptidesUS
    20mg
    $55.00
    Price/mg
    $2.75/mg
    View
  • BioLongevity LabsUS
    20mg
    $79.97
    $67.97
    Price/mg
    $4.00$3.40/mg
    View−15% · PEPSTACK
  • Umbrella LabsUS
    10mg
    $39.99
    Price/mg
    $4.00/mg
    View
  • Behemoth LabzUS
    20mg
    —
    Price/mg
    —
    View

Top 5 of 10 offers from 7 vendors. Prices updated daily.

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Mechanism

Tools

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Mechanism

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Legal Disclaimer

This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer