Wiki · Profile

Collagen Peptides

Hydrolyzed Collagen · Collagen Hydrolysate

Anti-Aging & SkinPreclinical

Collagen peptides are bioactive fragments derived from collagen, the most abundant protein in the human body, primarily sourced from animal connective tissues. Researchers primarily study collagen peptides for their potential benefits in enhancing connective tissue recovery, improving skin health, and supporting bone density. Key findings indicate that collagen peptide supplementation may reduce pain and improve function in active adults, while also promoting dermal matrix synthesis and reducing skin wrinkles in aging populations. Additionally, studies suggest that specific collagen peptides can positively influence bone mineral density and markers of bone formation in postmenopausal women. Current research is ongoing to further elucidate the mechanisms and benefits of collagen peptides across various health domains.

Chemical Profile

Half-Life

INIntranasal

Not applicable

POOral

Moderate bioavailability

Oral administration is the most common route, with peptides rapidly absorbed and distributed.

Mechanism

Mechanism of Action

Collagen peptides are believed to exert their effects through the activation of specific receptors on fibroblasts and other connective tissue cells, leading to the upregulation of signaling pathways such as the TGF-β and Wnt/β-catenin pathways, which are crucial for collagen synthesis and extracellular matrix remodeling. These bioactive peptides may also enhance the production of procollagen I, elastin, and glycosaminoglycans, contributing to improved skin hydration and dermal matrix synthesis. However, the precise mechanisms and receptor interactions involved in collagen peptide action are not fully understood and warrant further investigation.

Research

76 Research Publications

3,140

Total Citations

Human/RCT

4.4

Avg. Influence

2023

Latest

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01Top

#01

Identification of food-derived collagen peptides in human blood after oral ingestion of gelatin hydrolysates.

In VitroInfluence17.0

380

The study demonstrated that food-derived collagen peptides were identified in human blood following oral ingestion of gelatin hydrolysates, indicating bioavailability.

2.5 goral(human)8 weeks10 g/doral(human)3-9 months5 goral(human)12 months2.5 goral(human)8 weeks5.0 goral(human)8 weeks5 goral(human)90 days2.5 goral(human)90 days5.0 goral(human)90 days10.0 goral(human)90 days500 mg/kgoral(mouse)6 weeks1000 mg/kgoral(mouse)6 weeks5 goral(human)84 days

PubMed

02Top

#02

Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study.

Proksch E, et al. · Skin pharmacology and physiology · 2014

HumanInfluence19.0

231

Researchers observed that oral supplementation with collagen hydrolysate significantly improved skin elasticity and moisture in women aged 35-55 years after 8 weeks.

Key findings

01Skin elasticity improved significantly in women taking collagen peptides compared to those on a placebo.
02Positive effects on skin moisture and evaporation were noted, although they were not statistically significant.
03No side effects were reported during the study.

PubMed

03Top

#03

The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials.

HumanInfluence10.0

227

The study demonstrated that oral collagen peptide supplementation significantly improved skin hydration and reduced collagen fragmentation in human skin after 8 weeks.

PubMed

#04

Preparation of low-molecular-weight, collagen hydrolysates (peptides): Current progress, challenges, and future perspectives.

ReviewInfluence8.0

206

The study demonstrated that the preparation of low-molecular-weight collagen hydrolysates from food processing byproducts is challenged by structural properties, but offers promising health benefits.

PubMed

#05

Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis.

HumanInfluence10.0

170

Researchers observed that the oral intake of specific bioactive collagen peptides significantly reduced eye wrinkle volume and increased procollagen I and elastin biosynthesis in human skin.

PubMed

#06

What is the role of peptide fragments of collagen I and IV in health and disease?

ReviewInfluence5.0

135

The review emphasized the functional roles of collagen peptides in regulating cellular processes and their potential therapeutic implications in health and disease.

PubMed

#07

Exploration of collagen recovered from animal by-products as a precursor of bioactive peptides: Successes and challenges.

ReviewInfluence8.0

133

Researchers observed that collagen peptides derived from animal by-products possess various bioactivities and potential for revalorization in functional food applications, despite existing challenges in development.

2.5 goral(human)8 weeks10 g/doral(human)6 months2.5 goral(human)8 weeks5 goral(human)84 days1,650 mg/dayoral(human)8 weeks500 mg/kgoral(mouse)6 weeks1,000 mg/kgoral(mouse)6 weeks

PubMed

#08

Specific Collagen Peptides Improve Bone Mineral Density and Bone Markers in Postmenopausal Women-A Randomized Controlled Study.

HumanInfluence3.0

127

Researchers observed that daily oral administration of specific collagen peptides significantly increased bone mineral density in postmenopausal women after 12 months.

PubMed

#09

Ingestion of bioactive collagen hydrolysates enhance facial skin moisture and elasticity and reduce facial ageing signs in a randomised double-blind placebo-controlled clinical study.

HumanInfluence3.0

108

The study demonstrated that ingestion of collagen hydrolysate with higher bioactive peptide content significantly improved facial skin moisture, elasticity, wrinkles, and roughness compared to placebo.

PubMed

#10

Recognition and catabolism of synthetic heterotrimeric collagen peptides by matrix metalloproteinases.

In VitroInfluence5.0

104

Researchers observed that synthetic heterotrimeric collagen peptides effectively mimic natural collagen and gelatin, revealing distinct proteolytic mechanisms of matrix metalloproteinases during digestion.

2.5 goral(human)8 weeks10 g/doral(human)6 months2.5 goral(human)8 weeks5 goral(human)84 days1,650 mg/dayoral(human)8 weeks500 mg/kgoral(mouse)6 weeks1,000 mg/kgoral(mouse)6 weeks

PubMed

Safety

Safety & Handling

Research Gaps

While several studies have demonstrated the short-term benefits of collagen peptide supplementation, there is a notable lack of long-term randomized controlled trials specifically assessing its effects on pain, function, and mental health in diverse populations. Additionally, the precise mechanisms by which bioactive peptides contribute to collagen turnover and their specific roles in various tissues remain unclear, warranting further investigation.

Solubility

Collagen peptides are highly soluble in water.

Storage & Handling

Lyophilized

Stable for 2+ years at -20°C, 12 months at 4°C

Reconstituted

Use within 14 days when refrigerated at 4°C

Avoid

Avoid repeated freeze-thaw cycles, direct light

Solvent

Bacteriostatic water or sterile saline recommended

Safety information is derived from published research and may not reflect all known risks. This is not medical advice.

Legal Status

🇩🇪DE

Not approved as a medicinal product. Not a controlled substance. Sale as a dietary supplement is permitted.

🇺🇸US

Recognized as a dietary supplement by the FDA. Not a controlled substance.

🇦🇺AU

Listed as a complementary medicine by the TGA. Not a controlled substance.

🇬🇧UK

Recognized as a food supplement by the MHRA. Not a controlled substance.

Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.

Community Insights

Publications per Year

50 total

Pricing

Price Comparison

BESTVerified PeptidesUS
20mg
$55.00
Price/mg
$2.75/mg
View
crownwellresearch.comUS
20mg
$57.00
Price/mg
$2.85/mg
View
BioLongevity LabsUS
20mg
$79.97
$67.97
Price/mg
$4.00$3.40/mg
View−15% · PEPSTACK
NovumLabEU
20mg
—
Price/mg
—
View
Welli LabsUS
$119.99
Price/mg
—
View

Vendor	Amount	Price	Price/mg	Link
BESTVerified PeptidesUS	20mg	$55.00	$2.75/mg	View
crownwellresearch.comUS	20mg	$57.00	$2.85/mg	View
BioLongevity LabsUS	20mg	$79.97$67.97	$4.00$3.40/mg	View−15% · PEPSTACK
NovumLabEU	20mg	—	—	View
Welli LabsUS	—	$119.99	—	View

Top 5 of 6 offers from 6 vendors. Prices updated daily.

See all Collagen Peptides prices

Mechanism

Tools

Reconstitution Calculator

Calculate reconstitution volumes for Collagen Peptides

Serum Level Visualizer

Visualize Collagen Peptides serum levels over time

Mechanism

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Legal Disclaimer

This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer