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Collagen Peptides

Hydrolyzed Collagen · Collagen Hydrolysate

Anti-Aging & SkinPreclinical

Collagen peptides are bioactive fragments derived from collagen, the most abundant protein in the human body, primarily sourced from animal tissues such as skin, bones, and cartilage. Researchers primarily study these peptides for their potential benefits in skin health, bone density, muscle recovery, and joint function. Key findings from clinical trials indicate that oral intake of specific collagen peptides can significantly reduce skin wrinkles and enhance dermal matrix synthesis, while also improving bone mineral density in postmenopausal women. Additionally, studies suggest that collagen peptide supplementation may aid in muscle recovery and reduce pain associated with physical activity. Current research continues to explore the diverse applications of collagen peptides in nutrition and health, with a focus on understanding their mechanisms of action and long-term effects.

Chemical Profile

Half-Life

INIntranasal

Not applicable

POOral

Moderate bioavailability

Oral administration is the most common route, with peptides rapidly absorbed and distributed.

Mechanism

Mechanism of Action

Collagen peptides are thought to exert their effects through binding to specific receptors such as the glycine-proline-proline (GPP) motif that interacts with fibroblast receptors, leading to the activation of signaling pathways like the TGF-β and Wnt/β-catenin pathways. This activation promotes the synthesis of extracellular matrix components, including collagen and elastin, enhancing dermal matrix synthesis and improving skin hydration and elasticity. While the precise mechanisms are still being elucidated, evidence suggests that collagen peptides also influence bone metabolism by modulating osteoblast activity and increasing bone formation markers such as P1NP.

Research

142 Research Publications

3,892

Total Citations

Human/RCT

4.2

Avg. Influence

2023

Latest

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01Top

#01

Identification of food-derived collagen peptides in human blood after oral ingestion of gelatin hydrolysates.

AnimalInfluence19.0

397

Researchers observed that food-derived collagen peptides were identified in human blood after oral ingestion of gelatin hydrolysates, indicating their absorption and presence in circulation.

2.5 goral(human)8 weeks5 goral(human)8 weeks5 goral(human)12 weeks10 g/doral(human)6 months1 goral(human)12 weeks5000 mg/dayoral(human)12 weeks1 mg/kgoral(mouse)6 weeks500 mg/kgoral(mouse)6 weeks1000 mg/kgoral(mouse)6 weeks1 goral(human)12 weeks5 goral(human)12 weeks2.5 goral(human)12 weeks9.4-23 goral(human)not mentioned

PubMed

02Top

#02

The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials.

HumanInfluence13.0

243

Researchers observed that oral collagen peptide supplementation significantly improved skin hydration and reduced collagen fragmentation in human participants after 8 weeks.

PubMed

03Top

#03

Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study.

Proksch E, et al. · Skin pharmacology and physiology · 2014

HumanInfluence21.0

241

The study demonstrated that oral supplementation of specific collagen peptides significantly improved skin elasticity and moisture in human participants after 8 weeks.

Key findings

01Skin elasticity improved significantly in women taking collagen peptides compared to those on a placebo.
02Positive effects on skin moisture and evaporation were noted, although they were not statistically significant.
03No side effects were reported during the study.

PubMed

#04

Preparation of low-molecular-weight, collagen hydrolysates (peptides): Current progress, challenges, and future perspectives.

ReviewInfluence8.0

217

Researchers observed that the preparation of low-molecular-weight collagen hydrolysates from food processing byproducts presents challenges but offers promising bioactivities for various applications.

PubMed

#05

Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis.

HumanInfluence12.0

180

Researchers observed that oral intake of specific bioactive collagen peptides significantly reduced eye wrinkle volume and increased procollagen I and elastin synthesis in human participants aged 45-65 years.

PubMed

#06

What is the role of peptide fragments of collagen I and IV in health and disease?

ReviewInfluence6.0

145

The review highlights that collagen peptide fragments play significant roles in regulating cellular processes related to health and disease through integrin receptors.

PubMed

#07

Exploration of collagen recovered from animal by-products as a precursor of bioactive peptides: Successes and challenges.

ReviewInfluence8.0

136

The review discussed the potential of collagen peptides derived from animal by-products as high-value bio-functional ingredients with various health benefits, while addressing the challenges in their development.

2.5 goral(human)8 weeks5 goral(human)12 months1,650 mg/dayoral(human)8 weeks10 g/doral(human)6 months2.5 goral(human)8 weeks5 goral(human)12 weeks500 mg/kgoral(mouse)6 weeks1000 mg/kgoral(mouse)6 weeks9.4-23 goral(human)not specified

PubMed

#08

Novel Antioxidant Collagen Peptides of Siberian Sturgeon (Acipenserbaerii) Cartilages: The Preparation, Characterization, and Cytoprotection of H2O2-Damaged Human Umbilical Vein Endothelial Cells (HUVECs).

AnimalInfluence1.0

131

The study demonstrated that thirteen antioxidant peptides isolated from Siberian sturgeon cartilages exhibited significant cytoprotection against H2O2 injury in human umbilical vein endothelial cells.

2.5 goral(human)8 weeks5 goral(human)12 months1,650 mg/dayoral(human)8 weeks10 g/doral(human)6 to 9 months20 g/doral(human)3 to 9 months5 goral(human)84 days5 goral(human)12 weeks500 mg/kgoral(mouse)6 weeks1000 mg/kgoral(mouse)6 weeks9.4-23 goral(human)12 h fasting

PubMed

#09

Specific Collagen Peptides Improve Bone Mineral Density and Bone Markers in Postmenopausal Women-A Randomized Controlled Study.

HumanInfluence3.0

131

The study demonstrated that daily oral supplementation with specific collagen peptides significantly increased bone mineral density in postmenopausal women after 12 months.

PubMed

#10

Ingestion of bioactive collagen hydrolysates enhance facial skin moisture and elasticity and reduce facial ageing signs in a randomised double-blind placebo-controlled clinical study.

HumanInfluence4.0

119

The study demonstrated that ingestion of collagen hydrolysate with a higher content of Pro-Hyp and Hyp-Gly significantly improved facial skin moisture, elasticity, wrinkles, and roughness in human participants.

PubMed

Safety

Safety & Handling

Research Gaps

While several studies have demonstrated the short-term benefits of collagen peptide supplementation on skin health, bone density, and muscle recovery, there is a lack of long-term randomized controlled trials specifically assessing the sustained effects and safety of collagen peptides in diverse populations. Additionally, the precise mechanisms by which collagen peptides exert their beneficial effects on muscle recovery and pain reduction remain unclear, warranting further investigation into the biochemical pathways involved.

Solubility

Collagen peptides are highly soluble in water.

Storage & Handling

Lyophilized

Stable for 2+ years at -20°C, 12 months at 4°C

Reconstituted

Use within 14 days when refrigerated at 4°C

Avoid

Avoid repeated freeze-thaw cycles, direct light

Solvent

Bacteriostatic water or sterile saline recommended

Safety information is derived from published research and may not reflect all known risks. This is not medical advice.

Legal Status

🇩🇪DE

Not approved as a medicinal product. Not a controlled substance. Sale as a dietary supplement is permitted.

🇺🇸US

Recognized as a dietary supplement by the FDA. Not a controlled substance.

🇦🇺AU

Listed as a complementary medicine by the TGA. Not a controlled substance.

🇬🇧UK

Recognized as a food supplement by the MHRA. Not a controlled substance.

Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.

Community Insights

Publications per Year

50 total

Pricing

Price Comparison

BESTVerified PeptidesUS
20mg
$55.00
Price/mg
$2.75/mg
View
BioLongevity LabsUS
20mg
$79.97
$67.97
Price/mg
$4.00$3.40/mg
View−15% · PEPSTACK
Umbrella LabsUS
10mg
$39.99
Price/mg
$4.00/mg
View
Behemoth LabzUS
20mg
—
Price/mg
—
View
NovumLabEU
20mg
—
Price/mg
—
View

Vendor	Amount	Price	Price/mg	Link
BESTVerified PeptidesUS	20mg	$55.00	$2.75/mg	View
BioLongevity LabsUS	20mg	$79.97$67.97	$4.00$3.40/mg	View−15% · PEPSTACK
Umbrella LabsUS	10mg	$39.99	$4.00/mg	View
Behemoth LabzUS	20mg	—	—	View
NovumLabEU	20mg	—	—	View

Top 5 of 8 offers from 6 vendors. Prices updated daily.

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Mechanism

Tools

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Mechanism

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Legal Disclaimer

This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer