Matrixyl · Pal-KTTKS
Palmitoyl pentapeptide-4, commonly known as Matrixyl, is a synthetic peptide derived from the natural protein sequence found in collagen. Researchers primarily study it for its potential anti-aging effects on the skin, particularly in reducing the appearance of fine lines and wrinkles. Key findings from clinical trials indicate that palmitoyl pentapeptide-4 can enhance collagen and hyaluronic acid production, improve skin elasticity, and mitigate signs of photoaging. Additionally, preclinical evidence suggests that its efficacy may be further enhanced when delivered through innovative transdermal systems or in combination with other bioactive compounds. Current research continues to explore its mechanisms of action and optimize delivery methods to maximize its benefits in cosmetic applications.
| Formula | C39H75N7O10 |
| Molecular Weight | 802.1 g/mol |
| CAS Number | 214047-00-4 |
| PubChem CID | 9897237 |
Not applicable
Poor bioavailability
Primarily used topically in cosmetic formulations; systemic pharmacokinetic data is limited.
Palmitoyl Pentapeptide-4 (PPP-4) primarily exerts its effects by stimulating fibroblast activity and enhancing collagen synthesis through interaction with specific receptors involved in the extracellular matrix (ECM) remodeling. Although the precise receptors and signaling pathways remain partially elucidated, it is suggested that PPP-4 may activate pathways such as the TGF-β signaling pathway, promoting fibroblast proliferation and ECM component expression, thereby contributing to skin rejuvenation and elasticity. Additionally, it may influence the regulation of hyaluronic acid synthesis, enhancing skin hydration and reducing the appearance of wrinkles.
441
Total Citations
10
Human/RCT
1.7
Avg. Influence
2025
Latest
Researchers observed a 2 to 22 fold improvement in microneedle enhanced delivery of peptides, including pal-KTTKS, into human skin using fluorescence imaging.
The study demonstrated that the peptide amphiphile C16-KTTKS stimulates collagen production in human fibroblasts in a concentration-dependent manner, correlating with its self-assembly into nanotape structures.
Researchers observed that the novel lipopeptide C16KTTβAH selectively induces cytotoxicity against breast cancer cells while demonstrating tunable hydrogel properties for potential biomedical applications.
The study demonstrated that anti-aging products containing Pal-KT and Pal-KTTKS significantly improved the smoothness and reduced the depth of periorbital wrinkles in human subjects after four weeks.
Researchers observed that a developed LC-MS/MS method reliably quantified pal-KTTKS in anti-wrinkle creams, highlighting the impact of formulation on peptide availability.
Wang Zhuxian, et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
Researchers observed that bioactive ionic liquids significantly enhanced the solubility and transdermal delivery of palmitoyl pentapeptide-4, improving its anti-photoaging effects in cellular and animal models.
Key findings
Tałałaj Urszula, et al. · Molecules (Basel, Switzerland) · 2019
Researchers observed that palmitoyl pentapeptide-4 analogues exhibited no cytotoxicity on fibroblasts while showing effective inhibition of plasmin activity.
Key findings
The study demonstrated that the hybrid peptide 3.1-PP4 effectively inhibits multidrug-resistant Gram-negative bacteria and promotes collagen synthesis, indicating its potential for treating infected skin injuries.
Researchers observed that the acetylated and amidated hexapeptide from Spirulina platensis significantly reduced oxidative stress and matrix metalloproteinase expression in UVB-irradiated human keratinocytes and mice.
The study demonstrated that pal-KT and Pal-KTTKS peptides enhance skin matrix responses in human skin equivalent cultures, contributing to skin hydration and barrier function.
No long-term human trials have been conducted to assess the sustained efficacy and safety of palmitoyl pentapeptide-4 in diverse populations, particularly in Asian skin types. Additionally, the precise molecular mechanisms by which palmitoyl pentapeptide-4 enhances collagen production and its interactions with other skin components remain unclear, warranting further investigation.
Solubility
Soluble in water and DMSO; limited solubility in organic solvents like acetonitrile.
Lyophilized
Stable for 2+ years at -20°C, 12 months at 4°C
Reconstituted
Use within 14 days when refrigerated at 4°C
Avoid
Avoid repeated freeze-thaw cycles, direct light
Solvent
Bacteriostatic water or sterile saline recommended
Safety information is derived from published research and may not reflect all known risks. This is not medical advice.
🇩🇪DE
Not approved as a medicinal product. Not a controlled substance. Sale as research chemical is a legal grey area.
🇺🇸US
Not approved by the FDA as a drug. Used in cosmetics.
🇦🇺AU
Not scheduled by the TGA. Used in cosmetics.
🇬🇧UK
Not regulated as a medicinal product by the MHRA. Used in cosmetics.
Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.
Publications per Year
4 total| Vendor | Amount | Price | Price/mg | Link |
|---|---|---|---|---|
BESTIon PeptideUS | 1000mg | $139.00 | $0.14/mg | |
RCpeptidesEU | 10mg | $32.40 | $3.24/mg | |
Ion PeptideUS | 10mg | $129.00 | $12.90/mg | |
PeptaNovaEU | 0.5mg | $54.00 | $108.00/mg | |
Behemoth LabzUS | 10mg | — | — |
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This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer