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BPC-157

Body Protection Compound 157 · BPC157 · Pentadecapeptide BPC-157

Wound Healing & RegenerationPreclinical
From$2.80/mgCompare prices
MW
1419.5g/mol
Formula
C62H98N16O22

BPC-157, or Body Protection Compound 157, is a stable pentadecapeptide derived from human gastric juice, recognized for its potential therapeutic properties. Researchers primarily study BPC-157 for its ability to promote healing in various tissues, including musculoskeletal injuries and gastrointestinal ulcers. Key findings from preclinical studies suggest that BPC-157 accelerates recovery from soft tissue damage, enhances angiogenesis, and exhibits a favorable safety profile with minimal reported side effects. Despite its promising effects observed in animal models, the peptide has not yet received approval from regulatory authorities for clinical use in humans. Current research continues to explore its mechanisms of action and efficacy, with a growing interest reflected in numerous studies and patent applications.

Chemical Profile

Chemical Profile

Chemical structure
Chemical Structure
FormulaC62H98N16O22
Molecular Weight1419.5 g/mol
CAS Number137525-51-0
PubChem CID9941957
ChEMBL IDCHEMBL4297358

Half-Life

INIntranasal

Not applicable

POOral

Poor bioavailability

Pharmacokinetic data is limited, and more research is needed to determine precise half-life values.

Mechanism

Mechanism of Action

BPC-157 enhances the expression of growth hormone receptors and activates multiple signaling pathways, including the NO/cGMP pathway, which promotes angiogenesis and tissue repair. It reduces inflammatory cytokines and stimulates the healing of soft tissues by modulating the vascular endothelial growth factor (VEGF) signaling pathway, thereby facilitating cell proliferation, migration, and survival. While its precise mechanisms remain incompletely understood, BPC-157 consistently demonstrates beneficial effects across various injury models, including musculoskeletal and gastrointestinal tissues.

Research

73 Research Publications

2,777

Total Citations

5

Human/RCT

2.5

Avg. Influence

2025

Latest

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#01

The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration.

Chang Chung-Hsun, et al. · Journal of applied physiology (Bethesda, Md. : 1985) · 2011

In VitroInfluence5.0
116
The study demonstrated that BPC 157 promotes tendon fibroblast outgrowth, survival under stress, and migration in vitro, likely through the activation of the FAK-paxillin pathway.

Key findings

  1. 01BPC 157 accelerated the outgrowth of tendon cells from tissue samples.
  2. 02The peptide increased the survival of tendon cells when exposed to stress.
  3. 03BPC 157 enhanced the migration and spreading of tendon cells in a dose-dependent manner.
10 mgintravenous(human)1 hour20 mgintravenous(human)1 hour100 mg/kgintraperitoneal(rat)50 µg/kgintraperitoneal(rat)10 µg/kgintraperitoneal(rat)10 ng/kgintraperitoneal(rat)10 pg/kgintraperitoneal(rat)
PubMed
#02

A new gastric juice peptide, BPC. An overview of the stomach-stress-organoprotection hypothesis and beneficial effects of BPC.

ReviewInfluence4.0
106
The study demonstrated that BPC 157 acts as an organoprotective agent, benefiting multiple organ systems under stress conditions in various species.
10 mgintravenous(human)1 hour20 mgintravenous(human)1 hour100 mg/kgintraperitoneal(rat)50 µg/kgintraperitoneal(rat)10 µg/kgintraperitoneal(rat)10 ng/kgintraperitoneal(rat)10 pg/kgintraperitoneal(rat)
PubMed
#03

The beneficial effect of BPC 157, a 15 amino acid peptide BPC fragment, on gastric and duodenal lesions induced by restraint stress, cysteamine and 96% ethanol in rats. A comparative study with H2 receptor antagonists, dopamine promotors and gut peptides.

AnimalInfluence3.0
104
The study demonstrated that BPC 157 provides significant protection against gastric and duodenal lesions induced by restraint stress, cysteamine, and ethanol in rats, outperforming several reference standards.
10 mgintravesical injection(human)single procedure10 mgintravenous infusion(human)one hour20 mgintravenous infusion(human)one hour100 mg/kgintraperitoneal(rat)not mentioned50 µg/kgintraperitoneal(rat)not mentioned10 µg/kgintraperitoneal(rat)not mentioned10 ng/kgintraperitoneal(rat)not mentioned10 pg/kgintraperitoneal(rat)not mentioned
PubMed
#04

Stable gastric pentadecapeptide BPC 157-NO-system relation.

ReviewInfluence5.0
97
Researchers observed that BPC 157 significantly enhances healing responses in various tissues after vascular integrity loss, demonstrating its role in modulating the nitric oxide system in injury recovery.
10 mgintravenous(human)1 hour20 mgintravenous(human)1 hour100 mg/kgintraperitoneal(rat)50 µg/kgintraperitoneal(rat)10 µg/kgintraperitoneal(rat)10 ng/kgintraperitoneal(rat)10 pg/kgintraperitoneal(rat)
PubMed
#05

The influence of BPC 157 on nitric oxide agonist and antagonist induced lesions in broiler chicks.

AnimalInfluence4.0
86
Researchers observed that BPC 157 significantly prevented tissue damage caused by nitric oxide antagonists in broiler chicks, highlighting its organoprotective effects.
50 µg/kgintraperitoneal(rat)10 µg/kgperoral(rat)4 weeks10 ng/kgperoral(rat)4 weeks0.4 µg/eyeeye drops(rat)10 mginjection(human)
PubMed
#06

Modulatory effect of gastric pentadecapeptide BPC 157 on angiogenesis in muscle and tendon healing.

AnimalInfluence5.0
82
Researchers observed that BPC 157 modulated angiogenesis during muscle and tendon healing in rats, correlating with increased VEGF expression.
50 µg/kgintraperitoneal(rat)10 µg/kgperoral(rat)4 weeks10 ng/kgperoral(rat)4 weeks0.4 µg/eyeeye drops(rat)10 mginjection(human)
PubMed
#07

Pentadecapeptide BPC 157 cream improves burn-wound healing and attenuates burn-gastric lesions in mice.

AnimalInfluence1.0
79
Researchers observed that BPC 157 cream enhanced burn wound healing and reduced gastric lesions in burned mice compared to untreated controls.
50 µg/kgintraperitoneal(rat)10 µg/kgperoral(rat)4 weeks10 ng/kgperoral(rat)4 weeks0.4 µg/eyeeye drops(rat)10 mginjection(human)
PubMed
#08

BPC 157 and Standard Angiogenic Growth Factors. Gastrointestinal Tract Healing, Lessons from Tendon, Ligament, Muscle and Bone Healing.

Seiwerth Sven, et al. · Current pharmaceutical design · 2018

ReviewInfluence3.0
79
Researchers observed that BPC 157 consistently improves healing in gastrointestinal and extragastrointestinal tissues, outperforming standard angiogenic growth factors in various injury models.

Key findings

  1. 01BPC 157 was effective in healing injuries in the gastrointestinal tract, including the esophagus, stomach, and intestines.
  2. 02In contrast to other growth factors like EGF, FGF, and VEGF, BPC 157 demonstrated consistent healing benefits across multiple tissue types.
  3. 03The study highlighted BPC 157's unique role in promoting healing through its own angiogenic effects.
10 mgintravenous(human)1 hour20 mgintravenous(human)1 hour100 mg/kgintraperitoneal(rat)50 µg/kgintraperitoneal(rat)10 µg/kgintraperitoneal(rat)10 ng/kgintraperitoneal(rat)10 pg/kgintraperitoneal(rat)
PubMed
#09

Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocytes growth.

AnimalInfluence3.0
76
Researchers observed that BPC 157 significantly improved healing of transected Achilles tendons in rats, enhancing biomechanical and histological recovery metrics.
50 µg/kgintraperitoneal(rat)10 µg/kgperoral(rat)4 weeks10 ng/kgperoral(rat)4 weeks0.4 µg/eyeeye drops(rat)10 mginjection(human)
PubMed
#10

Revised Robert's cytoprotection and adaptive cytoprotection and stable gastric pentadecapeptide BPC 157. Possible significance and implications for novel mediator.

ReviewInfluence5.0
74
Researchers observed that BPC 157 plays a significant role in mediating cytoprotection and adaptive cytoprotection in the gastrointestinal tract, with implications for wound healing.
10 mgintravenous(human)1 hour20 mgintravenous(human)1 hour100 mg/kgintraperitoneal(rat)50 µg/kgintraperitoneal(rat)10 µg/kgintraperitoneal(rat)10 ng/kgintraperitoneal(rat)10 pg/kgintraperitoneal(rat)
PubMed
Safety

Safety & Handling

Research Gaps

No comprehensive clinical trials in humans have been conducted to confirm the efficacy and safety of BPC-157, leaving its long-term effects and potential interactions with existing medications largely unknown. Additionally, the precise mechanisms by which BPC-157 promotes healing in various tissues remain unclear, necessitating further investigation to elucidate its pharmacological actions.

Solubility

BPC-157 is soluble in water and saline solutions.

Storage & Handling

Lyophilized

Stable for 2+ years at -20°C, 12 months at 4°C

Reconstituted

Use within 14 days when refrigerated at 4°C

Avoid

Avoid repeated freeze-thaw cycles, direct light

Solvent

Bacteriostatic water or sterile saline recommended

Safety information is derived from published research and may not reflect all known risks. This is not medical advice.

Legal Status

Legal Status

🇩🇪DE

Not approved as a medicinal product. Not a controlled substance. Sale as research chemical is a legal grey area.

🇺🇸US

Not approved by the FDA as a medicinal product. Not scheduled by the DEA.

🇦🇺AU

Not approved by the TGA as a therapeutic good.

🇬🇧UK

Not approved by the MHRA as a medicinal product.

Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.

Community Insights

Community Insights

Publications per Year

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Pricing

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Mechanism

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Mechanism

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Legal Disclaimer

This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer