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BPC-157

Body Protection Compound 157 · BPC157 · Pentadecapeptide BPC-157

Wound Healing & RegenerationPhase I
From$2.20/mgCompare prices
MW
1419.5g/mol
Formula
C62H98N16O22

BPC-157, or Body Protection Compound 157, is a pentadecapeptide derived from human gastric juice that has garnered attention for its potential therapeutic applications. Researchers primarily study BPC-157 for its regenerative properties and effects on various medical conditions, including musculoskeletal injuries, inflammatory bowel disease, and central nervous system disorders. Key findings from studies indicate that BPC-157 may accelerate healing in soft tissues, improve outcomes in knee pain, and show promise in alleviating symptoms of interstitial cystitis. Despite its encouraging preclinical evidence and a favorable safety profile, BPC-157 has not yet received approval from regulatory authorities like the FDA for standard medical use, and further clinical research is necessary to validate its efficacy in humans.

Chemical Profile

Chemical Profile

Chemical structure
Chemical Structure
FormulaC62H98N16O22
Molecular Weight1419.5 g/mol
CAS Number137525-51-0
PubChem CID9941957
ChEMBL IDCHEMBL4297358

Half-Life

INIntranasal

Not applicable

POOral

Poor bioavailability

Pharmacokinetic data is limited, and more research is needed to determine precise half-life values.

Mechanism

Mechanism of Action

BPC-157 exerts its effects primarily through the modulation of various growth factor signaling pathways, including the VEGF signaling pathway, which promotes angiogenesis and tissue repair. It also influences the NO/cGMP pathway, enhancing nitric oxide production, thereby facilitating vasodilation and improving blood flow to injured tissues. While the precise molecular mechanisms and specific receptors involved remain incompletely understood, BPC-157 is known to accelerate healing processes in musculoskeletal tissues and mitigate inflammation.

Research

80 Research Publications

3,008

Total Citations

3

Human/RCT

2.4

Avg. Influence

2025

Latest

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#01

The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration.

Chang Chung-Hsun, et al. · Journal of applied physiology (Bethesda, Md. : 1985) · 2011

AnimalInfluence6.0
118
The study demonstrated that BPC 157 promotes tendon fibroblast outgrowth, cell survival under oxidative stress, and migration through the activation of the FAK-paxillin pathway in rat Achilles tendon fibroblasts.

Key findings

  1. 01BPC 157 accelerated the outgrowth of tendon cells from tissue samples.
  2. 02The peptide increased the survival of tendon cells when exposed to stress.
  3. 03BPC 157 enhanced the migration and spreading of tendon cells in a dose-dependent manner.
10 mgintravenous(human)single procedure20 mgintravenous(human)single procedure
PubMed
#02

A new gastric juice peptide, BPC. An overview of the stomach-stress-organoprotection hypothesis and beneficial effects of BPC.

ReviewInfluence4.0
106
Researchers observed that BPC-157 may serve as a novel organoprotective agent, demonstrating beneficial effects across multiple organ systems in response to stress-induced pathology in various species.
10 mgintravenous(human)1 hour20 mgintravenous(human)1 hour100 mg/kgintraperitoneal(rat)50 µg/kgintraperitoneal(rat)10 µg/kgintraperitoneal(rat)10 ng/kgintraperitoneal(rat)10 pg/kgintraperitoneal(rat)
PubMed
#03

The beneficial effect of BPC 157, a 15 amino acid peptide BPC fragment, on gastric and duodenal lesions induced by restraint stress, cysteamine and 96% ethanol in rats. A comparative study with H2 receptor antagonists, dopamine promotors and gut peptides.

AnimalInfluence3.0
104
The study demonstrated that BPC 157 provides significant protection against gastric and duodenal lesions induced by restraint stress, cysteamine, and ethanol in rats, outperforming several reference standards.
10 mgintravesical injection(human)single procedure10 mgintravenous infusion(human)one hour20 mgintravenous infusion(human)one hour100 mg/kgintraperitoneal(rat)not mentioned50 µg/kgintraperitoneal(rat)not mentioned10 µg/kgintraperitoneal(rat)not mentioned10 ng/kgintraperitoneal(rat)not mentioned10 pg/kgintraperitoneal(rat)not mentioned
PubMed
#04

Stable gastric pentadecapeptide BPC 157-NO-system relation.

ReviewInfluence4.0
97
Researchers observed that BPC 157 modulates the nitric oxide system, enhancing healing responses after vascular integrity loss in various injury models.
10 mgintravenous(human)single procedure20 mgintravenous(human)single procedure
PubMed
#05

Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts.

AnimalInfluence5.0
92
The study demonstrated that BPC 157 significantly increases growth hormone receptor expression in tendon fibroblasts from rat Achilles tendon, potentially enhancing cell proliferation and contributing to tendon healing.
PubMed
#06

The influence of BPC 157 on nitric oxide agonist and antagonist induced lesions in broiler chicks.

AnimalInfluence4.0
86
Researchers observed that BPC 157 significantly prevented tissue damage caused by nitric oxide antagonists in broiler chicks, highlighting its organoprotective effects.
50 µg/kgintraperitoneal(rat)10 µg/kgperoral(rat)4 weeks10 ng/kgperoral(rat)4 weeks0.4 µg/eyeeye drops(rat)10 mginjection(human)
PubMed
#07

Modulatory effect of gastric pentadecapeptide BPC 157 on angiogenesis in muscle and tendon healing.

AnimalInfluence5.0
82
Researchers observed that BPC 157 modulated angiogenesis during muscle and tendon healing in rats, correlating with increased VEGF expression.
50 µg/kgintraperitoneal(rat)10 µg/kgperoral(rat)4 weeks10 ng/kgperoral(rat)4 weeks0.4 µg/eyeeye drops(rat)10 mginjection(human)
PubMed
#08

BPC 157 and Standard Angiogenic Growth Factors. Gastrointestinal Tract Healing, Lessons from Tendon, Ligament, Muscle and Bone Healing.

Seiwerth Sven, et al. · Current pharmaceutical design · 2018

ReviewInfluence2.0
82
Researchers observed that BPC 157 consistently improves healing in gastrointestinal and extragastrointestinal tissues, demonstrating its unique pharmacological role.

Key findings

  1. 01BPC 157 was effective in healing injuries in the gastrointestinal tract, including the esophagus, stomach, and intestines.
  2. 02In contrast to other growth factors like EGF, FGF, and VEGF, BPC 157 demonstrated consistent healing benefits across multiple tissue types.
  3. 03The study highlighted BPC 157's unique role in promoting healing through its own angiogenic effects.
10 mgintravenous(human)single procedure20 mgintravenous(human)single procedure
PubMed
#09

Pentadecapeptide BPC 157 cream improves burn-wound healing and attenuates burn-gastric lesions in mice.

AnimalInfluence1.0
80
Researchers observed that BPC-157, administered topically or systemically, significantly improved burn-wound healing and reduced gastric lesions in mice compared to untreated controls.
10 mgintravenous(human)single procedure20 mgintravenous(human)single procedure
PubMed
#10

Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocytes growth.

AnimalInfluence3.0
76
Researchers observed that BPC 157 significantly improved healing of transected Achilles tendons in rats, enhancing biomechanical and histological recovery metrics.
50 µg/kgintraperitoneal(rat)10 µg/kgperoral(rat)4 weeks10 ng/kgperoral(rat)4 weeks0.4 µg/eyeeye drops(rat)10 mginjection(human)
PubMed
Safety

Safety & Handling

Research Gaps

No comprehensive randomized controlled trials have been conducted to confirm the efficacy and safety of BPC-157 in humans, particularly for its use in treating conditions like knee pain and interstitial cystitis. Additionally, the precise mechanisms of action of BPC-157 in promoting healing and its long-term effects on human health remain unclear, necessitating further investigation.

Solubility

BPC-157 is soluble in water and saline solutions.

Storage & Handling

Lyophilized

Stable for 2+ years at -20°C, 12 months at 4°C

Reconstituted

Use within 14 days when refrigerated at 4°C

Avoid

Avoid repeated freeze-thaw cycles, direct light

Solvent

Bacteriostatic water or sterile saline recommended

Safety information is derived from published research and may not reflect all known risks. This is not medical advice.

Legal Status

Legal Status

🇩🇪DE

Not approved as a medicinal product. Not a controlled substance. Sale as research chemical is a legal grey area.

🇺🇸US

Not approved by the FDA as a medicinal product. Not scheduled by the DEA.

🇦🇺AU

Not approved by the TGA as a therapeutic good.

🇬🇧UK

Not approved by the MHRA as a medicinal product.

Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.

Community Insights

Community Insights

Publications per Year

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Mechanism

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Mechanism

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Legal Disclaimer

This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer