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BPC-157

Body Protection Compound 157 · BPC157 · Pentadecapeptide BPC-157

Wound Healing & RegenerationPreclinical

MW: 1419.5g/mol
Formula: C62H98N16O22

BPC-157, or Body Protection Compound 157, is a stable pentadecapeptide derived from human gastric juice, primarily studied for its potential in promoting healing and recovery from various musculoskeletal injuries and tissue damage. Researchers observed its pleiotropic effects in preclinical models, showing promise in enhancing the healing of soft tissues such as tendons, ligaments, and muscles, as well as in wound healing across different tissue types. Key findings indicate that BPC-157 may improve functional and structural outcomes while exhibiting a favorable safety profile with minimal reported side effects. Despite its encouraging preclinical results, the peptide has not yet received approval from regulatory authorities like the FDA, and its efficacy in human subjects remains to be fully established. Current research continues to explore its mechanisms of action and potential applications in both clinical and sports medicine settings.

Chemical Profile

Chemical Structure

Formula	C62H98N16O22
Molecular Weight	1419.5 g/mol
CAS Number	137525-51-0
PubChem CID	9941957
ChEMBL ID	CHEMBL4297358

Half-Life

INIntranasal

Not applicable

POOral

Poor bioavailability

Pharmacokinetic data is limited, and more research is needed to determine precise half-life values.

Mechanism

Mechanism of Action

BPC-157 enhances growth hormone receptor expression and activates multiple signaling pathways, including the VEGF signaling pathway, which promotes angiogenesis and tissue repair. It also modulates the NO/cGMP pathway, leading to increased nitric oxide production and improved blood flow, while simultaneously reducing inflammatory cytokines, thereby facilitating healing processes in musculoskeletal injuries. The precise molecular mechanisms of BPC-157 remain incompletely understood, necessitating further research to elucidate its full range of actions.

Research

68 Research Publications

2,598

Total Citations

Human/RCT

2.5

Avg. Influence

2025

Latest

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01Top

#01

The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration.

Chang Chung-Hsun, et al. · Journal of applied physiology (Bethesda, Md. : 1985) · 2011

In VitroInfluence5.0

114

Researchers observed that BPC 157 promotes tendon healing by enhancing fibroblast outgrowth, survival under stress, and migration in vitro.

Key findings

01BPC 157 accelerated the outgrowth of tendon cells from tissue samples.
02The peptide increased the survival of tendon cells when exposed to stress.
03BPC 157 enhanced the migration and spreading of tendon cells in a dose-dependent manner.

10 mgintravenous(human)single procedure20 mgintravenous(human)single procedure100 mg/kgintraperitoneal(rat)not mentioned50 µg/kgintraperitoneal(rat)not mentioned10 µg/kgintraperitoneal(rat)not mentioned10 ng/kgintraperitoneal(rat)not mentioned10 pg/kgintraperitoneal(rat)not mentioned10 mgintravesical(human)single procedure

PubMed

02Top

#02

A new gastric juice peptide, BPC. An overview of the stomach-stress-organoprotection hypothesis and beneficial effects of BPC.

ReviewInfluence4.0

105

Researchers observed that BPC 157 may serve as a prototype for a new class of organoprotective agents, demonstrating beneficial effects across various organ systems under stress conditions.

PubMed

03Top

#03

The beneficial effect of BPC 157, a 15 amino acid peptide BPC fragment, on gastric and duodenal lesions induced by restraint stress, cysteamine and 96% ethanol in rats. A comparative study with H2 receptor antagonists, dopamine promotors and gut peptides.

AnimalInfluence3.0

104

The study demonstrated that BPC 157 provides significant protection against gastric and duodenal lesions induced by various stressors in rats, outperforming several reference treatments in effectiveness.

PubMed

#04

Stable gastric pentadecapeptide BPC 157-NO-system relation.

ReviewInfluence5.0

The study demonstrated that BPC 157 exhibits a significant relationship with the NO-system, enhancing healing and modulating vascular integrity in various injury models.

PubMed

#05

The influence of BPC 157 on nitric oxide agonist and antagonist induced lesions in broiler chicks.

AnimalInfluence4.0

Researchers observed that BPC 157 significantly prevented tissue damage caused by nitric oxide antagonists in broiler chicks, highlighting its organoprotective effects.

50 µg/kgintraperitoneal(rat)10 µg/kgperoral(rat)4 weeks10 ng/kgperoral(rat)4 weeks0.4 µg/eyeeye drops(rat)10 mginjection(human)

PubMed

#06

Modulatory effect of gastric pentadecapeptide BPC 157 on angiogenesis in muscle and tendon healing.

AnimalInfluence5.0

Researchers observed that BPC 157 modulated angiogenesis during muscle and tendon healing in rats, correlating with increased VEGF expression.

50 µg/kgintraperitoneal(rat)10 µg/kgperoral(rat)4 weeks10 ng/kgperoral(rat)4 weeks0.4 µg/eyeeye drops(rat)10 mginjection(human)

PubMed

#07

Pentadecapeptide BPC 157 cream improves burn-wound healing and attenuates burn-gastric lesions in mice.

AnimalInfluence1.0

Researchers observed that BPC 157 cream enhanced burn wound healing and reduced gastric lesions in burned mice compared to untreated controls.

50 µg/kgintraperitoneal(rat)10 µg/kgperoral(rat)4 weeks10 ng/kgperoral(rat)4 weeks0.4 µg/eyeeye drops(rat)10 mginjection(human)

PubMed

#08

BPC 157 and Standard Angiogenic Growth Factors. Gastrointestinal Tract Healing, Lessons from Tendon, Ligament, Muscle and Bone Healing.

Seiwerth Sven, et al. · Current pharmaceutical design · 2018

ReviewInfluence4.0

The study demonstrated that BPC 157 consistently improves healing in gastrointestinal and extragastrointestinal tissues in animal models, outperforming standard angiogenic growth factors.

Key findings

01BPC 157 was effective in healing injuries in the gastrointestinal tract, including the esophagus, stomach, and intestines.
02In contrast to other growth factors like EGF, FGF, and VEGF, BPC 157 demonstrated consistent healing benefits across multiple tissue types.
03The study highlighted BPC 157's unique role in promoting healing through its own angiogenic effects.

PubMed

#09

Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocytes growth.

AnimalInfluence3.0

Researchers observed that BPC 157 significantly improved healing of transected Achilles tendons in rats, enhancing biomechanical and histological recovery metrics.

50 µg/kgintraperitoneal(rat)10 µg/kgperoral(rat)4 weeks10 ng/kgperoral(rat)4 weeks0.4 µg/eyeeye drops(rat)10 mginjection(human)

PubMed

#10

Revised Robert's cytoprotection and adaptive cytoprotection and stable gastric pentadecapeptide BPC 157. Possible significance and implications for novel mediator.

ReviewInfluence4.0

The study demonstrated that BPC 157 exhibits significant cytoprotective and adaptive cytoprotective effects, contributing to its potential as a mediator in gastrointestinal defense and wound healing.

PubMed

Safety

Safety & Handling

Research Gaps

No randomized controlled trials in humans have been conducted to confirm the efficacy and safety of BPC-157, leaving its clinical application unvalidated. Additionally, the precise mechanisms of action underlying its therapeutic effects remain unclear, particularly regarding its long-term effects and potential interactions with other medications.

Solubility

BPC-157 is soluble in water and saline solutions.

Storage & Handling

Lyophilized

Stable for 2+ years at -20°C, 12 months at 4°C

Reconstituted

Use within 14 days when refrigerated at 4°C

Avoid

Avoid repeated freeze-thaw cycles, direct light

Solvent

Bacteriostatic water or sterile saline recommended

Safety information is derived from published research and may not reflect all known risks. This is not medical advice.

Legal Status

🇩🇪DE

Not approved as a medicinal product. Not a controlled substance. Sale as research chemical is a legal grey area.

🇺🇸US

Not approved by the FDA as a medicinal product. Not scheduled by the DEA.

🇦🇺AU

Not approved by the TGA as a therapeutic good.

🇬🇧UK

Not approved by the MHRA as a medicinal product.

Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.

Community Insights

Publications per Year

43 total

Pricing

Price Comparison

BESTBioLongevity LabsUS
500mg
$179.97
$152.97
Price/mg
$0.36$0.31/mg
View−15% · PEPSTACK
Welli LabsUS
10mg
$27.99
Price/mg
$2.80/mg
View
Sunrise BioresearchUS
50mg
$144.98
Price/mg
$2.90/mg
View
Sunrise BioresearchUS
10mg
$29.57
Price/mg
$2.96/mg
View
Puratek PeptidesUS
10mg
$29.95
$26.95
Price/mg
$3.00$2.70/mg
View−10% · PEPSTACKS10

Vendor	Amount	Price	Price/mg	Link
BESTBioLongevity LabsUS	500mg	$179.97$152.97	$0.36$0.31/mg	View−15% · PEPSTACK
Welli LabsUS	10mg	$27.99	$2.80/mg	View
Sunrise BioresearchUS	50mg	$144.98	$2.90/mg	View
Sunrise BioresearchUS	10mg	$29.57	$2.96/mg	View
Puratek PeptidesUS	10mg	$29.95$26.95	$3.00$2.70/mg	View−10% · PEPSTACKS10

Top 5 of 128 offers from 88 vendors. Prices updated daily.

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Mechanism

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Mechanism

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Legal Disclaimer

This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer