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BPC-157

Body Protection Compound 157 · BPC157 · Pentadecapeptide BPC-157

Wound Healing & RegenerationPhase I
From$1.80/mgCompare prices
MW
1419.5g/mol
Formula
C62H98N16O22

BPC-157, or Body Protection Compound-157, is a stable pentadecapeptide derived from human gastric juice, classified as a bioactive peptide. Researchers primarily study it for its potential regenerative effects on various tissues, particularly in the context of musculoskeletal injuries, gastrointestinal healing, and inflammatory conditions. Key findings from the literature indicate that BPC-157 may enhance healing processes by promoting angiogenesis, reducing inflammatory cytokines, and improving functional outcomes in preclinical models of tendon, ligament, and muscle injuries. Additionally, studies suggest its efficacy in accelerating wound healing across different tissue types, including skin and gastrointestinal tract injuries. Despite its promising preclinical results, BPC-157 has not yet received approval from regulatory authorities for clinical use, and further research is needed to fully elucidate its mechanisms and confirm its safety and effectiveness in humans.

Chemical Profile

Chemical Profile

Chemical structure
Chemical Structure
FormulaC62H98N16O22
Molecular Weight1419.5 g/mol
CAS Number137525-51-0
PubChem CID9941957
ChEMBL IDCHEMBL4297358

Half-Life

INIntranasal

Not applicable

POOral

Poor bioavailability

Pharmacokinetic data is limited, and more research is needed to determine precise half-life values.

Mechanism

Mechanism of Action

BPC-157 enhances healing by promoting the expression of growth hormone receptors and activating several signaling pathways, including the NO/cGMP pathway and angiogenic pathways, which facilitate cell proliferation, migration, and angiogenesis. It reduces inflammatory cytokines, thereby modulating the inflammatory response, and has been shown to improve functional and structural outcomes in musculoskeletal injuries. While its precise mechanism of action remains incompletely understood, BPC-157's effects on various biological processes, including wound healing and tissue regeneration, suggest a multifaceted role in promoting recovery.

Research

85 Research Publications

3,132

Total Citations

5

Human/RCT

2.5

Avg. Influence

2025

Latest

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#01

The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration.

Chang Chung-Hsun, et al. · Journal of applied physiology (Bethesda, Md. : 1985) · 2011

AnimalInfluence6.0
119
Researchers observed that BPC 157 promotes tendon fibroblast outgrowth, survival under stress, and migration, likely mediated by the activation of the FAK-paxillin pathway in vitro.

Key findings

  1. 01BPC 157 accelerated the outgrowth of tendon cells from tissue samples.
  2. 02The peptide increased the survival of tendon cells when exposed to stress.
  3. 03BPC 157 enhanced the migration and spreading of tendon cells in a dose-dependent manner.
10 µg/kgintraperitoneal(rat)not specified20 mgintravenous(human)not specified10 mgintravenous(human)not specified10 µg/kgintraperitoneal(rat)not specified10 ng/kgintraperitoneal(rat)not specified
PubMed
#02

A new gastric juice peptide, BPC. An overview of the stomach-stress-organoprotection hypothesis and beneficial effects of BPC.

ReviewInfluence4.0
106
The study demonstrated that BPC-157 exhibits organoprotective effects across multiple organ systems, supporting its potential as a novel therapeutic agent.
10 mgintravenous(human)one hour20 mgintravenous(human)one hour10 mginjection(human)single procedure
PubMed
#03

The beneficial effect of BPC 157, a 15 amino acid peptide BPC fragment, on gastric and duodenal lesions induced by restraint stress, cysteamine and 96% ethanol in rats. A comparative study with H2 receptor antagonists, dopamine promotors and gut peptides.

AnimalInfluence3.0
104
The study demonstrated that BPC 157 provides significant protection against gastric and duodenal lesions induced by restraint stress, cysteamine, and ethanol in rats, outperforming several reference standards.
10 mgintravesical injection(human)single procedure10 mgintravenous infusion(human)one hour20 mgintravenous infusion(human)one hour100 mg/kgintraperitoneal(rat)not mentioned50 µg/kgintraperitoneal(rat)not mentioned10 µg/kgintraperitoneal(rat)not mentioned10 ng/kgintraperitoneal(rat)not mentioned10 pg/kgintraperitoneal(rat)not mentioned
PubMed
#04

Stable gastric pentadecapeptide BPC 157-NO-system relation.

ReviewInfluence4.0
97
Researchers observed that BPC 157 interacts with the NO-system to enhance healing responses after vascular injuries, demonstrating its potential in promoting tissue repair.
10 µg/kgintraperitoneal(rat)not specified20 mgintravenous(human)not specified10 mgintravenous(human)not specified10 µg/kgintraperitoneal(rat)not specified10 ng/kgintraperitoneal(rat)not specified
PubMed
#05

Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts.

AnimalInfluence5.0
92
Researchers observed that BPC 157 increased growth hormone receptor expression in tendon fibroblasts, potentially enhancing the proliferation-promoting effects of growth hormone.
10 µg/kgintraperitoneal(rat)not specified20 mgintravenous(human)not specified10 mgintravenous(human)not specified10 µg/kgintraperitoneal(rat)not specified10 ng/kgintraperitoneal(rat)not specified
PubMed
#06

The influence of BPC 157 on nitric oxide agonist and antagonist induced lesions in broiler chicks.

AnimalInfluence4.0
86
Researchers observed that BPC 157 significantly prevented tissue damage caused by nitric oxide antagonists in broiler chicks, highlighting its organoprotective effects.
50 µg/kgintraperitoneal(rat)10 µg/kgperoral(rat)4 weeks10 ng/kgperoral(rat)4 weeks0.4 µg/eyeeye drops(rat)10 mginjection(human)
PubMed
#07

Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocytes growth.

AnimalInfluence4.0
84
Researchers observed that BPC 157 significantly improves recovery metrics in transected rat Achilles tendon models, indicating its potential for enhancing tendon healing.
10 µg/kgintraperitoneal(rat)not specified20 mgintravenous(human)not specified10 mgintravenous(human)not specified10 µg/kgintraperitoneal(rat)not specified10 ng/kgintraperitoneal(rat)not specified
PubMed
#08

BPC 157 and Standard Angiogenic Growth Factors. Gastrointestinal Tract Healing, Lessons from Tendon, Ligament, Muscle and Bone Healing.

Seiwerth Sven, et al. · Current pharmaceutical design · 2018

ReviewInfluence2.0
83
Researchers observed that BPC 157 is consistently effective in promoting healing across gastrointestinal and extragastrointestinal tissues, outperforming standard angiogenic growth factors in various injury models.

Key findings

  1. 01BPC 157 was effective in healing injuries in the gastrointestinal tract, including the esophagus, stomach, and intestines.
  2. 02In contrast to other growth factors like EGF, FGF, and VEGF, BPC 157 demonstrated consistent healing benefits across multiple tissue types.
  3. 03The study highlighted BPC 157's unique role in promoting healing through its own angiogenic effects.
10 µg/kgintraperitoneal(rat)not specified20 mgintravenous(human)not specified10 mgintravenous(human)not specified10 µg/kgintraperitoneal(rat)not specified10 ng/kgintraperitoneal(rat)not specified
PubMed
#09

Modulatory effect of gastric pentadecapeptide BPC 157 on angiogenesis in muscle and tendon healing.

AnimalInfluence5.0
82
Researchers observed that BPC 157 modulated angiogenesis during muscle and tendon healing in rats, correlating with increased VEGF expression.
50 µg/kgintraperitoneal(rat)10 µg/kgperoral(rat)4 weeks10 ng/kgperoral(rat)4 weeks0.4 µg/eyeeye drops(rat)10 mginjection(human)
PubMed
#10

Pentadecapeptide BPC 157 cream improves burn-wound healing and attenuates burn-gastric lesions in mice.

AnimalInfluence1.0
80
The study demonstrated that BPC 157 cream significantly improved burn-wound healing and reduced gastric lesions in burned mice, enhancing tissue repair and inflammatory response.
10 mgintravenous(human)not mentioned20 mgintravenous(human)not mentioned100 mg/kgintraperitoneal(rat)not mentioned50 µg/kgintraperitoneal(rat)not mentioned10 µg/kgintraperitoneal(rat)not mentioned10 ng/kgintraperitoneal(rat)not mentioned1.0 mg/kgintramuscular(rat)not mentioned10 µg/kgintraperitoneal(rat)not mentioned10 ng/kgintraperitoneal(rat)not mentioned
PubMed
Safety

Safety & Handling

Research Gaps

No comprehensive clinical trials in humans have been conducted to confirm the efficacy and safety of BPC-157, with only one clinical study identified in the systematic review. Additionally, the precise mechanisms by which BPC-157 promotes healing in various tissues remain unclear, and there is a lack of data on the long-term effects and potential adverse reactions associated with its use in humans.

Solubility

BPC-157 is soluble in water and saline solutions.

Storage & Handling

Lyophilized

Stable for 2+ years at -20°C, 12 months at 4°C

Reconstituted

Use within 14 days when refrigerated at 4°C

Avoid

Avoid repeated freeze-thaw cycles, direct light

Solvent

Bacteriostatic water or sterile saline recommended

Safety information is derived from published research and may not reflect all known risks. This is not medical advice.

Legal Status

Legal Status

🇩🇪DE

Not approved as a medicinal product. Not a controlled substance. Sale as research chemical is a legal grey area.

🇺🇸US

Not approved by the FDA as a medicinal product. Not scheduled by the DEA.

🇦🇺AU

Not approved by the TGA as a therapeutic good.

🇬🇧UK

Not approved by the MHRA as a medicinal product.

Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.

Community Insights

Community Insights

Publications per Year

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Mechanism

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Legal Disclaimer

This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer