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Cerebrolysin

FPF-1070

Nootropic & CNSApproved
From$0.63/mgCompare prices

Cerebrolysin is a neuropeptide preparation derived from porcine brain tissue, consisting of low-molecular-weight peptides and amino acids. Researchers primarily study it for its potential neuroprotective and neurotrophic properties, particularly in the context of neurological disorders such as acute ischaemic stroke and neurodegenerative diseases. Key findings from various studies indicate that while Cerebrolysin may not significantly affect all-cause mortality or the overall incidence of serious adverse events, there is evidence suggesting a potential increase in non-fatal serious adverse events associated with its use. Current research continues to evaluate its efficacy and safety through randomized controlled trials, with mixed results regarding its clinical benefits in treating acute ischaemic stroke.

Chemical Profile

Chemical Profile

Half-Life

INIntranasal

Not applicable

POOral

Poor bioavailability

Pharmacokinetic data is limited, with rapid distribution and elimination observed.

Mechanism

Mechanism of Action

Cerebrolysin, a mixture of low-molecular-weight peptides and amino acids derived from porcine brain, is thought to exert its neuroprotective effects through the activation of neurotrophic receptors, including the TrkB receptor, which is involved in the Brain-Derived Neurotrophic Factor (BDNF) signaling pathway. This activation promotes neuronal survival, enhances synaptic plasticity, and stimulates neurogenesis, potentially through downstream signaling pathways such as the PI3K/Akt and MAPK/ERK pathways. However, the precise mechanisms and all receptor interactions remain incompletely understood.

Research

76 Research Publications

1,676

Total Citations

8

Human/RCT

1.7

Avg. Influence

2025

Latest

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#01

Sonic hedgehog signaling pathway mediates cerebrolysin-improved neurological function after stroke.

AnimalInfluence2.0
137
Researchers observed that Cerebrolysin enhances neurogenesis and improves neurological function after stroke in rats, mediated by the Sonic hedgehog signaling pathway.
10 and 30 mL(human)2.5 ml/kgintraperitoneal(rat)10 consecutive days2.5 mL/kg per dayi.p.(mouse)
PubMed
#02

The pharmacology of neurotrophic treatment with Cerebrolysin: brain protection and repair to counteract pathologies of acute and chronic neurological disorders.

ReviewInfluence5.0
125
The study demonstrated that Cerebrolysin mimics endogenous neurotrophic factors, enhancing brain protection and repair in various neurological disorders.
30 mL for 10 days10 days10 and 30 mL60 mL2.5 mL/kg per dayintraperitoneal(mouse)per day
PubMed
#03

Cerebrolysin for vascular dementia.

Chen Ning, et al. · The Cochrane database of systematic reviews · 2013

Meta-AnalysisInfluence2.0
101
Researchers studied the effects of Cerebrolysin on cognitive function in elderly patients with vascular dementia. They found that Cerebrolysin may improve general cognitive abilities and overall clinical function, although the evidence is not strong enough to recommend it as a standard treatment.

Key findings

  1. 01Cerebrolysin showed a beneficial effect on cognitive function as measured by standard assessments.
  2. 02The treatment also improved global clinical function in participants.
  3. 03Only non-serious side effects were reported, with no significant difference in side effects between treatment and control groups.
PubMed
#04

Apoptosis modulators in the therapy of neurodegenerative diseases.

ReviewInfluence1.0
93
The study demonstrated that various apoptosis modulators, including Cerebrolysin, exhibit neuroprotective properties and may be beneficial in treating neurodegenerative diseases.
30 mL for 10 days10 days10 and 30 mL60 mL2.5 mL/kg per dayintraperitoneal(mouse)per day
PubMed
#05

Cerebrolysin: a review of its use in dementia.

HumanInfluence1.0
78
The study demonstrated that Cerebrolysin was superior to placebo in improving global outcome measures and cognitive ability in patients with Alzheimer's disease.
30 mL for 10 days10 days10 and 30 mL60 mL2.5 mL/kg per dayintraperitoneal(mouse)per day
PubMed
#06

Cerebrolysin for acute ischaemic stroke.

Ziganshina Liliya Eugenevna, et al. · The Cochrane database of systematic reviews · 2020

Human
70
The study demonstrated that moderate-quality evidence indicates Cerebrolysin probably has little or no beneficial effect on preventing all-cause death in acute ischaemic stroke.

Key findings

  1. 01Cerebrolysin probably results in little to no difference in all-cause death rates among stroke patients.
  2. 02There is likely no significant difference in the total number of serious adverse events between those treated with Cerebrolysin and those given a placebo.
  3. 03The study suggests a potential increase in non-fatal serious adverse events associated with Cerebrolysin use.
30 mL for 10 days10 days10 and 30 mL60 mL2.5 mL/kg per dayintraperitoneal(mouse)per day
PubMed
#07

Neurotrophic activities and therapeutic experience with a brain derived peptide preparation.

ReviewInfluence1.0
68
Researchers observed that Cerebrolysin exhibits neurotrophic and neuroprotective effects, improving cognitive performance in Alzheimer's patients without serious side effects.
30 mL for 10 days10 days10 and 30 mL60 mL2.5 mL/kg per dayintraperitoneal(mouse)per day
PubMed
#08

Neuroprotective effects of cerebrolysin, a combination of different active fragments of neurotrophic factors and peptides on the whole body hyperthermia-induced neurotoxicity: modulatory roles of co-morbidity factors and nanoparticle intoxication.

AnimalInfluence1.0
57
The study demonstrated that Cerebrolysin significantly reduced neurotoxicity and blood-brain barrier disruption following whole body hyperthermia in animal models.
30 mL for 10 days10 days10 and 30 mL60 mL2.5 mL/kg per dayintraperitoneal(mouse)per day
PubMed
#09

Cerebrolysin reduces amyloid-β deposits, apoptosis and autophagy in the thalamus and improves functional recovery after cortical infarction.

AnimalInfluence2.0
55
The study demonstrated that Cerebrolysin significantly reduces amyloid-β deposits, apoptosis, and autophagy in the thalamus, leading to improved sensory function after cortical infarction in rats.
30 mL for 10 days10 days10 and 30 mL60 mL2.5 mL/kg per dayintraperitoneal(mouse)per day
PubMed
#10

Cerebrolysin improves symptoms and delays progression in patients with Alzheimer's disease and vascular dementia.

HumanInfluence1.0
47
The study demonstrated that Cerebrolysin significantly improves cognitive and functional outcomes in patients with Alzheimer's disease and vascular dementia, with effects persisting for several months.
30 mL for 10 days10 days10 and 30 mL60 mL2.5 mL/kg per dayintraperitoneal(mouse)per day
PubMed
Safety

Safety & Handling

Research Gaps

The existing studies primarily focus on short-term outcomes, with no long-term follow-up data available to assess the enduring effects of Cerebrolysin on functional recovery and quality of life in patients with acute ischaemic stroke. Additionally, the precise neuroprotective mechanisms of action of Cerebrolysin remain unclear, as the studies do not adequately explore the biochemical pathways involved in its therapeutic effects.

Solubility

Cerebrolysin is soluble in water and commonly used solvents such as saline.

Storage & Handling

Lyophilized

Stable for 2+ years at -20°C, 12 months at 4°C

Reconstituted

Use within 14 days when refrigerated at 4°C

Avoid

Avoid repeated freeze-thaw cycles, direct light

Solvent

Bacteriostatic water or sterile saline recommended

Safety information is derived from published research and may not reflect all known risks. This is not medical advice.

Legal Status

Legal Status

🇩🇪DE

Not approved as a medicinal product. Not a controlled substance. Sale as research chemical is a legal grey area.

🇺🇸US

Not approved by the FDA as a medicinal product. Not a controlled substance.

🇦🇺AU

Not approved by the TGA as a medicinal product.

🇬🇧UK

Not approved by the MHRA as a medicinal product.

Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.

Community Insights

Community Insights

Publications per Year

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Pricing

Price Comparison

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Mechanism

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Mechanism

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Legal Disclaimer

This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer