Wiki · Profile

Cerebrolysin

FPF-1070

Nootropic & CNSApproved

Cerebrolysin is a peptide mixture derived from porcine brain tissue, composed of low-molecular-weight peptides and amino acids, classified primarily as a neuropeptide preparation. Researchers primarily study it for its potential neuroprotective and neurotrophic properties, particularly in the context of acute ischaemic stroke and other neurological disorders. Key findings from various studies suggest that while Cerebrolysin may not significantly reduce all-cause mortality or serious adverse events in stroke patients, there is moderate-quality evidence indicating a potential increase in non-fatal serious adverse events associated with its use. Current research continues to evaluate its efficacy and safety in clinical settings, with ongoing trials and systematic reviews assessing its role in neurological recovery.

Chemical Profile

Half-Life

INIntranasal

Not applicable

POOral

Poor bioavailability

Pharmacokinetic data is limited, with rapid distribution and elimination observed.

Mechanism

Mechanism of Action

Cerebrolysin, a mixture of low-molecular-weight peptides and amino acids, is believed to exert its neuroprotective effects primarily through the activation of neurotrophic factor receptors, such as the TrkB receptor, which initiates the MAPK/ERK signaling pathway, promoting neuronal survival and differentiation. Additionally, it may enhance synaptic plasticity and neurogenesis by modulating pathways like the PI3K/Akt pathway and the NO/cGMP pathway, although the precise mechanisms and full spectrum of its actions remain not entirely understood.

Research

90 Research Publications

2,118

Total Citations

Human/RCT

1.8

Avg. Influence

2025

Latest

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01Top

#01

Sonic hedgehog signaling pathway mediates cerebrolysin-improved neurological function after stroke.

AnimalInfluence2.0

137

Researchers observed that the Sonic hedgehog signaling pathway mediates cerebrolysin-induced neurogenesis and improves neurological function after stroke in rats.

2.5 mL/kgintraperitoneal(mouse)seven days30 mL for 10 days (cumulative dose 300 mL)not specified(not specified)10 days10 and 30 mLnot specified(not specified)not specifiedup to 60 mLnot specified(not specified)not specified

PubMed

02Top

#02

The pharmacology of neurotrophic treatment with Cerebrolysin: brain protection and repair to counteract pathologies of acute and chronic neurological disorders.

ReviewInfluence5.0

124

The review highlighted that Cerebrolysin mimics endogenous neurotrophic factors, promoting brain protection and repair in various neurological disorders.

PubMed

03Top

#03

Cerebrolysin, a mixture of neurotrophic factors induces marked neuroprotection in spinal cord injury following intoxication of engineered nanoparticles from metals.

AnimalInfluence2.0

105

The study demonstrated that cerebrolysin significantly reduced spinal cord injury pathology in rats following nanoparticle intoxication, indicating its potential as a neuroprotective agent.

PubMed

#04

Cerebrolysin for vascular dementia.

Chen Ning, et al. · The Cochrane database of systematic reviews · 2013

Meta-AnalysisInfluence2.0

101

Researchers studied the effects of Cerebrolysin on cognitive function in elderly patients with vascular dementia. They found that Cerebrolysin may improve general cognitive abilities and overall clinical function, although the evidence is not strong enough to recommend it as a standard treatment.

Key findings

01Cerebrolysin showed a beneficial effect on cognitive function as measured by standard assessments.
02The treatment also improved global clinical function in participants.
03Only non-serious side effects were reported, with no significant difference in side effects between treatment and control groups.

PubMed

#05

Apoptosis modulators in the therapy of neurodegenerative diseases.

ReviewInfluence1.0

The review summarized that Cerebrolysin supports neuronal survival and has potential as a neuroprotective agent in various neurodegenerative diseases.

PubMed

#06

Cerebrolysin: a review of its use in dementia.

ReviewInfluence1.0

The study demonstrated that Cerebrolysin was superior to placebo in improving cognitive ability and global outcome measures in human patients with Alzheimer's disease.

PubMed

#07

Cerebrolysin for acute ischaemic stroke.

Ziganshina Liliya Eugenevna, et al. · The Cochrane database of systematic reviews · 2020

Meta-Analysis

The study demonstrated that cerebrolysin likely has little or no beneficial effect on preventing all-cause death and may increase non-fatal serious adverse events in acute ischaemic stroke.

Key findings

01Cerebrolysin probably results in little to no difference in all-cause death rates among stroke patients.
02There is likely no significant difference in the total number of serious adverse events between those treated with Cerebrolysin and those given a placebo.
03The study suggests a potential increase in non-fatal serious adverse events associated with Cerebrolysin use.

PubMed

#08

Neurotrophic activities and therapeutic experience with a brain derived peptide preparation.

ReviewInfluence1.0

Researchers observed that cerebrolysin exhibited neurotrophic and neuroprotective properties in various neuronal populations, suggesting its potential for treating neurodegenerative disorders.

PubMed

#09

Cerebrolysin improves cognitive performance in rats after mild traumatic brain injury.

AnimalInfluence3.0

Researchers observed that cerebrolysin improved long-term cognitive performance and neurogenesis in rats following mild traumatic brain injury.

PubMed

#10

Neuroprotective effects of cerebrolysin, a combination of different active fragments of neurotrophic factors and peptides on the whole body hyperthermia-induced neurotoxicity: modulatory roles of co-morbidity factors and nanoparticle intoxication.

ReviewInfluence1.0

Researchers observed that cerebrolysin administration significantly reduced blood-brain barrier disruption and neurotoxicity following whole body hyperthermia in rats, indicating its potential therapeutic value against heat-induced brain injury.

30 mL for 10 days10 days10 and 30 mL60 mL2.5 mL/kg per dayintraperitoneal(mouse)per day

PubMed

Safety

Safety & Handling

Research Gaps

No randomized controlled trials have reported on poor functional outcomes, such as death or dependence at the end of the follow-up period, early death within two weeks of stroke onset, or quality of life assessments. Additionally, the specific neuroprotective mechanisms of action of Cerebrolysin remain unclear, as the studies do not elucidate how the peptide composition translates to clinical efficacy or safety in humans.

Solubility

Cerebrolysin is soluble in water and commonly used solvents such as saline.

Storage & Handling

Lyophilized

Stable for 2+ years at -20°C, 12 months at 4°C

Reconstituted

Use within 14 days when refrigerated at 4°C

Avoid

Avoid repeated freeze-thaw cycles, direct light

Solvent

Bacteriostatic water or sterile saline recommended

Safety information is derived from published research and may not reflect all known risks. This is not medical advice.

Legal Status

🇩🇪DE

Not approved as a medicinal product. Not a controlled substance. Sale as research chemical is a legal grey area.

🇺🇸US

Not approved by the FDA as a medicinal product. Not a controlled substance.

🇦🇺AU

Not approved by the TGA as a medicinal product.

🇬🇧UK

Not approved by the MHRA as a medicinal product.

Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.

Community Insights

Publications per Year

50 total

Pricing

Price Comparison

BESTbulkpeptidesupply.comUS
60mg
$12.50
Price/mg
$0.21/mg
View
Receptor ChemUK
60mg
$38.09
Price/mg
$0.63/mg
View
RCpeptidesEU
60mg
$81.00
Price/mg
$1.35/mg
View
Oasis LabsUS
60mg
$106.00
Price/mg
$1.77/mg
View
Iron PeptidesUS
60mg
$109.00
Price/mg
$1.82/mg
View

Vendor	Amount	Price	Price/mg	Link
BESTbulkpeptidesupply.comUS	60mg	$12.50	$0.21/mg	View
Receptor ChemUK	60mg	$38.09	$0.63/mg	View
RCpeptidesEU	60mg	$81.00	$1.35/mg	View
Oasis LabsUS	60mg	$106.00	$1.77/mg	View
Iron PeptidesUS	60mg	$109.00	$1.82/mg	View

Top 5 of 7 offers from 6 vendors. Prices updated daily.

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Mechanism

Tools

Reconstitution Calculator

Calculate reconstitution volumes for Cerebrolysin

Serum Level Visualizer

Visualize Cerebrolysin serum levels over time

Mechanism

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Legal Disclaimer

This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer