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Selank

TP-7 · Selanc

Nootropic & CNSPreclinical

MW: 751.9g/mol
Formula: C33H57N11O9

Selank is a synthetic heptapeptide derived from the endogenous peptide tuftsin, classified as an anxiolytic and nootropic agent. Researchers primarily study Selank for its potential effects on anxiety, cognitive function, and neuroplasticity. Key findings indicate that Selank may enhance brain-derived neurotrophic factor (BDNF) levels in the hippocampus and prefrontal cortex, potentially mitigating memory impairments associated with ethanol exposure, while also exhibiting positive allosteric modulation of GABA receptors. Additionally, studies suggest that Selank may possess antidepressant-like properties, influencing monoaminergic systems and reducing symptoms of depression in animal models. Current research is focused on elucidating the molecular mechanisms underlying its effects and exploring its clinical applications, although comprehensive clinical trials are still needed to establish its efficacy in humans.

Chemical Profile

Chemical Structure

Formula	C33H57N11O9
Molecular Weight	751.9 g/mol
CAS Number	129954-34-3
PubChem CID	11765600
ChEMBL ID	CHEMBL4585920

Half-Life

INIntranasal

~15 minutes

POOral

Poor bioavailability

Intranasal administration is preferred due to rapid absorption and onset of action.

Mechanism

Mechanism of Action

Selank acts as a positive allosteric modulator of GABA receptors, influencing [3H]GABA binding and potentially modulating the activity of benzodiazepines like Diazepam and Olanzapine. It enhances brain-derived neurotrophic factor (BDNF) signaling in the hippocampus and prefrontal cortex, promoting neuroplasticity and cognitive function while also activating monoaminergic systems, including dopamine synthesis and turnover. Although the exact mechanisms remain partially understood, Selank's effects on anxiety and cognitive enhancement suggest involvement in multiple signaling pathways, including those related to neurotrophins and GABAergic modulation.

Research

61 Research Publications

447

Total Citations

Human/RCT

1.1

Avg. Influence

2023

Latest

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01Top

#01

Natural and hybrid ("chimeric") stable regulatory glyproline peptides.

Animal

Researchers observed that glyproline peptides, including Selank, exhibit stability comparable to major pharmacological preparations and can be administered orally, suggesting potential for new therapeutic applications.

0.3 mg/kg a dayintraperitoneally(rat)7 days100 μg/kgintraperitoneally(rat)20 days300 mg/kgintravenously(cat)not mentioned0.3 mg/kgintraperitoneally(rat)not mentioned100 μg/kgintraperitoneally(rat)not mentioned300 μg/kgnot mentioned(rat)not mentioned300 μg/kgnot mentioned(rat)not mentioned300 μg/kg/day for 5 daysintraperitoneally(mouse)5 days100 μg/kgintraperitoneally(mouse)not mentioned0.3 mg/kgintraperitoneally(mouse)not mentioned

PubMed

02Top

#02

Tuftsin - Properties and Analogs.

Siebert Agnieszka, et al. · Current medicinal chemistry · 2017

ReviewInfluence1.0

Researchers observed that tuftsin and its analogs exhibit various biological activities, including anti-tumor and anti-inflammatory effects, highlighting their potential therapeutic applications.

Key findings

01The review included 86 documents, highlighting tuftsin's significant biological activities.
02Thirty-two studies focused on tuftsin's effects in humans, while others explored its analogs' properties.
03Many tuftsin derivatives demonstrated potential in cancer treatment and as components of vaccines.

0.3 mg/kg a dayintraperitoneally(rat)7 days1000-2000 microg/kginjection(rat)not mentioned100 and 300 microg/kginjection(mouse)not mentioned0.3 mg/kgintraperitoneal(rat)not mentioned300 μg/kgintraperitoneal(rat)not mentioned80, 250, and 750 μg/kgintraperitoneal(rat)not mentioned300 μg/kg/day for 5 daysintraperitoneal(mouse)5 days

PubMed

03Top

#03

Atrial fibrillation-associated electrical remodelling in human induced pluripotent stem cell-derived atrial cardiomyocytes: a novel pathway for antiarrhythmic therapy development.

Seibertz Fitzwilliam, et al. · Cardiovascular research · 2023

In VitroInfluence1.0

Researchers studied how atrial fibrillation (AF) affects heart cell function using human heart cells created from stem cells. They found that mimicking AF conditions led to significant changes in electrical activity and heart cell behavior, which could help in developing new treatments for AF.

Key findings

01Researchers observed that electrical pacing mimicking AF conditions caused decreased calcium current and impaired potassium current in heart cells.
02The study found that long-term pacing resulted in changes such as increased potassium current and altered heart cell contractility.
03Researchers successfully modeled AF-associated changes in heart cells, providing a new platform for discovering potential antiarrhythmic therapies.

PubMed

#04

Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission.

Volkova Anastasiya, et al. · Frontiers in pharmacology · 2016

Unknown

The study demonstrated that Selank alters the expression of multiple genes involved in neurotransmission in rat frontal cortex, suggesting a complex mechanism of action similar to benzodiazepines.

Key findings

01Researchers observed significant changes in the expression of 45 genes one hour after administering Selank or GABA.
02Three hours post-administration, 22 genes showed altered expression.
03The study found a positive correlation in gene expression changes between Selank and GABA within the first hour.

PubMed

#05

Sedative-Hypnotic Agents That Impact Gamma-Aminobutyric Acid Receptors: Focus on Flunitrazepam, Gamma-Hydroxybutyric Acid, Phenibut, and Selank.

Human

Researchers observed that Selank, along with other GABAergic agents, has potential for abuse and dependence, highlighting the need for careful evaluation of its use.

PubMed

#06

Selank and short peptides of the tuftsin family in the regulation of adaptive behavior in stress.

AnimalInfluence2.0

Researchers observed that Selank and tuftsin family peptides positively influenced emotional behavior and exhibited antistress actions in male rats and mice under emotional stress conditions.

PubMed

#07

[Comparison of anticoagulant effects of regulatory proline-containing oligopeptides. Specificity of glyprolines, semax, and selank and potential of their practical application].

Review

Researchers observed that regulatory peptides, including selank, exhibit varying anticoagulant effects, highlighting their potential role in hemostatic processes.

6000 mcg/daynot mentioned(human)10 days12 mgnot mentioned(human)5 to 10 days18 mgnot mentioned(human)5 to 10 days100 mcg/kg/dayintraperitoneal(rat)20 days50 microg/kg bodyweightintranasal(rat)not mentioned250 microg/kg bodyweightintranasal(rat)not mentioned

PubMed

#08

The inhibitory effect of Selank on enkephalin-degrading enzymes as a possible mechanism of its anxiolytic activity.

Human

Researchers observed that selank inhibited enkephalin-degrading enzymes in patients with generalized anxiety, indicating its potential mechanism for alleviating anxiety symptoms.

PubMed

#09

Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity.

Animal

Researchers observed that Selank acts as a positive allosteric modulator of GABA receptors, contributing to its anti-anxiety effects distinct from traditional anxiolytics.

PubMed

#10

The temporary dynamics of inflammation-related genes expression under tuftsin analog Selank action.

Animal

The study demonstrated that Selank influences the expression of inflammation-related genes in mouse spleen, indicating its role in regulating immune responses.

PubMed

Safety

Safety & Handling

Research Gaps

No randomized controlled human trials have been conducted to assess the efficacy and safety of Selank in clinical settings. Additionally, the long-term effects of Selank on cognitive function and emotional regulation in humans remain unknown, and the precise molecular mechanisms underlying its anxiolytic and nootropic effects require further elucidation.

Solubility

Selank is soluble in water and saline solutions.

Storage & Handling

Lyophilized

Stable for 2+ years at -20°C, 12 months at 4°C

Reconstituted

Use within 14 days when refrigerated at 4°C

Avoid

Avoid repeated freeze-thaw cycles, direct light

Solvent

Bacteriostatic water or sterile saline recommended

Safety information is derived from published research and may not reflect all known risks. This is not medical advice.

Legal Status

🇩🇪DE

Not approved as a medicinal product. Not a controlled substance. Sale as research chemical is a legal grey area.

🇺🇸US

Not approved by the FDA. Not scheduled by the DEA.

🇦🇺AU

Not listed in the TGA schedules.

🇬🇧UK

Not approved as a medicinal product by the MHRA.

Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.

Community Insights

Publications per Year

49 total

Pricing

Price Comparison

BESTPeptiLab USAUS
10mg
$20.99
Price/mg
$2.10/mg
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Alpha PeptidesUS
10mg
$24.16
$21.74
Price/mg
$2.42$2.18/mg
View−10% · PEPSTACK10
Orbitrex PeptideUS
30mg
$79.99
Price/mg
$2.67/mg
View
Orbitrex PeptideUS
10mg
$29.99
Price/mg
$3.00/mg
View
Ignite PeptidesUS
10mg
$30.00
Price/mg
$3.00/mg
View

Vendor	Amount	Price	Price/mg	Link
BESTPeptiLab USAUS	10mg	$20.99	$2.10/mg	View
Alpha PeptidesUS	10mg	$24.16$21.74	$2.42$2.18/mg	View−10% · PEPSTACK10
Orbitrex PeptideUS	30mg	$79.99	$2.67/mg	View
Orbitrex PeptideUS	10mg	$29.99	$3.00/mg	View
Ignite PeptidesUS	10mg	$30.00	$3.00/mg	View

Top 5 of 59 offers from 56 vendors. Prices updated daily.

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Mechanism

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Mechanism

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Legal Disclaimer

This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer