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Selank

TP-7 · Selanc

Nootropic & CNSPreclinical

MW: 751.9g/mol
Formula: C33H57N11O9

Selank is a heptapeptide analogue of the endogenous peptide tuftsin, classified as a neuroactive peptide with anxiolytic and nootropic properties. Researchers primarily study Selank for its potential effects on anxiety, cognitive function, and neuroprotection. Key findings indicate that Selank can enhance brain-derived neurotrophic factor (BDNF) levels in the hippocampus and prefrontal cortex, which may mitigate memory impairment associated with chronic ethanol exposure, and it has shown promise in reducing withdrawal symptoms in morphine-dependent models. Additionally, studies suggest that Selank modulates GABA receptor activity, indicating a complex mechanism of action that differs from traditional anxiolytics. Current research is ongoing, with a focus on elucidating the molecular mechanisms underlying its effects and exploring its applications in various neuropsychiatric conditions.

Chemical Profile

Chemical Structure

Formula	C33H57N11O9
Molecular Weight	751.9 g/mol
CAS Number	129954-34-3
PubChem CID	11765600
ChEMBL ID	CHEMBL4585920

Half-Life

INIntranasal

~15 minutes

POOral

Poor bioavailability

Intranasal administration is preferred due to rapid absorption and onset of action.

Mechanism

Mechanism of Action

Selank acts as a positive allosteric modulator of GABA receptors, influencing the binding of [3H]GABA and potentially interacting with benzodiazepine sites, although the specific binding sites may partially overlap. It enhances brain-derived neurotrophic factor (BDNF) signaling in the hippocampus and prefrontal cortex, which is critical for neuroplasticity and cognitive function, while also modulating pathways associated with anxiety and stress responses. The exact molecular mechanisms and receptor interactions of Selank remain to be fully elucidated.

Research

55 Research Publications

354

Total Citations

Human/RCT

1.1

Avg. Influence

2023

Latest

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01Top

#01

Tuftsin - Properties and Analogs.

Siebert Agnieszka, et al. · Current medicinal chemistry · 2017

ReviewInfluence1.0

The study demonstrated that tuftsin and its analogs exhibit various biological activities, including anti-tumor and anti-inflammatory effects.

Key findings

01The review included 86 documents, highlighting tuftsin's significant biological activities.
02Thirty-two studies focused on tuftsin's effects in humans, while others explored its analogs' properties.
03Many tuftsin derivatives demonstrated potential in cancer treatment and as components of vaccines.

0.3 mg/kg a dayintraperitoneally(rat)7 days0.3 mg/kgintraperitoneal(rat)single injection2 mg/kgnot specified(rat)not specified300 μg/kgintraperitoneal(rat)not specified100 μg/kgintraperitoneal(rat)not specified80 μg/kgintraperitoneal(rat)not specified250 μg/kgintraperitoneal(rat)not specified750 μg/kgintraperitoneal(rat)not specified300 microg/kgnot specified(rat)not specified1000-2000 microg/kgnot specified(rat)not specified100 microg/kgnot specified(mouse)not specified300 μg/kgintraperitoneal(rat)not specified

PubMed

02Top

#02

Atrial fibrillation-associated electrical remodelling in human induced pluripotent stem cell-derived atrial cardiomyocytes: a novel pathway for antiarrhythmic therapy development.

Seibertz Fitzwilliam, et al. · Cardiovascular research · 2023

In VitroInfluence1.0

Researchers studied how atrial fibrillation (AF) affects heart cell function using human heart cells created from stem cells. They found that mimicking AF conditions led to significant changes in electrical activity and heart cell behavior, which could help in developing new treatments for AF.

Key findings

01Researchers observed that electrical pacing mimicking AF conditions caused decreased calcium current and impaired potassium current in heart cells.
02The study found that long-term pacing resulted in changes such as increased potassium current and altered heart cell contractility.
03Researchers successfully modeled AF-associated changes in heart cells, providing a new platform for discovering potential antiarrhythmic therapies.

PubMed

03Top

#03

Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission.

Volkova Anastasiya, et al. · Frontiers in pharmacology · 2016

Animal

Researchers observed that Selank caused significant alterations in the expression of neurotransmission-related genes in the frontal cortex of rats.

Key findings

01Researchers observed significant changes in the expression of 45 genes one hour after administering Selank or GABA.
02Three hours post-administration, 22 genes showed altered expression.
03The study found a positive correlation in gene expression changes between Selank and GABA within the first hour.

PubMed

#04

Sedative-Hypnotic Agents That Impact Gamma-Aminobutyric Acid Receptors: Focus on Flunitrazepam, Gamma-Hydroxybutyric Acid, Phenibut, and Selank.

Review

Researchers observed that Selank, a poorly studied GABAergic agent, shares similarities with other sedative-hypnotics but requires further evaluation for its abuse potential.

PubMed

#05

Selank and short peptides of the tuftsin family in the regulation of adaptive behavior in stress.

AnimalInfluence2.0

Researchers observed that Selank and tuftsin peptides exhibited positive emotional effects and antistress actions in stressed rats, indicating their potential for pharmacological applications.

PubMed

#06

The inhibitory effect of Selank on enkephalin-degrading enzymes as a possible mechanism of its anxiolytic activity.

Human

The study demonstrated that Selank inhibits enkephalin-degrading enzymes in humans, suggesting its potential efficacy in alleviating generalized anxiety disorders through increased enkephalin levels.

PubMed

#07

GABA, Selank, and Olanzapine Affect the Expression of Genes Involved in GABAergic Neurotransmission in IMR-32 Cells.

Filatova Elena, et al. · Frontiers in pharmacology · 2017

In Vitro

The study demonstrated that Selank did not directly affect GABAergic gene expression in neuroblastoma cells but may enhance the effects of GABA and olanzapine.

Key findings

01Selank showed an anxiolytic effect comparable to classical benzodiazepines.
02GABA and Selank influence gene expression related to GABAergic neurotransmission.
03Olanzapine also affects the expression of these genes in the studied cells.

PubMed

#08

Expression of inflammation-related genes in mouse spleen under tuftsin analog Selank.

Animal

The study demonstrated that Selank significantly altered the expression of 34 inflammation-related genes in the spleen of mice, indicating its role in regulating inflammatory processes.

PubMed

#09

[Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia].

Human

Researchers observed that Selank exhibited similar anxiolytic effects to medazepam while also demonstrating antiasthenic and psychostimulant effects in patients with generalized anxiety disorder.

PubMed

#10

Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity.

In Vitro

The study demonstrated that Selank acts as a positive allosteric modulator of GABA receptors, contributing to its anxiolytic effects.

PubMed

Safety

Safety & Handling

Research Gaps

No randomized controlled human trials have been conducted to assess the efficacy and safety of Selank in human populations. Additionally, the long-term effects of Selank on cognitive function and emotional regulation remain unclear, as well as the precise molecular mechanisms underlying its interaction with GABA receptors and its influence on neuroplasticity pathways.

Solubility

Selank is soluble in water and saline solutions.

Storage & Handling

Lyophilized

Stable for 2+ years at -20°C, 12 months at 4°C

Reconstituted

Use within 14 days when refrigerated at 4°C

Avoid

Avoid repeated freeze-thaw cycles, direct light

Solvent

Bacteriostatic water or sterile saline recommended

Safety information is derived from published research and may not reflect all known risks. This is not medical advice.

Legal Status

🇩🇪DE

Not approved as a medicinal product. Not a controlled substance. Sale as research chemical is a legal grey area.

🇺🇸US

Not approved by the FDA. Not scheduled by the DEA.

🇦🇺AU

Not listed in the TGA schedules.

🇬🇧UK

Not approved as a medicinal product by the MHRA.

Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.

Community Insights

Publications per Year

47 total

Pricing

Price Comparison

BESTXL PeptidesUK
10mg
$9.53
Price/mg
$0.95/mg
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PeptiLab USAUS
10mg
$20.99
Price/mg
$2.10/mg
View
Orbitrex PeptideUS
30mg
$79.99
Price/mg
$2.67/mg
View
FitSKNS PeptidesUS
10mg
$30.00
Price/mg
$3.00/mg
View
Orbitrex PeptideUS
10mg
$29.99
Price/mg
$3.00/mg
View

Vendor	Amount	Price	Price/mg	Link
BESTXL PeptidesUK	10mg	$9.53	$0.95/mg	View
PeptiLab USAUS	10mg	$20.99	$2.10/mg	View
Orbitrex PeptideUS	30mg	$79.99	$2.67/mg	View
FitSKNS PeptidesUS	10mg	$30.00	$3.00/mg	View
Orbitrex PeptideUS	10mg	$29.99	$3.00/mg	View

Top 5 of 58 offers from 54 vendors. Prices updated daily.

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Mechanism

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Mechanism

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Legal Disclaimer

This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer