Wiki · Profile

Selank

TP-7 · Selanc

Nootropic & CNSPreclinical

MW: 751.9g/mol
Formula: C33H57N11O9

Selank is a synthetic peptide analogue of tuftsin, classified as an anxiolytic and neuroactive compound. Researchers primarily study Selank for its potential effects on anxiety regulation and cognitive enhancement. Key findings from recent studies indicate that Selank can modulate brain-derived neurotrophic factor (BDNF) levels, which are crucial for memory and learning, and it has shown promise in improving cognitive function in models of ethanol-induced memory impairment. Additionally, studies suggest that Selank may influence functional connectivity in brain regions associated with anxiety and executive functions. Current research continues to explore its therapeutic applications and mechanisms of action, particularly in the context of anxiety disorders and cognitive decline.

Chemical Profile

Chemical Structure

Formula	C33H57N11O9
Molecular Weight	751.9 g/mol
CAS Number	129954-34-3
PubChem CID	11765600
ChEMBL ID	CHEMBL4585920

Half-Life

INIntranasal

~15 minutes

POOral

Poor bioavailability

Intranasal administration is preferred due to rapid absorption and onset of action.

Mechanism

Mechanism of Action

Selank, a peptide analogue of tuftsin, exerts its anxiolytic effects primarily through modulation of the brain-derived neurotrophic factor (BDNF) signaling pathway, enhancing neuroplasticity and cognitive function. It is believed to influence the levels of enkephalins, which are endogenous opioid peptides, thereby affecting the opioid signaling pathway and potentially modulating the PI3K/Akt and MAPK pathways involved in cellular survival and stress response. While the precise mechanisms remain partially understood, Selank's impact on functional connectivity in brain regions associated with anxiety and cognition suggests a multifaceted role in neurochemical regulation.

Research

58 Research Publications

417

Total Citations

Human/RCT

1.1

Avg. Influence

2023

Latest

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01Top

#01

Natural and hybrid ("chimeric") stable regulatory glyproline peptides.

Review

Researchers observed that glyproline peptides, including Selank, exhibit stability comparable to major pharmacological preparations, allowing for potential oral administration.

0.3 mg/kg a dayintraperitoneally(rat)7 days100 μg/kgintraperitoneally(rat)20 days300 mg/kgi.v.(cat)not mentioned0.3 mg/kgintraperitoneally(rat)not mentioned100 μg/kgintraperitoneally(rat)not mentioned300 μg/kgnot mentioned(rat)not mentioned300 μg/kgintraperitoneally(mouse)5 days100 μg/kgintraperitoneal(mouse)not mentioned

PubMed

02Top

#02

Tuftsin - Properties and Analogs.

Siebert Agnieszka, et al. · Current medicinal chemistry · 2017

ReviewInfluence1.0

The review summarized the biological activities and clinical potential of tuftsin and its analogs, emphasizing their anti-tumor, anti-inflammatory, and antimicrobial properties.

Key findings

01The review included 86 documents, highlighting tuftsin's significant biological activities.
02Thirty-two studies focused on tuftsin's effects in humans, while others explored its analogs' properties.
03Many tuftsin derivatives demonstrated potential in cancer treatment and as components of vaccines.

PubMed

03Top

#03

Atrial fibrillation-associated electrical remodelling in human induced pluripotent stem cell-derived atrial cardiomyocytes: a novel pathway for antiarrhythmic therapy development.

Seibertz Fitzwilliam, et al. · Cardiovascular research · 2023

In VitroInfluence1.0

Researchers studied how atrial fibrillation (AF) affects heart cell function using human heart cells created from stem cells. They found that mimicking AF conditions led to significant changes in electrical activity and heart cell behavior, which could help in developing new treatments for AF.

Key findings

01Researchers observed that electrical pacing mimicking AF conditions caused decreased calcium current and impaired potassium current in heart cells.
02The study found that long-term pacing resulted in changes such as increased potassium current and altered heart cell contractility.
03Researchers successfully modeled AF-associated changes in heart cells, providing a new platform for discovering potential antiarrhythmic therapies.

PubMed

#04

Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission.

Volkova Anastasiya, et al. · Frontiers in pharmacology · 2016

Animal

The study demonstrated that selank significantly altered the expression of genes involved in GABAergic neurotransmission in the frontal cortex of rats.

Key findings

01Researchers observed significant changes in the expression of 45 genes one hour after administering Selank or GABA.
02Three hours post-administration, 22 genes showed altered expression.
03The study found a positive correlation in gene expression changes between Selank and GABA within the first hour.

PubMed

#05

Sedative-Hypnotic Agents That Impact Gamma-Aminobutyric Acid Receptors: Focus on Flunitrazepam, Gamma-Hydroxybutyric Acid, Phenibut, and Selank.

Review

Researchers observed that Selank, along with other GABAergic agents, is associated with significant toxicities related to abuse and dependence, highlighting the need for careful evaluation of its abuse potential.

PubMed

#06

Selank and short peptides of the tuftsin family in the regulation of adaptive behavior in stress.

AnimalInfluence2.0

The study demonstrated that Selank and tuftsin peptides positively influenced emotional stress responses in various rodent models.

PubMed

#07

Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity.

In Vitro

The study demonstrated that Selank acts as a positive allosteric modulator of GABA receptors, potentially contributing to its anxiolytic effects.

PubMed

#08

The inhibitory effect of Selank on enkephalin-degrading enzymes as a possible mechanism of its anxiolytic activity.

Human

The study demonstrated that Selank inhibited enkephalin-degrading enzymes, which may contribute to its efficacy in managing anxiety and phobic disorders.

PubMed

#09

The temporary dynamics of inflammation-related genes expression under tuftsin analog Selank action.

Animal

Researchers observed that selank and its fragment Gly-Pro significantly altered the expression of inflammation-related genes in mouse spleen, indicating its immunomodulatory potential.

PubMed

#10

GABA, Selank, and Olanzapine Affect the Expression of Genes Involved in GABAergic Neurotransmission in IMR-32 Cells.

Filatova Elena, et al. · Frontiers in pharmacology · 2017

In Vitro

The study demonstrated that Selank did not directly affect GABAergic gene expression in neuroblastoma cells but may enhance the effects of GABA and olanzapine on gene expression.

Key findings

01Selank showed an anxiolytic effect comparable to classical benzodiazepines.
02GABA and Selank influence gene expression related to GABAergic neurotransmission.
03Olanzapine also affects the expression of these genes in the studied cells.

PubMed

Safety

Safety & Handling

Research Gaps

No randomized controlled trials have been conducted to assess the long-term effects of Selank in human populations. Additionally, the precise mechanisms through which Selank exerts its anxiolytic and cognitive-enhancing effects, particularly in relation to BDNF modulation and its interaction with other neurochemical pathways, remain unclear.

Solubility

Selank is soluble in water and saline solutions.

Storage & Handling

Lyophilized

Stable for 2+ years at -20°C, 12 months at 4°C

Reconstituted

Use within 14 days when refrigerated at 4°C

Avoid

Avoid repeated freeze-thaw cycles, direct light

Solvent

Bacteriostatic water or sterile saline recommended

Safety information is derived from published research and may not reflect all known risks. This is not medical advice.

Legal Status

🇩🇪DE

Not approved as a medicinal product. Not a controlled substance. Sale as research chemical is a legal grey area.

🇺🇸US

Not approved by the FDA. Not scheduled by the DEA.

🇦🇺AU

Not listed in the TGA schedules.

🇬🇧UK

Not approved as a medicinal product by the MHRA.

Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.

Community Insights

Publications per Year

48 total

Pricing

Price Comparison

BESTSunrise BioresearchUS
10mg
$16.19
Price/mg
$1.62/mg
View
PeptiLab USAUS
10mg
$20.99
Price/mg
$2.10/mg
View
Alpha PeptidesUS
10mg
$24.16
$21.74
Price/mg
$2.42$2.18/mg
View−10% · PEPSTACK10
Nextech LabsUS
10mg
$24.75
Price/mg
$2.48/mg
View
Orbitrex PeptideUS
30mg
$79.99
Price/mg
$2.67/mg
View

Vendor	Amount	Price	Price/mg	Link
BESTSunrise BioresearchUS	10mg	$16.19	$1.62/mg	View
PeptiLab USAUS	10mg	$20.99	$2.10/mg	View
Alpha PeptidesUS	10mg	$24.16$21.74	$2.42$2.18/mg	View−10% · PEPSTACK10
Nextech LabsUS	10mg	$24.75	$2.48/mg	View
Orbitrex PeptideUS	30mg	$79.99	$2.67/mg	View

Top 5 of 61 offers from 55 vendors. Prices updated daily.

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Mechanism

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Mechanism

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Legal Disclaimer

This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer