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Selank

TP-7 · Selanc

Nootropic & CNSPreclinical

MW: 751.9g/mol
Formula: C33H57N11O9

Selank is a synthetic peptide analog of tuftsin, originally derived from the immune-regulating peptide found in the human body. Researchers primarily study Selank for its anxiolytic and nootropic effects, particularly in relation to cognitive function and stress response. Key findings from recent studies indicate that Selank can enhance brain-derived neurotrophic factor (BDNF) levels, which are crucial for memory and learning, and may mitigate the cognitive impairments associated with ethanol exposure and morphine withdrawal. Additionally, preclinical evidence suggests that Selank influences functional connectivity in brain regions associated with anxiety and executive functions. Despite promising results, the current research landscape is still limited, with a notable absence of extensive clinical trials to validate these findings in human populations.

Chemical Profile

Chemical Structure

Formula	C33H57N11O9
Molecular Weight	751.9 g/mol
CAS Number	129954-34-3
PubChem CID	11765600
ChEMBL ID	CHEMBL4585920

Half-Life

INIntranasal

~15 minutes

POOral

Poor bioavailability

Intranasal administration is preferred due to rapid absorption and onset of action.

Mechanism

Mechanism of Action

Selank, a peptide analog of tuftsin, primarily exerts its effects through modulation of brain-derived neurotrophic factor (BDNF) signaling, influencing neuroplasticity and cognitive function. It appears to interact with the central nervous system, particularly affecting the amygdala and prefrontal cortex, thereby altering functional connectivity and potentially engaging pathways such as the MAPK and PI3K/Akt signaling cascades. Although the precise receptors and complete mechanisms remain to be fully elucidated, Selank's anxiolytic and cognitive-enhancing properties suggest involvement in neurotrophic and neuroprotective processes.

Research

59 Research Publications

425

Total Citations

Human/RCT

1.1

Avg. Influence

2023

Latest

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01Top

#01

Natural and hybrid ("chimeric") stable regulatory glyproline peptides.

Review

Researchers observed that glyproline peptides, including selank, exhibit stability comparable to major pharmacological preparations, suggesting potential for oral administration in therapeutic applications.

0.3 mg/kg a dayintraperitoneally(rat)7 days0.3 mg/kgintraperitoneal(rat)single injection80 μg/kgintraperitoneally(rat)single injection250 μg/kgintraperitoneally(rat)single injection750 μg/kgintraperitoneally(rat)single injection100 μg/kgintraperitoneal(mouse)single injection300 μg/kgintraperitoneal(rat)single injection300 μg/kgintraperitoneal(rat)4 days

PubMed

02Top

#02

Tuftsin - Properties and Analogs.

Siebert Agnieszka, et al. · Current medicinal chemistry · 2017

ReviewInfluence1.0

The review confirmed that tuftsin and its analogs exhibit significant anti-tumor, anti-inflammatory, and antibacterial activities, highlighting their potential therapeutic applications.

Key findings

01The review included 86 documents, highlighting tuftsin's significant biological activities.
02Thirty-two studies focused on tuftsin's effects in humans, while others explored its analogs' properties.
03Many tuftsin derivatives demonstrated potential in cancer treatment and as components of vaccines.

PubMed

03Top

#03

Atrial fibrillation-associated electrical remodelling in human induced pluripotent stem cell-derived atrial cardiomyocytes: a novel pathway for antiarrhythmic therapy development.

Seibertz Fitzwilliam, et al. · Cardiovascular research · 2023

In VitroInfluence1.0

Researchers studied how atrial fibrillation (AF) affects heart cell function using human heart cells created from stem cells. They found that mimicking AF conditions led to significant changes in electrical activity and heart cell behavior, which could help in developing new treatments for AF.

Key findings

01Researchers observed that electrical pacing mimicking AF conditions caused decreased calcium current and impaired potassium current in heart cells.
02The study found that long-term pacing resulted in changes such as increased potassium current and altered heart cell contractility.
03Researchers successfully modeled AF-associated changes in heart cells, providing a new platform for discovering potential antiarrhythmic therapies.

PubMed

#04

Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission.

Volkova Anastasiya, et al. · Frontiers in pharmacology · 2016

Animal

The study demonstrated that Selank significantly altered the expression of genes involved in GABAergic neurotransmission in the frontal cortex of rats, suggesting its complex effects on nerve cells.

Key findings

01Researchers observed significant changes in the expression of 45 genes one hour after administering Selank or GABA.
02Three hours post-administration, 22 genes showed altered expression.
03The study found a positive correlation in gene expression changes between Selank and GABA within the first hour.

PubMed

#05

Sedative-Hypnotic Agents That Impact Gamma-Aminobutyric Acid Receptors: Focus on Flunitrazepam, Gamma-Hydroxybutyric Acid, Phenibut, and Selank.

Review

Researchers observed that Selank shares GABAergic mechanisms with other sedative-hypnotics, indicating its potential therapeutic applications and risks of abuse.

PubMed

#06

Selank and short peptides of the tuftsin family in the regulation of adaptive behavior in stress.

AnimalInfluence2.0

The study demonstrated that selank and other tuftsin family peptides exhibit positive emotional effects and antistress actions in various rodent models of emotional stress.

PubMed

#07

[Comparison of anticoagulant effects of regulatory proline-containing oligopeptides. Specificity of glyprolines, semax, and selank and potential of their practical application].

Review

The study demonstrated that various regulatory peptides, including Selank, exhibit distinct anticoagulant effects, suggesting their potential application in hemostatic processes.

60 nmol/kg of body weight (BW)intraperitoneal(male adult Sprague-Dawley rats)daily5, 50, 150, and 450 μg/kgintraperitoneal(Wistar male rats)12-15 min before modeling restraint stress1 μMperfusion solution(isolated cerebral neurons)not mentioned0.1 and 1 μMperfusion solution(hippocampal pyramidal neurons)not mentioned0.15 mg/kgintraperitoneal(rodents)not mentioned

PubMed

#08

The inhibitory effect of Selank on enkephalin-degrading enzymes as a possible mechanism of its anxiolytic activity.

In Vitro

The study demonstrated that Selank inhibited enkephalin-degrading enzymes in human plasma, suggesting a mechanism for its anxiolytic activity in anxiety disorders.

PubMed

#09

Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity.

In Vitro

The study demonstrated that Selank acts as a positive allosteric modulator of GABA receptors, contributing to its anxiolytic effects.

PubMed

#10

GABA, Selank, and Olanzapine Affect the Expression of Genes Involved in GABAergic Neurotransmission in IMR-32 Cells.

Filatova Elena, et al. · Frontiers in pharmacology · 2017

In Vitro

The study demonstrated that Selank does not directly affect GABAergic gene expression in neuroblastoma cells but may enhance the effects of GABA and olanzapine.

Key findings

01Selank showed an anxiolytic effect comparable to classical benzodiazepines.
02GABA and Selank influence gene expression related to GABAergic neurotransmission.
03Olanzapine also affects the expression of these genes in the studied cells.

PubMed

Safety

Safety & Handling

Research Gaps

No randomized controlled human trials specifically evaluating the efficacy and safety of Selank in diverse human populations have been published. Additionally, the long-term effects of Selank on cognitive function and neuroplasticity remain unclear, as well as the precise mechanisms by which it influences BDNF levels and functional connectivity in the brain.

Solubility

Selank is soluble in water and saline solutions.

Storage & Handling

Lyophilized

Stable for 2+ years at -20°C, 12 months at 4°C

Reconstituted

Use within 14 days when refrigerated at 4°C

Avoid

Avoid repeated freeze-thaw cycles, direct light

Solvent

Bacteriostatic water or sterile saline recommended

Safety information is derived from published research and may not reflect all known risks. This is not medical advice.

Legal Status

🇩🇪DE

Not approved as a medicinal product. Not a controlled substance. Sale as research chemical is a legal grey area.

🇺🇸US

Not approved by the FDA. Not scheduled by the DEA.

🇦🇺AU

Not listed in the TGA schedules.

🇬🇧UK

Not approved as a medicinal product by the MHRA.

Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.

Community Insights

Publications per Year

47 total

Pricing

Price Comparison

BESTPeptiLab USAUS
10mg
$20.99
Price/mg
$2.10/mg
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Alpha PeptidesUS
10mg
$24.16
$21.74
Price/mg
$2.42$2.18/mg
View−10% · PEPSTACK10
FitSKNS PeptidesUS
10mg
$30.00
Price/mg
$3.00/mg
View
Orbitrex PeptideUS
30mg
$89.99
Price/mg
$3.00/mg
View
Ignite PeptidesUS
10mg
$30.00
Price/mg
$3.00/mg
View

Vendor	Amount	Price	Price/mg	Link
BESTPeptiLab USAUS	10mg	$20.99	$2.10/mg	View
Alpha PeptidesUS	10mg	$24.16$21.74	$2.42$2.18/mg	View−10% · PEPSTACK10
FitSKNS PeptidesUS	10mg	$30.00	$3.00/mg	View
Orbitrex PeptideUS	30mg	$89.99	$3.00/mg	View
Ignite PeptidesUS	10mg	$30.00	$3.00/mg	View

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Mechanism

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Mechanism

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Legal Disclaimer

This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer