PNB-0408 · N-hexanoic-Tyr-Ile-(6) aminohexanoic amide
Dihexa is a small molecule peptide derived from angiotensin IV, specifically designed to enhance cognitive function and synaptic connectivity. Researchers primarily study it for its potential role in addressing neurodegenerative diseases, such as Alzheimer's disease, by promoting neuroplasticity and memory consolidation. Key findings indicate that Dihexa activates the hepatocyte growth factor/c-Met receptor system, leading to increased synaptogenesis and improved cognitive performance in animal models. Preclinical evidence suggests that this compound is orally active and capable of penetrating the blood-brain barrier, which enhances its therapeutic potential. Current research is focused on further elucidating its mechanisms of action and evaluating its efficacy in clinical settings.
| Formula | C27H44N4O5 |
| Molecular Weight | 504.7 g/mol |
| CAS Number | 1401708-83-5 |
| PubChem CID | 129010512 |
Poor bioavailability
Pharmacokinetic data is limited, with ongoing research to determine specific half-life values.
Dihexa acts primarily through the hepatocyte growth factor (HGF)/c-Met receptor system, promoting c-Met phosphorylation and enhancing HGF-dependent signaling pathways. This activation leads to increased synaptogenesis, dendritic arborization, and memory consolidation, likely by modulating processes such as neurogenesis and cell motility. While the precise biochemical mechanisms are still being elucidated, the evidence suggests that Dihexa facilitates synaptic connectivity and cognitive function through these pathways.
254
Total Citations
2
Human/RCT
2.8
Avg. Influence
2024
Latest
The study demonstrated that Dihexa shows promise in enhancing synaptic connectivity and overcoming memory and motor dysfunctions in neurodegenerative disease models.
The study demonstrated that Dihexa, a metabolically stabilized angiotensin IV analog, exhibits significant antidementia activity in rat models by enhancing synaptic connectivity.
Mathapati Santosh, et al. · Current protocols in stem cell biology · 2016
Researchers observed a new method to create liver-like cells from human stem cells using small molecules instead of traditional growth factors. This approach allows for more efficient and reproducible production of these cells, which are important for studying liver diseases and testing new drugs.
Key findings
Wright John W & Harding Joseph W · Journal of Alzheimer's disease : JAD · 2015
Researchers observed that Dihexa, an angiotensin-based analogue, promotes dendritic arborization and synaptogenesis, suggesting its potential for enhancing memory consolidation in Alzheimer's disease models.
Key findings
Benoist Caroline C, et al. · The Journal of pharmacology and experimental therapeutics · 2014
Researchers observed that Dihexa activates the hepatocyte growth factor/c-Met system, leading to enhanced synaptogenesis and cognitive benefits in animal models.
Key findings
Uribe Phillip M, et al. · Frontiers in cellular neuroscience · 2015
Researchers studied a compound called Dihexa to see if it could protect sensory hair cells from damage caused by certain antibiotics. They found that Dihexa effectively shields these cells from toxicity, suggesting it may have potential for preventing hearing loss related to chemical exposure.
Key findings
Pan Tingcai, et al. · Stem cell research & therapy · 2022
The study demonstrated that a small-molecule cocktail including Dihexa can effectively induce hepatic specification from human pluripotent stem cells, producing functional hepatocyte-like cells.
Key findings
Bapst Jean-Philippe, et al. · Journal of receptor and signal transduction research · 2007
Researchers observed that dimeric alpha-MSH analogs exhibit higher receptor affinity in vitro but show lower tumor uptake in vivo compared to monomeric counterparts.
Key findings
Weiss Jessica B, et al. · Annals of medicine and surgery (2012) · 2021
Researchers investigated the effects of stem cells, Granulocyte-Colony Stimulating Factor (G-CSF), and Dihexa on limb recovery after nerve damage in rats. They found that these treatments significantly improved sensory and motor function in the affected limbs over time, suggesting their potential as supportive therapies for nerve repair.
Key findings
Wells Russell G, et al. · Journal of Huntington's disease · 2024
The study demonstrated that Dihexa did not protect rats from 3-nitropropionic acid-induced Huntington's disease-like symptoms, indicating a lack of efficacy in this model.
Key findings
No randomized controlled human trials have been conducted to assess the efficacy and safety of Dihexa in human populations. Additionally, the long-term effects of Dihexa on cognitive function and potential side effects remain unknown, as well as the precise molecular mechanisms underlying its interaction with the HGF/c-Met system in the context of neurodegenerative diseases.
Solubility
Dihexa is soluble in DMSO and has limited solubility in water.
Lyophilized
Stable for 2+ years at -20°C, 12 months at 4°C
Reconstituted
Use within 14 days when refrigerated at 4°C
Avoid
Avoid repeated freeze-thaw cycles, direct light
Solvent
Bacteriostatic water or sterile saline recommended
Safety information is derived from published research and may not reflect all known risks. This is not medical advice.
🇩🇪DE
Not approved as a medicinal product. Not a controlled substance. Sale as research chemical is a legal grey area.
🇺🇸US
Not approved by the FDA. Not scheduled by the DEA.
🇦🇺AU
Not listed in the TGA schedules.
🇬🇧UK
Not approved by the MHRA as a medicinal product.
Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.
Publications per Year
9 total| Vendor | Amount | Price | Price/mg | Link |
|---|---|---|---|---|
BESTUmbrella LabsUS | 10mg | $49.99 | $5.00/mg | |
Umbrella LabsUS | 20mg | $119.99 | $6.00/mg | |
Ruo BioUS | 5mg | $38.00 | $7.60/mg | |
MoglabsUS | 5mg | $40.00 | $8.00/mg | |
Bulk Peptide WholesaleUS | 10mg | $100.00 | $10.00/mg |
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This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer