Wiki · Profile

DSIP

Delta Sleep-Inducing Peptide

Nootropic & CNSPreclinical

MW: 848.8g/mol
Formula: C35H48N10O15

Delta sleep-inducing peptide (DSIP) is a neuropeptide originally isolated from rabbit cerebral venous blood in the 1970s, classified as a sleep-related peptide. Researchers primarily study DSIP for its potential role in sleep regulation and its effects on neurotransmitter balance. Key findings indicate that DSIP can influence neurotransmitter levels such as serotonin and dopamine, with studies suggesting its involvement in promoting slow-wave sleep and modulating responses to emotional stress. Additionally, preclinical evidence indicates that structural analogues of DSIP may exhibit enhanced protective effects against ischemia-reperfusion injuries. Despite its intriguing properties, the precise mechanisms of DSIP and its biological activities remain poorly characterized, prompting ongoing research into its functions and therapeutic applications.

Chemical Profile

Chemical Structure

Formula	C35H48N10O15
Molecular Weight	848.8 g/mol
CAS Number	62568-57-4
PubChem CID	68816

Half-Life

POOral

Poor bioavailability

DSIP's pharmacokinetic properties are not well-documented, and values may vary based on administration route.

Mechanism

Mechanism of Action

The mechanism of action of delta sleep-inducing peptide (DSIP) remains poorly understood, but it is hypothesized to modulate neurotransmitter systems, particularly through adrenergic transmission, potentially involving receptors in the hypothalamic parvocellular paraventricular nucleus (pPVN) and limbic structures. DSIP appears to influence Fos expression, which is linked to stress response pathways, suggesting a role in neuroendocrine regulation and sleep promotion, although specific receptor interactions and signaling pathways remain to be fully elucidated. Additionally, DSIP's effects on neurotransmitter levels, such as serotonin and dopamine, indicate involvement in sleep regulation and emotional stress responses, but definitive mechanisms are still unresolved.

Research

61 Research Publications

1,332

Total Citations

Human/RCT

1.6

Avg. Influence

2006

Latest

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01Top

#01

Biochemical regulation of non-rapid-eye-movement sleep.

ReviewInfluence7.0

322

Researchers observed that several substances, including delta-sleep-inducing peptide (DSIP), may play a role in modulating non-rapid-eye-movement sleep, although their physiological roles remain unclear.

30 μg/kgintraperitoneal(rat)7 nmol/kgintracerebroventricular(cat)120 microgram/kgintraperitoneal(rat)1 or 2 mgintravenous(dog)50 microgram/kgintravenous(rabbit)25 nmol/kgintravenous(human)10 ng1 microgram6 nmol/kgintraventricular(rabbit)

PubMed

02Top

#02

Delta-sleep-inducing peptide (DSIP): an update.

Graf M V & Kastin A J · Peptides · 1986

ReviewInfluence1.0

100

The review summarized that DSIP has been associated with various sleep-inducing effects and potential therapeutic applications, although its physiological mechanisms remain to be fully elucidated.

Key findings

01Researchers observed that DSIP has sleep-inducing effects in animals.
02The study highlighted the potential therapeutic uses of DSIP for insomnia, pain, and withdrawal symptoms.
03Researchers noted that DSIP's distribution in the body may relate to various diseases.

PubMed

03Top

#03

Peptides and thermoregulation.

Animal

The study demonstrated that delta-sleep-inducing peptide (DSIP) interacts with other peptides to influence thermoregulation in various species.

PubMed

#04

Delta-sleep-inducing peptide (DSIP): a review.

Graf M V & Kastin A J · Neuroscience and biobehavioral reviews · 1984

ReviewInfluence1.0

The review highlighted that delta sleep-inducing peptide (DSIP) induces delta sleep in various species and influences multiple physiological activities, including neurotransmitter levels and circadian patterns.

Key findings

01DSIP is a peptide that induces mainly delta-sleep in multiple species, including humans.
02The peptide affects brain activity and neurotransmitter levels, influencing overall sleep quality.
03DSIP also impacts circadian rhythms, hormonal levels, and psychological performance.

PubMed

#05

Circadian effects of beta-endorphin, melatonin, DSIP, and amphetamine on pentylenetetrazol-induced seizures.

AnimalInfluence2.0

The study demonstrated that DSIP and beta-endorphin increased seizure thresholds during night periods in male rats, suggesting a circadian modulation of seizure susceptibility.

30 μg/kgintraperitoneal(rat)50 microgram/kgintravenous(rabbit)6-day consecutive120 microgram/kgintraperitoneal(rat)25 nmol/kgintravenous(human)5 microgramsintraventricular(rat)0.1 microgram(rat)10(-12) M(rat)10(-10) M(rat)10(-7)(rat)10(-5) M(rat)6 nmol/kgintraventricular(rabbit)over 3.5 min1-6intraventricular(rabbit)

PubMed

#06

Characterization, properties and multivariate functions of delta-sleep-inducing peptide (DSIP).

Review

The review outlined the multifaceted roles of DSIP, including its effects on sleep induction, circadian rhythms, and interactions with various neurotransmitters and stress responses.

PubMed

#07

Thermoregulatory and locomotor effects of DSIP: paradoxical interaction with d-amphetamine.

AnimalInfluence1.0

The study demonstrated that the effects of delta-sleep-inducing peptide (DSIP) on thermoregulation and locomotion in rats are influenced by ambient temperature.

PubMed

#08

Entry of DSIP peptides into dog CSF: role of physicochemical and pharmacokinetic parameters.

Animal

The study demonstrated that the penetration of DSIP into the cerebrospinal fluid of dogs is significantly correlated with its plasma concentration, half-life, and lipophilicity.

PubMed

#09

Effect of delta sleep inducing peptide (DSIP) and arginine vasotocin (AVT) on sleep and motor activity in the rat.

AnimalInfluence1.0

Researchers observed that neither delta sleep-inducing peptide (DSIP) nor arginine vasotocin (AVT) significantly enhanced sleep or reduced motor activity in rats, indicating their limited sleep-promoting properties.

PubMed

#10

Delta sleep-inducing peptide (DSIP) stimulates growth hormone (GH) release in the rat by hypothalamic and pituitary actions.

Animal

The study demonstrated that delta sleep-inducing peptide (DSIP) stimulates growth hormone release in rats through hypothalamic and pituitary mechanisms, with a dose-dependent response.

PubMed

Safety

Safety & Handling

Research Gaps

No randomized controlled human trials have been conducted to evaluate the efficacy and safety of DSIP and its analogues in sleep disorders or stress-related conditions. Additionally, the precise mechanisms by which DSIP modulates neurotransmitter levels and its long-term effects on human health remain poorly understood, particularly regarding its interaction with various neuroendocrine pathways.

Solubility

DSIP is soluble in water and aqueous buffers, but data on solubility in organic solvents like acetonitrile or DMSO is limited.

Storage & Handling

Lyophilized

Stable for 2+ years at -20°C, 12 months at 4°C

Reconstituted

Use within 14 days when refrigerated at 4°C

Avoid

Avoid repeated freeze-thaw cycles, direct light

Solvent

Bacteriostatic water or sterile saline recommended

Safety information is derived from published research and may not reflect all known risks. This is not medical advice.

Legal Status

🇩🇪DE

Not approved as a medicinal product. Not a controlled substance. Sale as research chemical is a legal grey area.

🇺🇸US

Not approved by the FDA as a medicinal product. Not scheduled by the DEA.

🇦🇺AU

Not listed on the TGA schedule.

🇬🇧UK

Not approved by the MHRA as a medicinal product.

Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.

Community Insights

Publications per Year

46 total

Pricing

Price Comparison

BESTXL PeptidesUK
10mg
$22.21
Price/mg
$2.22/mg
View
Research Peptides UKUK
5mg
$15.18
Price/mg
$3.04/mg
View
Puratek PeptidesUS
10mg
$31.45
$28.30
Price/mg
$3.15$2.83/mg
View−10% · PEPSTACKS10
PeptaNovaEU
25mg
$86.40
Price/mg
$3.46/mg
View
Double R LabsUS
15mg
$59.99
Price/mg
$4.00/mg
View

Vendor	Amount	Price	Price/mg	Link
BESTXL PeptidesUK	10mg	$22.21	$2.22/mg	View
Research Peptides UKUK	5mg	$15.18	$3.04/mg	View
Puratek PeptidesUS	10mg	$31.45$28.30	$3.15$2.83/mg	View−10% · PEPSTACKS10
PeptaNovaEU	25mg	$86.40	$3.46/mg	View
Double R LabsUS	15mg	$59.99	$4.00/mg	View

Top 5 of 79 offers from 61 vendors. Prices updated daily.

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Mechanism

Tools

Reconstitution Calculator

Calculate reconstitution volumes for DSIP

Serum Level Visualizer

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Mechanism

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Legal Disclaimer

This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer