Wiki · Profile

DSIP

Delta Sleep-Inducing Peptide

Nootropic & CNSPreclinical

MW: 848.8g/mol
Formula: C35H48N10O15

Delta sleep-inducing peptide (DSIP) is a nonapeptide originally isolated from rabbit cerebral venous blood and classified as a neuropeptide with potential roles in sleep regulation and other physiological processes. Researchers primarily study DSIP for its effects on sleep promotion and its interactions with neurotransmitter systems. Key findings indicate that DSIP and its phosphorylated analogue, P-DSIP, enhance hypothermia induced by dopamine agonists, suggesting a relationship with the dopaminergic system, while other studies demonstrate its potential to modulate neurotransmitter levels in insomnia models. Current research continues to explore the biological activity and mechanisms of DSIP, as well as its interactions with various proteins and potential therapeutic applications in sleep-related disorders.

Chemical Profile

Chemical Structure

Formula	C35H48N10O15
Molecular Weight	848.8 g/mol
CAS Number	62568-57-4
PubChem CID	68816

Half-Life

POOral

Poor bioavailability

DSIP's pharmacokinetic properties are not well-documented, and values may vary based on administration route.

Mechanism

Mechanism of Action

Delta sleep-inducing peptide (DSIP) appears to interact with the dopaminergic system, influencing thermoregulatory mechanisms and potentially modulating neurotransmitter levels such as serotonin (5-HT), glutamate, and dopamine. Its exact mechanism of action remains poorly characterized, with no specific receptors or signaling pathways definitively identified, although it may involve interactions with the pineal gland and influence on sleep regulation. Additionally, DSIP has shown potential neuroprotective effects during ischemia-reperfusion injuries, suggesting involvement in cellular stress response pathways, but further elucidation of its biological activity is needed.

Research

89 Research Publications

1,798

Total Citations

Human/RCT

1.8

Avg. Influence

2006

Latest

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01Top

#01

Biochemical regulation of non-rapid-eye-movement sleep.

ReviewInfluence7.0

320

The study demonstrated that various substances, including delta sleep-inducing peptide (DSIP), may play roles in non-REM sleep regulation, although their physiological significance remains to be fully determined.

2 mg/kgintraperitoneal(rat)10 ng1 microgram1 or 2 mgintravenous(dog)120 microgram/kgintraperitoneal(rat)30 μg/kgintraperitoneal(rat)5 microgram/rabbitintravenous(rabbit)7 nmol/kgintracerebroventricular(cat)

PubMed

02Top

#02

Delta-sleep-inducing peptide (DSIP): an update.

Graf M V & Kastin A J · Peptides · 1986

ReviewInfluence1.0

100

The study demonstrated that delta sleep-inducing peptide (DSIP) has diverse physiological effects, including sleep induction and modulation of neurotransmitter levels, but its mechanisms remain to be fully established.

Key findings

01Researchers observed that DSIP has sleep-inducing effects in animals.
02The study highlighted the potential therapeutic uses of DSIP for insomnia, pain, and withdrawal symptoms.
03Researchers noted that DSIP's distribution in the body may relate to various diseases.

PubMed

03Top

#03

Characterization of a delta-electroencephalogram (-sleep)-inducing peptide.

AnimalInfluence3.0

Researchers confirmed that synthetic DSIP significantly enhances delta and spindle EEG activity in rabbits, establishing its role in sleep induction.

2 or 10 microgramsintraventricular(rat)not mentioned25 nmol/kgintravenous(human)not mentioned2 mg/kginjected(rat)not mentioned120 nmol.kg-1subcutaneous(cat)not mentioned1 mg/kginjected(rat)not mentioned50 microgram/kgintravenous(rabbit)6 days120 microgram/kginjected(rat)prior to their subjection to hypoxia

PubMed

#04

Peptides and thermoregulation.

Animal

The study demonstrated that delta sleep-inducing peptide (DSIP) interacts with other peptides to influence thermoregulation, highlighting its role in temperature modulation.

PubMed

#05

Delta-sleep-inducing peptide (DSIP): a review.

Graf M V & Kastin A J · Neuroscience and biobehavioral reviews · 1984

ReviewInfluence1.0

Researchers observed that delta sleep-inducing peptide (DSIP) has been implicated in sleep regulation, but its multifaceted roles and interactions with other substances require further investigation.

Key findings

01DSIP is a peptide that induces mainly delta-sleep in multiple species, including humans.
02The peptide affects brain activity and neurotransmitter levels, influencing overall sleep quality.
03DSIP also impacts circadian rhythms, hormonal levels, and psychological performance.

PubMed

#06

HPA-related CSF neuropeptides in suicide attempters.

HumanInfluence2.0

Researchers observed lower levels of delta-sleep inducing peptide (DSIP) in lumbar CSF of major depressive disorder patients, correlating with other neuropeptides involved in HPA regulation.

PubMed

#07

Delta sleep-inducing peptide crosses the blood-brain-barrier in dogs: some correlations with protein binding.

Animal

The study demonstrated that DSIP and its analogs can cross the blood-brain barrier in dogs, with significant increases in cerebrospinal fluid levels after intravenous injection.

10 ng(rat)1 microgram(rat)120 microgram/kgintraperitoneal(rat)25 nmol/kgintravenous(human)30 μg/kgintraperitoneal(rat)7 nmol/kgintracerebroventricular(cat)1 or 2 mgintravenous(dog)

PubMed

#08

Circadian effects of beta-endorphin, melatonin, DSIP, and amphetamine on pentylenetetrazol-induced seizures.

AnimalInfluence2.0

The study demonstrated that DSIP and beta-endorphin increased seizure thresholds during night periods in male rats, suggesting a circadian modulation of seizure susceptibility.

30 μg/kgintraperitoneal(rat)50 microgram/kgintravenous(rabbit)6-day consecutive120 microgram/kgintraperitoneal(rat)25 nmol/kgintravenous(human)5 microgramsintraventricular(rat)0.1 microgram(rat)10(-12) M(rat)10(-10) M(rat)10(-7)(rat)10(-5) M(rat)6 nmol/kgintraventricular(rabbit)over 3.5 min1-6intraventricular(rabbit)

PubMed

#09

Characterization, properties and multivariate functions of delta-sleep-inducing peptide (DSIP).

Animal

Researchers observed that delta sleep-inducing peptide (DSIP) influences various physiological functions, including sleep induction and neurotransmitter modulation, with significant species-specific responses.

PubMed

#10

Presence of delta-sleep-inducing peptide-like material in human milk.

In Vitro

Researchers observed the presence of delta-sleep-inducing peptide (DSIP)-like material in human breast milk, indicating a potential role in neonatal sleep-wake cycles.

2 mg/kgintraperitoneal(rat)10 ng1 microgram30 μg/kgintraperitoneal(rat)120 microgram/kgintraperitoneal(rat)25 nmol/kgintravenous(human)50 microgram/kgintravenous(rabbit)1 or 2 mgintravenous(dog)

PubMed

Safety

Safety & Handling

Research Gaps

No clinical trials involving human subjects have been conducted to assess the efficacy and safety of DSIP or its analogs for sleep regulation or other therapeutic applications. Additionally, the long-term effects of DSIP and its structural analogs on human health remain unknown, as well as the precise mechanisms through which DSIP interacts with neurotransmitter systems and its potential receptors, which have yet to be identified.

Solubility

DSIP is soluble in water and aqueous buffers, but data on solubility in organic solvents like acetonitrile or DMSO is limited.

Storage & Handling

Lyophilized

Stable for 2+ years at -20°C, 12 months at 4°C

Reconstituted

Use within 14 days when refrigerated at 4°C

Avoid

Avoid repeated freeze-thaw cycles, direct light

Solvent

Bacteriostatic water or sterile saline recommended

Safety information is derived from published research and may not reflect all known risks. This is not medical advice.

Legal Status

🇩🇪DE

Not approved as a medicinal product. Not a controlled substance. Sale as research chemical is a legal grey area.

🇺🇸US

Not approved by the FDA as a medicinal product. Not scheduled by the DEA.

🇦🇺AU

Not listed on the TGA schedule.

🇬🇧UK

Not approved by the MHRA as a medicinal product.

Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.

Community Insights

Publications per Year

49 total

Pricing

Price Comparison

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10mg
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Price/mg
$2.29/mg
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Orbitrex PeptideUS
10mg
$29.99
Price/mg
$3.00/mg
View
Research Peptides UKUK
5mg
$15.18
Price/mg
$3.04/mg
View
PeptaNovaEU
25mg
$86.40
Price/mg
$3.46/mg
View
Puratek PeptidesUS
10mg
$34.95
$31.46
Price/mg
$3.50$3.15/mg
View−10% · PEPSTACKS10

Vendor	Amount	Price	Price/mg	Link
BESTXL PeptidesUK	10mg	$22.85	$2.29/mg	View
Orbitrex PeptideUS	10mg	$29.99	$3.00/mg	View
Research Peptides UKUK	5mg	$15.18	$3.04/mg	View
PeptaNovaEU	25mg	$86.40	$3.46/mg	View
Puratek PeptidesUS	10mg	$34.95$31.46	$3.50$3.15/mg	View−10% · PEPSTACKS10

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Mechanism

Tools

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Mechanism

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Legal Disclaimer

This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer