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DSIP

Delta Sleep-Inducing Peptide

Nootropic & CNSPreclinical
From$2.29/mgCompare prices
MW
848.8g/mol
Formula
C35H48N10O15

Delta sleep-inducing peptide (DSIP) is a neuropeptide originally isolated from rabbit cerebral venous blood, classified as a sleep-promoting factor. Researchers primarily study DSIP for its potential effects on sleep regulation and neurotransmitter balance. Key findings indicate that DSIP can enhance sleep duration and efficiency in human subjects, while preclinical studies suggest its ability to modulate neurotransmitter levels and exhibit antioxidative properties. Additionally, analogues of DSIP have shown promise in reducing oxidative stress and improving outcomes in models of ischemia-reperfusion injuries. Current research continues to explore the biological activity and mechanisms of DSIP and its analogues, aiming to clarify their roles in sleep and neuroprotection.

Chemical Profile

Chemical Profile

Chemical structure
Chemical Structure
FormulaC35H48N10O15
Molecular Weight848.8 g/mol
CAS Number62568-57-4
PubChem CID68816

Half-Life

POOral

Poor bioavailability

DSIP's pharmacokinetic properties are not well-documented, and values may vary based on administration route.

Mechanism

Mechanism of Action

The precise mechanism of action for delta sleep-inducing peptide (DSIP) remains poorly characterized, with no specific receptors or signaling pathways definitively identified. However, DSIP is implicated in modulating neurotransmitter levels, particularly serotonin (5-HT), dopamine, and melatonin, suggesting involvement in sleep regulation and neurotransmitter balance. Additionally, DSIP analogues exhibit antioxidative and detoxifying effects, potentially through pathways related to cellular stress response and inflammation, but further research is needed to elucidate these mechanisms fully.

Research

79 Research Publications

1,763

Total Citations

15

Human/RCT

1.8

Avg. Influence

2006

Latest

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#01

Biochemical regulation of non-rapid-eye-movement sleep.

ReviewInfluence7.0
322
The study demonstrated that delta sleep-inducing peptide (DSIP) is one of several sleep regulatory substances identified through transfer experiments in animals.
10 ng(rat)1 microgram(rat)120 microgram/kgintraperitoneal(rat)25 nmol/kgintravenous(human)30 μg/kgintraperitoneal(rat)7 nmol/kgintracerebroventricular(cat)1 or 2 mgintravenous(dog)
PubMed
#02

Delta-sleep-inducing peptide (DSIP): an update.

Graf M V & Kastin A J · Peptides · 1986

ReviewInfluence1.0
100
Researchers observed that DSIP has various physiological effects and potential therapeutic applications, although its mechanisms remain to be fully established.

Key findings

  1. 01Researchers observed that DSIP has sleep-inducing effects in animals.
  2. 02The study highlighted the potential therapeutic uses of DSIP for insomnia, pain, and withdrawal symptoms.
  3. 03Researchers noted that DSIP's distribution in the body may relate to various diseases.
10 ng(rat)1 microgram(rat)120 microgram/kgintraperitoneal(rat)25 nmol/kgintravenous(human)30 μg/kgintraperitoneal(rat)7 nmol/kgintracerebroventricular(cat)1 or 2 mgintravenous(dog)
PubMed
#03

Characterization of a delta-electroencephalogram (-sleep)-inducing peptide.

AnimalInfluence3.0
95
The study demonstrated that only synthetic DSIP significantly enhances delta and spindle EEG patterns in rabbits, confirming its specific activity.
PubMed
#04

Peptides and thermoregulation.

Review
93
Researchers observed that DSIP, among other peptides, affects thermoregulation, interacting with ambient temperature and administration route.
10 ng(rat)1 microgram(rat)120 microgram/kgintraperitoneal(rat)25 nmol/kgintravenous(human)30 μg/kgintraperitoneal(rat)7 nmol/kgintracerebroventricular(cat)1 or 2 mgintravenous(dog)
PubMed
#05

Delta-sleep-inducing peptide (DSIP): a review.

Graf M V & Kastin A J · Neuroscience and biobehavioral reviews · 1984

ReviewInfluence1.0
81
Researchers observed that DSIP induces delta sleep across multiple species and influences various physiological and psychological parameters.

Key findings

  1. 01DSIP is a peptide that induces mainly delta-sleep in multiple species, including humans.
  2. 02The peptide affects brain activity and neurotransmitter levels, influencing overall sleep quality.
  3. 03DSIP also impacts circadian rhythms, hormonal levels, and psychological performance.
10 ng(rat)1 microgram(rat)120 microgram/kgintraperitoneal(rat)25 nmol/kgintravenous(human)30 μg/kgintraperitoneal(rat)7 nmol/kgintracerebroventricular(cat)1 or 2 mgintravenous(dog)
PubMed
#06

HPA-related CSF neuropeptides in suicide attempters.

HumanInfluence2.0
77
Researchers observed lower levels of delta sleep-inducing peptide in patients with major depressive disorders compared to other groups, suggesting a potential link to mood regulation.
10 ng(rat)1 microgram(rat)120 microgram/kgintraperitoneal(rat)25 nmol/kgintravenous(human)30 μg/kgintraperitoneal(rat)7 nmol/kgintracerebroventricular(cat)1 or 2 mgintravenous(dog)
PubMed
#07

Delta sleep-inducing peptide crosses the blood-brain-barrier in dogs: some correlations with protein binding.

Animal
52
The study demonstrated that DSIP and its analogs can cross the blood-brain barrier in dogs, with significant increases in cerebrospinal fluid levels after intravenous injection.
10 ng(rat)1 microgram(rat)120 microgram/kgintraperitoneal(rat)25 nmol/kgintravenous(human)30 μg/kgintraperitoneal(rat)7 nmol/kgintracerebroventricular(cat)1 or 2 mgintravenous(dog)
PubMed
#08

Circadian effects of beta-endorphin, melatonin, DSIP, and amphetamine on pentylenetetrazol-induced seizures.

AnimalInfluence2.0
45
The study demonstrated that DSIP and beta-endorphin increased seizure thresholds during night periods in male rats, suggesting a circadian modulation of seizure susceptibility.
30 μg/kgintraperitoneal(rat)50 microgram/kgintravenous(rabbit)6-day consecutive120 microgram/kgintraperitoneal(rat)25 nmol/kgintravenous(human)5 microgramsintraventricular(rat)0.1 microgram(rat)10(-12) M(rat)10(-10) M(rat)10(-7)(rat)10(-5) M(rat)6 nmol/kgintraventricular(rabbit)over 3.5 min1-6intraventricular(rabbit)
PubMed
#09

Characterization, properties and multivariate functions of delta-sleep-inducing peptide (DSIP).

Review
41
Researchers observed that DSIP influences sleep induction, neurotransmitter levels, and circadian rhythms, with its effects being species-specific.
10 ng(rat)1 microgram(rat)120 microgram/kgintraperitoneal(rat)25 nmol/kgintravenous(human)30 μg/kgintraperitoneal(rat)7 nmol/kgintracerebroventricular(cat)1 or 2 mgintravenous(dog)
PubMed
#10

Presence of delta-sleep-inducing peptide-like material in human milk.

In Vitro
41
Researchers observed the presence of delta-sleep-inducing peptide (DSIP)-like material in human breast milk, indicating a potential role in neonatal sleep-wake cycles.
2 mg/kgintraperitoneal(rat)10 ng1 microgram30 μg/kgintraperitoneal(rat)120 microgram/kgintraperitoneal(rat)25 nmol/kgintravenous(human)50 microgram/kgintravenous(rabbit)1 or 2 mgintravenous(dog)
PubMed
Safety

Safety & Handling

Research Gaps

No comprehensive studies have been conducted to elucidate the exact mechanisms by which DSIP and its analogues exert their effects on sleep regulation and neurotransmitter modulation in humans. Additionally, the long-term effects of DSIP administration on human sleep behavior and overall health remain unknown, as current research primarily focuses on short-term outcomes.

Solubility

DSIP is soluble in water and aqueous buffers, but data on solubility in organic solvents like acetonitrile or DMSO is limited.

Storage & Handling

Lyophilized

Stable for 2+ years at -20°C, 12 months at 4°C

Reconstituted

Use within 14 days when refrigerated at 4°C

Avoid

Avoid repeated freeze-thaw cycles, direct light

Solvent

Bacteriostatic water or sterile saline recommended

Safety information is derived from published research and may not reflect all known risks. This is not medical advice.

Legal Status

Legal Status

🇩🇪DE

Not approved as a medicinal product. Not a controlled substance. Sale as research chemical is a legal grey area.

🇺🇸US

Not approved by the FDA as a medicinal product. Not scheduled by the DEA.

🇦🇺AU

Not listed on the TGA schedule.

🇬🇧UK

Not approved by the MHRA as a medicinal product.

Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.

Community Insights

Community Insights

Publications per Year

49 total
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Pricing

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Mechanism

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Mechanism

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Legal Disclaimer

This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer