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DSIP

Delta Sleep-Inducing Peptide

Nootropic & CNSPreclinical
From$2.22/mgCompare prices
MW
848.8g/mol
Formula
C35H48N10O15

Delta sleep-inducing peptide (DSIP) is a nonapeptide originally isolated from rabbit cerebral venous blood in 1977, primarily studied for its potential role in sleep regulation. Researchers have focused on its unique structure and biological activities, which appear to extend beyond sleep induction, including effects on neurotransmitter levels and circadian rhythms. Key findings suggest that while DSIP has shown sleep-promoting properties in various animal models, its direct connection to sleep mechanisms remains poorly characterized, and its biological activity may involve interactions with the dopaminergic system. Additionally, studies have identified structural analogues of DSIP, such as the KND peptide, which demonstrate enhanced protective effects in models of ischemia-reperfusion injury. Current research continues to explore the multifaceted roles of DSIP and its analogues, aiming to clarify their mechanisms of action and potential therapeutic applications.

Chemical Profile

Chemical Profile

Chemical structure
Chemical Structure
FormulaC35H48N10O15
Molecular Weight848.8 g/mol
CAS Number62568-57-4
PubChem CID68816

Half-Life

POOral

Poor bioavailability

DSIP's pharmacokinetic properties are not well-documented, and values may vary based on administration route.

Mechanism

Mechanism of Action

The mechanism of action of delta sleep-inducing peptide (DSIP) remains poorly understood, as specific receptors and signaling pathways have not been definitively identified. However, studies suggest that DSIP may interact with the dopaminergic system, influencing thermoregulatory mechanisms and neurotransmitter levels, particularly serotonin (5-HT), glutamate, and dopamine, potentially through pathways like the NO/cGMP pathway. Furthermore, DSIP has been implicated in modulating circadian rhythms and stress responses, although the exact molecular mechanisms and receptor interactions are still unresolved.

Research

66 Research Publications

1,446

Total Citations

11

Human/RCT

1.7

Avg. Influence

2006

Latest

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#01

Biochemical regulation of non-rapid-eye-movement sleep.

ReviewInfluence7.0
322
The study demonstrated that several substances, including delta sleep inducing peptide (DSIP), are implicated in sleep regulation, although their physiological roles remain unclear.
10 ng(rat)1 microgram(rat)30 μg/kgintraperitoneal(rat)120 microgram/kgintraperitoneal(rat)25 nmol/kgintravenous(human)50 microgram/kgintravenous(rabbit)1 or 2 mgintravenous(dog)
PubMed
#02

Delta-sleep-inducing peptide (DSIP): an update.

Graf M V & Kastin A J · Peptides · 1986

ReviewInfluence1.0
100
The study demonstrated that DSIP has diverse physiological effects and potential therapeutic applications, although its mechanisms of action remain to be fully elucidated.

Key findings

  1. 01Researchers observed that DSIP has sleep-inducing effects in animals.
  2. 02The study highlighted the potential therapeutic uses of DSIP for insomnia, pain, and withdrawal symptoms.
  3. 03Researchers noted that DSIP's distribution in the body may relate to various diseases.
10 ng(rat)1 microgram(rat)30 μg/kgintraperitoneal(rat)120 microgram/kgintraperitoneal(rat)25 nmol/kgintravenous(human)50 microgram/kgintravenous(rabbit)1 or 2 mgintravenous(dog)
PubMed
#03

Peptides and thermoregulation.

Review
93
Researchers observed that delta sleep inducing peptide (DSIP) interacts with thermoregulation, influencing the thermal effects of drugs like d-amphetamine.
10 ng(rat)1 microgram(rat)30 μg/kgintraperitoneal(rat)120 microgram/kgintraperitoneal(rat)25 nmol/kgintravenous(human)50 microgram/kgintravenous(rabbit)1 or 2 mgintravenous(dog)
PubMed
#04

Delta-sleep-inducing peptide (DSIP): a review.

Graf M V & Kastin A J · Neuroscience and biobehavioral reviews · 1984

ReviewInfluence1.0
81
Researchers observed that DSIP induces delta sleep in multiple species and affects various physiological functions, including neurotransmitter levels and circadian rhythms.

Key findings

  1. 01DSIP is a peptide that induces mainly delta-sleep in multiple species, including humans.
  2. 02The peptide affects brain activity and neurotransmitter levels, influencing overall sleep quality.
  3. 03DSIP also impacts circadian rhythms, hormonal levels, and psychological performance.
10 ng(rat)1 microgram(rat)30 μg/kgintraperitoneal(rat)120 microgram/kgintraperitoneal(rat)25 nmol/kgintravenous(human)50 microgram/kgintravenous(rabbit)1 or 2 mgintravenous(dog)
PubMed
#05

HPA-related CSF neuropeptides in suicide attempters.

In VitroInfluence2.0
77
Researchers observed significantly lower levels of delta-sleep inducing peptide (DSIP) in patients with major depressive disorders compared to other patients, suggesting potential neuropeptide involvement in depression.
10 ng(rat)1 microgram(rat)30 μg/kgintraperitoneal(rat)120 microgram/kgintraperitoneal(rat)25 nmol/kgintravenous(human)50 microgram/kgintravenous(rabbit)1 or 2 mgintravenous(dog)
PubMed
#06

Circadian effects of beta-endorphin, melatonin, DSIP, and amphetamine on pentylenetetrazol-induced seizures.

AnimalInfluence2.0
45
The study demonstrated that DSIP and beta-endorphin increased seizure thresholds during night periods in male rats, suggesting a circadian modulation of seizure susceptibility.
30 μg/kgintraperitoneal(rat)50 microgram/kgintravenous(rabbit)6-day consecutive120 microgram/kgintraperitoneal(rat)25 nmol/kgintravenous(human)5 microgramsintraventricular(rat)0.1 microgram(rat)10(-12) M(rat)10(-10) M(rat)10(-7)(rat)10(-5) M(rat)6 nmol/kgintraventricular(rabbit)over 3.5 min1-6intraventricular(rabbit)
PubMed
#07

Characterization, properties and multivariate functions of delta-sleep-inducing peptide (DSIP).

Review
41
Researchers observed that delta sleep-inducing peptide (DSIP) induces sleep in various animal species and influences neurotransmitter levels and circadian rhythms.
10 ng(rat)1 microgram(rat)30 μg/kgintraperitoneal(rat)120 microgram/kgintraperitoneal(rat)25 nmol/kgintravenous(human)50 microgram/kgintravenous(rabbit)1 or 2 mgintravenous(dog)
PubMed
#08

Thermoregulatory and locomotor effects of DSIP: paradoxical interaction with d-amphetamine.

AnimalInfluence1.0
37
The study demonstrated that delta sleep-inducing peptide (DSIP) has paradoxical effects on thermoregulation and locomotion in rats, influenced by ambient temperature.
30 μg/kgintraperitoneal(rat)7 nmol/kgintracerebroventricular(cat)120 microgram/kgintraperitoneal(rat)1 or 2 mgintravenous(dog)50 microgram/kgintravenous(rabbit)25 nmol/kgintravenous(human)10 ng1 microgram6 nmol/kgintraventricular(rabbit)
PubMed
#09

Entry of DSIP peptides into dog CSF: role of physicochemical and pharmacokinetic parameters.

Animal
35
The study demonstrated that the penetration of DSIP into the cerebrospinal fluid of dogs is significantly correlated with its plasma concentration, half-life, and lipophilicity.
30 μg/kgintraperitoneal(rat)50 microgram/kgintravenous(rabbit)6-day consecutive120 microgram/kgintraperitoneal(rat)25 nmol/kgintravenous(human)5 microgramsintraventricular(rat)0.1 microgram(rat)10(-12) M(rat)10(-10) M(rat)10(-7)(rat)10(-5) M(rat)6 nmol/kgintraventricular(rabbit)over 3.5 min1-6intraventricular(rabbit)
PubMed
#10

Effect of delta sleep inducing peptide (DSIP) and arginine vasotocin (AVT) on sleep and motor activity in the rat.

AnimalInfluence1.0
34
The study demonstrated that neither DSIP nor arginine vasotocin significantly promoted sleep or reduced motor activity in rats, although DSIP affected dark-time activity days after administration.
10 ng(rat)1 microgram(rat)30 μg/kgintraperitoneal(rat)120 microgram/kgintraperitoneal(rat)25 nmol/kgintravenous(human)50 microgram/kgintravenous(rabbit)1 or 2 mgintravenous(dog)
PubMed
Safety

Safety & Handling

Research Gaps

No randomized controlled human trials have been conducted to evaluate the efficacy and safety of DSIP or its analogs in sleep disorders or ischemia-reperfusion injuries. Additionally, the precise mechanisms by which DSIP and its derivatives exert their biological effects, particularly in relation to neurotransmitter modulation and sleep regulation, remain poorly understood. Long-term effects of DSIP administration on human health and potential side effects are also not yet characterized.

Solubility

DSIP is soluble in water and aqueous buffers, but data on solubility in organic solvents like acetonitrile or DMSO is limited.

Storage & Handling

Lyophilized

Stable for 2+ years at -20°C, 12 months at 4°C

Reconstituted

Use within 14 days when refrigerated at 4°C

Avoid

Avoid repeated freeze-thaw cycles, direct light

Solvent

Bacteriostatic water or sterile saline recommended

Safety information is derived from published research and may not reflect all known risks. This is not medical advice.

Legal Status

Legal Status

🇩🇪DE

Not approved as a medicinal product. Not a controlled substance. Sale as research chemical is a legal grey area.

🇺🇸US

Not approved by the FDA as a medicinal product. Not scheduled by the DEA.

🇦🇺AU

Not listed on the TGA schedule.

🇬🇧UK

Not approved by the MHRA as a medicinal product.

Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.

Community Insights

Community Insights

Publications per Year

47 total
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Pricing

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Mechanism

Tools

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Mechanism

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Legal Disclaimer

This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer