Skip to main content
PepStack
Wiki · Profile

Pinealon

Ala-Glu-Asp · EDR tripeptide

Nootropic & CNSPreclinical
From$2.20/mgCompare prices
MW
418.4g/mol
Formula
C15H26N6O8

Pinealon is a synthetic tripeptide composed of glutamic acid, aspartic acid, and arginine, classified within the group of therapeutic peptides. Researchers primarily study Pinealon for its potential neuroprotective and regenerative properties, particularly in the context of oxidative stress and neuroinflammation. Key findings indicate that Pinealon can suppress reactive oxygen species accumulation and reduce necrotic cell death, while also influencing cell cycle modulation and neurochemical processes in aged models under stress conditions. Additionally, studies suggest that Pinealon may enhance neurogenesis and modulate inflammatory responses in the brain during hypoxic events. Current research is ongoing, focusing on its mechanisms of action and potential applications in neurobiology and regenerative medicine.

Chemical Profile

Chemical Profile

Chemical structure
Chemical Structure
FormulaC15H26N6O8
Molecular Weight418.4 g/mol
CAS Number175175-23-2
PubChem CID10273502

Half-Life

POOral

Poor bioavailability

Pharmacokinetic data on Pinealon is limited, and further research is needed to determine its half-life and bioavailability across different administration routes.

Mechanism

Mechanism of Action

Pinealon (Glu-Asp-Arg) exerts its effects primarily through the modulation of reactive oxygen species (ROS) levels, leading to increased cell viability and reduced necrotic cell death, likely via the activation of the ERK 1/2 signaling pathway. Additionally, it appears to interact with the cell genome, influencing gene expression and potentially regulating epigenetic modifications through specific binding to DNA sequences. While its antioxidant activity and neuroprotective effects in stress models suggest involvement in neurogenesis and inflammation resolution, the precise receptors and full mechanistic pathways remain to be fully elucidated.

Research

14 Research Publications

66

Total Citations

5

Human/RCT

1.7

Avg. Influence

2016

Latest

Sort
Filter
#01

Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA.

Fedoreyeva L I, et al. · Biochemistry. Biokhimiia · 2011

In VitroInfluence3.0
32
The study demonstrated that Pinealon can penetrate the nucleus of HeLa cells and interact with DNA, suggesting its potential role in regulating gene activity.

Key findings

  1. 01Peptides labeled with fluorescence were able to penetrate HeLa cells, highlighting their ability to enter cell nuclei.
  2. 02Different peptides showed varying effects on the fluorescence of DNA, suggesting specific interactions with nucleic acids.
  3. 03Some peptides preferentially bind to DNA sequences associated with cytosine methylation, which may influence gene regulation.
1 mgsubcutaneously(mouse)5 times a week0.1 microgdaily(rat)5 times a week from the age of 4 months1 microgramsubcutaneously(mouse)for 5 consecutive days
PubMed
#02

Pinealon increases cell viability by suppression of free radical levels and activating proliferative processes.

Khavinson V, et al. · Rejuvenation research · 2011

In Vitro
17
The study demonstrated that Pinealon increases cell viability by suppressing reactive oxygen species and activating proliferative processes in cerebellar granule cells, neutrophils, and PC12 cells.

Key findings

  1. 01Pinealon reduces the accumulation of reactive oxygen species (ROS) in various cell types.
  2. 02The compound decreases necrotic cell death in tested cells.
  3. 03Pinealon affects the cell cycle, indicating a direct interaction with the cell genome.
PubMed
#03

[Neuroprotective effects of peptides bioregulators in people of various age].

ReviewInfluence1.0
7
The review demonstrated that peptide neuroprotectors, including Pinealon, exhibit beneficial effects on the central nervous system in elderly individuals.
PubMed
#04

[Biological activity of regulatory peptides in model experiments in vitro].

In Vitro
3
Researchers observed that short regulatory peptides, including Pinealon, can restrict lipid peroxidation and regulate apoptosis/necrosis in neuronal populations in vitro.
PubMed
#05

[The peptide correction of neurotic disorders among professional truck-drivers].

Case ReportInfluence1.0
3
The study demonstrated that the application of Pinealon improved psychoemotional indices and reduced occupational risk of borderline mental disorders among professional truck drivers.
PubMed
#06

[Regulation of content of cytokines in blood serum and of caspase-3 activity in brains of old rats in model of sharp hypoxic hypoxia with Cortexin and Pinealon].

Animal
2
Researchers observed that Pinealon increases neurogenesis and reduces neuroinflammatory reactions in the brains of old rats under hypoxic conditions.
PubMed
#07

[Effect of peptide geroprotectors on the navigation system learning and caspase-3 in brain structures in rats of different age].

Animal
1
The study demonstrated that Pinealon positively affects learning abilities in both young and old rats, as indicated by improved performance in the Morris labyrinth.
PubMed
#08

[EFFECT OF SYNTHETIC PEPTIDES ON AGING OF PATIENTS WITH CHRONIC POLYMORBIDITY AND ORGANIC BRAIN SYNDROME OF THE CENTRAL NERVOUS SYSTEM IN REMISSION].

Meshchaninov V N, et al. · Advances in gerontology = Uspekhi gerontologii · 2015

Case Report
1
Researchers observed that Pinealon and Vesugen have significant anabolic effects, improving central nervous system activity and slowing biological aging in patients with organic brain syndrome.

Key findings

  1. 01Both Vesugen and Pinealon demonstrated significant positive effects on the central nervous system and vital organs.
  2. 02Vesugen was found to have a more pronounced effect on slowing biological aging compared to Pinealon.
  3. 03The peptides did not impact the genetic material in cells, suggesting they are safe for use at the nuclear level.
PubMed
#09

[Effects of introduction of short peptides before carotid artery occlusion on behaviour and caspase-3 activity in the brain of old rats].

Animal
The study demonstrated that Pinealon administration before carotid artery occlusion improved survival rates and behavioral outcomes in old rats.
PubMed
#10

[Investigation of antihypoxic properties of short peptides].

Animal
The study demonstrated that Pinealon exhibits pronounced antihypoxic properties, enhancing neuronal resistance to hypoxic stress in a model of prenatal hypoxia.
PubMed
Safety

Safety & Handling

Research Gaps

No randomized controlled human trials have been conducted to assess the efficacy and safety of Pinealon in clinical settings. Additionally, the long-term effects of Pinealon on human health and its precise mechanisms of action at the genomic level remain unclear, particularly in relation to its interactions with DNA and potential epigenetic influences.

Solubility

Pinealon is soluble in water and aqueous solutions.

Storage & Handling

Lyophilized

Stable for 2+ years at -20°C, 12 months at 4°C

Reconstituted

Use within 14 days when refrigerated at 4°C

Avoid

Avoid repeated freeze-thaw cycles, direct light

Solvent

Bacteriostatic water or sterile saline recommended

Safety information is derived from published research and may not reflect all known risks. This is not medical advice.

Legal Status

Legal Status

🇩🇪DE

Not approved as a medicinal product. Not a controlled substance. Sale as research chemical is a legal grey area.

🇺🇸US

Not approved by the FDA. Not scheduled by the DEA.

🇦🇺AU

Not listed in the TGA schedules.

🇬🇧UK

Not approved as a medicinal product by the MHRA.

Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.

Community Insights

Community Insights

Publications per Year

14 total
2
08
3
11
2
12
2
13
1
14
2
15
1
16
1
26
Pricing

Price Comparison

  • BESTPeptide CraftersUS
    25mg
    $55.00
    Price/mg
    $2.20/mg
    View
  • Verified PeptidesUS
    20mg
    $55.00
    Price/mg
    $2.75/mg
    View
  • RCpeptidesEU
    20mg
    $59.40
    Price/mg
    $2.97/mg
    View
  • PeptaNovaEU
    25mg
    $75.60
    Price/mg
    $3.02/mg
    View
  • Soma ChemsUS
    20mg
    $64.99
    Price/mg
    $3.25/mg
    View

Top 5 of 29 offers from 24 vendors. Prices updated daily.

See all Pinealon prices
Mechanism

Tools

Reconstitution Calculator

Calculate reconstitution volumes for Pinealon

Serum Level Visualizer

Visualize Pinealon serum levels over time

Mechanism

Related Peptides

CerebrolysinSelankCortagenDSIPN-Acetyl Semax AmidateDihexa

Track Pinealon in PepStack

Log your research cycles, set reminders and visualize serum levels.

Download on theApp StoreGet it onGoogle Play
Legal Disclaimer

This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer