Mechano Growth Factor · IGF-1Ec
Mechano growth factor (MGF) is a peptide derived from the insulin-like growth factor 1 (IGF-1) gene, classified as a member of the IGF family. Researchers primarily study MGF for its potential role in promoting tissue repair and regeneration, particularly in bone, muscle, and ligament injuries. Key findings from recent studies indicate that MGF E peptides significantly enhance the proliferation, differentiation, and mineralization of osteoblasts, while also protecting anterior cruciate ligament fibroblasts from apoptosis in hypoxic conditions. Furthermore, preclinical evidence suggests that MGF may facilitate angiogenesis and stem cell recruitment, highlighting its multifaceted role in regenerative medicine. Current research continues to explore the therapeutic applications of MGF in various tissue repair contexts, emphasizing its potential in clinical settings.
| Formula | F3Mg- |
| Molecular Weight | 81.301 g/mol |
| PubChem CID | 447728 |
Not applicable
Poor bioavailability
Pharmacokinetic data on MGF is limited, with variability depending on administration route.
MGF primarily acts through the IGF-1 receptor, activating the PI3K-Akt and MEK-ERK1/2 signaling pathways, which promote cell proliferation, differentiation, and survival. It has been shown to inhibit apoptosis in various cell types, including ACL fibroblasts and myocytes, by regulating caspase expression and enhancing anti-apoptotic protein levels such as Bcl-2. Additionally, MGF stimulates angiogenesis via the recruitment of proangiogenic cells through the stromal cell-derived factor 1α/CXCR4 axis and upregulation of vascular endothelial growth factor α, although some aspects of its mechanism remain not fully understood.
5,919
Total Citations
15
Human/RCT
4.4
Avg. Influence
2025
Latest
Researchers observed that mechano-growth factor (MGF) acts as a ligand for the c-kit proto-oncogene, stimulating proliferation in interleukin 3-dependent cell lines.
Researchers observed that mechanical strain induces the expression of mechano-growth factor (MGF) in muscle, which is critical for local tissue adaptation and repair.
Researchers observed that mechano-growth factor (MGF) promotes myoblast proliferation while inhibiting differentiation, functioning through a distinct receptor pathway compared to mature IGF-I.
The review describes the interplay between myogenic regulatory factors and insulin-like growth factors, including mechano growth factor (MGF), in regulating skeletal muscle hypertrophy and regeneration.
The study demonstrated that KIT and KIT LIGAND interactions are crucial for oogenesis and folliculogenesis, influencing various stages of ovarian function.
Researchers observed that mechano-growth factor (MGF) is essential for muscle hypertrophy and local tissue repair following resistance exercise, with impaired expression linked to muscle mass loss in aging.
Matheny Ronald W, et al. · Endocrinology · 2010
Researchers observed that mechano-growth factor (MGF) plays a significant role in muscle remodeling by promoting myoblast proliferation following injury, with differential regulation of IGF-I splice variants.
Key findings
The study demonstrated that differential expression of IGF-1 isoforms, including mechano-growth factor, plays a crucial role in regulating muscle fiber regeneration and hypertrophy following mechanical overload and damage.
Researchers observed that levels of insulin-like growth factor-1 (IGF-1) and mechano growth factor (MGF) are independently associated with reduced skeletal muscle mass in elderly individuals with sarcopenia.
Researchers observed that MGF/Stat5 is activated by prolactin signaling in mammary epithelial cells, playing a central role in milk protein gene transcription.
No clinical trials involving human subjects have been conducted to evaluate the efficacy and safety of MGF peptides for bone, muscle, or ligament repair. Additionally, the long-term effects of MGF treatment on tissue regeneration and potential adverse outcomes remain unclear, particularly concerning its role in modulating apoptosis and angiogenesis in various tissues.
Solubility
MGF is soluble in water and commonly used solvents like DMSO.
Lyophilized
Stable for 2+ years at -20°C, 12 months at 4°C
Reconstituted
Use within 14 days when refrigerated at 4°C
Avoid
Avoid repeated freeze-thaw cycles, direct light
Solvent
Bacteriostatic water or sterile saline recommended
Safety information is derived from published research and may not reflect all known risks. This is not medical advice.
🇩🇪DE
Not approved as a medicinal product. Not a controlled substance. Sale as research chemical is a legal grey area.
🇺🇸US
Not approved by the FDA. Not scheduled by the DEA.
🇦🇺AU
Not listed in the TGA scheduling.
🇬🇧UK
Not approved by the MHRA as a medicinal product.
Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.
Publications per Year
50 total| Vendor | Amount | Price | Price/mg | Link |
|---|---|---|---|---|
BESTModern ResearchUS | 1500mg | $46.99 | $0.03/mg | |
Research PeptidesUS | 1500mg | $84.99 | $0.06/mg | |
Modern ResearchUS | 500mg | $34.99 | $0.07/mg | |
Peptide ProsUS | 50mg | $47.25 | $0.95/mg | |
Modern ResearchUS | 70mg | $71.99 | $1.03/mg |
Top 5 of 54 offers from 30 vendors. Prices updated daily.
See all MGF pricesLog your research cycles, set reminders and visualize serum levels.
This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer