Mechano Growth Factor · IGF-1Ec
Mechano growth factor (MGF) is a peptide derived from insulin-like growth factor 1 (IGF-1) that plays a crucial role in tissue repair and regeneration. Researchers primarily study MGF for its potential applications in enhancing stem cell recruitment, reducing apoptosis, and promoting tissue healing in various contexts, including cardiac and bone injuries. Key findings indicate that MGF can attract stem cells and inhibit cell death in cardiac myocytes, while also promoting proliferation and differentiation of osteoblasts in bone repair models. Additionally, studies suggest that MGF may improve the repair of anterior cruciate ligaments by mitigating hypoxia-induced apoptosis and facilitating angiogenesis. Current research is focused on elucidating the mechanisms of MGF action and exploring its therapeutic potential in clinical settings.
| Formula | F3Mg- |
| Molecular Weight | 81.301 g/mol |
| PubChem CID | 447728 |
Not applicable
Poor bioavailability
Pharmacokinetic data on MGF is limited, with variability depending on administration route.
MGF primarily acts through an IGF-1R independent pathway, influencing cellular processes such as proliferation and apoptosis in various cell types, including cardiomyocytes and fibroblasts. It modulates apoptotic signaling by regulating caspase expression and activates the MEK-ERK1/2 signaling pathway, while also enhancing angiogenesis via the SDF-1α/CXCR4 axis and stimulating VEGF expression. The precise mechanisms of MGF's action remain incompletely understood, particularly regarding its receptor interactions and downstream signaling pathways.
4,523
Total Citations
9
Human/RCT
4.3
Avg. Influence
2025
Latest
The study demonstrated that mechanical overload induces the expression of a splice variant of IGF-1, MGF, which is essential for muscle repair and adaptation.
Researchers observed that the MGF E domain promotes myoblast proliferation while inhibiting differentiation, indicating a distinct mechanism of action compared to mature IGF-I.
Researchers observed that mechano growth factor (MGF) plays a crucial role in muscle regeneration and hypertrophy by regulating myogenic regulatory factors (MRFs) during muscle repair.
Researchers observed that KIT and KIT LIGAND interactions are crucial for oogenesis and folliculogenesis, influencing cell survival and differentiation in mouse models.
Researchers observed that MGF is crucial for initiating muscle hypertrophy and local tissue repair following resistance exercise, with impaired expression linked to muscle mass loss in aging and certain diseases.
Matheny Ronald W, et al. · Endocrinology · 2010
Researchers observed that mechano-growth factor (MGF) plays a novel role in myoblast proliferation and muscle repair following injury, with potential implications for muscle regeneration.
Key findings
The study demonstrated that IGF-1 and MGF levels are independently associated with reduced skeletal muscle mass in elderly individuals with sarcopenia.
Researchers observed that MGF/Stat5 is activated by prolactin and plays a central role in the transcriptional regulation of milk protein genes in mammary epithelial cells.
The study demonstrated that MGF expression in muscle is regulated by mechanical stimulation and is crucial for muscle repair and hypertrophy, especially in response to physical activity.
The study demonstrated that mechano growth factor (MGF) and transforming growth factor β3 significantly enhanced cartilage regeneration in a rabbit model, leading to improved integration and extracellular matrix formation.
No clinical trials involving human subjects have been conducted to evaluate the efficacy and safety of MGF peptides in cardiac or bone repair therapies. Additionally, the long-term effects of MGF peptide treatment on tissue regeneration and potential side effects remain unclear, as well as the precise molecular mechanisms underlying its action in various cell types and conditions.
Solubility
MGF is soluble in water and commonly used solvents like DMSO.
Lyophilized
Stable for 2+ years at -20°C, 12 months at 4°C
Reconstituted
Use within 14 days when refrigerated at 4°C
Avoid
Avoid repeated freeze-thaw cycles, direct light
Solvent
Bacteriostatic water or sterile saline recommended
Safety information is derived from published research and may not reflect all known risks. This is not medical advice.
🇩🇪DE
Not approved as a medicinal product. Not a controlled substance. Sale as research chemical is a legal grey area.
🇺🇸US
Not approved by the FDA. Not scheduled by the DEA.
🇦🇺AU
Not listed in the TGA scheduling.
🇬🇧UK
Not approved by the MHRA as a medicinal product.
Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.
Publications per Year
49 total| Vendor | Amount | Price | Price/mg | Link |
|---|---|---|---|---|
BESTModern ResearchUS | 1500mg | $46.99 | $0.03/mg | |
Research PeptidesUS | 1500mg | $84.99 | $0.06/mg | |
Research Peptides EuropeEU | 1500mg | $91.79 | $0.06/mg | |
Modern ResearchUS | 500mg | $34.99 | $0.07/mg | |
Polaris PeptidesUS | 600mg | $60.00 | $0.10/mg |
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This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer