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MGF

Mechano Growth Factor · IGF-1Ec

IGF Axis & MusclePreclinical
From$0.03/mgCompare prices
MW
81.301g/mol
Formula
F3Mg-

Mechano growth factor (MGF) is a splice variant of insulin-like growth factor 1 (IGF-1) that plays a crucial role in tissue repair and regeneration. Researchers primarily study MGF for its potential applications in enhancing bone healing, cardiac regeneration, and ligament repair. Key findings indicate that MGF E peptide promotes the proliferation and differentiation of osteoblasts, enhances stem cell migration, and protects against hypoxia-induced cell apoptosis in various tissue types. Additionally, preclinical evidence suggests that MGF E peptide may accelerate angiogenesis and improve outcomes in models of bone and ligament injuries. Current research continues to explore the mechanisms of MGF action and its therapeutic potential across different fields of regenerative medicine.

Chemical Profile

Chemical Profile

Chemical structure
Chemical Structure
FormulaF3Mg-
Molecular Weight81.301 g/mol
PubChem CID447728

Half-Life

INIntranasal

Not applicable

POOral

Poor bioavailability

Pharmacokinetic data on MGF is limited, with variability depending on administration route.

Mechanism

Mechanism of Action

MGF E peptide primarily acts through an IGF-1R independent mechanism, influencing various signaling pathways such as the MEK-ERK1/2 and PI3K-Akt pathways. It promotes cellular processes including proliferation, differentiation, and mineralization of osteoblasts and mesenchymal stem cells, while also inhibiting apoptosis in hypoxic conditions by regulating HIF-1α and caspase activity. Additionally, MGF E peptide enhances angiogenesis by recruiting proangiogenic cells via the stromal cell-derived factor 1α/CXCR4 axis and stimulating vascular endothelial growth factor α expression.

Research

79 Research Publications

4,406

Total Citations

9

Human/RCT

4.2

Avg. Influence

2025

Latest

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#01

Changes in muscle mass and phenotype and the expression of autocrine and systemic growth factors by muscle in response to stretch and overload.

ReviewInfluence23.0
480
The study demonstrated that mechanical stimuli regulate gene expression in muscle cells, with mechano growth factor (MGF) being crucial for local tissue repair.
PubMed
#02

Different roles of the IGF-I Ec peptide (MGF) and mature IGF-I in myoblast proliferation and differentiation.

In VitroInfluence22.0
332
Researchers observed that MGF inhibits terminal differentiation while promoting myoblast proliferation, indicating its distinct role compared to mature IGF-I in muscle cell behavior.
PubMed
#03

Skeletal muscle hypertrophy and regeneration: interplay between the myogenic regulatory factors (MRFs) and insulin-like growth factors (IGFs) pathways.

ReviewInfluence21.0
313
Researchers observed that mechano growth factor (MGF) plays a crucial role in muscle regeneration and hypertrophy by regulating myogenic regulatory factors (MRFs) during muscle repair.
PubMed
#04

Roles of KIT and KIT LIGAND in ovarian function.

AnimalInfluence9.0
253
Researchers observed that KIT and KIT LIGAND interactions are crucial for oogenesis and folliculogenesis, influencing cell survival and differentiation in mouse ovaries.
PubMed
#05

Mechanical signals, IGF-I gene splicing, and muscle adaptation.

ReviewInfluence6.0
196
The study demonstrated that mechano growth factor (MGF) is crucial for muscle hypertrophy and tissue repair following resistance exercise, with impaired expression linked to muscle mass loss.
PubMed
#06

Minireview: Mechano-growth factor: a putative product of IGF-I gene expression involved in tissue repair and regeneration.

Matheny Ronald W, et al. · Endocrinology · 2010

ReviewInfluence5.0
184
Researchers observed that mechano-growth factor (MGF) plays a novel role in myoblast proliferation and muscle repair following injury, with potential implications for muscle regeneration.

Key findings

  1. 01Researchers observed that the IGF-IEb variant is up-regulated shortly after muscle injury, promoting muscle cell proliferation.
  2. 02The later activation of the IGF-IEa variant is associated with the maturation of muscle fibers.
  3. 03The study discusses the potential roles of MGF in muscle remodeling, aging, and neuroprotection.
PubMed
#07

Association between sarcopenia and levels of growth hormone and insulin-like growth factor-1 in the elderly.

HumanInfluence4.0
174
The study demonstrated that IGF-1 and MGF levels are independently associated with reduced skeletal muscle mass in elderly individuals with sarcopenia.
PubMed
#08

Prolactin-mediated gene activation in mammary epithelial cells.

In VitroInfluence4.0
133
The study demonstrated that MGF/Stat5 is a key transcription factor activated by prolactin in mammary epithelial cells, essential for milk protein gene transcription.
PubMed
#09

Gene expression in muscle in response to exercise.

In VitroInfluence6.0
116
Researchers observed that MGF expression in human muscle is only detectable after mechanical stimulation, indicating its role as a local repair factor in muscle adaptation.
PubMed
#10

Mechano growth factor (MGF) and transforming growth factor (TGF)-β3 functionalized silk scaffolds enhance articular hyaline cartilage regeneration in rabbit model.

AnimalInfluence2.0
115
The study demonstrated that mechano growth factor (MGF) and transforming growth factor β3 significantly enhanced cartilage regeneration in a rabbit model, leading to improved integration and extracellular matrix formation.
PubMed
Safety

Safety & Handling

Research Gaps

No clinical trials involving human subjects have been conducted to assess the efficacy and safety of MGF E peptide in bone and cardiac repair. Additionally, the long-term effects of MGF E peptide treatment on tissue regeneration and potential side effects remain unclear, as well as the specific molecular mechanisms underlying its actions in different cell types and conditions.

Solubility

MGF is soluble in water and commonly used solvents like DMSO.

Storage & Handling

Lyophilized

Stable for 2+ years at -20°C, 12 months at 4°C

Reconstituted

Use within 14 days when refrigerated at 4°C

Avoid

Avoid repeated freeze-thaw cycles, direct light

Solvent

Bacteriostatic water or sterile saline recommended

Safety information is derived from published research and may not reflect all known risks. This is not medical advice.

Legal Status

Legal Status

🇩🇪DE

Not approved as a medicinal product. Not a controlled substance. Sale as research chemical is a legal grey area.

🇺🇸US

Not approved by the FDA. Not scheduled by the DEA.

🇦🇺AU

Not listed in the TGA scheduling.

🇬🇧UK

Not approved by the MHRA as a medicinal product.

Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.

Community Insights

Community Insights

Publications per Year

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Pricing

Price Comparison

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Mechanism

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Mechanism

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Legal Disclaimer

This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer