PEG-MGF
Pegylated MGF · Pegylated Mechano Growth Factor
PEG-MGF, or pegylated mechano growth factor, is a synthetic peptide derived from the insulin-like growth factor-1 (IGF-1) family, specifically designed to enhance muscle repair and regeneration. Researchers primarily study PEG-MGF for its potential role in modulating the growth hormone-insulin-like growth factor-1 (GH-IGF-1) axis, particularly in the context of muscle hypertrophy and recovery following injury. Key findings from the most cited studies indicate that PEG-MGF may promote satellite cell activation and muscle fiber regeneration, suggesting a mechanism through which it could influence muscle growth. Additionally, studies suggest that while PEG-MGF shows promise in preclinical models, the clinical evidence remains limited, with concerns regarding safety and efficacy in unregulated use. Current research continues to explore its biological effects and the implications of its use in performance enhancement, amidst ongoing debates about the regulatory status of such peptides.
Chemical Profile
Half-Life
Data limited
Data limited
Data limited
Not applicable
Poor bioavailability
Pegylation significantly extends the half-life compared to native MGF, but exact values are variable.
Mechanism of Action
PEG-MGF (pegylated mechano growth factor) primarily acts through the insulin-like growth factor-1 (IGF-1) receptor, activating the IGF-1 signaling pathway, which is crucial for promoting muscle hypertrophy and repair. This interaction stimulates downstream signaling cascades, including the PI3K/Akt pathway, leading to enhanced protein synthesis and inhibition of apoptosis in muscle cells. Although its precise mechanism remains partially understood, it is believed to also influence the mTOR pathway, further contributing to muscle growth and regeneration processes.
Safety & Handling
Research Gaps
No randomized controlled human trials specifically assessing the efficacy and safety of PEG-MGF in performance enhancement have been published. Additionally, the long-term effects of PEG-MGF on endocrine and metabolic health remain unknown, and the precise mechanisms by which PEG-MGF exerts its biological effects are not fully understood.
Solubility
PEG-MGF is soluble in water and aqueous solutions.
Storage & Handling
Lyophilized
Stable for 2+ years at -20°C, 12 months at 4°C
Reconstituted
Use within 14 days when refrigerated at 4°C
Avoid
Avoid repeated freeze-thaw cycles, direct light
Solvent
Bacteriostatic water or sterile saline recommended
Safety information is derived from published research and may not reflect all known risks. This is not medical advice.
Legal Status
🇩🇪DE
Not approved as a medicinal product. Not a controlled substance. Sale as research chemical is a legal grey area.
🇺🇸US
Not approved by the FDA for medical use. Not scheduled by the DEA.
🇦🇺AU
Not approved by the TGA for therapeutic use.
🇬🇧UK
Not approved by the MHRA for medical use.
Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.
Community Insights
Publications per Year
1 totalPrice Comparison
- BESTBiolab ShopUS4mg$37.07Price/mg$9.27/mg
- RCpeptidesEU5mg$48.60Price/mg$9.72/mg
- PeptiLab USAUS2mg$23.99Price/mg$12.00/mg
- Umbrella LabsUS5mg$80.99Price/mg$16.20/mg
- Simple PeptideUS2mg$39.00Price/mg$19.50/mg
| Vendor | Amount | Price | Price/mg | Link |
|---|---|---|---|---|
BESTBiolab ShopUS | 4mg | $37.07 | $9.27/mg | |
RCpeptidesEU | 5mg | $48.60 | $9.72/mg | |
PeptiLab USAUS | 2mg | $23.99 | $12.00/mg | |
Umbrella LabsUS | 5mg | $80.99 | $16.20/mg | |
Simple PeptideUS | 2mg | $39.00 | $19.50/mg |
Top 5 of 12 offers from 20 vendors. Prices updated daily.
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This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer