PEG-MGF
Pegylated MGF · Pegylated Mechano Growth Factor
PEG-MGF, or pegylated mechano growth factor, is a synthetic peptide derived from the insulin-like growth factor-1 (IGF-1) family, specifically designed to enhance muscle repair and growth. Researchers primarily study PEG-MGF for its potential role in modulating the growth hormone-insulin-like growth factor-1 (GH-IGF-1) axis, particularly in the context of muscle regeneration and performance enhancement. Key findings from the most cited studies suggest that PEG-MGF may promote muscle hypertrophy and improve recovery following injury, with some evidence indicating its involvement in cellular signaling pathways related to muscle growth. Current research status reflects a growing interest in understanding the pharmacokinetics, pharmacodynamics, and safety profile of PEG-MGF, especially as it is increasingly encountered in unregulated performance-enhancing contexts.
Chemical Profile
Half-Life
Data limited
Data limited
Data limited
Not applicable
Poor bioavailability
Pegylation significantly extends the half-life compared to native MGF, but exact values are variable.
Mechanism of Action
PEG-MGF (pegylated mechano growth factor) primarily acts through the insulin-like growth factor-1 (IGF-1) receptor, initiating signaling cascades that activate the PI3K/Akt and MAPK/ERK pathways, which are crucial for promoting cellular proliferation, differentiation, and muscle hypertrophy. While its precise mechanisms remain incompletely understood, PEG-MGF is believed to enhance muscle repair and regeneration following mechanical stress by modulating satellite cell activation and promoting myogenesis.
Safety & Handling
Research Gaps
No randomized controlled human trials specifically evaluating the efficacy and safety of PEG-MGF have been published. Additionally, the long-term effects of PEG-MGF on endocrine and metabolic health remain unknown, and the precise mechanisms by which it modulates the GH-IGF-1 axis are not fully understood.
Solubility
PEG-MGF is soluble in water and aqueous solutions.
Storage & Handling
Lyophilized
Stable for 2+ years at -20°C, 12 months at 4°C
Reconstituted
Use within 14 days when refrigerated at 4°C
Avoid
Avoid repeated freeze-thaw cycles, direct light
Solvent
Bacteriostatic water or sterile saline recommended
Safety information is derived from published research and may not reflect all known risks. This is not medical advice.
Legal Status
🇩🇪DE
Not approved as a medicinal product. Not a controlled substance. Sale as research chemical is a legal grey area.
🇺🇸US
Not approved by the FDA for medical use. Not scheduled by the DEA.
🇦🇺AU
Not approved by the TGA for therapeutic use.
🇬🇧UK
Not approved by the MHRA for medical use.
Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.
Community Insights
Publications per Year
1 totalPrice Comparison
- BESTBiolab ShopUS4mg$37.07Price/mg$9.27/mg
- RCpeptidesEU5mg$48.60Price/mg$9.72/mg
- PeptiLab USAUS2mg$23.99Price/mg$12.00/mg
- Simple PeptideUS2mg$39.00Price/mg$19.50/mg
- Ruo BioUS2mg$40.00Price/mg$20.00/mg
| Vendor | Amount | Price | Price/mg | Link |
|---|---|---|---|---|
BESTBiolab ShopUS | 4mg | $37.07 | $9.27/mg | |
RCpeptidesEU | 5mg | $48.60 | $9.72/mg | |
PeptiLab USAUS | 2mg | $23.99 | $12.00/mg | |
Simple PeptideUS | 2mg | $39.00 | $19.50/mg | |
Ruo BioUS | 2mg | $40.00 | $20.00/mg |
Top 5 of 11 offers from 22 vendors. Prices updated daily.
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This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer