Ang(1-7) · Ang 1-7 · ACE2 pathway peptide
Angiotensin 1-7 (Ang-(1-7)) is a heptapeptide derived from the renin-angiotensin system (RAS), specifically formed through the action of angiotensin-converting enzyme 2 (ACE2) on angiotensin II. Researchers primarily study Ang-(1-7) for its potential protective effects against cardiovascular diseases and metabolic disorders, particularly its role in counteracting the harmful effects of angiotensin II. Key findings suggest that Ang-(1-7) exhibits anti-inflammatory properties, improves insulin sensitivity, and enhances lipid profiles, thereby modulating body homeostasis in conditions such as obesity and type 2 diabetes mellitus. Additionally, preclinical evidence indicates that Ang-(1-7) may play a significant role in mitigating vascular aging and promoting endothelial health. Current research continues to explore its mechanisms of action and therapeutic potential within the broader context of cardiovascular health and metabolic regulation.
| Formula | C41H62N12O11 |
| Molecular Weight | 899 g/mol |
| CAS Number | 51833-78-4 |
| PubChem CID | 123805 |
Data limited
Data limited
~30 minutes
Data limited
Poor bioavailability
The short half-life and poor oral bioavailability limit its therapeutic use without modification or alternative delivery methods.
Angiotensin-(1-7) exerts its effects primarily through the Mas receptor (MasR) and the Mas-related G-protein-coupled receptor D (MrgD), activating signaling pathways that promote vasodilation, anti-inflammatory responses, and cytoprotection. It enhances nitric oxide (NO) production via the NO/cGMP pathway, counteracting the vasoconstrictive and proliferative actions of angiotensin II mediated by the AT1 receptor. While the protective mechanisms of Ang-(1-7) are increasingly understood, some aspects of its signaling and interactions remain to be fully elucidated.
5,300
Total Citations
8
Human/RCT
6.3
Avg. Influence
2025
Latest
Researchers observed that the renin-angiotensin system has expanded functions and components, indicating its complex role in regulating cardiovascular health and disease.
Ferrario C M, et al. · Hypertension (Dallas, Tex. : 1979) · 1997
Researchers found that angiotensin-(1-7), a component of the renin-angiotensin system, has effects that counteract the actions of angiotensin II, particularly in lowering blood pressure. This study highlights how angiotensin-(1-7) can promote vasodilation and has potential benefits in managing hypertension.
Key findings
Santos R A, et al. · Regulatory peptides · 2000
The study demonstrated that Ang-(1-7) plays a significant role in counteracting the effects of angiotensin II and mediating various actions within the renin-angiotensin system.
Key findings
Ferreira A J & Santos R A S · Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2005
Researchers observed that angiotensin-(1-7) exerts protective cardiovascular effects, opposing those of angiotensin II, and may serve as a target for new drug development.
Key findings
Ferrario Carlos M · Current opinion in nephrology and hypertension · 2011
Researchers observed that the body has two opposing systems for regulating blood pressure: one that increases it through angiotensin II (Ang II) and another that counteracts it with angiotensin-(1-7) (Ang-(1-7). This study highlights the importance of the Ang-(1-7)/ACE2/Mas pathway in managing blood pressure and kidney health, suggesting that enhancing this pathway could lead to new treatments for cardiovascular diseases.
Key findings
The study demonstrated that angiotensin (1-7) induced significant natriuresis and diuresis in isolated rat kidneys without affecting renal vascular resistance.
Researchers observed that the ACE2-angiotensin-(1-7)-Mas axis plays a critical protective role in cardiovascular health by regulating redox signaling and counteracting the effects of angiotensin II.
The review emphasizes the role of angiotensin-(1-7) as a counter-regulatory peptide within the renin-angiotensin system, highlighting its potential as a target for cardiovascular drug development.
Ferrario C M & Chappell M C · Cellular and molecular life sciences : CMLS · 2004
Researchers observed that angiotensin-(1-7) functions as an antagonist to angiotensin II, suggesting a complex regulatory role of the renin-angiotensin system in tissue homeostasis.
Key findings
The study demonstrated that FGF21 protects against angiotensin II-induced hypertension and vascular dysfunction in mice by activating the ACE2/angiotensin-(1-7) axis.
No randomized controlled human trials have been published to assess the long-term effects of angiotensin-(1-7) and alamandine in humans, particularly concerning their roles in preventing vascular aging and atherosclerosis. Additionally, the specific mechanisms by which angiotensin-(1-7) modulates adipokines and its interactions with other components of the renin-angiotensin system remain unclear, necessitating further investigation.
Solubility
Soluble in water and saline solutions; limited solubility in organic solvents like acetonitrile and DMSO.
Lyophilized
Stable for 2+ years at -20°C, 12 months at 4°C
Reconstituted
Use within 14 days when refrigerated at 4°C
Avoid
Avoid repeated freeze-thaw cycles, direct light
Solvent
Bacteriostatic water or sterile saline recommended
Safety information is derived from published research and may not reflect all known risks. This is not medical advice.
🇩🇪DE
Not approved as a medicinal product. Not a controlled substance. Sale as research chemical is a legal grey area.
🇺🇸US
Not approved by the FDA as a medicinal product. Not scheduled by the DEA.
🇦🇺AU
Not listed in the TGA scheduling. Primarily available for research purposes.
🇬🇧UK
Not approved by the MHRA as a medicinal product. Available for research use.
Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.
Publications per Year
44 total| Vendor | Amount | Price | Price/mg | Link |
|---|---|---|---|---|
BESTPeptaNovaEU | 25mg | $405.00 | $16.20/mg | |
PeptaNovaEU | 0.5mg | $48.60 | $97.20/mg | |
PeptaNovaEU | 5mg | $685.80 | $137.16/mg |
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This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer