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Angiotensin 1-7

Ang(1-7) · Ang 1-7 · ACE2 pathway peptide

Immune System
From$5.08/mgCompare prices
MW
899g/mol
Formula
C41H62N12O11

Angiotensin 1-7 (Ang-(1-7)) is a heptapeptide derived from the renin-angiotensin system (RAS), formed by the enzymatic cleavage of angiotensin II through the action of angiotensin-converting enzyme 2 (ACE2). Researchers primarily study Ang-(1-7) for its potential role in counteracting the effects of angiotensin II, particularly in the context of cardiovascular health and metabolic disorders. Key findings suggest that Ang-(1-7) possesses anti-inflammatory properties, improves lipid profiles, and enhances insulin sensitivity, making it a significant player in regulating body homeostasis. Additionally, preclinical evidence indicates that Ang-(1-7) may protect against vascular aging by promoting endothelial function and reducing fibrosis and oxidative stress. Current research continues to explore its mechanisms of action and potential therapeutic applications in various cardiovascular and metabolic conditions.

Chemical Profile

Chemical Profile

Chemical structure
Chemical Structure
FormulaC41H62N12O11
Molecular Weight899 g/mol
CAS Number51833-78-4
PubChem CID123805

Half-Life

SCSubcutaneous

Data limited

IMIntramuscular

Data limited

IVIntravenous

~30 minutes

INIntranasal

Data limited

POOral

Poor bioavailability

The short half-life and poor oral bioavailability limit its therapeutic use without modification or alternative delivery methods.

Mechanism

Mechanism of Action

Angiotensin-(1-7) exerts its effects primarily through the Mas receptor (MasR) and, to a lesser extent, the MrgD receptor, activating protective signaling pathways that counteract the vasoconstrictive and proliferative actions of angiotensin II. This interaction promotes vasodilation via the nitric oxide (NO)/cGMP pathway, enhances cytoprotective mechanisms, reduces inflammation, and improves endothelial function, thereby playing a crucial role in regulating blood pressure and protecting against vascular aging and metabolic disorders. While the precise molecular mechanisms remain incompletely understood, the involvement of these receptors in mediating the biological actions of Ang-(1-7) is well established.

Research

79 Research Publications

4,322

Total Citations

8

Human/RCT

5.7

Avg. Influence

2025

Latest

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#01

Counterregulatory actions of angiotensin-(1-7).

Ferrario C M, et al. · Hypertension (Dallas, Tex. : 1979) · 1997

ReviewInfluence28.0
514
Researchers found that angiotensin-(1-7), a component of the renin-angiotensin system, has effects that counteract the actions of angiotensin II, particularly in lowering blood pressure. This study highlights how angiotensin-(1-7) can promote vasodilation and has potential benefits in managing hypertension.

Key findings

  1. 01Angiotensin-(1-7) mimics some effects of angiotensin II but does not cause vasoconstriction or increase thirst.
  2. 02The peptide has been observed to lower blood pressure and promote relaxation of blood vessels, especially in hypertensive individuals.
  3. 03Increased levels of angiotensin-(1-7) were correlated with the effectiveness of blood pressure-lowering medications in both humans and animal studies.
PubMed
#02

Angiotensin-(1-7): an update.

Santos R A, et al. · Regulatory peptides · 2000

ReviewInfluence34.0
428
The study demonstrated that angiotensin-(1-7) plays a crucial role in counteracting the effects of angiotensin II within the renin-angiotensin system.

Key findings

  1. 01Researchers observed that Angiotensin-(1-7) is involved in regulating blood pressure and fluid balance.
  2. 02The study highlighted the complex interactions between Ang-(1-7) and other peptides in the renin-angiotensin system.
  3. 03Researchers found that Ang-(1-7) may help mitigate the negative effects of Angiotensin II, which can lead to increased blood pressure.
21-24 mg/kgnot mentioned(juvenile rats)6 weeks24 µg/kg/hnot mentioned(juvenile rats)not mentioned
PubMed
#03

Cardiovascular actions of angiotensin-(1-7).

Ferreira A J & Santos R A S · Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2005

ReviewInfluence15.0
247
Researchers observed that angiotensin-(1-7) exerts cardiovascular effects that are often opposite to those of angiotensin II, suggesting its potential as a target for new cardiovascular drugs.

Key findings

  1. 01Angiotensin-(1-7) is formed from angiotensin II and plays a crucial role in cardiovascular function.
  2. 02Chronic use of ACE inhibitors significantly increases levels of angiotensin-(1-7), which may contribute to their beneficial effects.
  3. 03The discovery of the receptor for angiotensin-(1-7) opens up potential avenues for developing new heart-related medications.
21-24 mg/kgnot mentioned(juvenile rats)6 weeks24 µg/kg/hnot mentioned(juvenile rats)not mentioned
PubMed
#04

ACE2: more of Ang-(1-7) or less Ang II?

Ferrario Carlos M · Current opinion in nephrology and hypertension · 2011

ReviewInfluence13.0
163
Researchers observed that the body has two opposing systems for regulating blood pressure: one that increases it through angiotensin II (Ang II) and another that counteracts it with angiotensin-(1-7) (Ang-(1-7). This study highlights the importance of the Ang-(1-7)/ACE2/Mas pathway in managing blood pressure and kidney health, suggesting that enhancing this pathway could lead to new treatments for cardiovascular diseases.

Key findings

  1. 01Researchers found that angiotensin-(1-7) acts as a natural counterbalance to the harmful effects of angiotensin II.
  2. 02The study observed that the Ang-(1-7)/ACE2/Mas pathway plays a significant role in hypertension and kidney disease progression.
  3. 03Evidence suggests that lower levels of ACE2 may contribute to worsening cardiovascular conditions.
PubMed
#05

Natriuretic action of angiotensin(1-7).

AnimalInfluence5.0
161
The study demonstrated that angiotensin (1-7) induced significant natriuresis and diuresis in isolated rat kidneys without affecting renal vascular resistance.
5 mg/kgnot mentioned(not mentioned)not mentioned6, 24, or 62 μg/kg per hournot mentioned(mouse)10 days85%not mentioned(rat)not mentioned60%not mentioned(rat)not mentioned
PubMed
#06

Angiotensin-(1-7) and the renin-angiotensin system.

ReviewInfluence8.0
157
Researchers observed that angiotensin-(1-7) functions as a counter-regulatory peptide in the renin-angiotensin system, revealing new therapeutic possibilities for cardiovascular diseases.
21-24 mg/kgnot mentioned(juvenile rats)6 weeks24 µg/kg/hnot mentioned(juvenile rats)not mentioned
PubMed
#07

ACE2-angiotensin-(1-7)-Mas axis and oxidative stress in cardiovascular disease.

ReviewInfluence4.0
157
Researchers observed that the ACE2-angiotensin-(1-7)-Mas axis exerts protective effects against oxidative stress in cardiovascular disease, presenting a novel therapeutic target.
21-24 mg/kgnot mentioned(juvenile rats)6 weeks24 µg/kg/hnot mentioned(juvenile rats)not mentioned
PubMed
#08

Novel angiotensin peptides.

Ferrario C M & Chappell M C · Cellular and molecular life sciences : CMLS · 2004

ReviewInfluence9.0
153
Researchers observed that angiotensin-(1-7) antagonizes the effects of angiotensin II, suggesting a complex regulatory role within the renin-angiotensin system.

Key findings

  1. 01Researchers found that angiotensin II can enhance the effects of other substances like catecholamines and cytokines.
  2. 02The study identified angiotensin-(1-7) as a peptide that may inhibit the actions of angiotensin II.
  3. 03This research highlights the potential for a more intricate understanding of how the renin-angiotensin system regulates blood pressure and fluid metabolism.
21-24 mg/kgnot mentioned(juvenile rats)6 weeks24 µg/kg/hnot mentioned(juvenile rats)not mentioned
PubMed
#09

FGF21 Prevents Angiotensin II-Induced Hypertension and Vascular Dysfunction by Activation of ACE2/Angiotensin-(1-7) Axis in Mice.

AnimalInfluence3.0
150
Researchers observed that FGF21 activates the ACE2/angiotensin-(1-7) axis to mitigate angiotensin II-induced hypertension and vascular dysfunction in mice.
21-24 mg/kgnot mentioned(juvenile rats)6 weeks24 µg/kg/hnot mentioned(juvenile rats)not mentioned
PubMed
#10

ACE2, angiotensin-(1–7), and Mas: the other side of the coin.

ReviewInfluence7.0
146
The study demonstrated that the ACE2/angiotensin-(1-7)/Mas axis exerts protective cardiovascular effects, counteracting the harmful actions of angiotensin II.
21-24 mg/kgnot mentioned(juvenile rats)6 weeks24 µg/kg/hnot mentioned(juvenile rats)not mentioned
PubMed
Safety

Safety & Handling

Research Gaps

No randomized controlled human trials have been conducted to assess the long-term effects of angiotensin-(1-7) on vascular aging and metabolic disorders. Additionally, the specific mechanisms by which angiotensin-(1-7) interacts with other components of the renin-angiotensin system, particularly in the context of atherosclerosis and its potential synergistic effects with alamandine, remain unclear.

Solubility

Soluble in water and saline solutions; limited solubility in organic solvents like acetonitrile and DMSO.

Storage & Handling

Lyophilized

Stable for 2+ years at -20°C, 12 months at 4°C

Reconstituted

Use within 14 days when refrigerated at 4°C

Avoid

Avoid repeated freeze-thaw cycles, direct light

Solvent

Bacteriostatic water or sterile saline recommended

Safety information is derived from published research and may not reflect all known risks. This is not medical advice.

Legal Status

Legal Status

🇩🇪DE

Not approved as a medicinal product. Not a controlled substance. Sale as research chemical is a legal grey area.

🇺🇸US

Not approved by the FDA as a medicinal product. Not scheduled by the DEA.

🇦🇺AU

Not listed in the TGA scheduling. Primarily available for research purposes.

🇬🇧UK

Not approved by the MHRA as a medicinal product. Available for research use.

Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.

Community Insights

Community Insights

Publications per Year

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Pricing

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Mechanism

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Mechanism

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Legal Disclaimer

This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer