Ang(1-7) · Ang 1-7 · ACE2 pathway peptide
Angiotensin 1-7, a peptide derived from the renin-angiotensin system (RAS), is recognized for its role in cardiovascular and metabolic regulation. Researchers primarily study it for its potential to counteract the effects of angiotensin II, a peptide associated with hypertension and metabolic disorders. Key findings suggest that the activation of the ACE2/Ang-(1-7)/Mas receptor axis can improve lipid profiles, enhance insulin sensitivity, and reduce inflammation, particularly in the context of obesity and type 2 diabetes. Current research continues to explore the therapeutic implications of Angiotensin 1-7, with a growing body of evidence highlighting its protective effects against various pathologies, including metabolic syndrome and cardiovascular diseases.
| Formula | C41H62N12O11 |
| Molecular Weight | 899 g/mol |
| CAS Number | 51833-78-4 |
| PubChem CID | 123805 |
Data limited
Data limited
~30 minutes
Data limited
Poor bioavailability
The short half-life and poor oral bioavailability limit its therapeutic use without modification or alternative delivery methods.
Angiotensin-(1-7) primarily interacts with the Mas receptor, a G-protein-coupled receptor, and to a lesser extent with the MrgD receptor, activating protective signaling pathways that counteract the effects of angiotensin II. This activation leads to the modulation of lipid and glucose metabolism, reduction of inflammation, and improvement of insulin sensitivity, primarily through pathways such as the NO/cGMP pathway and the inhibition of pro-inflammatory cytokines. While the complete mechanism of action is still being elucidated, the ACE2/Ang-(1-7)/Mas axis is recognized for its role in promoting cardiovascular homeostasis and metabolic health.
7,497
Total Citations
18
Human/RCT
6.2
Avg. Influence
2025
Latest
The study demonstrated that the renin-angiotensin system has expanded functions beyond classical pathways, including local and intracellular actions of angiotensin peptides like angiotensin-(1-7).
Ferrario C M, et al. · Hypertension (Dallas, Tex. : 1979) · 1997
Researchers found that angiotensin-(1-7), a component of the renin-angiotensin system, has effects that counteract the actions of angiotensin II, particularly in lowering blood pressure. This study highlights how angiotensin-(1-7) can promote vasodilation and has potential benefits in managing hypertension.
Key findings
Santos R A, et al. · Regulatory peptides · 2000
Researchers observed that angiotensin-(1-7) plays a significant role in counteracting the effects of angiotensin II within the renin-angiotensin system, influencing cardiovascular physiology.
Key findings
The study demonstrated that angiotensin-converting enzyme 2 (ACE2) regulates cardiovascular function by converting angiotensin II to angiotensin-(1-7), highlighting a novel feedforward mechanism in the renin-angiotensin system.
Researchers observed increased expression of angiotensin-(1-7) and ACE2 in placentas from early pregnancy failures compared to normal pregnancies, suggesting a role in the regulation of placentation.
Ferreira A J & Santos R A S · Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2005
Researchers observed that angiotensin-(1-7) has cardiovascular actions that are often opposite to those of angiotensin II, suggesting its potential as a target for new cardiovascular drugs.
Key findings
Ferrario Carlos M · Current opinion in nephrology and hypertension · 2011
Researchers observed that the body has two opposing systems for regulating blood pressure: one that increases it through angiotensin II (Ang II) and another that counteracts it with angiotensin-(1-7) (Ang-(1-7). This study highlights the importance of the Ang-(1-7)/ACE2/Mas pathway in managing blood pressure and kidney health, suggesting that enhancing this pathway could lead to new treatments for cardiovascular diseases.
Key findings
The study demonstrated that the ACE2-angiotensin-(1-7)-Mas axis plays a critical protective role in cardiovascular health by regulating redox signaling and counteracting the prooxidant effects of angiotensin II.
The study demonstrated that angiotensin (1-7) induced significant natriuresis and diuresis in isolated rat kidneys without affecting renal vascular resistance.
No comprehensive long-term human trials have been conducted to evaluate the sustained effects and safety of Angiotensin-(1-7) in metabolic syndrome treatment. Additionally, the precise molecular mechanisms by which Ang-(1-7) modulates adipokines and inflammation in humans remain poorly understood, particularly in diverse populations with varying metabolic conditions.
Solubility
Soluble in water and saline solutions; limited solubility in organic solvents like acetonitrile and DMSO.
Lyophilized
Stable for 2+ years at -20°C, 12 months at 4°C
Reconstituted
Use within 14 days when refrigerated at 4°C
Avoid
Avoid repeated freeze-thaw cycles, direct light
Solvent
Bacteriostatic water or sterile saline recommended
Safety information is derived from published research and may not reflect all known risks. This is not medical advice.
🇩🇪DE
Not approved as a medicinal product. Not a controlled substance. Sale as research chemical is a legal grey area.
🇺🇸US
Not approved by the FDA as a medicinal product. Not scheduled by the DEA.
🇦🇺AU
Not listed in the TGA scheduling. Primarily available for research purposes.
🇬🇧UK
Not approved by the MHRA as a medicinal product. Available for research use.
Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.
Publications per Year
44 total| Vendor | Amount | Price | Price/mg | Link |
|---|---|---|---|---|
BESTPeptaNovaEU | 25mg | $405.00 | $16.20/mg | |
PeptaNovaEU | 0.5mg | $48.60 | $97.20/mg | |
PeptaNovaEU | 5mg | $685.80 | $137.16/mg |
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This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer