VIP
Vasoactive Intestinal Peptide · Vasoactive Intestinal Polypeptide
- MW
- 3326.8g/mol
- Formula
- C147H237N43O43S
Vasoactive intestinal peptide (VIP) is a 28-amino acid neuropeptide originally isolated from the porcine duodenum, classified as a regulatory peptide involved in various physiological and pathological processes. Researchers primarily study VIP for its roles in neurotransmission, neuroendocrine functions, and its potential implications in neurodegenerative disorders. Key findings indicate that VIP interacts with specific receptors, such as VPAC(1) and VPAC(2), and exhibits significant species differences in pharmacological activity, highlighting the complexity of its mechanisms. Additionally, studies suggest that VIP is involved in critical functions such as cardiac activity, respiration, and digestion, with ongoing research focused on developing stable analogs for therapeutic applications. Current investigations continue to explore VIP's multifaceted roles and its potential as a target for novel peptide-based therapies.
Chemical Profile
| Formula | C147H237N43O43S |
| Molecular Weight | 3326.8 g/mol |
| CAS Number | 37221-79-7 |
| PubChem CID | 53314964 |
| ChEMBL ID | CHEMBL1981592 |
Half-Life
~2 minutes
Poor bioavailability
VIP is rapidly degraded by peptidases, limiting its half-life and bioavailability.
Mechanism of Action
Vasoactive intestinal peptide (VIP) primarily exerts its effects through the VPAC(1) and VPAC(2) receptors, activating intracellular signaling pathways such as the cAMP pathway. VIP plays crucial roles in various biological processes, including neuroendocrine regulation, cardiac function, and gastrointestinal motility. While the pharmacological mechanisms of VIP are well-studied, certain aspects of its action and receptor interactions remain incompletely understood.
Safety & Handling
Research Gaps
There is a lack of comprehensive studies on the long-term effects and safety of VIP-based therapies in human populations, particularly regarding their potential neuroprotective roles in neurodegenerative disorders. Additionally, the specific mechanisms by which VIP interacts with its receptors, especially in the context of VPAC(2), remain inadequately understood, particularly in human systems compared to animal models.
Solubility
VIP is soluble in water and dilute acetic acid but has limited solubility in organic solvents like acetonitrile and DMSO.
Storage & Handling
Lyophilized
Stable for 2+ years at -20°C, 12 months at 4°C
Reconstituted
Use within 14 days when refrigerated at 4°C
Avoid
Avoid repeated freeze-thaw cycles, direct light
Solvent
Bacteriostatic water or sterile saline recommended
Safety information is derived from published research and may not reflect all known risks. This is not medical advice.
Legal Status
🇩🇪DE
Not approved as a medicinal product. Not a controlled substance. Sale as research chemical is a legal grey area.
🇺🇸US
Not approved by the FDA as a medicinal product. Not scheduled by the DEA.
🇦🇺AU
Not listed in the TGA schedules.
🇬🇧UK
Not approved by the MHRA as a medicinal product.
Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.
Community Insights
Publications per Year
48 totalTools
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This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer