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CJC-1295

CJC1295 · CJC-1295 without DAC · CJC-1295 with DAC · DAC:GRF

GH SecretagoguePreclinical
From$4.50/mgCompare prices
MW
3647.2g/mol
Formula
C165H269N47O46

CJC-1295 is a synthetic peptide and a long-acting analog of growth hormone-releasing hormone (GHRH), designed to stimulate the secretion of growth hormone (GH) from the pituitary gland. Researchers primarily study CJC-1295 for its potential to enhance GH and insulin-like growth factor I (IGF-I) levels in healthy adults. Key findings from clinical trials indicate that a single injection of CJC-1295 can lead to significant, sustained increases in plasma GH concentrations by 2- to 10-fold for over six days, and IGF-I levels can remain elevated for up to 28 days after multiple doses. Current research status reflects a growing interest in its pharmacokinetic profile and safety, although further studies are needed to fully understand its therapeutic applications and long-term effects.

Chemical Profile

Chemical Profile

Chemical structure
Chemical Structure
FormulaC165H269N47O46
Molecular Weight3647.2 g/mol
CAS Number446262-90-4
PubChem CID91971820

Half-Life

SCSubcutaneous

~6 to 8 days (with DAC)

INIntranasal

Not applicable

POOral

Poor bioavailability

The presence of DAC in CJC-1295 extends its half-life significantly compared to the form without DAC.

Mechanism

Mechanism of Action

CJC-1295 acts as a long-acting analog of growth hormone-releasing hormone (GHRH), stimulating the GHRH receptor (GHRHR) on pituitary somatotrophs, leading to increased secretion of growth hormone (GH). This, in turn, enhances the insulin-like growth factor 1 (IGF-1) signaling pathway, promoting anabolic processes such as protein synthesis, tissue growth, and regeneration. While the precise downstream mechanisms remain to be fully elucidated, the activation of the PI3K/Akt and mTOR signaling pathways is implicated in mediating these biological effects.

Research

22 Research Publications

527

Total Citations

8

Human/RCT

2.9

Avg. Influence

2023

Latest

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#01

Immunoaffinity purification of peptide hormones prior to liquid chromatography-mass spectrometry in doping controls.

Review
92
Researchers observed that immunoaffinity purification combined with mass spectrometry effectively detects prohibited peptides, including CJC-1295, at low concentrations in doping control samples.
30 or 60 µg/kgsubcutaneous(human)60 or 90 µg/kgsubcutaneous(human)
PubMed
#02

Identification of CJC-1295, a growth-hormone-releasing peptide, in an unknown pharmaceutical preparation.

Henninge John, et al. · Drug testing and analysis · 2010

UnknownInfluence2.0
55
The analysis revealed that an unknown pharmaceutical preparation contained CJC-1295, indicating its potential illicit use in the bodybuilding community.

Key findings

  1. 01The analysis revealed the presence of a 29 amino acid peptide consistent with CJC-1295.
  2. 02CJC-1295 is classified as a prohibited substance by the World Anti-Doping Agency (WADA).
  3. 03There are concerns about the illicit use of this peptide in bodybuilding and athletic circles.
30 or 60 µg/kgsubcutaneous(human)60 or 90 µg/kgsubcutaneous(human)
PubMed
#03

Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults.

Teichman Sam L, et al. · The Journal of clinical endocrinology and metabolism · 2006

HumanInfluence4.0
44
The study demonstrated that subcutaneous administration of CJC-1295 in healthy adults resulted in sustained, dose-dependent increases in growth hormone and insulin-like growth factor I levels for up to 28 days.

Key findings

  1. 01CJC-1295 led to a 2- to 10-fold increase in GH levels for over 6 days.
  2. 02IGF-I levels increased by 1.5- to 3-fold and remained elevated for up to 28 days after multiple doses.
  3. 03The study reported no serious adverse reactions, indicating that CJC-1295 was safe for use in the participants.
30 or 60 µg/kgsubcutaneous(human)60 or 90 µg/kgsubcutaneous(human)
PubMed
#04

Neuronal M3 muscarinic acetylcholine receptors are essential for somatotroph proliferation and normal somatic growth.

AnimalInfluence3.0
40
Researchers observed that treatment with CJC-1295 restored normal growth hormone levels and pituitary size in mutant mice lacking M(3) muscarinic acetylcholine receptors, indicating its role in somatotroph proliferation.
30 or 60 µg/kgsubcutaneous(human)60 or 90 µg/kgsubcutaneous(human)
PubMed
#05

Netnography of Female Use of the Synthetic Growth Hormone CJC-1295: Pulses and Potions.

Van Hout Marie Claire & Hearne Evelyn · Substance use & misuse · 2016

ReviewInfluence6.0
40
Researchers found that female users of CJC-1295 on online forums reported motivations for its use including weight loss and muscle enhancement, alongside concerns about potential adverse health consequences.

Key findings

  1. 01Researchers observed that women use CJC-1295 primarily for weight loss, muscle enhancement, and skin improvement.
  2. 02The study found that forum users were knowledgeable about various performance-enhancing drugs and their effects.
  3. 03Concerns were raised about the unique health risks women may face when using synthetic growth hormones like CJC-1295.
30 or 60 µg/kgsubcutaneous(human)60 or 90 µg/kgsubcutaneous(human)
PubMed
#06

Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog.

AnimalInfluence3.0
38
The study demonstrated that CJC-1295, a long-lasting GRF analog, significantly enhances GH secretion in rats compared to its parent compound.
30 or 60 µg/kgsubcutaneous(human)60 or 90 µg/kgsubcutaneous(human)
PubMed
#07

Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog.

HumanInfluence3.0
36
Researchers observed that CJC-1295 administration increased trough and mean GH secretion and IGF-I production while preserving GH pulsatility in healthy human subjects.
30 or 60 µg/kgsubcutaneous(human)60 or 90 µg/kgsubcutaneous(human)
PubMed
#08

Qualitative identification of growth hormone-releasing hormones in human plasma by means of immunoaffinity purification and LC-HRMS/MS.

Human
34
Researchers observed that a validated method using immunoaffinity purification and mass spectrometry can simultaneously detect multiple GHRHs, including CJC-1295, in human plasma.
30 or 60 µg/kgsubcutaneous(human)60 or 90 µg/kgsubcutaneous(human)
PubMed
#09

Expanded test method for peptides >2 kDa employing immunoaffinity purification and LC-HRMS/MS.

Human
31
The study demonstrated that an immunoaffinity purification method combined with LC-HRMS/MS can effectively detect peptides like CJC-1295 in doping control samples.
30 or 60 µg/kgsubcutaneous(human)60 or 90 µg/kgsubcutaneous(human)
PubMed
#10

Activation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjects.

Sackmann-Sala Lucila, et al. · Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society · 2009

HumanInfluence1.0
31
Researchers observed changes in serum protein profiles following CJC-1295 administration in healthy adults, suggesting potential biomarkers of growth hormone and insulin-like growth factor 1 action.

Key findings

  1. 01Two proteins decreased in intensity after CJC-1295 treatment, indicating potential markers of growth hormone activity.
  2. 02Three proteins increased after treatment, including beta-hemoglobin and albumin fragments, which may relate to insulin-like growth factor 1 levels.
  3. 03The study highlights the need for further research to understand how these proteins connect to growth hormone and insulin-like growth factor 1 functions.
30 or 60 µg/kgsubcutaneous(human)60 or 90 µg/kgsubcutaneous(human)
PubMed
Safety

Safety & Handling

Research Gaps

No randomized controlled human trials specifically evaluating the long-term effects of CJC-1295 on musculoskeletal recovery or performance enhancement have been published. Additionally, the precise mechanisms by which CJC-1295 influences tissue regeneration and its interaction with other therapeutic peptides remain unclear and require further investigation.

Solubility

CJC-1295 is soluble in water and aqueous solutions but has limited solubility in organic solvents like acetonitrile and DMSO.

Storage & Handling

Lyophilized

Stable for 2+ years at -20°C, 12 months at 4°C

Reconstituted

Use within 14 days when refrigerated at 4°C

Avoid

Avoid repeated freeze-thaw cycles, direct light

Solvent

Bacteriostatic water or sterile saline recommended

Safety information is derived from published research and may not reflect all known risks. This is not medical advice.

Legal Status

Legal Status

🇩🇪DE

Not approved as a medicinal product. Not a controlled substance. Sale as research chemical is a legal grey area.

🇺🇸US

Not approved by the FDA for therapeutic use. Not scheduled by the DEA.

🇦🇺AU

Not listed in the TGA's approved medicines. Considered a research chemical.

🇬🇧UK

Not approved by the MHRA for medical use. Available only for research purposes.

Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.

Community Insights

Community Insights

Publications per Year

33 total
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Pricing

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Mechanism

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Mechanism

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Legal Disclaimer

This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer