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CJC-1295

CJC1295 · CJC-1295 without DAC · CJC-1295 with DAC · DAC:GRF

GH SecretagoguePreclinical
From$4.50/mgCompare prices
MW
3647.2g/mol
Formula
C165H269N47O46

CJC-1295 is a synthetic peptide classified as a long-acting analog of growth hormone-releasing hormone (GHRH). Researchers primarily study it for its potential to enhance growth hormone (GH) and insulin-like growth factor I (IGF-I) secretion in healthy adults. Key findings from clinical studies indicate that a single injection of CJC-1295 can lead to sustained, dose-dependent increases in plasma GH concentrations for over six days and IGF-I levels for up to eleven days, with a half-life ranging from 5.8 to 8.1 days. Additionally, multiple doses have shown a cumulative effect, maintaining elevated IGF-I levels for extended periods. Current research continues to explore the safety and efficacy of CJC-1295, particularly in the context of regenerative medicine and athletic performance enhancement.

Chemical Profile

Chemical Profile

Chemical structure
Chemical Structure
FormulaC165H269N47O46
Molecular Weight3647.2 g/mol
CAS Number446262-90-4
PubChem CID91971820

Half-Life

SCSubcutaneous

~6 to 8 days (with DAC)

INIntranasal

Not applicable

POOral

Poor bioavailability

The presence of DAC in CJC-1295 extends its half-life significantly compared to the form without DAC.

Mechanism

Mechanism of Action

CJC-1295 acts as a long-acting analog of growth hormone-releasing hormone (GHRH), stimulating the GHRH receptor on pituitary somatotrophs, which activates the cAMP/PKA signaling pathway leading to increased secretion of growth hormone (GH). This, in turn, enhances insulin-like growth factor I (IGF-I) production via the GH receptor, promoting anabolic processes such as protein synthesis, tissue growth, and regeneration. While the precise mechanisms underlying its prolonged effects are not fully understood, it is known to sustain elevated GH and IGF-I levels, influencing metabolic and regenerative pathways.

Research

22 Research Publications

527

Total Citations

8

Human/RCT

2.4

Avg. Influence

2023

Latest

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#01

Immunoaffinity purification of peptide hormones prior to liquid chromatography-mass spectrometry in doping controls.

In Vitro
90
The study demonstrated that immunoaffinity purification combined with nano-scale liquid chromatography-mass spectrometry effectively detects prohibited peptides, including CJC-1295, at low concentrations in urine samples.
30 or 60 µg/kgsubcutaneous(human)60 or 90 µg/kgsubcutaneous(human)1 week
PubMed
#02

Identification of CJC-1295, a growth-hormone-releasing peptide, in an unknown pharmaceutical preparation.

Henninge John, et al. · Drug testing and analysis · 2010

In VitroInfluence2.0
55
The analysis confirmed the presence of CJC-1295 in an unknown pharmaceutical preparation, indicating its potential use as a performance-enhancing substance in the bodybuilding community.

Key findings

  1. 01The analysis revealed the presence of a 29 amino acid peptide consistent with CJC-1295.
  2. 02CJC-1295 is classified as a prohibited substance by the World Anti-Doping Agency (WADA).
  3. 03There are concerns about the illicit use of this peptide in bodybuilding and athletic circles.
30 or 60 µg/kgsubcutaneous(human)60 or 90 µg/kgsubcutaneous(human)1 week
PubMed
#03

Neuronal M3 muscarinic acetylcholine receptors are essential for somatotroph proliferation and normal somatic growth.

AnimalInfluence3.0
40
Researchers observed that treatment with CJC-1295 restored normal pituitary size and serum growth hormone levels in Br-M3-KO mice, highlighting the critical role of central M(3) receptors in somatic growth regulation.
30 or 60 µg/kgsubcutaneous(human)60 or 90 µg/kgsubcutaneous(human)1 week
PubMed
#04

Netnography of Female Use of the Synthetic Growth Hormone CJC-1295: Pulses and Potions.

Van Hout Marie Claire & Hearne Evelyn · Substance use & misuse · 2016

Case ReportInfluence6.0
40
Researchers found that female users of CJC-1295 discussed its perceived benefits for weight loss and muscle enhancement on online forums, while expressing concerns about dosage and long-term health consequences.

Key findings

  1. 01Researchers observed that women use CJC-1295 primarily for weight loss, muscle enhancement, and skin improvement.
  2. 02The study found that forum users were knowledgeable about various performance-enhancing drugs and their effects.
  3. 03Concerns were raised about the unique health risks women may face when using synthetic growth hormones like CJC-1295.
30 or 60 µg/kgsubcutaneous(human)60 or 90 µg/kgsubcutaneous(human)1 week
PubMed
#05

Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults.

Teichman Sam L, et al. · The Journal of clinical endocrinology and metabolism · 2006

HumanInfluence2.0
39
The study demonstrated that subcutaneous administration of CJC-1295 in healthy adults resulted in sustained, dose-dependent increases in growth hormone and IGF-I levels, with no serious adverse reactions reported.

Key findings

  1. 01CJC-1295 led to a 2- to 10-fold increase in GH levels for over 6 days.
  2. 02IGF-I levels increased by 1.5- to 3-fold and remained elevated for up to 28 days after multiple doses.
  3. 03The study reported no serious adverse reactions, indicating that CJC-1295 was safe for use in the participants.
30 or 60 µg/kgsubcutaneous(human)60 or 90 µg/kgsubcutaneous(human)1 week
PubMed
#06

Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog.

AnimalInfluence3.0
38
The study identified CJC-1295 as a stable and long-lasting growth hormone-releasing factor analog, demonstrating enhanced GH secretion in rats compared to its parent compound.
30 or 60 µg/kgsubcutaneous(human)60 or 90 µg/kgsubcutaneous(human)1 week
PubMed
#07

Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog.

HumanInfluence3.0
35
The study demonstrated that CJC-1295 administration in healthy men increased mean growth hormone levels while preserving pulsatile secretion, with significant increases in trough GH and IGF-I levels.
30 or 60 µg/kgsubcutaneous(human)60 or 90 µg/kgsubcutaneous(human)1 week
PubMed
#08

Qualitative identification of growth hormone-releasing hormones in human plasma by means of immunoaffinity purification and LC-HRMS/MS.

In Vitro
33
The study demonstrated a validated method for detecting multiple GHRHs, including CJC-1295, in human plasma, suitable for sports doping testing.
30 or 60 µg/kgsubcutaneous(human)60 or 90 µg/kgsubcutaneous(human)1 week
PubMed
#09

Expanded test method for peptides >2 kDa employing immunoaffinity purification and LC-HRMS/MS.

In Vitro
31
Researchers observed that an expanded test method effectively detects peptides, including CJC-1295, in doping controls, fulfilling the required performance levels for both blood and urine samples.
30 or 60 µg/kgsubcutaneous(human)60 or 90 µg/kgsubcutaneous(human)1 week
PubMed
#10

Activation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjects.

Sackmann-Sala Lucila, et al. · Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society · 2009

HumanInfluence1.0
31
Researchers observed that CJC-1295 administration in healthy adult men resulted in significant changes in serum protein profiles, suggesting potential biomarkers for GH and IGF-1 action.

Key findings

  1. 01Two proteins decreased in intensity after CJC-1295 treatment, indicating potential markers of growth hormone activity.
  2. 02Three proteins increased after treatment, including beta-hemoglobin and albumin fragments, which may relate to insulin-like growth factor 1 levels.
  3. 03The study highlights the need for further research to understand how these proteins connect to growth hormone and insulin-like growth factor 1 functions.
30 or 60 µg/kgsubcutaneous(human)60 or 90 µg/kgsubcutaneous(human)1 week
PubMed
Safety

Safety & Handling

Research Gaps

No extensive clinical trials specifically evaluating the long-term safety and efficacy of CJC-1295 in diverse populations have been conducted. Additionally, the precise mechanisms by which CJC-1295 influences muscle enhancement, fat loss, and other purported benefits in humans remain unclear, particularly regarding gender-specific responses and potential adverse effects.

Solubility

CJC-1295 is soluble in water and aqueous solutions but has limited solubility in organic solvents like acetonitrile and DMSO.

Storage & Handling

Lyophilized

Stable for 2+ years at -20°C, 12 months at 4°C

Reconstituted

Use within 14 days when refrigerated at 4°C

Avoid

Avoid repeated freeze-thaw cycles, direct light

Solvent

Bacteriostatic water or sterile saline recommended

Safety information is derived from published research and may not reflect all known risks. This is not medical advice.

Legal Status

Legal Status

🇩🇪DE

Not approved as a medicinal product. Not a controlled substance. Sale as research chemical is a legal grey area.

🇺🇸US

Not approved by the FDA for therapeutic use. Not scheduled by the DEA.

🇦🇺AU

Not listed in the TGA's approved medicines. Considered a research chemical.

🇬🇧UK

Not approved by the MHRA for medical use. Available only for research purposes.

Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.

Community Insights

Community Insights

Publications per Year

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Pricing

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Mechanism

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Mechanism

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Legal Disclaimer

This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer