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CJC-1295

CJC1295 · CJC-1295 without DAC · CJC-1295 with DAC · DAC:GRF

GH SecretagoguePreclinical
From$4.50/mgCompare prices
MW
3647.2g/mol
Formula
C165H269N47O46

CJC-1295 is a synthetic analog of growth hormone-releasing hormone (GHRH) classified as a growth hormone secretagogue. Researchers primarily study it for its potential to stimulate the secretion of growth hormone (GH) and insulin-like growth factor I (IGF-I) in healthy adults. Key findings from studies indicate that CJC-1295 administration leads to sustained, dose-dependent increases in plasma GH concentrations for several days, with IGF-I levels remaining elevated for up to 28 days after multiple doses. Current research status highlights ongoing investigations into its pharmacokinetic profile, safety, and potential applications in various therapeutic contexts, although clinical evidence remains limited.

Chemical Profile

Chemical Profile

Chemical structure
Chemical Structure
FormulaC165H269N47O46
Molecular Weight3647.2 g/mol
CAS Number446262-90-4
PubChem CID91971820

Half-Life

SCSubcutaneous

~6 to 8 days (with DAC)

INIntranasal

Not applicable

POOral

Poor bioavailability

The presence of DAC in CJC-1295 extends its half-life significantly compared to the form without DAC.

Mechanism

Mechanism of Action

CJC-1295 acts as a long-acting analog of growth hormone-releasing hormone (GHRH), binding to GHRH receptors on pituitary somatotrophs, which stimulates the secretion of growth hormone (GH). This increase in GH subsequently enhances insulin-like growth factor 1 (IGF-1) levels through the activation of the GH/IGF-1 signaling pathway, promoting anabolic processes such as tissue growth, muscle hypertrophy, and fat metabolism. While the precise details of its mechanism are not fully understood, it is known to influence pathways such as the PI3K/Akt and mTOR signaling pathways, which are critical for cellular growth and metabolism.

Research

28 Research Publications

554

Total Citations

8

Human/RCT

2.3

Avg. Influence

2026

Latest

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#01

Immunoaffinity purification of peptide hormones prior to liquid chromatography-mass spectrometry in doping controls.

In Vitro
89
The study demonstrated that immunoaffinity purification combined with mass spectrometry can effectively detect prohibited peptides like CJC-1295 at low concentrations in doping control samples.
30 or 60 µg/kgsubcutaneous(human)60 or 90 µg/kgsubcutaneous(human)
PubMed
#02

Identification of CJC-1295, a growth-hormone-releasing peptide, in an unknown pharmaceutical preparation.

Henninge John, et al. · Drug testing and analysis · 2010

In VitroInfluence2.0
55
Researchers identified CJC-1295 in an unknown pharmaceutical preparation, confirming its presence as a prohibited substance with potential performance-enhancing effects.

Key findings

  1. 01The analysis revealed the presence of a 29 amino acid peptide consistent with CJC-1295.
  2. 02CJC-1295 is classified as a prohibited substance by the World Anti-Doping Agency (WADA).
  3. 03There are concerns about the illicit use of this peptide in bodybuilding and athletic circles.
30 or 60 µg/kgsubcutaneous(human)60 or 90 µg/kgsubcutaneous(human)
PubMed
#03

Neuronal M3 muscarinic acetylcholine receptors are essential for somatotroph proliferation and normal somatic growth.

AnimalInfluence3.0
40
Researchers observed that CJC-1295 treatment rescued growth deficits in Br-M3-KO mice, indicating its potential role in promoting somatotroph proliferation and normal growth.
30 or 60 µg/kgsubcutaneous(human)60 or 90 µg/kgsubcutaneous(human)
PubMed
#04

Netnography of Female Use of the Synthetic Growth Hormone CJC-1295: Pulses and Potions.

Van Hout Marie Claire & Hearne Evelyn · Substance use & misuse · 2016

In VitroInfluence6.0
40
Researchers found that female users of CJC-1295 on online forums reported its use for weight loss, muscle enhancement, and injury healing, while expressing concerns about potential adverse health effects.

Key findings

  1. 01Researchers observed that women use CJC-1295 primarily for weight loss, muscle enhancement, and skin improvement.
  2. 02The study found that forum users were knowledgeable about various performance-enhancing drugs and their effects.
  3. 03Concerns were raised about the unique health risks women may face when using synthetic growth hormones like CJC-1295.
30 or 60 µg/kgsubcutaneous(human)60 or 90 µg/kgsubcutaneous(human)
PubMed
#05

Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog.

AnimalInfluence3.0
38
The study identified CJC-1295 as a long-lasting growth hormone-releasing factor analog, demonstrating enhanced stability and bioactivity in rat models.
30 or 60 µg/kgsubcutaneous(human)60 or 90 µg/kgsubcutaneous(human)
PubMed
#06

Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults.

Teichman Sam L, et al. · The Journal of clinical endocrinology and metabolism · 2006

HumanInfluence2.0
36
The study demonstrated that subcutaneous administration of CJC-1295 resulted in sustained, dose-dependent increases in growth hormone and insulin-like growth factor I levels in healthy adults.

Key findings

  1. 01CJC-1295 led to a 2- to 10-fold increase in GH levels for over 6 days.
  2. 02IGF-I levels increased by 1.5- to 3-fold and remained elevated for up to 28 days after multiple doses.
  3. 03The study reported no serious adverse reactions, indicating that CJC-1295 was safe for use in the participants.
30 or 60 µg/kgsubcutaneous(human)60 or 90 µg/kgsubcutaneous(human)
PubMed
#07

Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog.

HumanInfluence3.0
34
Researchers observed that CJC-1295 administration preserved pulsatile growth hormone secretion while significantly increasing trough and mean GH levels in healthy men.
30 or 60 µg/kgsubcutaneous(human)60 or 90 µg/kgsubcutaneous(human)
PubMed
#08

Qualitative identification of growth hormone-releasing hormones in human plasma by means of immunoaffinity purification and LC-HRMS/MS.

Animal
33
The study demonstrated that immunoaffinity purification combined with LC-HRMS/MS can successfully detect GHRHs, including CJC-1295, in human plasma, revealing their stability and metabolism.
30 or 60 µg/kgsubcutaneous(human)60 or 90 µg/kgsubcutaneous(human)
PubMed
#09

Doping control analysis of seven bioactive peptides in horse plasma by liquid chromatography-mass spectrometry.

In VitroInfluence1.0
31
The study demonstrated a method for detecting multiple bioactive peptides, including CJC-1295, in horse plasma, achieving limits of detection below 50 pg/mL.
10 mgsubcutaneous(horse)10 mgsubcutaneous(horse)
PubMed
#10

Expanded test method for peptides >2 kDa employing immunoaffinity purification and LC-HRMS/MS.

In Vitro
31
The study demonstrated an expanded test method for detecting peptides over 2 kDa, including CJC-1295, in blood and urine samples, validated for specificity and sensitivity.
30 or 60 µg/kgsubcutaneous(human)60 or 90 µg/kgsubcutaneous(human)
PubMed
Safety

Safety & Handling

Research Gaps

No randomized controlled human trials specifically evaluating the long-term effects of CJC-1295 in diverse populations have been published. Additionally, the precise mechanisms by which CJC-1295 influences muscle enhancement and fat loss, particularly in females, remain unclear and warrant further investigation.

Solubility

CJC-1295 is soluble in water and aqueous solutions but has limited solubility in organic solvents like acetonitrile and DMSO.

Storage & Handling

Lyophilized

Stable for 2+ years at -20°C, 12 months at 4°C

Reconstituted

Use within 14 days when refrigerated at 4°C

Avoid

Avoid repeated freeze-thaw cycles, direct light

Solvent

Bacteriostatic water or sterile saline recommended

Safety information is derived from published research and may not reflect all known risks. This is not medical advice.

Legal Status

Legal Status

🇩🇪DE

Not approved as a medicinal product. Not a controlled substance. Sale as research chemical is a legal grey area.

🇺🇸US

Not approved by the FDA for therapeutic use. Not scheduled by the DEA.

🇦🇺AU

Not listed in the TGA's approved medicines. Considered a research chemical.

🇬🇧UK

Not approved by the MHRA for medical use. Available only for research purposes.

Legal status information is provided for general reference only and may not reflect the most current regulatory changes. Always verify with official government sources before making any decisions.

Community Insights

Community Insights

Publications per Year

26 total
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Pricing

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Mechanism

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Mechanism

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Legal Disclaimer

This page is for informational and research purposes only. All information is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Many substances listed may not be approved for human use and may be subject to drug regulation laws (e.g., AMG in Germany, FDA in the US). PepStack does not encourage the use of any substance on humans. Always consult a qualified healthcare professional before making any health-related decisions. Use of this information is entirely at your own risk. PepStack assumes no liability for the accuracy, completeness, or timeliness of the content provided. Full disclaimer